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Recent Advances and Perspectives in Deoxynivalenol Research

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ISBN: 9783038424703 9783038424710 Year: Pages: X, 290 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2017-08-23 08:50:49
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Mycotoxins are secondary metabolites produced by molds. Although the primary role of these toxins is thought to be related to the colonisation of the environment by the fungi—mycotoxins are able to kill other micro-organisms (antimicrobial effect) and/or plant cells (mycotoxin-producing fungi being necrophagic)—the exposure of animals and humans to mycotoxins through the consumption of mycotoxin-contaminated food and feeds leads to diseases and death. Among the different mycotoxins described (more than 350 mycotoxins have been identified), deoxynivalenol (DON or vomitoxin) produced by Fusarium species has attracted the most attention due to its prevalence and toxicity. DON is part of a family of mycotoxins called trichothecenes that are small sesquiterpenoids with an epoxide group at positions 12–13 allowing their binding to ribosomes causing the so-called ribosome stress response, characterized by the activation of various protein kinases that lead to alterations in gene expression and cellular toxicity in animals, humans and plants. Here, we compiled very recent findings regarding DON and its derivatives: i) their prevalence in human food; ii) the estimation of the exposure of humans to them using biological markers; iii) their roles during plant–fungi interaction; iv) the alteration caused by them in animals and humans, particularly at low doses that are close to those observed in farm animals and human consumers; v) possible strategies to decrease their presence in food and feeds. Overall, this book will give the reader a clear and global view on this important mycotoxin produced by Fusarium species which is responsible for huge economic loss and health issues.

Geometric Regularization in Bioluminescence Tomography

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ISBN: 9783731501428 Year: Pages: IX, 185 p. DOI: 10.5445/KSP/1000037411 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Mathematics
Added to DOAB on : 2019-07-30 20:02:00
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Bioluminescence tomography is a recent biomedical imaging technique which allows to study molecular and cellular activities in vivo. From a mathematical point of view, it is an ill-posed inverse source problem: the location and the intensity of a photon source inside an organism have to be determined, given the photon count on the organism's surface. To face the ill-posedness of this problem, a geometric regularization approach is introduced, analyzed and numerically verified in this book.

Mechanisms of Adiponectin Action

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ISBN: 9783039212453 / 9783039212460 Year: Pages: 222 DOI: 10.3390/books978-3-03921-246-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Sociology
Added to DOAB on : 2019-08-28 11:21:27
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The adipokine adiponectin is very concentrated in plasma, and decreased levels of adiponectin are associated with pathological conditions such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. When produced in its full-length form, adiponectin self-associates to generate multimeric complexes. The full-length form of adiponectin can be cleaved by the globular form of elastase that is produced locally, and the resulting biological effects are exerted in a paracrine or autocrine manner. The different forms of adiponectin bind to specific receptors consisting of two G-protein-independent, seven-transmembrane-spanning receptors, called AdipoR1 and AdipoR2, while T-cadherin has been identified as a potential receptor for high molecular weight complexes of adiponectin. Adiponectin exerts a key role in cellular metabolism, regulating glucose levels as well as fatty acid breakdown. However, its biological effects are heterogeneous, involving multiple target tissues. The Special Issue “Mechanisms of Adiponectin Action” highlights the pleiotropic role of this hormone through 3 research articles and 7 reviews. These papers focus on the recent knowledge regarding adiponectin in different target tissues, both in healthy and in diseased conditions.

Advances in Chitin/Chitosan Characterization and Applications

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ISBN: 9783038978022 9783038978039 Year: Pages: 414 DOI: 10.3390/books978-3-03897-803-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2019-04-25 16:37:17
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Functional advanced biopolymers have received far less attention than renewable biomass (cellulose, rubber, etc.) used for energy production. Among the most advanced biopolymers known is chitosan. The term chitosan refers to a family of polysaccharides obtained by partial de-N-acetylation from chitin, one of the most abundant renewable resources in the biosphere. Chitosan has been firmly established as having unique material properties as well as biological activities. Either in its native form or as a chemical derivative, chitosan is amenable to being processed&mdash;typically under mild conditions&mdash;into soft materials such as hydrogels, colloidal nanoparticles, or nanofibers. Given its multiple biological properties, including biodegradability, antimicrobial effects, gene transfectability, and metal adsorption&mdash;to name but a few&mdash;chitosan is regarded as a widely versatile building block in various sectors (e.g., agriculture, food, cosmetics, pharmacy) and for various applications (medical devices, metal adsorption, catalysis, etc.). This Special Issue presents an updated account addressing some of the major applications, including also chemical and enzymatic modifications of oligos and polymers. A better understanding of the properties that underpin the use of chitin and chitosan in different fields is key for boosting their more extensive industrial utilization, as well as to aid regulatory agencies in establishing specifications, guidelines, and standards for the different types of products and applications.

Keywords

aerogels --- chitosan --- ionic liquids --- ionogels --- zinc–chitosan complexes --- characterization --- bio-sorbent --- phosphate --- adsorption --- mechanism --- thermodynamic --- chitosan --- hydrogel --- phase transition --- gelation mechanism --- chitosan --- defense responses --- fruits --- nanoparticles --- plant growth --- pesticides --- Boron --- chitosan --- iron(III) hydroxide --- neodymium --- sorption --- chitin --- chitosan --- chitosan derivative --- chitin derivative --- oral care --- skin care --- hear care --- marine resources --- over-the counter-drug --- polymer carrier --- chitin --- chitosan --- nanostructured biomaterial --- polymer --- self-masking nanosphere lithography --- cicada --- chitosan --- self-assembled --- polyelectrolyte complex --- nanoparticle --- drug delivery --- Citrobacter --- biosynthesis --- bioflocculant --- chitosan --- metabolic pathway --- PEO/chitosan blend --- swelling --- mechanical properties --- wet and dried states --- chitosan --- biological activity --- medical applications --- chitosan --- PCL --- strontium --- scaffolds --- craniofacial engineering --- chitin --- chitosan --- derivatization --- controlled functionalization --- click chemistry --- graft copolymer --- cyclodextrin --- dendrimer --- ionic liquids --- chitin deacetylases --- chitosan --- chitooligosaccharides --- carbohydrate esterases --- structure --- substrate specificity --- deacetylation pattern --- binary --- chitosan --- desorption --- iron --- lead --- mercury --- salt effects --- single --- sorption competition --- chitosan supported copper --- heterogeneous catalyst --- organosilicon compound --- easily recyclable --- chitosan --- papermaking --- wet-end --- coating --- wastewater --- ionic cross-linking --- eco-friendly formulations --- thermal transition sol-gel --- drug delivery systems --- MTDSC --- DSC --- gene delivery --- non-viral vectors --- chitosan structure --- pDNA --- siRNA --- TEOS --- methylene blue --- chitosan --- modelling --- cross-linking --- interpenetrating --- XRD --- FTIR

Emerging Advances in Petrophysics. Porous Media Characterization and Modeling of Multiphase Flow

Authors: --- --- ---
ISBN: 9783038977940 9783038977957 Year: Pages: 258 DOI: 10.3390/books978-3-03897-795-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Physics (General) --- Geophysics and Geomagnetism
Added to DOAB on : 2019-04-25 16:37:17
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Due to the influence of pore-throat size distribution, pore connectivity, and microscale fractures, the transport, distribution, and residual saturation of fluids in porous media are difficult to characterize. Petrophysical methods in natural porous media have attracted great attention in a variety of fields, especially in the oil and gas industry. A wide range of research studies have been conducted on the characterization of porous media covers and multiphase flow therein. Reliable approaches for characterizing microstructure and multiphase flow in porous media are crucial in many fields, including the characterization of residual water or oil in hydrocarbon reservoirs and the long-term storage of supercritical CO2 in geological formations. This book gathers together 15 recent works to emphasize fundamental innovations in the field and novel applications of petrophysics in unconventional reservoirs, including experimental studies, numerical modeling (fractal approach), and multiphase flow modeling/simulations. The relevant stakeholders of this book are authorities and service companies working in the petroleum, subsurface water resources, air and water pollution, environmental, and biomaterial sectors.

Keywords

Wilkins equation --- non-laminar flow --- turbulence modelling --- porous media --- oil tanker --- temperature drop --- oscillating motion --- numerical simulation --- soil-water characteristic curve --- initial void ratio --- air-entry value --- fractal dimension --- fractal model --- oil properties --- diffusion coefficient --- supercritical CO2 --- Peng-Robinson equation of state (PR EOS) --- CT --- digital rock --- microfractures --- Lattice Boltzmann method --- pore-scale simulations --- tight sandstone --- pore structure --- multifractal --- classification --- Ordos Basin --- loose media --- coal --- porosity --- true density --- bulk density --- overburden pressure --- particle size --- tight conglomerate --- fracture characterization and prediction --- fractal method --- salt rock --- creep --- damage --- fractional derivative --- acoustic emission --- marine gas hydrate --- submarine landslide --- greenhouse gas emission --- lifecycle management --- hazard prevention --- multilayer reservoir --- interlayer interference --- producing degree --- seepage resistance --- wellbore multiphase flow --- inclined angle --- liquid rate --- gas rate --- pressure drawdown model with new coefficients --- base-level cycle --- pore structure --- mouth bar sand body --- Huanghua Depression --- isotopic composition --- methane --- gas hydrate --- South China Sea --- Bakken Formation --- pore structure --- controlling factors --- low-temperature nitrogen adsorption --- petrophysics --- fractal porous media --- unconventional reservoirs --- multiphase flow

Selected Papers from the 2018 41st International Conference on Telecommunications and Signal Processing (TSP)

Authors: --- ---
ISBN: 9783039210404 / 9783039210411 Year: Pages: 194 DOI: 10.3390/books978-3-03921-041-1 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-08-28 11:21:27
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This Special Issue contains a series of excellent research works on telecommunications and signal processing, selected from the 2018 41st International Conference on Telecommunications and Signal Processing (TSP) which was held on July 4–6, 2018, in Athens, Greece. The conference was organized in cooperation with the IEEE Region 8 (Europe, Middle East, and Africa), IEEE Greece Section, IEEE Czechoslovakia Section, and IEEE Czechoslovakia Section SP/CAS/COM Joint Chapter by seventeen universities from the Czech Republic, Hungary, Turkey, Taiwan, Japan, Slovak Republic, Spain, Bulgaria, France, Slovenia, Croatia, and Poland, for academics, researchers, and developers, and serves as a premier international forum for the annual exchange and promotion of the latest advances in telecommunication technology and signal processing. The aim of the conference is to bring together both novice and experienced scientists, developers, and specialists, to meet new colleagues, collect new ideas, and establish new cooperation between research groups from universities, research centers, and private sectors worldwide. This collection of 10 papers is highly recommended for researchers, and believed to be interesting, inspiring, and motivating for readers in their further research.

Carbon Fibers and Their Composite Materials

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ISBN: 9783039211029 / 9783039211036 Year: Pages: 186 DOI: 10.3390/books978-3-03921-103-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-08-28 11:21:27
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Carbon fiber is an oft-referenced material that serves as a means to remove mass from large transport infrastructure. Carbon fiber composites, typically plastics reinforced with the carbon fibers, are key materials in the 21st century and have already had a significant impact on reducing CO2 emissions. Though, as with any composite material, the interface where each component meets, in this case the fiber and plastic, is critical to the overall performance.

Isolation and Structure Elucidation of Bioactive Compounds (Dedicated to the memory of the late Professor Charles D. Hufford)

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ISBN: 9783038977803 9783038977810 Year: Pages: 276 DOI: 10.3390/books978-3-03897-781-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-04-25 16:37:17
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We are very pleased to introduce the Book Version of our Special Issue in Molecules dedicated to the memory of the late Professor Dr. Charles D. Hufford. The issue has been a huge success, with 22 full-length peer-reviewed papers and a tribute by Professor Alice M.Clark. Authors, reviewers, and collaborators from many countries across the worldhave contributed to this endeavour, and we are truly grateful to all. This Special Issue isrepresentative of the broad impact that &ldquo;Charlie&rdquo; had on the field of bioactive naturalproducts. This Special Issue comprises papers from Professor Hufford&rsquo;s former students,colleagues, and collaborators throughout the world who have utilized a wide array ofstate-of-the-art techniques to examine diverse natural sources to isolate and identify avariety of natural products with a wide spectrum of biological activities, including somenew microbial transformations and insights into bioactive molecules. Many new bioactive compounds are described and reported here for the first time. Bioactivities reportedinclude cytotoxicity, antimicrobial activity, anti-inflammatory activity, antileishmanialactivity, antitrypanosomal activity, antimalarial activity, analgesic activity, and beneficialliver activities, just to name a few. This Special Issue will undoubtedly have a lasting impact on the field of bioactive natural products, as exemplified by the career of Dr. Hufford.Lastly, without the timely and outstanding contributions from all of you, this Special Issue would not have been possible. We thank you all very much for your contributions and your time devoted to this Special Issue in memory of a special person. Finally, we express ourgratitude and thanks to the journal Molecules and their excellent team of expert reviewers for giving us the support and opportunity to make this Special Issue a huge success!

Keywords

fusidic acid --- Cunninghamella echinulata --- C-26-oxidation --- C-27-oxidation --- Morus alba L. --- aldose reductase inhibitor --- neuroprotective agent --- natural products --- Mitracarpus scaber Zucc. --- pentalogin --- anti-inflammatory --- MS/MS --- Il-8 --- Crinum amabile --- augustine N-oxide --- buphanisine N-oxide --- biological activities --- Cryptococcus neoformans --- cryptococcosis --- HepG2 --- Prosopis glandulosa --- prosopilosidine --- amphotericin B --- fluconazole --- resveratrol --- dietary supplement --- gastro-resistant --- microparticles --- obesity --- HPLC --- Jatropha pelargoniifolia --- alkaloids --- flavonoids --- coumarinolignans --- diterpenes --- anti-inflammatory --- analgesic --- antipyretic --- Cochlospermum vitifolium --- Cochlospermaceae --- flavonoids --- lignans --- aromatic compounds --- carotenoids --- sterols --- liver activity --- Arthrinium sp. --- chromone --- polyketide --- antioxidant activity --- Rubiaceae --- jenipapo --- HPLC-ESI-IT-MS/MS --- flavonoids glycosides --- Baccharis --- antimalarial activity --- antitrypanosomal activity --- insecticidal activity --- GC/MS --- DNA barcoding --- microscopy --- antibacterial --- channel catfish --- columnaris disease --- Flavobacterium columnare --- stilbenes --- muscadine --- pyranoanthocyanin --- anti-leishmanial activity --- Leishmania donovani --- maleimides --- cytotoxicity --- SAR --- phlorogluciniol --- acylphloroglucinol --- anti-inflammatory --- iNOS --- NF-?B --- endophytic fungi --- sesterterpene --- cytotoxic activity --- pancreatic cancer --- Stevia rebaudiana --- diterpene glycosides --- rebaudioside A isomers --- 13(S)-hydroxyatisenoic acid derivative --- iso-stevioside X-ray structure --- Litsea cubeba --- cytotoxicity --- isolation and elucidation --- lignans --- antimicrobial resistance --- multi-drug resistant (MDR) --- methicillin resistant Staphylococcus aureus (MRSA) --- Zingiber monatnum --- terpenes --- (E)-8(17),12-labdadiene-15,16-dial --- zerumbol --- microbial transformation --- hop prenylflavanone --- isoxanthohumol --- cardiomyogenesis --- factor VII --- factor X --- inflammation --- thrombosis --- vasculogenesis --- herbal medicine --- n/a --- Nemania --- Xylariaceae --- Torreya taxifolia --- plant pathogenic and endophytic fungi --- cytochalasins --- malaria --- cytotoxicity --- phytotoxicity --- acacetin 7-methyl ether --- acacetin --- monoamine oxidase-A --- monoamine oxidase-B --- molecular docking --- molecular dynamics --- neurological disorder --- Turnera diffusa

Outstanding Topics in Ocean Optics

Authors: ---
ISBN: 9783038977049 9783038977056 Year: Pages: 454 DOI: 10.3390/books978-3-03897-705-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Oceanography
Added to DOAB on : 2019-04-25 16:37:17
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Ocean optics is a branch of oceanography which is firmly embedded in studies of a great variety of ocean science and engineering questions. The interactive nature between radiative transfer of light and various dissolved and particulate constituents of seawater is at the core of ocean optics science and applications. The transfer of radiant solar energy has vital implications to life and climate on Earth, and the large variety of subjects of ocean optics ranges from the subtle problems of physical optics to optical remote sensing towards a better understanding of ocean biology, biogeochemistry and ecosystems and their roles in the Earth's system processes. The intention of this book is to present a collection of papers that generally share a common denominator of frontier topics in ocean optics which are unique, uncommon or outstanding in the literature, and to provide a balanced view of the extraordinary breadth of research in this field. Topics as diverse as measurements and modeling of radiative transfer, light fields, light scattering and polarization, ocean color, benthic optical properties, and the use of optics for characterizing seawater constituents are addressed in this book. The book is expected to be of interest and useful to a broad audience of professional ocean scientists, engineers and advanced students with an interest in ocean optics and applications of optical methods in oceanography.

Keywords

forward modeling --- suspended matter --- marine particles --- fractal structure --- organic carbon --- chlorophyll-a --- oceanic light field --- irradiance quartet --- apparent optical properties --- inelastic processes --- Gershun equation --- ocean euphotic zone --- phytoplankton pigments --- ocean color --- remote sensing --- MERIS --- global oceans --- light scattering --- light scattering by pure water --- light scattering by pure seawater --- anomalous properties of water --- remote-sensing reflectance --- bathymetry --- hyperspectral --- bottom mapping --- radiative transfer --- apparent optical properties --- 3D Monte Carlo numerical simulations --- downward irradiance --- upward radiance --- sea ice heterogeneity --- vertical attenuation coefficient --- melt ponds --- remote sensing --- coral reef --- sensor noise --- retrieval uncertainty --- particle dynamics --- optical properties --- suspended sediment --- phytoplankton --- PFT --- ocean colour --- satellite radiometry --- radiative transfer --- optical modelling --- vector radiative transfer --- polarization --- coupled systems --- atmosphere --- ocean --- forward modeling --- inverse problems --- marine optics --- inherent optical properties --- volume scattering function --- degree of linear polarization --- marine particles --- light scattering measurements --- LISST-VSF instrument --- ocean optics --- ocean color --- remote sensing --- radiative transfer approximation --- volume scattering function --- NASA PACE mission --- polarization --- ocean optics --- upwelling radiance distribution --- remote sensing --- remote sensing --- hyperspectral --- shallow water --- coral --- derivative --- radiative transfer --- canopy --- ocean color database --- oceanic carbon --- chromophoric dissolved organic matter --- dissolved organic carbon --- CDOM spectral slope --- ocean color remote sensing --- algorithm development --- ocean color algorithm validation --- ocean optics --- CDOM climatology --- CDOM and ENSO --- machine learning --- ocean optics --- backscattering ratio --- phytoplankton --- coated-sphere model --- bulk refractive index --- seawater component --- natural organic matter --- DOM --- FDOM --- CDOM --- Gelbstoff --- EEMS --- PARAFAC --- marine sensors --- Kallemeter --- FerryBox --- Trondheimsfjord --- Norway --- ocean optics --- light scattering --- Mueller matrix --- volume and surface integral methods

Advanced Numerical Methods in Applied Sciences

Authors: ---
ISBN: 9783038976660 / 9783038976677 Year: Pages: 306 DOI: 10.3390/books978-3-03897-667-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Mathematics
Added to DOAB on : 2019-06-26 08:44:06
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The use of scientific computing tools is currently customary for solving problems at several complexity levels in Applied Sciences. The great need for reliable software in the scientific community conveys a continuous stimulus to develop new and better performing numerical methods that are able to grasp the particular features of the problem at hand. This has been the case for many different settings of numerical analysis, and this Special Issue aims at covering some important developments in various areas of application.

Keywords

time fractional differential equations --- mixed-index problems --- analytical solution --- asymptotic stability --- conservative problems --- Hamiltonian problems --- energy-conserving methods --- Poisson problems --- Hamiltonian Boundary Value Methods --- HBVMs --- line integral methods --- constrained Hamiltonian problems --- Hamiltonian PDEs --- highly oscillatory problems --- boundary element method --- finite difference method --- floating strike Asian options --- continuous geometric average --- barrier options --- isogeometric analysis --- adaptive methods --- hierarchical splines --- THB-splines --- local refinement --- linear systems --- preconditioners --- Cholesky factorization --- limited memory --- Volterra integral equations --- Volterra integro–differential equations --- collocation methods --- multistep methods --- convergence --- B-spline --- optimal basis --- fractional derivative --- Galerkin method --- collocation method --- spectral (eigenvalue) and singular value distributions --- generalized locally Toeplitz sequences --- discretization of systems of differential equations --- higher-order finite element methods --- discontinuous Galerkin methods --- finite difference methods --- isogeometric analysis --- B-splines --- curl–curl operator --- time harmonic Maxwell’s equations and magnetostatic problems --- low rank completion --- matrix ODEs --- gradient system --- ordinary differential equations --- Runge–Kutta --- tree --- stump --- order --- elementary differential --- edge-histogram --- edge-preserving smoothing --- histogram specification --- initial value problems --- one-step methods --- Hermite–Obreshkov methods --- symplecticity --- B-splines --- BS methods --- hyperbolic partial differential equations --- high order discontinuous Galerkin finite element schemes --- shock waves and discontinuities --- vectorization and parallelization --- high performance computing --- generalized Schur algorithm --- null-space --- displacement rank --- structured matrices --- stochastic differential equations --- stochastic multistep methods --- stochastic Volterra integral equations --- mean-square stability --- asymptotic stability --- numerical analysis --- numerical methods --- scientific computing --- initial value problems --- one-step methods --- Hermite–Obreshkov methods --- symplecticity --- B-splines --- BS methods

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