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New Approaches for the Discovery of Pharmacologically-Active Natural Compounds

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ISBN: 9783039211043 / 9783039211050 Year: Pages: 158 DOI: 10.3390/books978-3-03921-105-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-08-28 11:21:27
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Abstract

A major source of active compounds, natural products from different sources supply a large variety of molecules that have been approved for clinical use or used as the starting points of optimization programs. This book features nine papers (eight full articles and one review paper) written by more than 45 scientists from around the world. These papers illustrate the development and application of a broad range of computational and experimental techniques applied to natural product research. On behalf of the contributors to the book, our hope is that the research presented here contributes to advancements in the field, and encourages multidisciplinary teams, young scientists, and students to further advance in the discovery of pharmacologically-active natural compounds

Promising Detoxification Strategies to Mitigate Mycotoxins in Food and Feed

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ISBN: 9783038970286 / 9783038970279 Year: Pages: 306 DOI: 10.3390/books978-3-03897-027-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Public Health
Added to DOAB on : 2019-08-28 11:21:28
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This book is a printed edition of the Special Issue Promising Detoxification Strategies to Mitigate Mycotoxins in Food and Feed that was published in Toxins

Keywords

deoxynivalenol --- epimer --- polarity --- Tri101 --- molecular --- interactions --- spores of Ganoderma lucidum --- oxidative stress --- aflatoxins --- antioxidant capability --- mycotoxin --- patulin --- biodegradation --- Pichia caribbica --- proteomics --- intracellular and extracellular enzymes --- Bacillus licheniformis CK1 --- zearalenone (ZEA) --- serum hormones --- estrogen receptor (ER) --- post-weaning female piglets --- curcumin --- aflatoxin B1 --- CYP450 --- AFBO–DNA --- chicks --- aflatoxin B1 --- photodegradation product --- TQEF-MS/MS --- cell viability --- furan rings --- mycotoxin --- toxigenic Fusarium --- biological control --- Trichoderma --- modified mycotoxin --- aflatoxin B1 --- aflatoxin biodegradation preparation --- Bacillus subtilis ANSB060 --- ameliorating effects --- growth performance --- antioxidant function --- residue --- aflatoxins --- biotransformation --- enzymatic detoxification --- laccase --- mild technologies --- food safety --- mycotoxins mitigation --- aflatoxin B1 --- aflatoxin-degrading enzyme --- biodegradation --- Bacillus shackletonii --- purification --- Sporobolomyces sp. IAM 13481 --- microbial patulin degradation --- desoxypatulinic acid --- ascladiol --- aflatoxins --- Aspergillus flavus --- Corylus avellana --- fatty acids --- thermal treatment --- Aflatoxin B1 --- Aspergillus flavus --- hyssop --- inhibition --- oxidative stress --- DBD --- atmospheric pressure --- low temperature plasma --- mycotoxins --- degradation --- maize --- aflatoxins --- neutral electrolyzed water --- detoxification --- turkey --- mycotoxins --- biotransformation --- degradation --- enzymes --- application --- mycotoxin --- detoxification --- biodegradation --- biotransformation --- enzyme --- microorganism identification --- mycotoxin --- trichothecene --- deoxynivalenol --- bioprospecting --- detoxification --- Fusarium --- cold atmospheric pressure plasma technology --- mycotoxins --- physical decontamination --- chemical decontamination --- biological decontamination --- patulin --- mycotoxin --- mitigation --- decontamination --- food and beverage --- processing --- n/a

Plant Natural Products for Human Health

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ISBN: 9783038977124 Year: Pages: 514 DOI: 10.3390/books978-3-03897-713-1 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2019-04-05 10:34:31
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Abstract

Plants have served mankind as an important source of foods and medicines. While we all consume plants and their products for nutritional support, a majority of the world population also rely on botanical remedies to meet their health needs, either as their own “traditional medicine” or as “complementary and alternative medicine”. From a pharmaceutical point of view, many compounds obtained from plant sources have long been known to possess bio/pharmacological activities, and historically, plants have yielded many important drugs for human use, from morphine discovered in the early nineteenth century to the more recent paclitaxel and artemisinin. Today, we are witnessing a global resurgence in interest and use of plant-based therapies and botanical products, and natural products remain an important and viable source of lead compounds in many drug discovery programs.This Special Issue on “Plant Natural Products for Human Health” compiles a series of scientific reports to demonstrate the medicinal potentials of plant natural products. It covers a range of disease targets, such as diabetes, inflammation, cancer, neurological disease, cardiovascular disease, liver damage, bacterial, and fungus infection and malarial. These papers provide important insights into the current state of research on drug discovery and new techniques. It is hoped that this Special Issue will serve as a timely reference for researchers and scholars who are interested in the discovery of potentially useful molecules from plant sources for health-related applications.

Keywords

heat-process --- onion --- calorie restriction --- Amadori rearrangement compounds --- hyperglycemia --- A549 cells --- hinokitiol --- MMPs --- p53/Bax --- antioxidant enzymes --- caspases --- migration --- cannabinoid type 1 receptor --- endoplasmic reticulum stress --- gluconeogenesis --- gomisin N --- lipogenesis --- insulin resistance --- garlic --- ischemia --- heme oxygenase --- reperfusion --- heart --- Keap1 --- Nrf2 --- Neuroprotective --- PC12 cells --- PhGs --- anti-malaria activity --- plants --- natural products --- ethnopharmacology --- Plasmodium parasites --- copaiba --- oleoresin --- essential oil --- sesquiterpenoids --- diterpenoids --- biological activity --- molecular targets --- Astragali Radix --- astragaloside IV --- genistein --- mitochondrial bioenergetics --- oxygen consumption rate --- natural products --- drug design and development --- innovation --- automation --- computational softwares --- bioinformatics --- precision medicine --- omics --- global health --- sweet orange --- bitter orange --- neroli --- orange petitgrain --- mandarin --- lemon --- lime --- grapefruit --- bergamot --- yuzu --- kumquat --- cannabigerol --- Cannabis sativa --- neuroinflammation --- oxidative stress --- phytocannabinoid --- iridoids --- nuclear factor-kappaB --- mitogen-activated protein kinase --- anti-inflammation --- Ziziphus jujuba --- triterpenic acids --- pharmacokinetic study --- acute liver injury --- A? --- AD --- lychee seed --- neuroinflammation --- catechin --- procyanidin A2 --- apoptosis --- cinnamamides --- antistaphylococcal activity --- time-kill assay --- biofilm --- antitubercular activity --- MTT assay --- antifungal activity --- PET inhibition --- toxicity --- structure–activity relationship --- bleeding time --- flavonoid --- morin hydrate --- OH· free radical --- platelet activation --- protein kinase --- thromboembolism --- Glycyrrhiza uralensis --- prenylated flavonoids --- antiproliferation --- differentiation --- melanoma cell --- adjuvant-induced arthritis --- arthritis --- celastrol --- curcumin --- dietary supplements --- EGCG --- green tea --- inflammation --- liposomes --- microbiome --- nanoparticles --- natural products --- resveratrol --- rheumatoid arthritis --- targeted delivery --- traditional medicine --- Tripterygium wilfordii --- triptolide --- Penthorum chinense Pursh --- NAFLD --- hepatic steatosis --- flavonoids --- SIRT1 --- AMPK --- dihydromyricetin --- myocardial hypertrophy --- oxidative stress --- sirtuin 3 --- ginseng --- human-hair-follicle dermal papilla cells --- WNT/?-catenin --- Shh/Gli --- TGF-? --- BMP/Smad --- mouse-hair growth --- Panax notoginseng saponins --- aspirin --- HepaRG cells --- herb–drug interactions --- P. eryngii --- glucans --- inflammation --- inflammatory bowel disease --- medicinal plants --- phytochemicals --- scoulerine --- bergapten --- immunomodulator --- adjuvant --- cytoxicity --- dendritic cells --- immune modulation --- APAP --- acetaminophen --- hepatotoxicity --- hpatoprotection --- paracetamol --- animals --- preclinical studies --- natural products --- small molecules --- phytochemicals --- plants --- fucoidan --- acetaminophen --- Nrf2 --- oxidative stress --- hepatotoxicity --- plant natural product --- drug discovery --- human health

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eng (3)


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2019 (2)

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