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Synthetic and Biosynthetic Approaches to Marine Natural Products

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ISBN: 9783039284665 9783039284672 Year: Pages: 182 DOI: 10.3390/books978-3-03928-467-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-04-07 23:07:09
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Marine natural products containing a heterocyclic moiety in their structure are present in a wide variety of sponges, corals, algae, and fungi. Many of them show important biological activities such as cytotoxic properties against several cancer cell lines. Their challenging chemical structures have attracted the attention of many researchers who have developed various synthetic approaches. This Special Issue presents some examples of new synthetic or biosynthetic methodologies to access this type of marine natural drug.

Intrinsically Biocompatible Polymer Systems

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ISBN: 9783039284207 9783039284214 Year: Pages: 270 DOI: 10.3390/books978-3-03928-421-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Materials
Added to DOAB on : 2020-04-07 23:07:09
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Biocompatibility refers to the ability of a biomaterial to perform its desired function with respect to a medical therapy, without eliciting any undesirable local or systemic effects in the recipient or beneficiary of that therapy, but generating the most appropriate beneficial cellular or tissue response in that specific situation, and optimizing the clinically relevant performance of that therapy, which reflects current developments in the area of intrinsically biocompatible polymer systems. Polymeric biomaterials are presently used as, for example, long-term implantable medical devices, degradable implantable systems, transient invasive intravascular devices, and, recently, as tissue engineering scaffolds. This Special Issue welcomes full papers and short communications highlighting the aspects of the current trends in the area of intrinsically biocompatible polymer systems.

Keywords

antimicrobial peptides --- biodegradable polymers --- biocompatible polymers --- drug delivery systems --- controlled release --- citropin --- temporin --- ionic liquids --- chitooligosaccharide --- polyurethane --- biodegradability --- physicochemical properties --- hemocompatibility --- biological activity --- crosslinking --- drug delivery --- cosmetic --- food-supplement --- functionalization --- hyaluronan applications --- hyaluronan derivatives --- hyaluronan synthases --- hyaluronic acid --- hyaluronidases --- physico-chemical properties --- cyclohexanone --- ?-butyrolactone --- chloroform --- extraction --- polyhydroxyalkanoates --- PHB --- electrospraying --- biodegradable nano/microparticles --- drug delivery --- septic arthritis --- release characteristics --- biopolymers --- silk fibroin --- konjac glucomannan --- porous beads --- scaffolds --- tissue engineering --- microcarriers --- Poly (l-lactic) acid --- Chitosan --- nanohydroxyapatite --- osteoblasts --- ion-releasing materials --- shrinkage stress --- water sorption --- hydroscopic expansion --- photoelastic investigation --- enzymatic polymerization --- chemical polymerization --- poly(benzyl malate) --- biocompatible nanoparticles --- cell uptake --- cytotoxicity --- HepaRG cells --- human macrophages --- star polymers --- solution behavior --- ATRP --- SPION --- contrast agent --- MRI --- cancer diagnosis --- folate receptor --- pluronic F127 --- polylactide --- hydrolytic degradation --- mechanical properties --- PEEK copolymer synthesis --- PEEK composite --- Spine cage application --- In vitro biosafety --- degradation --- saliva --- mechanical properties --- molecular weight --- thermal properties --- activation energy of thermal decomposition --- anterior cruciate ligament reconstruction --- bone tunnel enlargement --- X-ray microtomography --- polylactide --- n/a

Advances in Chitin/Chitosan Characterization and Applications

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ISBN: 9783038978022 9783038978039 Year: Pages: 414 DOI: 10.3390/books978-3-03897-803-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2019-04-25 16:37:17
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Functional advanced biopolymers have received far less attention than renewable biomass (cellulose, rubber, etc.) used for energy production. Among the most advanced biopolymers known is chitosan. The term chitosan refers to a family of polysaccharides obtained by partial de-N-acetylation from chitin, one of the most abundant renewable resources in the biosphere. Chitosan has been firmly established as having unique material properties as well as biological activities. Either in its native form or as a chemical derivative, chitosan is amenable to being processed—typically under mild conditions—into soft materials such as hydrogels, colloidal nanoparticles, or nanofibers. Given its multiple biological properties, including biodegradability, antimicrobial effects, gene transfectability, and metal adsorption—to name but a few—chitosan is regarded as a widely versatile building block in various sectors (e.g., agriculture, food, cosmetics, pharmacy) and for various applications (medical devices, metal adsorption, catalysis, etc.). This Special Issue presents an updated account addressing some of the major applications, including also chemical and enzymatic modifications of oligos and polymers. A better understanding of the properties that underpin the use of chitin and chitosan in different fields is key for boosting their more extensive industrial utilization, as well as to aid regulatory agencies in establishing specifications, guidelines, and standards for the different types of products and applications.

Keywords

aerogels --- chitosan --- ionic liquids --- ionogels --- zinc–chitosan complexes --- characterization --- bio-sorbent --- phosphate --- adsorption --- mechanism --- thermodynamic --- chitosan --- hydrogel --- phase transition --- gelation mechanism --- chitosan --- defense responses --- fruits --- nanoparticles --- plant growth --- pesticides --- Boron --- chitosan --- iron(III) hydroxide --- neodymium --- sorption --- chitin --- chitosan --- chitosan derivative --- chitin derivative --- oral care --- skin care --- hear care --- marine resources --- over-the counter-drug --- polymer carrier --- chitin --- chitosan --- nanostructured biomaterial --- polymer --- self-masking nanosphere lithography --- cicada --- chitosan --- self-assembled --- polyelectrolyte complex --- nanoparticle --- drug delivery --- Citrobacter --- biosynthesis --- bioflocculant --- chitosan --- metabolic pathway --- PEO/chitosan blend --- swelling --- mechanical properties --- wet and dried states --- chitosan --- biological activity --- medical applications --- chitosan --- PCL --- strontium --- scaffolds --- craniofacial engineering --- chitin --- chitosan --- derivatization --- controlled functionalization --- click chemistry --- graft copolymer --- cyclodextrin --- dendrimer --- ionic liquids --- chitin deacetylases --- chitosan --- chitooligosaccharides --- carbohydrate esterases --- structure --- substrate specificity --- deacetylation pattern --- binary --- chitosan --- desorption --- iron --- lead --- mercury --- salt effects --- single --- sorption competition --- chitosan supported copper --- heterogeneous catalyst --- organosilicon compound --- easily recyclable --- chitosan --- papermaking --- wet-end --- coating --- wastewater --- ionic cross-linking --- eco-friendly formulations --- thermal transition sol-gel --- drug delivery systems --- MTDSC --- DSC --- gene delivery --- non-viral vectors --- chitosan structure --- pDNA --- siRNA --- TEOS --- methylene blue --- chitosan --- modelling --- cross-linking --- interpenetrating --- XRD --- FTIR

Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis

Authors: --- ---
ISBN: 9783039210848 9783039210855 Year: Pages: 308 DOI: 10.3390/books978-3-03921-085-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Chemical Engineering
Added to DOAB on : 2019-06-26 08:44:06
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The present Special Issue, “Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis”, aims to collect and to disseminate some of the most significant and recent contributions in the interdisciplinary area of innovative extraction procedures from complex matrices followed by validated analytical methods using hyphenated instrument configurations to support the optimization of the whole process and the scale-up possibility

Keywords

branched-chain keto acids --- serum --- muscle --- HPLC-Q-TOF/MS --- wood --- odor --- volatile organic compounds --- gas chromatography-olfactometry --- Wuyi Rock tea --- quality --- UPLC-QTOF MS --- UPLC-QqQ MS --- metabolite profiling --- metabolomics --- cluster analysis --- cultivars --- Lycium ruthenicun --- flavonoid --- ruthenicunoid A --- SIRT1 --- Asphodeline lutea --- HPLC-PDA --- heavy metals --- tyrosinase --- diabetes --- neurodegenerative disease --- color analysis --- pigments --- MAE --- HPLC-PDA --- SFE --- Thymus algeriensis --- rare earth elements --- flow injection --- inductively coupled plasma-mass spectrometry --- seawater --- Hericium erinaceuns mycelium --- high-speed counter-current chromatography (HSCCC) --- genistein --- daidzein --- Fe3O4 --- modification --- alginate --- alkaloid --- ultrasound assisted extraction --- gelatin --- actinidin --- bovine hide --- physicochemical properties --- gel strength --- Semen Cuscutae --- ultra-high-performance liquid chromatography coupled to electrospray ionization mass spectrometry --- chlorogenic acids --- flavonoids --- steamed Panax notoginseng --- saponins --- extraction --- optimization --- antioxidant activity --- response surface methodology --- hematopoiesis --- microwave processing --- response surface methodology --- minor ginsenosides --- blood-enriching activity --- hemostatic activity --- ionic liquids --- sample preparation --- microextraction --- solid-phase microextraction --- dispersive liquid-liquid microextraction --- single-drop microextraction --- stir bar sorptive extraction --- stir cake sorptive extraction --- rosuvastatin --- metformin --- HILIC --- LC-MS --- therapeutic drug monitoring --- oolong tea --- Tieguanyin tea cultivar --- metabolite profiling --- UPLC-QTOF MS --- metabolomics --- Ajuga genevensis --- near-infrared spectroscopy --- dry extract --- fluid bed process --- microNIR --- in-line monitoring --- total polyphenolic content --- antioxidant --- flavonoids --- mouse melanoma B16 cells --- Panax notoginseng --- surfactant --- n/a --- ultra-high-performance liquid chromatography tandem mass spectrometry --- GHB --- GHB glucuronide --- nails --- endogenous values --- walnut septum --- polyphenols --- phytosterols --- HPLC-MS/MS --- Ultra-Turrax extraction --- biological activity --- antioxidant activity --- experimental design --- optimization --- phytochemicals

Smart and Functional Polymers

Authors: --- ---
ISBN: 9783039215904 9783039215911 Year: Pages: 306 DOI: 10.3390/books978-3-03921-591-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Inorganic Chemistry
Added to DOAB on : 2019-12-09 11:49:16
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This book is based on the Special Issue of the journal Molecules on “Smart and Functional Polymers”. The collected research and review articles focus on the synthesis and characterization of advanced functional polymers, polymers with specific structures and performances, current improvements in advanced polymer-based materials for various applications, and the opportunities and challenges in the future. The topics cover the emerging synthesis and characterization technology of smart polymers, core?shell structure polymers, stimuli-responsive polymers, anhydrous electrorheological materials fabricated from conducting polymers, reversible polymerization systems, and biomedical polymers for drug delivery and disease theranostics. In summary, this book provides a comprehensive overview of the latest synthesis approaches, representative structures and performances, and various applications of smart and functional polymers. It will serve as a useful reference for all researchers and readers interested in polymer sciences and technologies.

Keywords

amphiphilicity --- phase change --- polyamino acids --- degradability --- fine-tuning --- pH responsive --- poly(methacrylamide)s --- phase transition --- catalyst --- CO2 --- heterogeneous catalysis --- molecular sieve --- polyether imidazole ionic liquid --- Vitamin E --- albumin --- core-shell nanoparticles --- paclitaxel --- multi-drug resistance --- breast cancer --- conducting polymer --- composite --- electrorheological --- smart fluid --- viscoelastic --- controlled polymerization --- reversible polymerization --- sustainable polymers --- pH responsive polymers --- nanomedicine --- tumor imaging --- drug delivery --- polymerization dispersion method --- polyaniline --- polyvinyl alcohol --- glutaraldehyde --- chemical activation --- Glycopolymer --- post-polymerization functionalization --- perfluoroaryl azides --- Staudinger reaction --- castor oil --- biomedical devices --- polyurethanes --- polycaprolactone-diol --- chitosan --- fluoropolymers --- melt-shear organization --- chemical resistance --- solvent responsiveness --- hydrophobicity --- core/shell particles --- emulsion polymerization --- particle processing --- ?-NaYF4 --- rare earth upconversion nanoparticles --- core–shell structure --- hydrogels --- applications --- targeted drug delivery --- drug release --- hydrophobic drug delivery --- clinical translation --- versatile platform --- administration routes --- diverse therapeutic areas --- hearing loss --- saffron --- endophytic exopolysaccharide --- gentamicin --- cochlear hair cell --- polymeric nanoparticles --- stimuli-sensitive polymers --- co-delivery systems --- synergistic effect --- nucleic acid delivery --- chemotherapy --- phenylboronic acid --- gel --- glucose sensitivity --- drug delivery --- diabetes therapy --- amphiphilic copolymer --- hydrolyzable polyurea --- micelle --- controlled drug delivery --- cancer chemotherapy --- polymerization or post-polymerization modification methods --- polymer-based supramolecular chemistry --- stimuli-responsive polymers --- shape memory polymers --- self-healing polymers --- polymers for industrial catalysis --- polymers for water or effluent treatment --- polymers for sensing, separation, and purification --- polymers for fabrication --- renewable polymer materials used for agriculture --- functional polymers used in food science --- polymers for information storage, electronics, and energy conversion --- functional polymers for diagnosis, imaging, drug delivery, and tissue engineering --- polymers with biological activity (e.g., antitumor, antidiabetic, and antimicrobial activity) --- polymer-based medical devices

Plant Natural Products for Human Health

Authors: ---
ISBN: 9783038977124 Year: Pages: 514 DOI: 10.3390/books978-3-03897-713-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2019-04-05 10:34:31
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Plants have served mankind as an important source of foods and medicines. While we all consume plants and their products for nutritional support, a majority of the world population also rely on botanical remedies to meet their health needs, either as their own “traditional medicine” or as “complementary and alternative medicine”. From a pharmaceutical point of view, many compounds obtained from plant sources have long been known to possess bio/pharmacological activities, and historically, plants have yielded many important drugs for human use, from morphine discovered in the early nineteenth century to the more recent paclitaxel and artemisinin. Today, we are witnessing a global resurgence in interest and use of plant-based therapies and botanical products, and natural products remain an important and viable source of lead compounds in many drug discovery programs.This Special Issue on “Plant Natural Products for Human Health” compiles a series of scientific reports to demonstrate the medicinal potentials of plant natural products. It covers a range of disease targets, such as diabetes, inflammation, cancer, neurological disease, cardiovascular disease, liver damage, bacterial, and fungus infection and malarial. These papers provide important insights into the current state of research on drug discovery and new techniques. It is hoped that this Special Issue will serve as a timely reference for researchers and scholars who are interested in the discovery of potentially useful molecules from plant sources for health-related applications.

Keywords

heat-process --- onion --- calorie restriction --- Amadori rearrangement compounds --- hyperglycemia --- A549 cells --- hinokitiol --- MMPs --- p53/Bax --- antioxidant enzymes --- caspases --- migration --- cannabinoid type 1 receptor --- endoplasmic reticulum stress --- gluconeogenesis --- gomisin N --- lipogenesis --- insulin resistance --- garlic --- ischemia --- heme oxygenase --- reperfusion --- heart --- Keap1 --- Nrf2 --- Neuroprotective --- PC12 cells --- PhGs --- anti-malaria activity --- plants --- natural products --- ethnopharmacology --- Plasmodium parasites --- copaiba --- oleoresin --- essential oil --- sesquiterpenoids --- diterpenoids --- biological activity --- molecular targets --- Astragali Radix --- astragaloside IV --- genistein --- mitochondrial bioenergetics --- oxygen consumption rate --- natural products --- drug design and development --- innovation --- automation --- computational softwares --- bioinformatics --- precision medicine --- omics --- global health --- sweet orange --- bitter orange --- neroli --- orange petitgrain --- mandarin --- lemon --- lime --- grapefruit --- bergamot --- yuzu --- kumquat --- cannabigerol --- Cannabis sativa --- neuroinflammation --- oxidative stress --- phytocannabinoid --- iridoids --- nuclear factor-kappaB --- mitogen-activated protein kinase --- anti-inflammation --- Ziziphus jujuba --- triterpenic acids --- pharmacokinetic study --- acute liver injury --- A? --- AD --- lychee seed --- neuroinflammation --- catechin --- procyanidin A2 --- apoptosis --- cinnamamides --- antistaphylococcal activity --- time-kill assay --- biofilm --- antitubercular activity --- MTT assay --- antifungal activity --- PET inhibition --- toxicity --- structure–activity relationship --- bleeding time --- flavonoid --- morin hydrate --- OH· free radical --- platelet activation --- protein kinase --- thromboembolism --- Glycyrrhiza uralensis --- prenylated flavonoids --- antiproliferation --- differentiation --- melanoma cell --- adjuvant-induced arthritis --- arthritis --- celastrol --- curcumin --- dietary supplements --- EGCG --- green tea --- inflammation --- liposomes --- microbiome --- nanoparticles --- natural products --- resveratrol --- rheumatoid arthritis --- targeted delivery --- traditional medicine --- Tripterygium wilfordii --- triptolide --- Penthorum chinense Pursh --- NAFLD --- hepatic steatosis --- flavonoids --- SIRT1 --- AMPK --- dihydromyricetin --- myocardial hypertrophy --- oxidative stress --- sirtuin 3 --- ginseng --- human-hair-follicle dermal papilla cells --- WNT/?-catenin --- Shh/Gli --- TGF-? --- BMP/Smad --- mouse-hair growth --- Panax notoginseng saponins --- aspirin --- HepaRG cells --- herb–drug interactions --- P. eryngii --- glucans --- inflammation --- inflammatory bowel disease --- medicinal plants --- phytochemicals --- scoulerine --- bergapten --- immunomodulator --- adjuvant --- cytoxicity --- dendritic cells --- immune modulation --- APAP --- acetaminophen --- hepatotoxicity --- hpatoprotection --- paracetamol --- animals --- preclinical studies --- natural products --- small molecules --- phytochemicals --- plants --- fucoidan --- acetaminophen --- Nrf2 --- oxidative stress --- hepatotoxicity --- plant natural product --- drug discovery --- human health

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MDPI - Multidisciplinary Digital Publishing Institute (6)


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english (6)


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2020 (2)

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