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Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts

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ISBN: 9783038426387 9783038426394 Year: Pages: VI, 250 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics
Added to DOAB on : 2018-06-22 11:29:17
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Abstract

The year 2017 marks the 20th anniversary of the molecular cloning of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1). This seminal discovery has opened up a “hot” new field of basic research and launched drug discovery efforts into the large family (by the latest count, 28 mammalian members and 27 in humans) of TRP ion channels. Indeed, it took less than a decade for the first potent, small molecule TRPV1 antagonists to enter phase 1 clinical trials, closely followed by TRPA1 and TRPM8 antagonists. The literature on TRP channels is immense. TRPV1 alone is a keyword in over 5000 publications searchable in PubMed. Clearly, it is not possible to capture the entire literature in a single thematic issue. Consequently, the selection of articles presented in this book represents a sampling of the literature, and is admittedly subjective. We tried to survey the wide range of human diseases in which TRP channels have been implicated, ranging from chronic pain through asthma and diabetes to cancer, and highlight the channels that appear to hold the greatest promise for therapeutic targeting. With this book, we hope to convince readers that TRP channels constitute a formidable family of potential therapeutic targets that will likely continue to demand attention.

Smart Nanovesicles for Drug Targeting and Delivery

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ISBN: 9783038978947 / 9783038978954 Year: Pages: 198 DOI: 10.3390/books978-3-03897-895-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-06-26 08:44:06
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Nanovesicles are highly-promising systems for the delivery and/or targeting of drugs, biomolecules and contrast agents. Despite the fact that initial studies in this area were performed on phospholipid vesicles, there is an ever-increasing interest in the use of other molecules to obtain smart vesicular carriers focusing on strategies for targeted delivery. These systems can be obtained using newly synthesized smart molecules, or by intelligent design of opportune carriers to achieve specific delivery to the site of action.

Protective and Detrimental Role of Heme Oxygenase-1

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ISBN: 9783039218066 / 9783039218073 Year: Pages: 220 DOI: 10.3390/books978-3-03921-807-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-12-09 11:49:16
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The book “Protective and Detrimental Role of Heme Oxygenase-1”, includes a selection of original research papers and reviews aimed at understanding the dual role (protective and detrimental) of HO-1 and the involved signaling pathways. Original research papers and reviews aimed at the identification of natural molecules or new synthetic compounds able to modulate HO-1 activity/expression help make HO-1 a potential therapeutic target for the amelioration of various diseases.

Keywords

ferroptosis --- heme oxygenase-1 --- iron --- reactive oxygen species --- glutathione --- chemotherapy --- paracetamol --- Myristica fragrans kernels --- heme oxygenase 1 --- liver --- glucocorticoid receptor --- GR --- heme oxygenase 1 --- HO-1 --- prostate cancer --- ANTIGEN presenting cell --- tolerance --- Tet-ON system --- antigen presentation --- analgesia --- carbon monoxide --- heme oxygenase 1 --- inflammatory pain --- locus coeruleus --- nitric oxide --- bilirubin --- Gunn rats --- hyperbilirubinemia --- inflammation --- LPS --- NF-?B --- caloric restriction --- Sirtuin 1 --- Heme Oxygenase-1 --- PGC-1? --- cardiomyopathy --- diabetes mellitus --- Type 1 diabetes mellitus (T1D) --- Pancreatic oxidative damage --- Heme oxygenase-1 (HO-1) inducers --- Caffeic acid phenethyl ester (CAPE) --- Reactive oxygen species (ROS) --- Dimethylarginine dimethylaminohydrolase-1 (DDAH-1) --- Inducible nitric oxide synthase (iNOS) --- Gamma-Glutamyl-Cysteine Ligase (GGCL) --- prostate cancer --- heme oxygenase --- metformin --- apoptosis --- ER stress --- HO-1 activity inhibitor --- carbon monoxide --- lung preservation --- ischemia–reperfusion injury --- high-pressure gas --- Colon cancer --- Betula etnensis Raf. --- oxidative stress --- heme oxigenase-1 --- ferroptosis --- thiol groups --- angiotensin II --- mineralocorticoid receptor --- heme oxygenase 1 --- sirtuin 1 --- adipocytes --- oxidative stress --- heme oxygenase-1 --- atherosclerosis --- coronary artery disease --- peripheral artery disease --- carotid plaque --- heme oxygenase --- endoplasmic reticulum stress --- hemoglobin --- heme --- n/a

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