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Neural and Computational Modeling of Movement Control

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889451302 Year: Pages: 178 DOI: 10.3389/978-2-88945-130-2 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2017-07-06 13:27:36
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In the study of sensorimotor systems, an important research goal has been to understand the way neural networks in the spinal cord and brain interact to control voluntary movement. Computational modeling has provided insight into the interaction between centrally generated commands, proprioceptive feedback signals and the biomechanical responses of the moving body. Research in this field is also driven by the need to improve and optimize rehabilitation after nervous system injury and to devise biomimetic methods of control in robotic devices. This research topic is focused on efforts dedicated to identify and model the neuromechanical control of movement. Neural networks in the brain and spinal cord are known to generate patterned activity that mediates coordinated activation of multiple muscles in both rhythmic and discrete movements, e.g. locomotion and reaching. Commands descending from the higher centres in the CNS modulate the activity of spinal networks, which control movement on the basis of sensory feedback of various types, including that from proprioceptive afferents. The computational models will continue to shed light on the central strategies and mechanisms of sensorimotor control and learning. This research topic demonstrated that computational modeling is playing a more and more prominent role in the studies of postural and movement control. With increasing ability to gather data from all levels of the neuromechanical sensorimotor systems, there is a compelling need for novel, creative modeling of new and existing data sets, because the more systematic means to extract knowledge and insights about neural computations of sensorimotor systems from these data is through computational modeling. While models should be based on experimental data and validated with experimental evidence, they should also be flexible to provide a conceptual framework for unifying diverse data sets, to generate new insights of neural mechanisms, to integrate new data sets into the general framework, to validate or refute hypotheses and to suggest new testable hypotheses for future experimental investigation. It is thus expected that neural and computational modeling of the sensorimotor system should create new opportunities for experimentalists and modelers to collaborate in a joint endeavor to advance our understanding of the neural mechanisms for postural and movement control. The editors would like to thank Professor Arthur Prochazka, who helped initially to set up this research topic, and all authors who contributed their articles to this research topic. Our appreciation also goes to the reviewers, who volunteered their time and effort to help achieve the goal of this research topic. We would also like to thank the staff members of editorial office of Frontiers in Computational Neuroscience for their expertise in the process of manuscript handling, publishing, and in bringing this ebook to the readers. The support from the Editor-in-Chief, Dr. Misha Tsodyks and Dr. Si Wu is crucial for this research topic to come to a successful conclusion. We are indebted to Dr. Si Li and Ms. Ting Xu, whose assistant is important for this ebook to become a reality. Finally, this work is supported in part by grants to Dr. Ning Lan from the Ministry of Science and Technology of China (2011CB013304), the Natural Science Foundation of China (No. 81271684, No. 61361160415, No. 81630050), and the Interdisciplinary Research Grant cross Engineering and Medicine by Shanghai Jiao Tong University (YG20148D09). Dr. Vincent Cheung is supported by startup funds from the Faculty of Medicine of The Chinese University of Hong Kong. Guest Associate EditorsNing Lan, Vincent Cheung, and Simon Gandevia

Basal ganglia: physiological, behavioral, and computational studies

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193882 Year: Pages: 494 DOI: 10.3389/978-2-88919-388-2 Language: English
Publisher: Frontiers Media SA
Subject: Science (General)
Added to DOAB on : 2015-12-03 13:02:24
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The basal ganglia has received much attention over the last two decades, as it has been implicated in many neurological and psychiatric disorders. Most of this research - in both animals and humans - attempt to understand the neural and biochemical substrates of basic motor and learning processes, and how these are affected in human patients as well as animal models of brain disorders. The current volume contains research articles and reviews describing basic, pre-clinical and clinical neuroscience research of the basal ganglia written by attendees of the 11th Triennial Meeting of the International Basal Ganglia Society (IBAGS) that was held March 3-7th, 2013 at the Princess Hotel, Eilat, Israel and by researchers of the basal ganglia. Specifically, articles in this volume include research reports on the biochemistry, computational theory, anatomy and physiology of single neurons and functional circuitry of the basal ganglia networks as well as the latest data on animal models of basal ganglia dysfunction and clinical studies in human patients.

Optogenetic Tools in the Molecular Spotlight

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198993 Year: Pages: 179 DOI: 10.3389/978-2-88919-899-3 Language: English
Publisher: Frontiers Media SA
Subject: Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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The rise of optogenetics as a standard technique to non-invasively probe and monitor biological function created an immense interest in the molecular function of photosensory proteins. These photoreceptors are usually protein/pigment complexes that translate light into biological information and have become essential tools in cell biology and neurobiology as their function is genetically encoded and can be conveniently delivered into a given cell. Like for fluorescent proteins that quickly became invaluable as genetically encodable reporters in microscopy and imaging, variants of photosensory proteins with customized sensitivity and functionality are nowadays in high demand. In this ebook we feature reviews and original research on molecular approaches from synthetic biology and molecular spectroscopy to computational molecular modelling that all aspire to elucidate the molecular prerequisites for the photosensory function of the given proteins. The principle property of changing activity of biological function simply by application of light is not only very attractive for cell biology, it also offers unique opportunities for molecular studies as excitation can be controlled with high time precision. Especially in spectroscopy the usually fully reversible photoactivation of photosensory proteins allows researchers to to perform time resolved studies with up to femtosecond resolution. In addition, functional variants can be investigated and quickly screened in common biochemical experiments. The insights that are obtained by the here presented various yet complementary methods will ultimately allow us write the script for a molecular movie from excitation of the protein by a photon to activation of its biological function. Such deep understanding does not only provide unique insights into the dynamics of protein function, it will also ultimately enable us to rationally design novel optogenetic tools to be used in cell biology and therapy.

Modeling of Visual Cognition, Body Sense, Motor Control and Their Integrations

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889451098 Year: Pages: 134 DOI: 10.3389/978-2-88945-109-8 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2017-07-06 13:27:36
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The interdisciplinary studies between neuroscience and information science have greatly promoted the development of these two fields. The achievements of these studies can help humans understand the essence of biological systems, provide computational platforms for biological experiments, and improve the intelligence and performance of the algorithms in information science. This research topic is focused on the computational modeling of visual cognition, body sense, motor control and their integrations. Firstly, the modeling and simulation of vision and body sense are achieved by 1) understanding neural mechanism underlying sensory perception and cognition, and 2) mimicking accordingly the structures and mechanisms of their signal propagation pathways. The achievement of this procedure could provide neural findings for better encoding and decoding visual and somatosensory perception of humans, and help robots or systems build humanoid robust vision, body sensing, and various emotions. Secondly, the modeling and simulation of the motor system of the primate are achieved by mimicking the coordination of bones, muscles and joints and the control mechanisms of the neural system in the brain and spinal cord. This procedure could help robots achieve fast, robust and accurate manipulations and be used for safe human-computer interaction. Finally, by integrating them, more complete and intelligent systems/robots could be built to accomplish various tasks self-adaptively and automatically.

Foundations of Theoretical Approaches in Systems Biology

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889456833 Year: Pages: 216 DOI: 10.3389/978-2-88945-683-3 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Biology
Added to DOAB on : 2019-01-23 14:53:43
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If biology in the 20th century was characterized by an explosion of new technologies and experimental methods, that of the 21st has seen an equally exuberant proliferation of mathematical and computational methods that attempt to systematize and explain the abundance of available data. As we live through the consolidation of a new paradigm where experimental data goes hand in hand with computational analysis, we contemplate the challenge of fusing these two aspects of the new biology into a consistent theoretical framework. Whether systems biology will survive as a field or be washed away by the tides of future fads will ultimately depend on its success to achieve this type of synthesis. The famous quote attributed to Kurt Lewin comes to mind: "there is nothing more practical than a good theory". This book presents a wide assortment of articles on systems biology in an attempt to capture the variety of current methods in systems biology and show how they can help to find answers to the challenges of modern biology.

50 years after the perceptron, 25 years after PDP: Neural computation in language sciences

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889192571 Year: Pages: 180 DOI: 10.3389/978-2-88919-257-1 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Psychology
Added to DOAB on : 2015-11-16 15:44:59
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This Research Topic aims to showcase the state of the art in language research while celebrating the 25th anniversary of the tremendously influential work of the PDP group, and the 50th anniversary of the perceptron. Although PDP models are often the gold standard to which new models are compared, the scope of this Research Topic is not constrained to connectionist models. Instead, we aimed to create a landmark forum in which experts in the field define the state of the art and future directions of the psychological processes underlying language learning and use, broadly defined. We thus called for papers involving computational modeling and original research as well as technical, philosophical, or historical discussions pertaining to models of cognition. We especially encouraged submissions aimed at contrasting different computational frameworks, and their relationship to imaging and behavioral data.

Neurobiological circuit function and computation of the serotonergic and related systems

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193844 Year: Pages: 165 DOI: 10.3389/978-2-88919-384-4 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2015-12-03 13:02:24
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Serotonin is one of the oldest neurotransmitters in evolutionary terms, and the serotonergic system is complex and multifaceted. Serotonin-producing neurons in the raphe nuclei provide serotonin innervations throughout various parts of the brain, modulating cellular excitability and network properties of targeted brain areas, and regulating mood, cognition and behavior. Dysfunctions of the serotonergic system are implicated in neuropsychiatric disorders including depression, schizophrenia, and drug abuse. Although the system has been studied for many years, an integrative account of its functions and computational principles remains elusive. This is partly attributed to the high variability and heterogeneity in terms of neuronal properties and receptor types, and its extensive connections with other brain regions. This Frontiers Research Topic e-book is a collection of recent experimental and computational work and approaches at multiple scales that provide the latest information regarding the integrated functions of the serotonergic system. The contributed papers include a variety of experimental and computational work, and human clinical studies.

Characterizing Cardiac Electrophysiology during Radiofrequency Ablation : An Integrative Ex vivo, In silico, and In vivo Approach

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Book Series: Karlsruhe transactions on biomedical engineering / Ed.: Karlsruhe Institute of Technology / Institute of Biomedical Engineering ISSN: 18645933 ISBN: 9783731508861 Year: Volume: 24 Pages: XI, 268 p. DOI: 10.5445/KSP/1000089807 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:58
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Catheter ablation is a major treatment for atrial tachycardias. Hereby, the precise monitoring of the lesion formation is an important success factor. This book presents computational, wet-lab, and clinical studies with the aim of evaluating the signal characteristics of the intracardiac electrograms (IEGMs) recorded around ablation lesions from different perspectives. The detailed analysis of the IEGMs can optimize the description of durable and complex lesions during the ablation procedure.

Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453177 Year: Pages: 220 DOI: 10.3389/978-2-88945-317-7 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2018-02-27 16:16:45
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The basal ganglia constitute a group of subcortical structures, highly interconnected among themselves, as well as with the cerebral cortex, thalamus and other brain areas. These nuclei play a central role in the control of voluntary movement, and their specific pathology comprises the group of diseases known as movement disorders, including Parkinson's disease, Huntington's disease, dystonia and Gilles de la Tourette syndrome, among others. Additionally, the presence of a number of circuits within the basal ganglia related to non-motor functions has been acknowledged. Currently, the basal ganglia are thought to participate in cognitive, limbic and learning functions. Moreover, disorders related to the basal ganglia are known to involve a number of complex, non-motor symptoms and syndromes (e.g. compulsive and addictive behavior). In the light of this evidence, it is becoming clear that our knowledge about the basal ganglia needs to be revised, and that new pathophysiological models of movement disorders are needed. In this context, the study of the pathophysiology of the basal ganglia and the treatment of their pathology is becoming increasingly interdisciplinary. Nowadays, an appropriate approach to the study of these problems must necessarily involve the use of complex mathematical modeling, computer simulations, basic research (ranging from biomolecular studies to animal experimentation), and clinical research. This research topic aims to bring together the most recent advances related to the pathophysiology of the basal ganglia and movement disorders.

Flow and Heat or Mass Transfer in the Chemical Process Industry

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ISBN: 9783038972389 9783038972396 Year: Pages: 214 DOI: 10.3390/books978-3-03897-239-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering
Added to DOAB on : 2018-09-28 12:14:25
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ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms.[Flow through process equipment in a chemical or manufacturing plant (e.g., heat exchangers, reactors, catalyst regeneration units, separation units, pumps, pipes, smoke stacks, etc.) is usually coupled with heat and/or mass transfer. Rigorous investigation of this coupling of momentum, heat, and mass transfer is not only important for the practice of designing process equipment, but is also important for improving our overall theoretical understanding of transfer phenomena. While generalizations and empiricisms, like the concept of the heat transfer coefficient or the widely used Reynolds analogy in turbulence, or the use of empirical transfer equations for flow in separation towers and reactors packed with porous media, have served practical needs in prior decades, such empiricisms can now be revised or altogether replaced by bringing modern experimental and computational tools to bear in understanding the interplay between flow and transfer. The patterns of flow play a critical role in enhancing the transfer of heat and mass. Typical examples are the coherent flow structures in turbulent boundary layers, which are responsible for turbulent transfer and mixing in a heat exchanger and for dispersion from a smoke stack, and the flow patterns that are a function of the configuration of a porous medium and are responsible for transfer in a fixed bed reactor or a fluid bed regenerator unit. The goal of this Special Issue is to be a forum for recent developments in theory, state-of-the-art experiments and computations on the interactions between flow and transfer in single and multi-phase flow, and from small scales to large scales, which can be important for the design of equipment in a chemical processing plant.]

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