Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book illustrates some of the most recent research efforts that have been made in lowering plasma cholesterol levels in patients with CVD. Selected articles aimed to illuminate advances and urgent challenges in the management of CVD, including disease management using statin-combined therapeutic strategies.

anacetrapib --- cholesteryl ester transfer protein --- cardiovascular disease --- apolipoprotein --- diabetes --- vaspin --- acute coronary syndrome --- NSTEMI --- STEMI --- lipoproteins --- atherosclerosis --- cardiovascular risk --- statin --- PCSK9 --- genetic --- nutrigenetics --- sterol --- cholesterol --- low-density lipoprotein cholesterol --- cardiovascular disease --- ABCA1 --- HDL --- miRNA --- circular RNA --- gene expression --- RNA-binding proteins --- reverse cholesterol transport --- cardiovascular diseases --- dyslipidemia --- type 2 diabetes --- PCSK9 --- nonstatin --- PCSK9 --- proprotein convertase subtilisin/kexin type 9 --- LDL subfractions --- sdLDL --- cardiovascular disease --- risk stratification --- proprotein convertase subtilisin-kexin type 9 (PCSK9) --- small interfering RNA (siRNA) --- inclisiran --- low-density lipoprotein-cholesterol (LDL-C) --- cardiovascular disease (CVD) --- cardiovascular risk --- atherosclerosis --- ceramides --- lipids --- lipoproteins --- miRNA --- sphingolipids --- sphingomyelin --- NAFLD --- NASH --- hepatic fibrosis --- hyperlipidemia --- statins --- statins --- coronary artery bypass grafting --- pleiotropic actions --- atrial fibrillation --- stroke --- acute kidney injury

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Nutrients is planning a Special Issue focusing on beverages and ingestive behavior. This Special Issue will focus on research related to all aspects of beverage consumption and post-ingestive consequences. There continues to be much controversy surrounding the influence of beverage choice on health outcomes. Research investigating the impact of beverage choice has on human health and post-ingestive consequences continue to grow. We know from the growing body of literature that beverage choice has a substantial impact on metabolism, food reinforcement and eating behaviors.

beverages --- sugar sweetened beverages --- overweight --- obesity --- (conjugated) plant sterols --- beverages --- cholesterol-lowering --- ergosterol --- anti-aging --- coronary heart disease --- health claims --- anti-inflammatory --- anti-carcinogenic --- toddlers --- preschoolers --- mothers --- parents --- sugar-sweetened beverages --- Repertory Grid Technique --- Laddering Technique --- qualitative methods --- Australia --- electroencephalography --- non-nutritive sweeteners --- sweet taste --- visual food cues --- food intake --- ad libitum buffet --- parenting practices --- sugar-sweetened beverages --- gain- and loss-framed messages --- self-determination --- planned behavior --- intention --- beverage consumption --- sport --- beverage consumption --- water consumption --- total water intake --- total energy intake --- adults --- Balearic Islands --- sugar-sweetened beverages --- children --- parents --- social cognitive theory --- nutrition education --- health promotion --- cardiovascular-risk-factors --- overweight --- obesity --- fermented-beverage --- lipoprotein-oxidation --- HDL-antioxidant-capacity --- cholesterol-efflux --- endothelial-function --- type 1 diabetes --- beta-casein --- cows’ milk --- epigenetics --- NOD mice --- gastric emptying --- gamma-scintigraphy --- yogurt --- in vitro digestion --- casein --- whey protein --- satiety

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The adipokine adiponectin is very concentrated in plasma, and decreased levels of adiponectin are associated with pathological conditions such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. When produced in its full-length form, adiponectin self-associates to generate multimeric complexes. The full-length form of adiponectin can be cleaved by the globular form of elastase that is produced locally, and the resulting biological effects are exerted in a paracrine or autocrine manner. The different forms of adiponectin bind to specific receptors consisting of two G-protein-independent, seven-transmembrane-spanning receptors, called AdipoR1 and AdipoR2, while T-cadherin has been identified as a potential receptor for high molecular weight complexes of adiponectin. Adiponectin exerts a key role in cellular metabolism, regulating glucose levels as well as fatty acid breakdown. However, its biological effects are heterogeneous, involving multiple target tissues. The Special Issue “Mechanisms of Adiponectin Action” highlights the pleiotropic role of this hormone through 3 research articles and 7 reviews. These papers focus on the recent knowledge regarding adiponectin in different target tissues, both in healthy and in diseased conditions.

adiponectin --- atherosclerosis --- cholesterol efflux --- diabetes --- inflammation --- endometrium --- implantation --- transcriptome --- microarray --- adiponectin --- pig --- fertility --- adipose tissue --- reproductive tract --- adipokines --- cell signaling --- skeletal muscle --- regeneration --- adiponectin isoforms --- exercise --- training --- adiponectin --- AMPK --- BIAcore --- extracellular signal-regulated kinase (ERK) --- matricellular proteins --- neuritogenesis --- NGF? --- PC12 cells --- Secreted protein --- acidic and rich in cysteine (SPARC) --- adiponectin --- muscle --- myopathies --- adiponectin --- metabolism --- AdipoRon --- lipotoxicity --- adiponectin --- adiponectin inducer --- kojyl cinnamate ester derivative --- adipogenesis --- hair growth-related factor --- human follicular dermal papilla cell --- obesity --- adipokines --- adiponectin --- breast cancer --- ovarian cancer --- endometrial cancer --- cervix cancer --- estrogen receptor --- adiponectin --- obesity --- cancer --- adiponectin --- adipose tissue --- obesity --- endocrine cancer --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse as algae, fungi, anthozoans, and echinoderms. Even fish of the genus Pardachirus produce glycosides, which they use as shark repellents.The major interest in these compounds as potential drugs stems from their broad spectrum of biological effects. They have been shown to have antimicrobial, antifungal, anti-inflammatory, immune modulatory, and anticancer effects. The anticancer effects of marine glycosides include cell cycle suppression, the induction of apoptosis, and the inhibition of migration, invasion, and metastasis, as well as antiangiogenesis. Marine glycosides influence membrane permeability and have been shown to influence membrane transport at the molecular level through effects on transport carriers and pumps, as well as effects on ligand-gated and voltage-gated channels. Various marine glycosides have been shown to activate sphingomyelinase and ceramide synthesis, to inhibit topoisomerase activity, receptor tyrosine kinase activity, and multidrug resistance protein activity, and to antagonize eicosanoid receptors.This Special Issue covers the entire scope of marine organism-derived glycosides that are of potential value as pharmaceutical agents or leads. These include, but are not limited to, tetracyclic triterpene glycosides, other triterpene glycosides, steroid glycosides, and glycosides of non-isoprenoid aglycones.

sponge --- saponins --- deep-sea --- Poecillastra compressa --- Neothyonidium magnum --- triterpene glycosides --- magnumosides --- sea cucumber --- cytotoxic activity --- radioactive irradiation --- sea cucumber --- Eupentacta fraudatrix --- triterpene glycoside --- liquid chromatography–tandem mass spectrometry --- metabolite profiling --- holostane --- nonholostane --- cucumarioside --- cytotoxic --- antifungal --- glycosides --- Conus pulicarius --- steroidal glycoside --- cholesterol sulfate --- cytotoxicity --- leukemia --- cancer --- frondoside A --- tumor growth --- metastases --- apoptosis --- invasion --- angiogenesis --- Culcita novaeguineae --- starfish --- polyhydroxysteroidal glycoside --- cytotoxicity --- mangrove-derived Streptomyces --- angucycline --- urdamycin --- marine organisms --- carbohydrate --- glycoside --- antioxidant --- anticoagulant --- anti-inflammatory --- antitumor --- antimicrobial --- glycolipids --- glycosphingolipids --- glycoglycerolipids --- natural products --- total synthesis --- triterpene glycosides --- saponin --- sea cucumber --- mass spectrometry --- MALDI --- ESI --- LC-MS --- Holothuroidea --- marine ginseng --- structure elucidation --- marine invertebrate --- natural products --- bioactive compounds --- antifungal --- antibacterial --- antioxidant --- Streptomyces --- angucycline glycosides --- saquayamycin --- cytotoxicity --- apoptosis --- SMMC-7721

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Obesity and related co-morbidities are increasing worldwide and pose a serious health problem. Changes in lifestyle and diet would be the best remedies to fight obesity; however, many people will still rely on medical aid. Marine organisms have been prolific in the production of bioactive compounds for many diseases, e.g., cancer, and promise to be an excellent source for natural-derived molecules and novel nutraceuticals. Bioactive compounds with beneficial activities towards obesity have been described from diverse marine organism including marine algae, bacteria, sponges, fungi, crustaceans or fish. This Special Issue will highlight the progress in the following topics: Bioactive compounds for the treatment of obesity and obesity-related co-morbidities (diabetes, fatty liver, hyperlipidemia) from marine organisms; the isolation of novel compounds, the bioactivity screening of marine organisms and the elucidation of molecular mode of action of marine bioactive compounds.

3T3-L1 cells --- fucan --- lipolytic --- obesity --- brown seaweed --- chitosan oligosaccharide --- obesity --- leptin --- JAK2-STAT3 --- adipogenesis --- collagen peptide --- skate skin --- high fat diet --- fatty acid metabolism --- cholesterol metabolism --- chitosan oligosaccharide --- glucolipid metabolism disorder --- high-fat diet --- inflammation --- peroxisome proliferator-activated receptor gamma --- cellularity --- adipocyte --- obesity --- nutrition --- fat --- proliferation --- white adipose tissue --- adipogenesis --- antiobesity --- adipocytes --- diphlorethohydroxycarmalol (DPHC) --- Skate skin --- Raja kenojei --- collagen --- body fat --- obesity --- Ishige okamurae --- marine alga --- obesity --- diabetes --- nutraceuticals --- zebrafish Nile red fat metabolism assay --- anti-obesity drugs --- chlorophyll derivatives --- murine pre-adipocytes --- PPAR? --- Arthrospira maxima --- dyslipidemia --- physical exercise --- obesity --- double-blind --- randomized controlled trial --- anti-obesity drugs --- metabolite profiling --- zebrafish Nile red fat metabolism assay --- uncoupling protein 1 --- bioactivity screening --- diabetes --- fatty liver disease --- cyanobacteria --- thermal proteome profiling --- mechanisms of action --- bioactive compound --- label-free quantitative proteomics --- marine biodiscovery --- marine sponges --- natural compounds --- bisabolane-related compounds --- bioactivity --- obesity --- whole small animal models