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Physiology and Pathophysiology of Musculoskeletal Aging

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193905 Year: Pages: 87 DOI: 10.3389/978-2-88919-390-5 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Physiology
Added to DOAB on : 2015-12-03 13:02:24
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Abstract

We live in a world with an ever-increasing aging population. This aging population is predicted to place a huge financial burden on healthcare systems around the world. Understanding healthy ageing is a key research priority, along with a better understanding of the pathophysiology of ageing that occurs in a number of age related diseases, such as arthritis. By gaining a better understanding of healthy musculoskeletal ageing we can provide better care and new therapies for common musculoskeletal problems. This Research Topic is intended to bring together basic researchers and clinicians working in the broad area of musculoskeletal ageing. The topic includes mechanisms of healthy ageing in the musculoskeletal system, which we define as skeletal muscle and the synovial joint, particularly constituent structures including articular cartilage, subchondral bone tendon and ligament. A particular focus of this Research Topic is dietary modulation of musculoskeletal ageing.

Research of Pathogenesis and Novel Therapeutics in Arthritis

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ISBN: 9783038970651 / 9783038970668 Year: Pages: 366 DOI: 10.3390/books978-3-03897-066-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-06-26 08:44:06
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Arthritis has a high prevalence globally and includes over 100 different types, the most common of which are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. The exact etiology of arthritis remains unclear and no cure exists. Anti-inflammatory drugs are commonly used in the treatment of arthritis but are associated with significant side effects. Novel modes of therapy and additional prognostic biomarkers are urgently needed for arthritis patients. This book summarizes and discusses the global picture of the current understanding of arthritis.

Keywords

biosimilars --- Th9 lymphocytes --- rheumatoid arthritis --- infliximab --- rheumatoid arthritis --- bone erosion --- osteoblasts --- next-generation sequencing --- bioinformatics --- microRNA --- messenger RNA --- osteoarthritis --- cell signaling --- IL1? --- WNT --- antagonists --- computational modeling --- nitric oxide --- clodronate --- gene expression --- osteoarthritis --- progenitor cells --- SOX9 --- spondyloarthropathies --- inflammation --- mesenchymal stem cells --- visfatin --- IL-6 --- TNF-? --- osteoarthritis --- miR-199a-5p --- Epstein-Barr virus --- glycoprotein 42 --- rheumatoid arthritis --- shared epitope --- triptolide --- rheumatoid arthritis --- basic research --- clinical translation --- osteoarthritis (OA) --- articular cartilage --- molecular pathology --- therapeutics --- rheumatoid arthritis --- antibodies --- collagen --- glycosylation --- disease pathways --- therapy --- experimental arthritis --- TNF? --- etanercept --- infliximab --- adalimumab --- certolizumab pegol --- golimumab --- rheumatoid arthritis --- therapeutic antibody --- structure --- fraxinellone --- collagen-induced arthritis --- rheumatoid arthritis --- inflammatory arthritis --- osteoclastogenesis --- sclareol --- rheumatoid arthritis --- synovial cell --- collagen --- mice --- cytokines --- Th17 --- MAPK --- arthritis --- osteoarthritis --- rheumatoid arthritis --- small-molecule inhibitor --- chondrocytes --- tumor necrosis factor-alpha --- inflammation --- rheumatoid arthritis --- osteoarthritis --- angiogenesis --- cytokines --- chemokines --- early osteoarthritis --- articular cartilage --- proliferation --- fibroblast growth factor 2 --- mitogen activated protein kinase --- transforming growth factor ? --- SMA- and MAD-related protein --- interleukin --- nuclear factor kappa B --- miRNA --- adjuvant arthritis --- arthritis --- biomarkers --- celastrol --- inflammation --- microRNA --- miRNA --- rat --- rheumatoid arthritis --- Traditional Chinese medicine --- tripterine --- triterpenoid --- spinal fusion --- biological --- osteoblast --- osteoclast --- bisphosphonate --- parathyroid hormone --- bone morphogenetic protein --- receptor activator of nuclear factor ?B --- stem cell --- drug delivery system --- anticitrullinated peptide antibodies --- antirheumatic drug --- autoimmune --- disease-modifying --- immunology --- pathology --- rheumatoid factor --- rheumatoid arthritis --- osteoarthritis --- adipokines --- obesity --- rheumatoid arthritis --- osteoarthritis --- anti-arthritis --- biomarkers

Dynamical Models of Biology and Medicine

Authors: --- --- ---
ISBN: 9783039212170 / 9783039212187 Year: Pages: 294 DOI: 10.3390/books978-3-03921-218-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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Abstract

Mathematical and computational modeling approaches in biological and medical research are experiencing rapid growth globally. This Special Issue Book intends to scratch the surface of this exciting phenomenon. The subject areas covered involve general mathematical methods and their applications in biology and medicine, with an emphasis on work related to mathematical and computational modeling of the complex dynamics observed in biological and medical research. Fourteen rigorously reviewed papers were included in this Special Issue. These papers cover several timely topics relating to classical population biology, fundamental biology, and modern medicine. While the authors of these papers dealt with very different modeling questions, they were all motivated by specific applications in biology and medicine and employed innovative mathematical and computational methods to study the complex dynamics of their models. We hope that these papers detail case studies that will inspire many additional mathematical modeling efforts in biology and medicine

Keywords

hemodynamic model --- microcirculation load --- liquid-solid-porous media seepage coupling --- 2-combination --- graphical representation --- cell-based vector --- numerical characterization --- phylogenetic analysis --- intraguild predation --- random perturbations --- persistence --- stationary distribution --- global asymptotic stability --- quorum sensing --- chemostat --- mathematical model --- differential equations --- delay --- bifurcations --- dynamical system --- numerical simulation --- predator-prey model --- switched harvest --- limit cycle --- rich dynamics --- algae growth models --- uncertainty quantification --- asymptotic theory --- bootstrapping --- model comparison tests --- Raphidocelis subcapitata --- Daphnia magna --- spotting --- wildfire --- transport equations --- spotting distribution --- obesity --- mechano-electrochemical model --- articular cartilage --- cartilage degeneration --- cartilage loading --- optimal control --- hepatitis B --- delay differential equations (DDE) --- immune response --- drug therapy --- dynamic model --- flocculation --- global stability --- uniform persistence --- epidermis --- mathematical model --- bacterial inflammation --- bacterial competition --- chronic myeloid leukemia --- tyrosine kinase inhibitors --- immunomodulatory therapies --- combination therapy --- equilibrium points --- mathematical modeling --- prostate cancer --- androgen deprivation therapy --- data fitting --- generalized pseudo amino acid composition --- numerical characterization --- phylogenetic analysis --- identification of DNA-binding proteins --- n/a

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