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Biological Potential and Medical Use of Secondary Metabolites

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ISBN: 9783039211876 / 9783039211883 Year: Pages: 284 DOI: 10.3390/books978-3-03921-188-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-08-28 11:21:27
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Abstract

Many macro and micro species, from terrestrial and aquatic environments, produce structurally unique compounds and, in many countries, still are the primary sources of medicines. In fact, secondary metabolites are an important source of chemotherapeutic agents but are also lead compounds for synthetic modification and the optimization of biological activity. Therefore, the exploitation of secondary metabolites, or their inspired synthetic compounds, offers excellent opportunities for the pharmaceutical industry. This Medicines Special Issue focuses on the great potential of secondary metabolites for therapeutic application. The Special Issue contains 16 articles reporting relevant experimental results, and an overview of bioactive secondary metabolites, their biological effects, and new methodologies that improve and accelerate the process of obtained lead compounds with regard to new drug development. We would like to thank all 83 authors, from all over the world, for their valuable contributions to this Special Issue.

Keywords

Juniperus --- secondary metabolites --- diterpenes --- flavonoids --- lignans --- cytotoxic --- antitumor --- antibacterial --- amentoflavone --- deoxypodophyllotoxin --- frankincense --- Boswellia --- cembranoids --- cneorubenoids --- boswellic acids --- molecular docking --- Scabiosa --- flavonoids --- iridoids --- pentacyclic triterpenoids --- antioxidant --- anti-inflammatory --- antibacterial --- anticancer --- Cordyceps militaris --- xanthine oxidase --- antioxidant --- antibacterial --- cordycepin --- GC-MS --- Artemisia species --- Artemisia vachanica --- artemisinin --- HPLC-PAD --- Tajikistan --- Malus x domestica --- Tuscany --- ancient varieties --- nutraceutics --- antioxidants --- polyphenols --- sugars --- pectin --- defensins --- secondary metabolites --- plant defense --- antimicrobial and anticancer activity --- medicine --- innate immunity --- cannabis --- cannabinoids --- therapeutics --- toxicology --- analytical determination --- legalization --- natural products --- biosynthetic gene clusters --- secondary metabolites --- antiSMASH --- Mitragyna speciosa --- kratom --- secondary metabolites --- therapeutic uses --- toxicology --- analysis --- Maytenus chiapensis --- Celastraceae --- quinonemethide triterpenoids --- pristimerin --- tingenone --- HPLC-PDA --- Ocimum sanctum --- Lamiaceae --- (-)-rabdosiin --- cytotoxic activity --- triterpenoids --- phenolic derivatives --- nanoemulsion --- essential oils --- vector control --- infectious diseases --- TCM --- phytochemistry --- LC-MS/MS --- antioxidant activity --- ABTS --- DPPH --- FRAP --- ascorbic acid --- EGCG --- total phenolics --- antimicrobial activity --- sargaquinoic acid --- sarganaphthoquinoic acid --- antiplasmodial --- malaria --- PPAR-? --- sargahydroquinoic acid --- sarganaphthoquinoic acid --- sargachromenoic acid --- inflammation --- bowel diseases --- secondary metabolites --- biological activities --- medicinal applications --- plants --- seaweeds

Special Issue Dedicated to Late Professor Takuo Okuda. Tannins and Related Polyphenols Revisited: Chemistry, Biochemistry and Biological Activities

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ISBN: 9783038978343 / 9783038978350 Year: Pages: 316 DOI: 10.3390/books978-3-03897-835-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2019-06-26 10:09:00
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Abstract

Antioxidative polyphenols represented by tannins and flavonoids are rich in numerous food sources and traditional natural medicines and currently attracting increased attention in health care and food industries because of their multiple biological activities that are favorable to human health. Commemorating the outstanding achievements on tannins by Dr. Takuo Okuda on the occasion of his passing away in December 2016, his colleagues, friends, and worldwide experts of polyphenol research have contributed 18 papers on their recent study to the Special Issue of Molecules. This book is its reprinted form. This covers reviews of structural features, historical usages, and biological activities of unique class of ellagitannins and condensed tannins, and original articles on the most up-to-date findings on the anticancer effect of green tea catechins, the antivirus effect of tannins comparing with the clinically used drugs, the analytical method of ellagitannins using quantitative NMR, the chemical structures of Hydrangea-blue complex (pigment) and condensed tannins in Ephedra sinica and purple prairie clover, and the relationship of condensed tannins in legumes and grape-marc with methane production in the in vitro ruminant system, and others. This book will be useful to natural product chemists and also to researchers in pharmaceutical and/or food industry.

Keywords

Dittrichia viscosa --- antifungal activities --- Candida spp. --- Malassezia spp. --- Microsporum canis --- Aspergillus fumigates --- Ephedra sinica --- proanthocyanidin --- oligomer --- thiolysis --- phloroglucinolysis --- TDDFT --- ECD --- neuraminidase --- inhibition --- tannins --- oseltamivir carboxylate --- zanamivir --- crystal structure --- molecular interactions --- oenothein B --- ellagitannin --- macrocyclic oligomer --- Onagraceae --- Myrtaceae --- Lythraceae --- antioxidants --- antitumor effect --- immunomodulatory effect --- anti-inflammation --- tannin composition --- purple prairie clover --- conservation method --- protein precipitation --- Escherichia coli --- Cynanchum wilfordii --- phenolic glycoside --- 2-O-?-laminaribiosyl-4-hydroxyacetophenone --- cynandione A --- thin layer chromatography --- Cynanchum auriculatum --- Acacia mearnsii bark --- wattle tannin --- proanthocyanidins --- biological activities --- tannins --- vegetable tanning --- European historic leathers --- colorimetric tests --- spectroscopy --- UV-Vis --- FTIR --- triple-negative breast cancer --- fatty acid synthase --- FASN inhibition --- polyphenolic FASN inhibitors --- (?)-epigallocatechin 3-gallate --- synthetic analogues --- apoptosis --- anticancer activity --- 1H-NMR --- quantitative NMR --- ellagitannin --- Geranium thunbergii --- geraniin --- Aluminum ion --- blue color development --- 5-O-caffeoylquinic acid --- 3-O-glucosyldelphinidin --- Hydrangea macrophylla --- ESI-mass --- metal complex --- Coreopsis lanceolata L. --- chalcone --- flavanone --- flavonol --- aurone --- Horner–Wadsworth–Emmons reaction --- condensed tannin --- bioactivity --- methanogenesis --- grape marc --- fatty acids --- in vitro batch fermentation --- neuroprotection --- PC12 --- NGF --- differentiation --- amyloid-? peptide --- taxanes --- hormesis --- polyphenol --- bamboo leaf extract --- overlay method --- ellagitannin --- structure --- revision --- (?)-epigallocatechin gallate --- immune checkpoint --- interferon-? --- epidermal growth factor --- lung tumor --- proanthocyanidins --- condensed tannins --- thiolysis --- NMR spectroscopy --- ultrahigh-resolution negative mode MALDI-TOF mass spectrometry --- antioxidant --- ORAC assay --- Acacia --- forage legume --- Trapa taiwanensis Nakai --- hydrolysable tannin --- stability --- gallotannin --- ellagitannin

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eng (2)


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2019 (2)