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Extractable and Non-Extractable Antioxidants

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ISBN: 9783039214372 9783039214389 Year: Pages: 234 DOI: 10.3390/books978-3-03921-438-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
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The Special Issue “Extractable and Non-Extractable Antioxidants” gives an updated view on antioxidants—both in their extractable and non-extractable form—in the different food groups, their products thereof, and food preparations as well as byproducts and biomass waste. The potential beneficial properties of these compounds and nutraceutical formulations are described in the various studies covered in this Special Issue.

Keywords

anthocyanins --- polyphenolic compounds --- classic extraction --- ultrasound assisted extraction --- antioxidant capacity --- daidzein --- cyclodextrin --- inclusion complex --- antioxidant activity --- trans-cinnamaldehyde --- ?-cyclodextrin --- self-inclusion --- anti-inflammation --- antioxidant --- Pleurotus ostreatus --- antioxidant activity --- polyphenols --- digestibility --- fermentation --- cereals --- legumes --- Chinese mistletoes --- phenolics --- phenolic contents --- antioxidant activity --- forest residues --- phenolic compounds --- natural antioxidants --- quercitrin --- value-added by-products --- Camellia sinensis --- black teas --- catechins --- antioxidant activity --- LC-ESI-Q-TOF-MS --- principal component analysis --- extractable --- non-extractable --- antioxidant activity --- agglomerative hierarchical clustering --- principal component analysis --- multivariate analysis --- nuclear magnetic spectroscopy --- nitric oxide scavengers --- pre-column HPLC method --- Aloysia triphylla --- phenolics --- antioxidants --- dietary supplements --- botanicals --- bioactive compounds --- antioxidants --- study approach --- integrated food research --- dedicated databases --- dietary assessment. --- biorefinery --- circular economy --- grape seed --- bio-based --- chemometrics --- Cagnulari marc --- Naviglio Extractor® --- green extraction --- endothelial cell --- oxidative stress --- polyphenols --- berries jam --- phenolic acids --- flavonols glycosides --- degradation --- HPLC-ESI/MS --- antioxidant properties --- digestive enzyme --- nutrient --- polymerization --- proanthocyanidins --- eggplant --- flour --- phenolics --- antioxidant activity --- functional ingredient --- sour cherry --- anthocyanins --- extractable polyphenols --- non-extractable polyphenols --- Italian popular recipes --- food composition database --- antioxidant properties --- extractable compounds --- non-extractable compounds --- ferric reducing antioxidant power (FRAP) --- total polyphenol content (TPC) --- n/a

Extraction Strategies to Recover Bioactive Compounds, Incorporation into Food and Health Benefits

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ISBN: 9783039289691 / 9783039289707 Year: Pages: 94 DOI: 10.3390/books978-3-03928-970-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
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We are pleased to present this book, which is a reprint of articles from the Special Issue entitled “Extraction Strategies to Recover Bioactive Compounds, Incorporation into Food, and Health Benefits” published online in the open access journal Foods (ISSN 2304-8158) from 2019 to 2020 (available at: https://www.mdpi.com/journal/foods/special_issues/extraction). Firstly, this book gathers studies addressing several strategies applied to obtain bioactive products and extracts, not only from food matrices but also from agri-food byproducts, which can serve as new natural additives, nutraceuticals, and functional ingredients for pharmaceutical, cosmetics, and food industries. In particular, free and bound phenolic compounds are explored in buckwheat, sesame, and olive leafy byproducts. Overall, these studies outline new valorization methods and offer new opportunities for alternative practices in the agro-industrial sector that help to migrate toward a circular bioeconomy model. This book also presents studies that predict bioactive components in fruits through mathematical tools and support the formulation of a novel beverage rich in resveratrol, a phenolic compound whose bioactivity is well recognized.

Peroxiredoxin 6 as a Unique Member of the Peroxiredoxin Family

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ISBN: 9783038979340 9783038979357 Year: Pages: 152 DOI: 10.3390/books978-3-03897-935-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-06-26 08:44:06
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The peroxiredoxin family was discovered approximately 30 years ago and is now recognized as one of the most important families of enzymes related to antioxidant defense and cellular signaling. Peroxiredoxin 6 shares the basic enzymatic functions that characterize this family, but also exhibits several unique and crucial activities. These include the ability to reduce phospholipid hydroperoxides, phospholipase A2 activity, and an acyl transferase activity that is important in phospholipid remodeling. This book describes the available models for investigating the unique functions of PRDX6 and its role in normal physiological function, as well its roles in the pathophysiology of diseases including cancer, diseases of the eye, and male fertility.

Biocatalysis and Pharmaceuticals: A Smart Tool for Sustainable Development

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ISBN: 9783039217083 9783039217090 Year: Pages: 176 DOI: 10.3390/books978-3-03921-709-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Biotechnology
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Biocatalysis, that is, the use of biological catalysts (enzymes, cells, etc.) for the preparation of highly valuable compounds is undergoing a great development, being considered an extremely sustainable approach to undertaking environmental demands. In this scenario, this book illustrates the versatility of applied biocatalysis for the preparation of drugs and other bioactive compounds through the presentation of different research articles and reviews, in which several authors describe the most recent developments in this appealing scientific area. By reading the excellent contributions gathered in this book, it is possible to have an updated idea about new advances and possibilities for a new exciting future.

Chemical/Instrumental Approaches to the Evaluation of Wine Chemistry

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ISBN: 9783039287345 / 9783039287352 Year: Pages: 148 DOI: 10.3390/books978-3-03928-735-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Analytical Chemistry
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Wine is a widely consumed beverage due to its unique and pleasant sensory properties. Wine is composed of more than one thousand chemical compounds (e.g., alcohols, esters, acids, terpenoids, phenolic compounds, flavonoids, anthocyanins, minerals, and vitamins, among others) resulting from several chemical and biochemical processes. Microextraction techniques in tandem with high-resolution analytical instruments have been applied by wine researchers to expand the knowledge of wine’s chemical composition with the purposes of improving wine quality, supporting winemaker decisions related to the winemaking process, and guaranteeing the authenticity of wine. As a result, we proposed “Chemical/Instrumental Approaches to the Evaluation of Wine Chemistry” as a topic for a Special Issue in Molecules. This Special Issue aims to provide an update on state-of-the-art extraction procedures (e.g., solid-phase microextraction (SPME)) and analytical tools (e.g., nuclear magnetic resonance (NMR), inductively coupled plasma mass spectrometry (ICP-MS), ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS)), emphasizing their use as suitable platforms for the establishment of the chemical composition of wine (volatomic profile, antioxidants, phenolic pattern, and elemental composition, among others). Information related to wine sensorial properties, contaminants, authenticity, and chemometric tools used for data treatment are described in this Issue.

Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis

Authors: --- ---
ISBN: 9783039210848 9783039210855 Year: Pages: 308 DOI: 10.3390/books978-3-03921-085-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Chemical Engineering
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The present Special Issue, “Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis”, aims to collect and to disseminate some of the most significant and recent contributions in the interdisciplinary area of innovative extraction procedures from complex matrices followed by validated analytical methods using hyphenated instrument configurations to support the optimization of the whole process and the scale-up possibility

Keywords

branched-chain keto acids --- serum --- muscle --- HPLC-Q-TOF/MS --- wood --- odor --- volatile organic compounds --- gas chromatography-olfactometry --- Wuyi Rock tea --- quality --- UPLC-QTOF MS --- UPLC-QqQ MS --- metabolite profiling --- metabolomics --- cluster analysis --- cultivars --- Lycium ruthenicun --- flavonoid --- ruthenicunoid A --- SIRT1 --- Asphodeline lutea --- HPLC-PDA --- heavy metals --- tyrosinase --- diabetes --- neurodegenerative disease --- color analysis --- pigments --- MAE --- HPLC-PDA --- SFE --- Thymus algeriensis --- rare earth elements --- flow injection --- inductively coupled plasma-mass spectrometry --- seawater --- Hericium erinaceuns mycelium --- high-speed counter-current chromatography (HSCCC) --- genistein --- daidzein --- Fe3O4 --- modification --- alginate --- alkaloid --- ultrasound assisted extraction --- gelatin --- actinidin --- bovine hide --- physicochemical properties --- gel strength --- Semen Cuscutae --- ultra-high-performance liquid chromatography coupled to electrospray ionization mass spectrometry --- chlorogenic acids --- flavonoids --- steamed Panax notoginseng --- saponins --- extraction --- optimization --- antioxidant activity --- response surface methodology --- hematopoiesis --- microwave processing --- response surface methodology --- minor ginsenosides --- blood-enriching activity --- hemostatic activity --- ionic liquids --- sample preparation --- microextraction --- solid-phase microextraction --- dispersive liquid-liquid microextraction --- single-drop microextraction --- stir bar sorptive extraction --- stir cake sorptive extraction --- rosuvastatin --- metformin --- HILIC --- LC-MS --- therapeutic drug monitoring --- oolong tea --- Tieguanyin tea cultivar --- metabolite profiling --- UPLC-QTOF MS --- metabolomics --- Ajuga genevensis --- near-infrared spectroscopy --- dry extract --- fluid bed process --- microNIR --- in-line monitoring --- total polyphenolic content --- antioxidant --- flavonoids --- mouse melanoma B16 cells --- Panax notoginseng --- surfactant --- n/a --- ultra-high-performance liquid chromatography tandem mass spectrometry --- GHB --- GHB glucuronide --- nails --- endogenous values --- walnut septum --- polyphenols --- phytosterols --- HPLC-MS/MS --- Ultra-Turrax extraction --- biological activity --- antioxidant activity --- experimental design --- optimization --- phytochemicals

Natural Products and Drug Discovery

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ISBN: 9783039287468 / 9783039287475 Year: Pages: 392 DOI: 10.3390/books978-3-03928-747-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
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Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.

Keywords

cytotoxicity-guided --- phenolic derivatives --- Dryopteris fragrans --- chemical derivatization --- immuno-regulation activity --- Imperata cylindrica --- HPLC --- ESI-MS/MS --- growth inhibitory activity --- cancer --- cardamonin --- antinociceptive --- TRPV1 --- glutamate --- opioid --- siphonous green algae --- sulfated coumarins --- Dasycladus vermicularis --- isolation and quantification --- Orobanche s.l. --- Orobanchaceae --- Lamiales --- natural products --- secondary metabolites --- phenylpropanoid glycosides --- phenylethanoid glycosides --- bioactivities of natural products --- chemosystematics --- FSE --- T2DM --- GLUT4 --- Ca2+ --- L6 cell --- marine peptides --- proliferation --- migration --- angiogenesis --- zebrafish --- antioxidant activity --- flavonoids --- isoflavones --- phenolics --- proanthocyanidins --- Trifolium --- Leea indica --- HPLC-ESI-microTOF-Q-MS/MS --- phenolics --- dihydrochalcones --- Humulus lupulus --- prenylated phenolic compounds --- antimicrobial agents --- methicillin-resistant Staphylococcus aureus --- Leishmania mexicana mexicana --- Trypanosoma brucei brucei --- Astragalus boeticus L. --- spectroscopic analysis --- cytotoxic activity --- human colon cancer cell lines --- acetylated astragalosides --- Fabaceae --- aging --- cancer --- cardiovascular disease --- dementia --- diabetes --- inflammation --- oxidative stress --- Harpagophytum procumbens --- devil’s claw --- harpagoside --- spagyric tincture --- antioxidant activity --- Cleistocalyx operculatus --- 2?,4?-dihydroxy-6?-methoxy-3?,5?-dimethylchalcone (DMC) --- pPancreatic cancer --- PANC-1 --- ACE inhibitory peptide --- antihypertensive --- bioactive peptides --- hypertension --- marine resources --- terpenes --- terpenoids --- antimicrobial resistance --- synergy --- Phyllanthus orbicularis --- C-glycoside --- flavonoid --- natural products --- traditional medicine --- Cuba --- Phyllanthus chamacristoides --- chromatography --- mass spectrometry --- NMR --- circular dichroism --- stereochemistry --- Fideloside --- cytokines --- anti-inflammatory activity --- metabolomics --- multivariate data analysis --- molecular network --- Bacopa monnieri --- LC-MS --- diabetic neuropathy --- neuropathic pain --- glucosinolates --- Eruca sativa --- glucoerucin --- H2S --- Kv7 potassium channels --- artemisinin --- Physcomitrella patens --- sesquiterpenoids --- malaria --- biotechnology --- ketamine --- psychosis --- cerebellum --- celastrol --- oxidative stress --- NADPH oxidases --- n/a

Synthesis and Applications of Biopolymer Composites

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ISBN: 9783039211326 9783039211333 Year: Pages: 312 DOI: 10.3390/books978-3-03921-133-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Chemical Engineering
Added to DOAB on : 2019-08-28 11:21:27
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This book, as a collection of 17 research articles, provides a selection of the most recent advances in the synthesis, characterization, and applications of environmentally friendly and biodegradable biopolymer composites and nanocomposites. Recently, the demand has been growing for a clean and pollution-free environment and an evident target regarding the minimization of fossil fuel usage. Therefore, much attention has been focused on research to replace petroleum-based commodity plastics by biodegradable materials arising from biological and renewable resources. Biopolymers—polymers produced from natural sources either chemically from a biological material or biosynthesized by living organisms—are suitable alternatives for addressing these issues due to their outstanding properties, including good barrier performance, biodegradation ability, and low weight. However, they generally possess poor mechanical properties, a short fatigue life, low chemical resistance, poor long-term durability, and limited processing capability. In order to overcome these deficiencies, biopolymers can be reinforced with fillers or nanofillers (with at least one of their dimensions in the nanometer range). Bionanocomposites are advantageous for a wide range of applications, such as in medicine, pharmaceutics, cosmetics, food packaging, agriculture, forestry, electronics, transport, construction, and many more.

Keywords

nanocellulose --- protease sensor --- human neutrophil elastase --- peptide-cellulose conformation --- aerogel --- glycol chitosan --- ?-tocopherol succinate --- amphiphilic polymer --- micelles --- paclitaxel --- chitosan --- PVA --- nanofibers --- electrospinning --- nanocellulose --- carbon nanotubes --- nanocomposite --- conductivity --- surfactant --- Poly(propylene carbonate) --- thermoplastic polyurethane --- compatibility --- toughness --- biopolyester --- compatibilizer --- cellulose --- elastomer --- toughening --- biodisintegration --- heat deflection temperature --- biopolymers composites --- MgO whiskers --- PLLA --- in vitro degradation --- natural rubber --- plasticized starch --- polyfunctional monomers --- physical and mechanical properties --- cross-link density --- water uptake --- chitosan --- deoxycholic acid --- folic acid --- amphiphilic polymer --- micelles --- paclitaxel --- silk fibroin --- glass transition --- DMA --- FTIR --- stress-strain --- active packaging materials --- alginate films --- antimicrobial agents --- antioxidant activity --- biodegradable films --- essential oils --- polycarbonate --- thermal decomposition kinetics --- TG/FTIR --- Py-GC/MS --- wheat gluten --- potato protein --- chemical pre-treatment --- structural profile --- tensile properties --- biocomposites --- natural fibers --- poly(3-hydroxybutyrate-3-hydroxyvalerate) --- biodegradation --- impact properties --- chitin nanofibrils --- poly(lactic acid) --- nanocomposites --- bio-based polymers --- natural fibers --- biomass --- biocomposites --- fiber/matrix adhesion --- bio-composites --- mechanical properties --- poly(lactic acid) --- cellulose fibers --- n/a

Biological Potential and Medical Use of Secondary Metabolites

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ISBN: 9783039211876 9783039211883 Year: Pages: 284 DOI: 10.3390/books978-3-03921-188-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-08-28 11:21:27
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Many macro and micro species, from terrestrial and aquatic environments, produce structurally unique compounds and, in many countries, still are the primary sources of medicines. In fact, secondary metabolites are an important source of chemotherapeutic agents but are also lead compounds for synthetic modification and the optimization of biological activity. Therefore, the exploitation of secondary metabolites, or their inspired synthetic compounds, offers excellent opportunities for the pharmaceutical industry. This Medicines Special Issue focuses on the great potential of secondary metabolites for therapeutic application. The Special Issue contains 16 articles reporting relevant experimental results, and an overview of bioactive secondary metabolites, their biological effects, and new methodologies that improve and accelerate the process of obtained lead compounds with regard to new drug development. We would like to thank all 83 authors, from all over the world, for their valuable contributions to this Special Issue.

Keywords

Juniperus --- secondary metabolites --- diterpenes --- flavonoids --- lignans --- cytotoxic --- antitumor --- antibacterial --- amentoflavone --- deoxypodophyllotoxin --- frankincense --- Boswellia --- cembranoids --- cneorubenoids --- boswellic acids --- molecular docking --- Scabiosa --- flavonoids --- iridoids --- pentacyclic triterpenoids --- antioxidant --- anti-inflammatory --- antibacterial --- anticancer --- Cordyceps militaris --- xanthine oxidase --- antioxidant --- antibacterial --- cordycepin --- GC-MS --- Artemisia species --- Artemisia vachanica --- artemisinin --- HPLC-PAD --- Tajikistan --- Malus x domestica --- Tuscany --- ancient varieties --- nutraceutics --- antioxidants --- polyphenols --- sugars --- pectin --- defensins --- secondary metabolites --- plant defense --- antimicrobial and anticancer activity --- medicine --- innate immunity --- cannabis --- cannabinoids --- therapeutics --- toxicology --- analytical determination --- legalization --- natural products --- biosynthetic gene clusters --- secondary metabolites --- antiSMASH --- Mitragyna speciosa --- kratom --- secondary metabolites --- therapeutic uses --- toxicology --- analysis --- Maytenus chiapensis --- Celastraceae --- quinonemethide triterpenoids --- pristimerin --- tingenone --- HPLC-PDA --- Ocimum sanctum --- Lamiaceae --- (-)-rabdosiin --- cytotoxic activity --- triterpenoids --- phenolic derivatives --- nanoemulsion --- essential oils --- vector control --- infectious diseases --- TCM --- phytochemistry --- LC-MS/MS --- antioxidant activity --- ABTS --- DPPH --- FRAP --- ascorbic acid --- EGCG --- total phenolics --- antimicrobial activity --- sargaquinoic acid --- sarganaphthoquinoic acid --- antiplasmodial --- malaria --- PPAR-? --- sargahydroquinoic acid --- sarganaphthoquinoic acid --- sargachromenoic acid --- inflammation --- bowel diseases --- secondary metabolites --- biological activities --- medicinal applications --- plants --- seaweeds

Curcumin in Health and Disease

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ISBN: 9783039214495 9783039214501 Year: Pages: 274 DOI: 10.3390/books978-3-03921-450-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-12-09 11:49:15
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The plant-derived polyphenol curcumin has been used in promoting health and combating disease for thousands of years. Its therapeutic effects have been successfully utilized in Ayurvedic and Traditional Chinese Medicine in order to treat inflammatory diseases. Current results from modern biomolecular research reveal the modulatory effects of curcumin on a variety of signal transduction pathways associated with inflammation and cancer. In this context, curcumin’s antioxidant, anti-inflammatory, anti-tumorigenic, and even anti-metastatic activities are discussed. On the cellular level, the reduced activity of several transcription factors (such as NFkB or AP-1) and the suppression of inflammatory cytokines, matrix degrading enzymes, metastasis related genes and even microRNAs are reported. On functional levels, these molecular effects translate into reduced proliferative, invasive, and metastatic capacity, as well as induced tumor cell apoptosis. All these effects have been observed not only in vitro but also in animal models. In combination with anti-neoplastic drugs like Taxol, kinase inhibitors, and radiation therapy, curcumin potentiates the drugs’ therapeutic power and can protect against undesired side effects. Natural plant-derived compounds like curcumin have one significant advantage: They do not usually cause side effects. This feature qualifies curcumin for primary prevention in healthy persons with a predisposition to cancer, arteriosclerosis, or chronic inflammatory diseases. Nonetheless, curcumin is considered safe, although potential toxic effects stemming from high dosages, long-term intake, and pharmacological interactions with other compounds have yet to be assessed. This Special Issue examines in detail and updates current research on the molecular targets, protective effects, and modes of action of natural plant-derived compounds and their roles in the prevention and treatment of human diseases.

Keywords

brain ischemia --- curcumin --- Alzheimer’s disease --- neurodegeneration --- amyloid --- tau protein --- autophagy --- mitophagy --- apoptosis --- genes --- glioblastoma multiforme --- autophagy --- mitophagy --- curcumin --- chaperone-mediated autophagy --- Akt/mTOR signaling --- transmission electron microscopy --- Curcuma longa --- turmeric tuber --- Zingiberaceae --- TLC bioautography --- antimicrobial agents --- ImageJ --- TLC-MS --- hydrostatic counter-current chromatography --- centrifugal partition chromatography --- curcumin --- death receptor --- apoptosis --- curcumin --- anticancer --- structure activity relationship --- cellular pathway --- mechanism of action --- delivery system --- wound --- wound healing --- diet --- nutrition --- micronutrients --- macronutrients --- curcumin --- amino-acids --- vitamins --- minerals --- curcumin --- oxidative metabolites --- inflamm-aging --- cancer --- metabolic reprogramming --- direct protein binding --- IL-17 --- STAT3 --- SHMT2 --- ageing --- anti-cancer --- autophagy --- microbiota --- senescence --- senolytics --- curcumin --- transthyretin --- amyloidosis --- protein aggregation --- protein misfolding --- drug discovery --- curcumin --- renal cell cancer --- tumor growth --- tumor proliferation --- cell cycling --- curcumin --- reflux esophagitis --- gastroprotection --- gastric ulcer --- Helicobacter pylori --- gastric cancer --- curcumin --- complementary medicine --- cancer treatment --- supportive care --- antioxidants --- anti-inflamation --- ulcerative colitis --- Crohn’s disease --- necrotizing enterocolitis --- curcumin --- inflammatory bowel disease --- curcumin --- silica --- chitosan --- nanoparticles --- anti-tumor --- antioxidant activity --- n/a

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