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Recent CMV Research

ISBN: 9783906980539 9783906980546 Year: Pages: 528 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2015-01-12 11:33:22
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I am very pleased with this Viruses Special Issue. Of particular interest to families and caregivers affected by CMV diseases are several papers: addressing prevention of CMV infection of trophoblast cells (Zydek et al., 2014), CMV latency (Sinclair and Reeves, 2013), as well as of CMV lung infections in non-HIV infected children (Restrepo-Gualteros et al., 2014). Our ability to enhance immune responses for controlling CMV infection (Hanley and Bollard, 2014) and new strategies for CMV vaccine development guided by non-human primate studies (Deere and Barry, 2014) are discussed in two excellent reviews. Several articles address the CMV manipulation of the immune system, both innate and adaptive immune responses (Stevenson et al., 2014, Fink et al, 2013, 2014, Raghavan et al., 2014) and of DNA damage responses (E and Kowalik, 2014; Kulkarni and Fortunato, 2014). [...]

Product/Process Fingerprint in Micro Manufacturing

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ISBN: 9783039210343 9783039210350 Year: Pages: 274 DOI: 10.3390/books978-3-03921-035-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General)
Added to DOAB on : 2019-06-26 08:44:06
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The continuous miniaturization of products and the growing complexity of their embedded multifunctionalities necessitates continuous research and development efforts regarding micro components and related micro manufacturing technologies. Highly miniaturized systems, manufactured using a wide variety of materials, have found application in key technological fields, such as healthcare devices, micro implants, mobility, communications, optics, and micro electromechanical systems. Innovations required for the high-precision manufacturing of micro components can specifically be achieved through optimizations using post-process (i.e., offline) and in-process (i.e., online) metrology of both process input and output parameters, as well as geometrical features of the produced micro parts. However, it is of critical importance to reduce the metrology and optimization efforts, since process and product quality control can represent a significant portion of the total production time in micro manufacturing. To solve this fundamental challenge, research efforts have been undertaken in order to define, investigate, implement, and validate the so-called “product/process manufacturing fingerprint” concept. The “product manufacturing fingerprint” concept refers to those unique dimensional outcomes (e.g., surface topography, form error, critical dimensions, etc.) on the produced component that, if kept under control and within specifications, ensure that the entire micro component complies to its specifications. The “process manufacturing fingerprint” is a specific process parameter or feature to be monitored and controlled, in order to maintain the manufacture of products within the specified tolerances. By integrating both product and process manufacturing fingerprint concepts, the metrology and optimization efforts are highly reduced. Therefore, the quality of the micro products increases, with an obvious improvement in production yield. Accordingly, this Special Issue seeks to showcase research papers, short communications, and review articles that focus on novel methodological developments and applications in micro- and sub-micro-scale manufacturing, process monitoring and control, as well as micro and sub-micro product quality assurance. Focus will be on micro manufacturing process chains and their micro product/process fingerprint, towards full process optimization and zero-defect micro manufacturing.

Keywords

micro-injection moulding --- quality assurance --- process monitoring --- micro metrology --- positioning platform --- Halbach linear motor --- commercial control hardware --- diffractive optics --- gratings --- microfabrication --- computer holography --- manufacturing signature --- process fingerprint --- Fresnel lenses --- injection compression molding --- injection molding --- micro structures replication --- confocal microscopy --- optical quality control --- uncertainty budget --- optimization --- precision injection molding --- quality control --- process monitoring --- product fingerprint --- process fingerprint --- electrical discharge machining --- electrical discharge machining (EDM) --- surface roughness --- surface integrity --- optimization --- desirability function --- satellite drop --- electrohydrodynamic jet printing --- charge relaxation time --- laser ablation --- superhydrophobic surface --- process fingerprint --- product fingerprint --- surface morphology --- artificial compound eye --- multi-spectral imaging --- lithography --- spectral splitting --- plasma-electrolytic polishing --- PeP --- surface modification --- finishing --- electro chemical machining --- ECM --- Electro sinter forging --- resistance sintering --- electrical current --- fingerprints --- electrical discharge machining --- micro drilling --- process monitoring --- quality control --- electrochemical machining (ECM) --- process control --- current monitoring --- current density --- surface roughness --- inline metrology --- haptic actuator --- impact analysis --- high strain rate effect --- damping --- 2-step analysis --- micro-grinding --- bioceramics --- materials characterisation --- dental implant --- microinjection moulding --- process fingerprints --- flow length --- quality assurance --- n/a

Biomimetic Radical Chemistry and Applications

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ISBN: 9783039283927 9783039283934 Year: Pages: 300 DOI: 10.3390/books978-3-03928-393-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology --- Science (General)
Added to DOAB on : 2020-04-07 23:07:09
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The enormous importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted a strong interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an important research area. When studying free-radical-based chemical mechanisms, biomimetic chemistry and the design of established biomimetic models come into play to perform experiments in a controlled environment that is suitably designed to be in strict connection with cellular conditions. This Special Issue gives the reader a wide overview of biomimetic radical chemistry, where molecular mechanisms have been defined and molecular libraries of products are developed to also be used as traces for the discovery of some relevant biological processes. Several subjects are presented, with 12 articles and 6 reviews written by specialists in the fields of DNA, proteins, lipids, biotechnological applications, and bioinspired synthesis, having “free radicals” as a common denominator.

Keywords

type 2 diabetes --- glycogen phosphorylase --- anomeric spironucleosides --- 1,6-dioxa-4-azaspiro[4.5]decane --- [1,5]-radical translocation --- DNA --- guanine quadruplexes --- radicals --- electron holes --- oxidative damage --- photo-ionization --- time-resolved spectroscopy --- inhomogeneous reactions --- radiosensitizers --- stationary radiolysis --- pulse radiolysis --- modified nucleosides --- cellular response --- liposomal somatostatin --- retarded delivery --- free radicals --- isomerization --- trans lipid --- peroxidation --- photolysis --- laser flash photolysis --- ?-radiolysis --- singlet oxygen --- nucleosides --- free radicals --- reaction mechanism --- catalase activity --- iron(IV)-oxo --- hydrogen peroxide --- oxidation --- kinetic studies --- gold nanoparticles --- albumin --- EPR spectroscopy --- Raman spectroscopy --- circular dichroism --- beta cells --- diabetes --- confocal microscopy --- lipidomics --- membrane fluidity maps --- cell micropolarity maps --- DNA damage --- 5?,8-cyclopurines --- 8-oxo-dG --- free radicals --- pulse radiolysis --- gamma radiolysis --- Fenton reaction --- oligonucleotides --- oxidative DNA damage --- DNA replication stress --- replication fork stalling --- genomic and epigenomic instability --- DNA methylation --- histone modifications --- miRNAs --- iron porphyrin --- heme --- ATRPase --- iron-mediated ATRP --- bio-mimicking catalyst --- biomimetic radical reaction --- bioinspired chemical catalysis --- protein labeling --- DNA oxidation --- DNA hole transfer --- DNA --- quantum dynamics --- electron transfer --- charge transfer --- radical reaction --- azidoalkylation --- carboazidation --- sulfones --- azides --- Julia–Kocienski olefination --- DNA damage --- copper --- chemical nuclease --- intercalation --- free radical oxidation --- protein stability --- therapeutic proteins --- thiyl radicals --- oxidation --- fragmentation --- cross-link --- 2-thiouracil --- radiosensitizers --- ?OH and ?N3 radicals --- 2c-3e S?S-bonded intermediates --- pulse radiolysis --- TD-DFT methods --- thiobases --- nucleobase derivatives --- reactive aldehydes --- hydroxynonenal --- oxononenal --- free fatty acids --- mitochondrial uncoupling protein --- lipid bilayer membranes

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