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Endocrinologie et communications cellulaires

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ISBN: 2868834760 Year: Pages: 584 DOI: 10.26530/OAPEN_519667 Language: French
Publisher: EDP SCIENCES
Subject: Medicine (General)
Added to DOAB on : 2015-02-10 11:01:11
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Cellular communication, endocrinology

Chapter 7 Cellular Control of Time, Size, and Shape in Development and Evolution (Book chapter)

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Book Series: Evolutionary Cell Biology ISBN: 9781315155968 9781498787864 Year: Pages: 48 Language: English
Publisher: Taylor & Francis
Subject: Biology
Added to DOAB on : 2019-01-17 11:44:13
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The rules by which anatomical size and shape are generated have intrigued scientists&#xD;for centuries. In 1638, Galileo suggested a mathematical relationship between proportional&#xD;changes in the shape of bones as animals increase in size, which he argued&#xD;was a functional necessity for weight bearing (1914). The formalism of Galileo,&#xD;whereby, physical forces and mathematical laws became integrated with studies&#xD;of size and shape in biology, was most conspicuously encapsulated over a hundred&#xD;years ago in the 1917 monumental tome by D’Arcy Thompson entitled, On Growth&#xD;and Form (Thompson 1917). In a breathtakingly comprehensive manner, Thompson&#xD;synthesized the observations of numerous predecessors and contemporaries, and&#xD;through countless examples built a theoretical and experimental framework for&#xD;describing changes in morphology that persists to this day (Stern and Emlen 1999;&#xD;Arthur 2006).

Inter-Vehicle Communication at Intersections : An Evaluation of Ad-Hoc and Cellular Communication

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ISBN: 9783866448995 Year: Pages: X, 191 p. DOI: 10.5445/KSP/1000029208 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Computer Science
Added to DOAB on : 2019-07-30 20:01:58
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This book evaluates the ability of ad-hoc and cellular communication to enable cross-traffic assistance at intersections. Potential issues like Non-Line-Of-Sight (NLOS) reception with ad-hoc and limited capacity, higher latency and costs with cellular technology are investigated in two individual evaluations. A method for efficient information delivery via cellular systems and an inter-vehicle NLOS radio propagation model are proposed. Finally, the suitability of both technologies is compared.

The Amygdala - Where Emotions Shape Perception, Learning and Memories

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ISBN: 9789535132493 9789535132509 Year: Pages: 336 DOI: 10.5772/63124 Language: English
Publisher: IntechOpen
Subject: Physiology --- Cytology
Added to DOAB on : 2019-10-03 07:51:50

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The amygdala is a central component of the limbic system, which is known to play a critical role in emotional processing of learning and memory. Over these last 20 years, major advances in techniques for examining brain activity greatly helped the scientific community to determine the nature of the contribution of the amygdala to these fundamental aspects of cognition. Combined with new conceptual breakthroughs, research data obtained in animals and humans have also provided major insights into our understanding of the processes by which amygdala dysfunction contributes to various brain disorders, such as autism or Alzheimer's disease. Although the primary goal of this book is to inform experts and newcomers of some of the latest data in the field of brain structures involved in the mechanisms underlying emotional learning and memory, we hope it will also help stimulate discussion on the functional role of the amygdala and connected brain structures in these mechanisms.

Sub-cellular Proteomics

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193028 Year: Pages: 254 DOI: 10.3389/978-2-88919-302-8 Language: English
Publisher: Frontiers Media SA
Subject: Botany --- Science (General)
Added to DOAB on : 2016-02-05 17:24:33
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Whilst significant advances have been made in whole organismal proteomics approaches, many researchers still rely on combinations of tissue selection and subcellular prefractionation methods to reduce the complexity of protein extracts from plants prior to proteomic analysis. Often this will allow identification of many lower abundance proteins of the target proteome and it may involve the selection of specific organs, cell types or the isolation of specific subcellular components. These subcellular proteomes provide insight into functions following various treatments and also contribute to the wider understanding of the entire organismal proteome by cataloguing a series of sub-proteome contents. The aim of this Research Topic is to bring together knowledge of sub cellular components in different plant species to provide a basis for accelerated research. It aims to provide a mini-review for each proposed section that summarizes the current understanding of a particular proteome, with the anticipation that every 5 - 10 years we can update these definitive publications.

The truth in complexes: why unraveling ion channel multi-protein signaling nexuses is critical for understanding the function of the nervous system

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194452 Year: Pages: 160 DOI: 10.3389/978-2-88919-445-2 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-02-05 17:24:33
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In the search for simple explanations of the natural world, its complicated textures are often filed down to a smoothened surface of our liking. The impetus for this Research Topic was borne out of a need to re-ignite interest in the complex – in this case in the context of ion channels in the nervous system. Ion channels are the large proteins that form regulated pores in the membranes of cells and, in the brain, are essential for the transfer, processing and storage of information. These pores full of twists and turns themselves are not just barren bridges into cells. More and more we are beginning to understand that ion channels are like bustling medieval bridges (packed with apartments and shops) rather than the more sleek modern variety – they are dynamic hubs connected with many structures facilitating associated activities. Our understanding of these networks continues to expand as our investigative tools advance. Together these articles highlight how the complexity of ion channel signaling nexuses is critical to the proper functioning of the nervous system.

Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194964 Year: Pages: 159 DOI: 10.3389/978-2-88919-496-4 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Oncology
Added to DOAB on : 2015-11-16 15:44:59
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In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour suppression as all of these outcomes result in restriction of the growth and/or elimination of damaged and pre-malignant cells. Thus, a large number of anti-cancer agents target specific components of stress response signalling pathways with the aim of causing tumour regression by stimulating cell death. However, the efficacy of these agents is often impaired due to mutations in genes that are involved in these stress-responsive signalling pathways and instead the oncogenic potential of a cell is increased leading to the initiation and/or progression of tumourigenesis. Moreover, these genetic defects can increase or contribute to resistance to chemotherapeutic agents and/or radiotherapy. Modulating the outcome of cellular stress responses towards cell death in tumour cells without affecting surrounding normal cells is thus one of the ultimate aims in the development of new cancer therapeutics. To achieve this aim, a detailed understanding of cellular stress response pathways and their aberrations in cancer is required.This Research topic aims to reflect the broadness and complexity of this important area of cancer research.

Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198153 Year: Pages: 191 DOI: 10.3389/978-2-88919-815-3 Language: English
Publisher: Frontiers Media SA
Subject: Therapeutics --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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Cyclic adenosine monophosphate (cAMP) is a second messenger of paramount biological importance, involved in the regulation of a significant number of cellular functions through the cAMP-dependent intracellular signal transduction pathways. The aim of this "Frontiers in Pharmacology" Research Topic was to attract contributions that highlight emerging ideas in the cAMP field that: (i) describe its role in cellular function and homeostasis, (ii) present the current approaches to its pharmacological manipulation, and (iii) clarify its central role in the development of more targeted therapeutic approaches toward a spectrum of diseases. The present collection of articles highlights, in a representative (but certainly not exhaustive) way, the research activity and emerging concepts in the field, while it also reveals the therapeutic potential that targeted pharmacological manipulation of intracellular cAMP levels could exert on a number of pathological conditions.

Current Challenges in Modeling Cellular Metabolism

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197545 Year: Pages: 115 DOI: 10.3389/978-2-88919-754-5 Language: English
Publisher: Frontiers Media SA
Subject: Biology --- Science (General) --- Biotechnology --- General and Civil Engineering
Added to DOAB on : 2016-04-07 11:22:02
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Mathematical and computational models play an essential role in understanding the cellular metabolism. They are used as platforms to integrate current knowledge on a biological system and to systematically test and predict the effect of manipulations to such systems. The recent advances in genome sequencing techniques have facilitated the reconstruction of genome-scale metabolic networks for a wide variety of organisms from microbes to human cells. These models have been successfully used in multiple biotechnological applications. Despite these advancements, modeling cellular metabolism still presents many challenges. The aim of this Research Topic is not only to expose and consolidate the state-of-the-art in metabolic modeling approaches, but also to push this frontier beyond the current edge through the introduction of innovative solutions. The articles presented in this e-book address some of the main challenges in the field, including the integration of different modeling formalisms, the integration of heterogeneous data sources into metabolic models, explicit representation of other biological processes during phenotype simulation, and standardization efforts in the representation of metabolic models and simulation results.

Recent Advances in Cellular D2D Communications

Authors: --- ---
ISBN: 9783038427384 9783038427377 Year: Pages: 182 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering
Added to DOAB on : 2018-03-16 13:18:28
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Device-to-device (D2D) communications have attracted a great deal of attention from researchers in recent years. It is a promising technique for offloading local traffic from cellular base stations by allowing local devices, in physical proximity, to communicate directly with each other. Furthermore, through relaying, D2D is also a promising approach to enhancing service coverage at cell edges or in black spots. However, there are many challenges to realizing the full benefits of D2D. For one, minimizing the interference between legacy cellular and D2D users operating in underlay mode is still an active research issue. With the 5th generation (5G) communication systems expected to be the main data carrier for the Internet-of-Things (IoT) paradigm, the potential role of D2D and its scalability to support massive IoT devices and their machine-centric (as opposed to human-centric) communications need to be investigated. New challenges have also arisen from new enabling technologies for D2D communications, such as non-orthogonal multiple access (NOMA) and blockchain technologies, which call for new solutions to be proposed. This edited book presents a collection of ten chapters, including one review and nine original research works on addressing many of the aforementioned challenges and beyond.

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