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Catalyzed Synthesis of Natural Products

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ISBN: 9783039219483 9783039219490 Year: Pages: 82 DOI: 10.3390/books978-3-03921-949-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Organic Chemistry
Added to DOAB on : 2020-01-07 09:08:26
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Abstract

Natural products have been a source of inspiration for chemists and chemical biologists for many years, and have a special relevance in the chemical space. In recent years, several novel synthetic strategies have appeared, such as diversity-oriented synthesis (DOS), biological-oriented synthesis (BiOS), and function-oriented synthesis (FOS), for accessing complex and functionally diverse molecules. In this manner, the synthesis of natural products has evolved towards simpler and ecological methods using biotransformation, combinatorial chemistry, or organocatalysts. In this issue, Prof. Chojnacka shows demonstrates the use of immobilized lipases as catalysts to aid in the synthesis of phosphatidylcholine enriched with myristic acid. Profs. Vila and Pedro used catalysts derived from (S)-mandelic acid to achieve the catalytic enantioselective addition of dimethylzinc to isatins. Prof. Diez shows the possibility of the obtention of 7,8-carvone epoxides in a diastereoselective manner using proline, quinidine, and diphenylprolinol as organocatalysts. A cheap, simple, clean, and scalable method involves the use of deep eutectic mixtures as reaction media, and Profs. Alonso and Guillena describe the use of this methodology for the enantioselective, organocatalyzed ?-amination of 1,3-dicarbonyl compounds. Biotransformations have been one of the methodologies for more efficient synthesis of natural products. Prof. Wu transforms ergostane triterpenoid antcin K using Psychrobacillus sp. Ak 187. Finally, Prof. Kovayashi reviews the total synthesis and biological evaluation of phaeosphaerides. The reader, through this issue, could gain an idea of the new directions that the synthesis of natural products using catalysts will have in the years to come.

Solid Catalysts for the Upgrading of Renewable Sources

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ISBN: 9783038975724 Year: Pages: 226 DOI: 10.3390/books978-3-03897-573-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General) --- Science (General)
Added to DOAB on : 2019-04-05 11:07:22
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The use of solid catalysts for the upgrade of renewable sources gives the opportunity to combine the two main cores of green chemistry, that is, on the one hand, the set-up of sustainable processes and, on the other, the use of biomass-derived materials. Solid catalysts have taken on a leading role in traditional petrochemical processes and could represent a key tool in new biorefinery-driven technologies.

Biocatalysis and Pharmaceuticals: A Smart Tool for Sustainable Development

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ISBN: 9783039217083 9783039217090 Year: Pages: 176 DOI: 10.3390/books978-3-03921-709-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Biotechnology
Added to DOAB on : 2019-12-09 11:49:16
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Biocatalysis, that is, the use of biological catalysts (enzymes, cells, etc.) for the preparation of highly valuable compounds is undergoing a great development, being considered an extremely sustainable approach to undertaking environmental demands. In this scenario, this book illustrates the versatility of applied biocatalysis for the preparation of drugs and other bioactive compounds through the presentation of different research articles and reviews, in which several authors describe the most recent developments in this appealing scientific area. By reading the excellent contributions gathered in this book, it is possible to have an updated idea about new advances and possibilities for a new exciting future.

Amide Bond Activation

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ISBN: 9783039212033 9783039212040 Year: Pages: 466 DOI: 10.3390/books978-3-03921-204-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-08-28 11:21:27
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The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N–C bond activation in electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This monograph on amide bonds offers a broad survey of recent advances in activation of amides and addresses various approaches in the field.

Keywords

fumardiamide --- primaquine --- succindiamide --- Michael acceptor --- biofilm eradication --- antibacterial screening --- antiviral activity --- cytostatic activity --- N,N-dimethylformamide --- DMF --- N,N-dimethylacetamide --- DMAc --- amination --- amidation --- thioamidation --- formylation --- carbonylation --- cyanation --- insertion --- cyclization --- amide --- arynes --- insertion --- activation --- heterocycles --- organic synthesis --- multi-component coupling reaction --- aryl thioamides --- thiourea --- C-H/C-N activation --- C-S formation --- transition-metal-free --- rotational barrier energy --- amide bond --- nuclear magnetic resonance --- kinetic --- density functional theory --- non planar amide --- base-catalyed hydrolysis --- water solvation --- entropy --- transamidation --- amide --- amine --- catalyst --- catalysis --- acylative cross-coupling --- trialkylborane --- amide activation --- palladium --- N-heterocyclic carbene --- ruthenium (Ru) --- N-heterocyclic carbenes (NHCs) --- homogeneous catalysis --- in situ --- amide bonds --- synthesis --- density functional theory --- cis/trans isomerization --- secondary amides --- dipeptides --- steric effects --- tert-butyl --- additivity principle --- amino acid transporters --- amide bond --- gemcitabine prodrug --- metabolic stability --- pancreatic cancer cells --- pharmacokinetics --- peptide bond cleavage --- amide bond resonance --- twisted amides --- enzymes --- metal complexes --- catalysts --- amide C–N bond activation --- nickel catalysis --- amidation --- DFT study --- reaction thermodynamics --- amide resonance --- anomeric effect --- HERON reaction --- pyramidal amides --- physical organic chemistry --- reaction mechanism --- amide --- activation --- amidicity --- carbonylicity --- transamidation --- acyl transfer --- excited state --- Suzuki-Miyaura --- cross-coupling --- aryl esters --- C–O activation --- Pd-catalysis --- amides --- carbanions --- C–H acidity --- nitro-aci tautomerism --- molecular dynamics --- density-functional theory --- alkynes --- C–H bond cleavage --- C–N bond cleavage --- cyclopentadienyl complexes --- N-(1-naphthyl)acetamide --- rhodium --- [2+2+2] annulation --- amide bond --- sulfonamide bond --- alkynes --- addition reaction --- aminoacylation --- aminosulfonylation --- pre-catalysts --- palladium catalysis --- amide bond activation --- ester bond activation --- cross-coupling --- amide bond --- bridged lactams --- twisted amides --- amides --- Winkler-Dunitz parameters --- N–C activation --- hypersensitivity --- nitrogen heterocycles --- distortion --- bridged sultams --- amides --- C-N ? bond cleavage --- sodium --- crown ether --- amide hydrolysis --- model compound --- intramolecular catalysis --- twisted amide --- protease --- intein --- C-H functionalization --- directing groups --- amides --- transition metals --- catalysis

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MDPI - Multidisciplinary Digital Publishing Institute (4)


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english (4)


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2019 (4)