Search results: Found 12

Listing 1 - 10 of 12 << page
of 2
>>
Sort by
Chapter: 'Analysis of Breast Cancer Cell Invasion Using an Organotypic Culture System' from book: 3D Cell Culture: Methods and Protocols (Book chapter)

Authors: ---
Book Series: Methods in Molecular Biology ISSN: 1064-3745 / 1940-6029 ISBN: 9781493970193 9781493970216 Year: Volume: 1612 Pages: 13 DOI: https://doi.org/10.1007/9781493970216_15 Language: English
Publisher: Springer
Subject: Oncology
Added to DOAB on : 2017-07-19 15:44:38
License:

Loading...
Export citation

Choose an application

Abstract

Metastasis is the main cause of cancer patient mortality. Local tumor invasion is a key step in metastatic dissemination whereby cancer cells dislodge from primary tumors, migrate through the peritumoral stroma and reach the circulation. This is a highly dynamic process occurring in three dimensions that involves interactions between tumor, stromal cells, and the extracellular matrix. Here we describe the organotypic culture system and its utility to study breast cancer cell invasion induced by cancer-associated fibroblasts. This is a three-dimensional model that reproduces the biochemical and physiological properties of real tissue and allows for investigating the molecular and cellular mechanisms involving tumor and its microenvironment, and their contribution to cancer cell invasion. This system provides a robust, accurate, and reproducible method for measuring cancer cell invasion and represents a valuable tool to improve the mechanistic understanding of the initial steps in metastasis.

Cardiovascular Toxicities of Breast Cancer Treatment: Emerging Issues in Cardio-Oncology

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195695 Year: Pages: 83 DOI: 10.3389/978-2-88919-569-5 Language: English
Publisher: Frontiers Media SA
Subject: Oncology --- Medicine (General)
Added to DOAB on : 2017-02-03 17:04:57
License:

Loading...
Export citation

Choose an application

Abstract

Cancer and cardiovascular disease (CVD) are the two most common causes of mortality and morbidity worldwide. The incidence of both cancer and cardiovascular disease increases with age. With increased life expectancy, the burden of both these diseases will increase substantially in coming years. Patients with CVD share multiple common risk factors and lifestyle behaviors in addition to frequently suffering from multiple comorbid conditions. Tobacco use, hypertension, high cholesterol, diabetes, physical inactivity, and poor nutrition are all established risk factors of heart disease. Patients with diseases such as breast cancer may develop CVD from treatment, such as use of chemotherapy and RT. Effects on the heart are a potentially significant and serious clinical problem in radiation therapy treatment of breast cancer. Over the course of the past 50 years, there have been great advances in the delivery of RT due to the development of new techniques, beam energy, improvement in imaging modalities, and development of image registration strategies. It is hypothesized that cardiac damage from RT is correlated to the dose absorbed by the heart and differs between left- and right-breast radiotherapy. The damage to cardiac micro- and macro-vasculature is the pathophysiological cause of RT-related heart disease. Given the growing clinical relevance of cardio-oncology, this Frontiers in Oncology Research Topic provides a venue for disseminating focused reviews and cutting edge research in this quickly growing field. We encourage submission of original papers and reviews dealing with cardiac toxicity after breast cancer treatment, motion management to reduce cardiac exposure, imaging to evaluate potential cardiac toxicities and primary prevention of cardiac disease in the breast cancer patient.

Cancer Care Delivery and Women's Health

Author:
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453092 Year: Pages: 153 DOI: 10.3389/978-2-88945-309-2 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Oncology
Added to DOAB on : 2018-02-27 16:16:45
License:

Loading...
Export citation

Choose an application

Abstract

Cancer care delivery refers to the multiple layers of the health care system that interact to affect outcomes for patients with cancer and the quality of that care. The factors included in the care delivery system that potentially alter outcomes include social dynamics, financing systems, organizational structures and processes, health technologies, provider and individual behaviors. Because women’s health care has its own unique challenges, the intersection between cancer care delivery and women’s health is to be examined in this Frontiers in Oncology issue. The unique opportunities and challenges of improving the health care system for women with breast and gynecologic cancers are to be explored in depth. We will visit many topics of cancer care delivery with the unique perspective geared towards the care of women’s malignancies.

Plastic Surgery for the Oncological Patient

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199877 Year: Pages: 76 DOI: 10.3389/978-2-88919-987-7 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Oncology --- Surgery
Added to DOAB on : 2016-01-19 14:05:46
License:

Loading...
Export citation

Choose an application

Abstract

The develoment of plastic surgery techniques allows for preserving and reconstruction of function after resection of malignant tumors. From split thickness skin grafts to pedicled and free tissue transfer multiple techniques are at hand to restore body integrity. Sufficient soft tissue coverage allows for adjuvant radiation therapy or can cure its sequelae. Nerve, tendon and muscle transfers are used to regain motor function of the extremities. Even large bony defects can be treated by microsurgically transferring fibula, pelvic and femoral bone. In case main vessels need to be resected reconstruction is possible with autologous and artificial grafts. By means of plastic surgery thoracic and abdominal defects can be covered so that foremost unresectable tumors become curable. Unfortunately the knowledge of these techniques is not very popular with oncologic surgeons. Therefore we suggest as a clinical topic the role of reconstructive surgery in the multimodal treatment of oncologic patients. The focus will be on different areas of the body, therefore articels for reconstructional procedures at the head, the extremities, the trunk, the thoracic wall, the breast, and the foot will be invited. Another focus will be the role of reconstructive procedures in the multimodal treatment concept consisting of radiation and chemotherapy as well. By knowing and applying the opportunities of plastic surgery the quality of live of the oncologic patient can be significantly improved.

AR Signaling in Human Malignancies: Prostate Cancer and Beyond

Author:
ISBN: 9783038427407 9783038427391 Year: Pages: 244 DOI: 10.3390/books978-3-03842-739-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2018-02-16 08:45:39
License:

Loading...
Export citation

Choose an application

Abstract

The notion that androgens and androgen receptor (AR) signaling are the hallmarks of prostate cancer oncogenesis and disease progression is generally well accepted. What is more poorly understood is the role of AR signaling in other human malignancies. This Special Issue of Cancers initially reviews the role of AR in advanced prostate cancer, and then explores the potential importance of AR signaling in other epithelial malignancies. The first few articles focus on the use of novel AR-targeting therapies in castration-resistant prostate cancer and the mechanisms of resistance to novel antiandrogens, and they also outline the interaction between AR and other cellular pathways, including PI3 kinase signaling, transcriptional regulation, angiogenesis, stromal factors, Wnt signaling, and epigenetic regulation in prostate cancer. The next several articles review the possible role of androgens and AR signaling in breast cancer, bladder cancer, salivary gland cancer, and hepatocellular carcinoma, as well as the potential treatment implications of using antiandrogen therapies in these non-prostatic malignancies.

Electromagnetic Technologies for Medical Diagnostics. Fundamental Issues, Clinical Applications and Perspectives

Authors: ---
ISBN: 9783038976769 Year: Pages: 240 DOI: 10.3390/books978-3-03897-677-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering --- Technology (General)
Added to DOAB on : 2019-04-05 10:34:31
License:

Loading...
Export citation

Choose an application

Abstract

The content of this Special Issue will highlight papers exploring non-commutative Fourier harmonic analysis, spectral properties of aperiodic order, the hypoelliptic heat equation, and the relativistic heat equation in the context of Information Theory and Geometric Science of Information.

Bioactive Compounds from Marine-Derived Aspergillus, Penicillium, Talaromyces and Trichoderma Species

Authors: ---
ISBN: 9783038979807 / 9783038979814 Year: Pages: 134 DOI: 10.3390/books978-3-03897-981-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Microbiology
Added to DOAB on : 2019-06-26 08:44:06
License:

Loading...
Export citation

Choose an application

Abstract

The importance of bioactive natural compounds in pharmacology and other biotechnological fields has stimulated the scientific community to explore new environmental contexts and their associated microbial diversity. As the largest frontier in biological discovery, the sea represents a significant source of organisms producing novel secondary metabolites with interesting bioactivities. Of the available biological material, fungi have received increasing consideration, both due to their pervasive occurrence in varying habitats as well as their aptitude to develop symbiotic associations with higher organisms in numerous contexts. In many cases, fungal strains have been reported as the real producers of drugs originally extracted from marine plants and animals. Due to the constantly increasing number of marine-derived fungi yielding valuable bioactive products, it is now appropriate to present these findings to a recipient audience in a more organized form. This Special Issue of Marine Drugs, entitled “Bioactive Compounds from Marine-Derived Aspergillus, Penicillium, Talaromyces, and Trichoderma Species"" is specifically focused on a few genera of ascomycetous fungi which are widespread regarding marine contexts and are particularly inclined to establishing symbiotic relationships. For this project, we welcome submissions of full research papers, short notes, and review articles reporting the discovery and characterization of products showing antibiotic, antitumor, antiviral, insecticidal, antimalarial, antifouling, antioxidant, plant growth-promoting and/or resistance-inducing, as well as other less-exploited activities.

Mechanisms of Adiponectin Action

Author:
ISBN: 9783039212453 / 9783039212460 Year: Pages: 222 DOI: 10.3390/books978-3-03921-246-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Sociology
Added to DOAB on : 2019-08-28 11:21:27
License:

Loading...
Export citation

Choose an application

Abstract

The adipokine adiponectin is very concentrated in plasma, and decreased levels of adiponectin are associated with pathological conditions such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. When produced in its full-length form, adiponectin self-associates to generate multimeric complexes. The full-length form of adiponectin can be cleaved by the globular form of elastase that is produced locally, and the resulting biological effects are exerted in a paracrine or autocrine manner. The different forms of adiponectin bind to specific receptors consisting of two G-protein-independent, seven-transmembrane-spanning receptors, called AdipoR1 and AdipoR2, while T-cadherin has been identified as a potential receptor for high molecular weight complexes of adiponectin. Adiponectin exerts a key role in cellular metabolism, regulating glucose levels as well as fatty acid breakdown. However, its biological effects are heterogeneous, involving multiple target tissues. The Special Issue “Mechanisms of Adiponectin Action” highlights the pleiotropic role of this hormone through 3 research articles and 7 reviews. These papers focus on the recent knowledge regarding adiponectin in different target tissues, both in healthy and in diseased conditions.

Emerging Technology Applications to Promote Physical Activity and Health

Authors: ---
ISBN: 9783038977087 Year: Pages: 176 DOI: 10.3390/books978-3-03897-709-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Sociology --- Social Sciences
Added to DOAB on : 2019-04-05 10:34:31
License:

Loading...
Export citation

Choose an application

Abstract

As technology becomes an ever-more prevalent part of everyday life, and population-based physical activity programs seek new ways to increase life-long engagement with physical activity, these two ideas have become increasingly linked. This Special Issue attempts to offer a thorough and critical examination of emerging technologies in physical activity and health promotion, considering technological interventions in different contexts (communities, clinics, schools, homes, etc.) among various populations, exploring the challenges of integrating technology into physical activity promotion, and offering solutions for its implementation. This Special Issue aims to take a broadly positive stance toward interactive technology initiatives and, while discussing some negative implications of an increased use of technology, offers practical recommendations for promoting physical activity through various emerging technologies, including, but not limited to: Active video games (exergaming); social media; mobile device apps; health wearables; mobile games, augmented reality games, global positioning and geographic information systems; and virtual reality. Offering a logical and clear critique of emerging technologies in physical activity and health promotion, this Special Issue will provide useful suggestions and practical implications for researchers, practitioners, and educators in the fields of public health, kinesiology, physical activity and health, and healthcare.

Keywords

anxiety --- depression --- exercise --- mental health --- virtual reality --- senior citizens --- perceived environmental factor --- recreational physical activity --- screen based sedentary behavior --- pedometers --- accelerometers --- measurement --- physical activity levels --- active video games --- motor activity --- intelligence quotient --- young children --- physical activity --- quality of life --- social cognitive theory --- wearable technology --- real-time physical activity --- wearable technology --- fitness --- Fitbits --- breast cancer --- mammogram --- mobile phone-based health intervention --- mHealth --- app --- health navigator --- Korean American immigrant women --- Autism --- autism spectrum disorder --- augmented reality --- technology --- Google Glass --- social communication --- safety --- smartglasses --- digital health --- Amazon --- Amazon Web Services --- Google --- sedentary behaviour --- air quality --- socio-ecological model --- wrist-worn activity tracker --- active video games --- cardiorespiratory fitness --- locomotor skills --- motor skill competence --- musculoskeletal fitness --- object control skills --- active video game --- accelerometry --- physical activity assessment --- epoch --- placement site --- heart rate --- preoperative anxiety --- virtual reality game --- preoperative experience --- active video game --- light physical activity --- moderate-to-vigorous physical activity --- sedentary behavior --- sex difference --- active video gaming --- serious games --- physical activity --- physical exercise --- sedentary behavior --- narrative review

Benefits of Resveratrol Supplementation

Authors: ---
ISBN: 9783039212750 / 9783039212767 Year: Pages: 260 DOI: 10.3390/books978-3-03921-276-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2019-08-28 11:21:27
License:

Loading...
Export citation

Choose an application

Abstract

In recent years, great attention has been paid to polyphenols due to their positive effects on health. One of the most widely-studied phenolic compounds is resveratrol. This molecule, which is naturally present in some foods, shows beneficial effects on various physiological and biochemical processes, thus representing a potential tool for the prevention or the treatment of diseases highly prevalent in our society. Several of these beneficial effects have been observed in human beings, but others only in pre-clinical studies so far, and therefore, it is mandatory to continue with the scientific research in this field. Indeed, new knowledge concerning these issues could enable the development of novel functional foods or nutraceuticals, incorporating resveratrol, suitable for preventing or treating diseases such as cancer, cardiovascular diseases, obesity, dislipemia, insulin resistance and diabetes, liver diseases, etc.

Listing 1 - 10 of 12 << page
of 2
>>
Sort by
Narrow your search