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Cancer Metabolomics 2018

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ISBN: 9783039213450 9783039213467 Year: Pages: 184 DOI: 10.3390/books978-3-03921-346-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2019-12-09 11:49:15
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The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.

Earth Observation, Remote Sensing and Geoscientific Ground Investigations for Archaeological and Heritage Research

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ISBN: 9783039211937 9783039211944 Year: Pages: 304 DOI: 10.3390/books978-3-03921-194-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General)
Added to DOAB on : 2019-08-28 11:21:27
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This book collects 15 papers written by renowned scholars from across the globe that showcase the forefront research in Earth observation (EO), remote sensing (RS), and geoscientific ground investigations to study archaeological records and cultural heritage.Archaeologists, anthropologists, geographers, remote sensing, and archaeometry experts share their methodologies relying on a wealth of techniques and data including, but not limited to: very high resolution satellite images from optical and radar space-borne sensors, air-borne surveys, geographic information systems (GIS), archaeological fieldwork, and historical maps.A couple of the contributions highlight the value of noninvasive and nondestructive laboratory analyses (e.g., neutron diffraction) to reconstruct ancient manufacturing technologies, and of geological ground investigations to corroborate hypotheses of historical events that shaped cultural landscapes.Case studies encompass famous UNESCO World Heritage Sites (e.g., the Nasca Lines in Peru), remote and yet-to-discover archaeological areas in tropical forests in central America, European countries, south Asian changing landscapes, and environments which are arid nowadays but were probably full of woody vegetation in the past.Finally, the reader can learn about the state-of-the-art of education initiatives to train site managers in the use of space technologies in support of their activities, and can understand the legal aspects involved in the application of EO and RS to address current challenges of African heritage preservation.

Keywords

analytic hierarchy process (AHP) --- archaeology --- predictive model --- tumuli --- remote sensing --- multi-criteria --- Saharan Morocco --- airborne laser scanning --- orthophotographs --- archaeological survey --- field reconnaissance --- Arran --- national archaeological mapping programme --- synthetic aperture radar --- subsurface imaging --- microwave penetration --- archaeology --- arid environments --- remote sensing --- Oman --- e-learning --- Earth observation --- education --- capacity development --- cultural and natural heritage --- UNESCO --- photogrammetry --- RPAS --- UAV --- Peru --- geoglyph Pista --- mapping --- drones --- remote sensing --- free satellite imagery --- GoogleEarth --- Bing Maps --- archaeological fieldwork --- arid environments --- basalt desert --- landscape accessibility --- Harra --- Jordan --- archaeological landscapes --- settlements --- historical maps --- Survey of India --- Archaeological Survey of India --- heritage --- colonial studies --- remote sensing --- historical landscapes --- landscape archaeology --- settlements --- colonial studies --- river morphology --- Indus --- floods --- remote sensing --- satellite --- Sentinel-2 --- surface survey --- Roman archaeology --- Sumerian pottery --- neutron techniques --- neutron diffraction --- chemometric analysis --- Mega El Niño --- pampa of Nazca --- Cuenca Pisco --- Rio Grande de Nazca --- grain-size --- volcaniclastic layer --- stratigraphy --- petrography --- Lidar --- GIS --- Mesoamerica --- Archaeology --- Caves --- Landscape --- Ritual --- Visualization --- Maya --- Belize --- Sacred --- automated detection --- OBIA --- LiDAR --- Difference Map --- field monument --- Burial Mound --- Motte-and-Bailey castle --- Ridge and Furrow --- space law --- disaster and conservation management --- Geographic Information System (GIS) --- international boundaries --- Africa --- Cameroon-Nigeria Mixed Commission --- satellite imagery --- Boundary Demarcation --- international law --- relict boundaries --- Earth Observation --- remote sensing --- optical --- SAR --- drone --- airborne LiDAR --- GIS --- OBIA --- neutron diffraction --- archaeological prospection --- pattern recognition --- archaeometry --- geological mapping

Looking Forward to the Future of Heparin: New Sources, Developments and Applications

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ISBN: 9783038429494 9783038429500 Year: Pages: 282 DOI: 10.3390/books978-3-03842-950-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-08-28 11:21:28
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This book is a printed edition of the Special Issue Looking Forward to the Future of Heparin: New Sources, Developments and Applications that was published in Molecules

Keywords

thrombin inhibition --- LMWH --- antithrombin --- heparin oligosaccharides --- ternary complex --- heparin --- hepcidin --- iron homeostasis --- anemia --- heparin-induced thrombocytopenia --- diagnosis --- functional assay --- platelets --- heparin --- heparan sulphate --- TGF-? --- bone morphogenetic protein (BMP) --- growth and differentiation factor (GDF) --- GDNF --- BMP antagonists --- noggin --- sclerostin --- gremlin --- heparin --- enoxaparin --- subarachnoid hemorrhage --- edema --- brain injury --- inflammation --- cisplatin --- low molecular weight heparin (LMWH) --- ovarian cancer --- resistance --- heparin --- glycosaminoglycans --- chondroitin sulfate --- perylene diimide dyes --- dermatan sulfate --- fluorescent probe --- Heparin Red --- assay --- dermatan sulfate --- human plasma --- heparin --- alginate --- sulfated alginate --- biomaterials --- heparin --- heparan sulfate --- serglycin --- proteoglycan --- recombinant expression --- bioreactor --- theranostics --- solid lipid nanoparticles --- iron oxide nanoparticles --- heparin coating --- intestinal lymphatic absorption --- heparin --- heparin process --- manufacturing methods --- industrial --- super paramagnetic iron oxide nanoparticles (SPION) --- hyaluronic acid (HA) --- bovine serum albumin (BSA) --- Fe3O4·DA-BSA/HA --- paclitaxel (PTX) --- magnetic resonance imaging (MRI) --- low-molecular-weight heparin --- dalteparin --- NMR --- LC-MS --- affinity chromatography --- danaparoid sodium --- low molecular weight glycosaminoglycans --- orthogonal multi-analytical methods --- sequence and compositional investigations --- component quantitative analysis --- heparin --- crude heparin --- NMR --- quantitative NMR --- PCA --- chemometric --- HSQC --- bovine heparin --- porcine heparin --- molecular weight --- size exclusion chromatography --- pharmacopeia --- Fondaparinux sodium --- extended physicochemical characterization --- qNMR --- single crystal X-ray structure --- reference standard --- iduronic acid conformation --- Arixtra® --- n/a --- n/a --- n/a

Advances in Food Analysis

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ISBN: 9783039217427 9783039217434 Year: Pages: 488 DOI: 10.3390/books978-3-03921-743-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Mathematics
Added to DOAB on : 2019-12-09 11:49:16
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This Topical Collection of Molecules provides the most recent advancements and trends within the framework of food analysis, confirming the growing public, academic, and industrial interest in this field. The articles broach topics related to sample preparation, separation science, spectroscopic techniques, sensors and biosensors, as well as investigations dealing with the characterization of macronutrients, micronutrients, and other biomolecules. It offers the latest updates regarding alternative food sources (e.g., algae), functional foods, effects of processing, chiral or achiral bioactive compounds, contaminants, and every topic related to food science that is appealing to readers. Nowadays, the increasing awareness of the close relation among diet, health, and social development is stimulating demands for high levels of quality and safety in agro-food production, as well as new studies to fill gaps in the actual body of knowledge about food composition. For these reasons, modern research in food science and human nutrition is moving from classical methodologies to advanced instrumental platforms for comprehensive characterization. Nondestructive spectroscopic and imaging technologies are also proposed for food process monitoring and quality control in real time.

Keywords

cuprous oxide nanoparticles --- reduced graphene oxide --- modified electrode --- sunset yellow --- second-derivative linear sweep voltammetry --- clenbuterol --- systematic evolution of ligands by exponential enrichment --- real-time quantitative PCR --- high-throughput sequencing technology --- aptamers --- gold nanoparticles biosensor --- carbamates --- multiple reaction monitoring (MRM) --- enhanced product ion (EPI) --- mass fragmentation --- confirmatory method --- pesticide residues --- Croatian wines --- biogenic amines --- HPLC --- geographical origin --- polyelectrolyte composite film --- nitrite detection --- differential pulse voltammetry --- cyclic voltammetry --- mycotoxin --- dimerization --- HRMS --- NMR --- fruit jams --- food security --- phenolic acids --- quercetin --- agro-biodiversity --- HPLC fingerprint --- Polygonatum cyrtonema --- saccharides --- oligosaccharides --- fructose --- HPLC–QTOF–MS/MS --- steaming --- essential oil --- extraction techniques --- hops extracts --- hydrodistillation --- Marynka strain --- microwave-assisted hydrodistillation --- anthocyanins --- bioactive compounds --- Box–Behnken design --- microwave-assisted extraction --- myrtle --- Myrtus communis --- phenolic compounds --- Chia seed oil --- polyunsaturated fatty acid --- antioxidant --- lipid-lowering effect --- collagen peptide --- HPLC fingerprint --- antioxidant --- anti-inflammatory --- spectrum-effect relationship --- amino acids --- carbohydrates --- acidity --- polarity --- molecular weight --- Tricholoma matsutake --- Pol gene --- qualitative and quantitative PCR --- DNA extraction --- ?-blockers --- metabolites --- milk powder --- Q-Orbitrap --- rosé wines --- white wines --- bottle aging --- flavor profile --- closures --- anthocyanins --- bioactive compounds --- Box–Behnken design --- ultrasound-assisted extraction --- myrtle --- Myrtus communis L. --- phenolic compounds --- food safety --- kiwifruit (Actinidia chinensis) --- molecular identification --- phylogeny --- DNA barcode --- hard clams --- Meretrix lyrata --- lipid classes --- fatty acids --- phospholipids --- molecular species of phospholipid --- high resolution mass spectrometry --- impedimetric aptasensor --- screen-printed interface --- bifunctional polymer arms --- PAT detection --- apple juice --- chiral --- chiral stationary phases --- enantiomers --- food --- review --- Piper methysticum (kava) --- kavalactones --- flavokavains --- UHPLC-UV --- mass spectra --- isomerization --- single-laboratory validation --- quality control --- Lactarius deliciosus --- chemical composition --- antioxidant --- antihyperglycemic --- ?13C-IRMS --- fatty acids composition --- 1H-NMR --- walnut varieties --- poultry eggs --- thiamphenicol --- florfenicol --- florfenicol amine --- ASE --- UPLC-FLD --- Sojae semen praeparatum (SSP) --- fermentation --- conversion --- ultra-fast liquid chromatography (UFLC)–TripleTOF MS --- principal component analysis (PCA) --- microalgae --- Scenedesmus --- supercritical fluid extraction --- carotenoids --- fat-soluble vitamins --- antioxidants --- fruit juice --- blends --- adulteration --- 1H NMR --- PLS --- chemometrics --- natural mature honey --- immature honey --- chemometric analysis --- multi-physicochemical parameters --- food quality --- IMS --- food composition --- food process control --- food authentication --- food adulteration --- food safety --- antibiotics --- liquid chromatography mass spectrometry --- milk --- muscle --- validation

Advances in Near Infrared Spectroscopy and Related Computational Methods

Authors: ---
ISBN: 9783039280520 9783039280537 Year: Pages: 496 DOI: 10.3390/books978-3-03928-053-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Analytical Chemistry
Added to DOAB on : 2020-01-30 16:39:46
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In the last few decades, near-infrared (NIR) spectroscopy has distinguished itself as one of the most rapidly advancing spectroscopic techniques. Mainly known as an analytical tool useful for sample characterization and content quantification, NIR spectroscopy is essential in various other fields, e.g. NIR imaging techniques in biophotonics, medical applications or used for characterization of food products. Its contribution in basic science and physical chemistry should be noted as well, e.g. in exploration of the nature of molecular vibrations or intermolecular interactions. One of the current development trends involves the miniaturization and simplification of instrumentation, creating prospects for the spread of NIR spectrometers at a consumer level in the form of smartphone attachments—a breakthrough not yet accomplished by any other analytical technique. A growing diversity in the related methods and applications has led to a dispersion of these contributions among disparate scientific communities. The aim of this Special Issue was to bring together the communities that may perceive NIR spectroscopy from different perspectives. It resulted in 30 contributions presenting the latest advances in the methodologies essential in near-infrared spectroscopy in a variety of applications.

Keywords

hyperspectral imaging --- variety discrimination --- Chrysanthemum --- deep convolutional neural network --- DNA --- FTIR spectroscopy --- rapid identification --- PLS-DA --- animal origin --- near-infrared hyperspectral imaging --- raisins --- support vector machine --- pixel-wise --- object-wise --- maize kernel --- hyperspectral imaging technology --- accelerated aging --- principal component analysis --- support vector machine model --- standard germination tests --- blackberries --- Rubus fructicosus --- phenolics --- carotenoids --- bioanalytical applications --- near infrared --- chemometrics --- VIS/NIR hyperspectral imaging --- corn seed --- classification --- freeze-damaged --- image processing --- imaging visualization --- wavelength selection --- NIR spectroscopy --- binary dragonfly algorithm --- ensemble learning --- quantitative analysis modeling --- NIR --- SCiO --- pocket-sized spectrometer --- cheese --- fat --- moisture --- multivariate data analysis --- Fourier-transform near-infrared spectroscopy --- glucose --- fructose --- dry matter --- partial least square regression --- Ewing sarcoma --- Fourier transform infrared spectroscopy --- FTIR --- chemotherapy --- bone cancer --- calibration transfer --- NIR spectroscopy --- PLS --- quantitative analysis model --- melamine --- FT-IR --- NIR spectroscopy --- quantum chemical calculation --- anharmonic calculation --- overtones --- combination bands --- near infrared spectroscopy --- Trichosanthis Fructus --- geographical origin --- chemometric techniques --- crude drugs --- prepared slices --- support vector machine-discriminant analysis --- near-infrared fluorescence --- fluorescent probes --- Zn(II) --- di-(2-picolyl)amine --- living cells --- cellular imaging --- near-infrared (NIR) spectroscopy --- calibration transfer --- affine invariance --- multivariate calibration --- partial least squares (PLS) --- NIR --- direct model transferability --- MicroNIR™ --- SVM --- hier-SVM --- SIMCA --- PLS-DA --- TreeBagger --- PLS --- calibration transfer --- agriculture --- photonics --- imaging --- spectral imaging --- spectroscopy --- handheld near-infrared spectroscopy --- pasta/sauce blends --- partial least squares calibration --- nutritional parameters --- bootstrapping soft shrinkage --- partial least squares --- extra virgin olive oil --- adulteration --- FT-NIR spectroscopy --- near-infrared spectroscopy --- ethanol --- anharmonic quantum mechanical calculations --- isotopic substitution --- overtones --- combinations bands --- seeds vitality --- rice seeds --- near-infrared spectroscopy --- hyperspectral image --- discriminant analysis --- near-infrared spectroscopy --- counter propagation artificial neural network --- detection --- auxiliary diagnosis --- BRAF V600E mutation --- colorectal cancer --- tissue --- paraffin-embedded --- deparaffinized --- stained --- ultra-high performance liquid chromatography --- Folin–Ciocalteu --- total hydroxycinnamic derivatives --- phytoextraction --- near-infrared spectroscopy --- origin traceability --- data fusion --- Paris polyphylla var. yunnanensis --- Fourier transform mid-infrared spectroscopy --- near-infrared spectroscopy --- aquaphotomics --- water --- light --- near infrared spectroscopy --- water-mirror approach --- perturbation --- biomeasurements --- biodiagnosis --- biomonitoring --- Vitis vinifera L. --- proximal sensing --- precision viticulture --- near infrared --- chemometrics --- non-destructive sensor --- NIRS --- osteopathy --- late preterm --- brain --- splanchnic --- Raman spectroscopy --- hyperspectral imaging --- analytical spectroscopy --- counterfeit and substandard pharmaceuticals --- DFT calculations --- chemometrics --- PLSR --- API --- lumefantrine --- artemether --- antimalarial tablets --- FT-NIR spectroscopy --- PLS-R --- water --- glucose --- test set validation --- RMSEP --- hyperspectral image processing --- perfusion measurements --- clinical classifications --- n/a

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