Search results: Found 33

Listing 1 - 10 of 33 << page
of 4
>>
Sort by
Starting with the End in Mind by Developing Diagnostics around User Needs (Book chapter)

Author:
ISBN: 9781498772938 Year: Pages: 14 Language: English
Publisher: Taylor & Francis
Subject: Medicine (General)
Added to DOAB on : 2019-01-17 11:46:28
License:

Loading...
Export citation

Choose an application

Abstract

As discussed in this chapter, the commercialization and adoption bottlenecks for these moderately complex diagnostics cannot be overcome by&#xD;technological innovation alone, particularly in the highly regulated and&#xD;payer-limited healthcare and public health markets. Diagnostics, unlike&#xD;other clinical products, is not an intervention but a decision-aid that guides&#xD;the use (or nonuse) of an intervention. It is important that the value proposition&#xD;for any technology-centric innovation in diagnostics include a strong&#xD;link to a gained efficiency in making a specific decision. Any assay developed&#xD;without context to the system, users, decision points, and downstream&#xD;interventions resembles one that is more targeted to the research community,&#xD;rather than clinical care or public health.

Liquid Biopsy

Authors: ---
ISBN: 9781838811297 9781838811303 9781838811310 Year: Pages: 158 DOI: 10.5772/intechopen.73612 Language: English
Publisher: IntechOpen
Subject: Medicine (General)
Added to DOAB on : 2019-10-03 07:51:53

Loading...
Export citation

Choose an application

Abstract

Reliable diagnosis is the cornerstone, starting point, and prerequisite of successful treatment. Therefore, development of innovative diagnostic technologies represents a hot topic in medical research. Liquid biopsy is a novel, minimally invasive laboratory evaluation concept for diagnostic, prognostic, and predictive testing, as well as dynamic monitoring of treatment or disease course. To achieve these goals, a multitude of specific, targeted tests can be performed to detect free nucleic acids, exosomes, microRNAs, tumor-educated platelets, and whole cells of tumor or fetal origin in different biological fluids, including blood, urine, cerebrospinal fluid, and others. Although tissue biopsy has long been considered the gold standard of diagnostics, especially regarding malignant tumors, liquid biopsy has the advantages of a non-invasive approach and thus low risk of complications. It is technically feasible even in serious general status or if tumors or metastases are not easily accessible using conventional tissue biopsy. The testing is fast, exact, and can be repeated to ensure real-time follow-up. In contrast to classic tumor markers, liquid biopsy is distinguished by high specificity at genomic, proteomic, and cellular levels. It is expected to equal and exceed the diagnostic value of tissue biopsy. The field of liquid biopsies is developing rapidly regarding the selection of targets, technological improvements, and quality assessment. This book, written by a global team of recognized scientists, comprises state-of-the-art reviews on the current knowledge and advances in the technologies and software for liquid biopsy. Examples of practical application of liquid biopsy to evaluate thyroid cancer, multiple myeloma, etc. are discussed as well. The book is intended to serve as a reference for scientists and clinicians interested in the development and practical implementation of liquid biopsy.

Diagnostic, Prognostic and Predictive Biological Markers in Bladder Cancer – Illumination of a Vision

Authors: ---
ISBN: 9783038976349 / 9783038976356 Year: Pages: 202 DOI: 10.3390/books978-3-03897-635-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics --- Pathology --- Urology
Added to DOAB on : 2019-02-21 09:26:53
License:

Loading...
Export citation

Choose an application

Abstract

This Special Issue has been introduced with the aim of offering the possibility to publish new research results from old and new pioneers in the field of bladder cancer basic research. While editing this Special Issue we learned that an enormous enthusiasm is necessary to go on in bladder cancer research. In our eyes, bladder cancer is on one hand a very heterogenous malignancy, which is what makes it so difficult to focus on only one bladder cancer marker in bladder cancer diagnostics and follow-up. On the other hand, it is very important to find prognostic and predictive factors for bladder cancer due to its high incidence and its enormous costs, as one of the most expensive malignancies in the world. Finding and developing new bladder cancer markers is still a very dynamic field. Because there are many of these markers, it is impossible to report all of them. This Special Issue attempts to highlight the role of bladder cancer markers in diagnosis, and the most important biomarkers that have been recently studied and reported. This Special Issue highlights some of the most important markers. Further determination of recurrence and progression markers will contribute to establishing better treatments for individual patients. Molecular staging of urological tumors will allow the selection of cases that will require systemic treatment. It is necessary and important to integrate basic and clinical research under the same objectives.

Magnetic Resonance Spectroscopy

Author:
ISBN: 9789535100652 Year: Pages: 276 DOI: 10.5772/1228 Language: English
Publisher: IntechOpen
Subject: Medicine (General)
Added to DOAB on : 2019-10-03 07:51:48

Loading...
Export citation

Choose an application

Abstract

Magnetic Resonance Spectroscopy (MRS) is a unique tool to probe the biochemistry in vivo providing metabolic information non-invasively. Applications using MRS has been found over a broad spectrum in investigating the underlying structures of compounds as well as in determining disease states. In this book, topics of MRS both relevant to the clinic and also those that are beyond the clinical arena are covered. The book consists of two sections. The first section is entitled 'MRS inside the clinic' and is focused on clinical applications of MRS while the second section is entitled 'MRS beyond the clinic' and discusses applications of MRS in other academic fields. Our hope is that through this book, readers can understand the broad applications that NMR and MRS can offer and also that there are enough references to guide the readers for further study in this important topic.

Biomarker

Author:
ISBN: 9789535105770 9789535142966 Year: Pages: 404 DOI: 10.5772/2376 Language: English
Publisher: IntechOpen
Subject: Pathology
Added to DOAB on : 2019-10-03 07:51:49

Loading...
Export citation

Choose an application

Abstract

Clinicians, scientists, and health care professionals use biomarkers or biological markers as a measure of a person’s present health condition or response to interventions. An ideal -biomarker should have the following criteria: (I) ability to detect fundamental features of the disease, (II) ability to differentiate from other closely related diseases, (III) ability to detect early stages and stages of progression, (IV) the method should be highly reliable, easy to perform and inexpensive, and (V) sample sources should be easily accessible from body. Most of the chapters in this book follow the basic principle of biomarkers.

Endoscopic Ultrasound - From Usual to Special

Author:
ISBN: 9789535129394 9789535129400 Year: Pages: 112 DOI: 10.5772/62925 Language: English
Publisher: IntechOpen
Subject: Medicine (General)
Added to DOAB on : 2019-10-03 07:51:49

Loading...
Export citation

Choose an application

Abstract

This book is oriented toward clinical studies in the field of endoscopic ultrasound. Due to the advancement in technology, resolution and development of accessory tools, the applications of endoscopic ultrasound have been widely extended. This book covers from usual to special applications of endoscopic ultrasound in various specialties. I hope this book can serve as a tiny telescope that shows how the techniques of endoscopic ultrasound can be used in various parts of the body.

Radiotherapy

Author:
ISBN: 9789535131496 9789535131502 Year: Pages: 290 DOI: 10.5772/63695 Language: English
Publisher: IntechOpen
Subject: Medicine (General)
Added to DOAB on : 2019-10-03 07:51:50

Loading...
Export citation

Choose an application

Abstract

Radiotherapy plays a key role in the treatment of many cancer types. This book is intended to bring forward the recent advancements in the field of radiation oncology. It presents the experience of several researchers who dedicate many hours a day to not only treat patients but also assess the physical aspects of newer radiotherapy facilities. This book contains many valuable contributions from radiation oncology physicians and medical physicists who are experts in their fields.

Photomedicine - Advances in Clinical Practice

Author:
ISBN: 9789535131557 9789535131564 Year: Pages: 262 DOI: 10.5772/62699 Language: English
Publisher: IntechOpen
Subject: Medicine (General)
Added to DOAB on : 2019-10-03 07:51:50

Loading...
Export citation

Choose an application

Abstract

Photomedicine is one of the most inspiring and interdisciplinary fields in medicine that involves the research and application of photobiology with respect to health and disease. Photomedicine has contributed to the clinical practice of a variety of medical fields, including dermatology, surgery, radiology, diagnostics, cardiology, and anticancer therapy. Furthermore, expansion of its scope and contribution can be expected. This book covers a wide range of aspects and issues related to photomedicine, which brings together researchers from many countries. These include the basic science of photodynamic therapy, clinical applications in various kinds of medical fields, photochemotherapy, laser therapy for musculoskeletal pain, intense pulsed light therapy for photorejuvenation, biological function of low-level laser therapy, and photobiology for skin rejuvenation. Not only will this be beneficial for readers, but it will also contribute to scientists making further breakthroughs in photomedicine.

Radionuclide Treatments

Author:
ISBN: 9789535133797 9789535133803 Year: Pages: 86 DOI: 10.5772/65461 Language: English
Publisher: IntechOpen
Subject: Medicine (General)
Added to DOAB on : 2019-10-03 07:51:50

Loading...
Export citation

Choose an application

Abstract

This book has been designed to give a brief information on the development and current status of radionuclide treatments. Today, despite most of them have been accepted experimentally in the clinical guidelines, the number of the radionuclide treatments has been increasing gradually. Theranostic concept is the leading cause for this increase. Behind the radioiodine treatment for benign and malignant thyroid diseases, other radionuclide treatments that consist of I-131 metaiodobenzylguanidine therapy for neuroectodermal tumors, radionuclide pain palliation for bone metastases, radiosynovectomy, and selective internal radiation therapy were included in the book. All the chapters have been written by experienced nuclear medicine physicians.

Computed Tomography - Advanced Applications

Author:
ISBN: 9789535133674 9789535133681 Year: Pages: 300 DOI: 10.5772/66614 Language: English
Publisher: IntechOpen
Subject: Medicine (General)
Added to DOAB on : 2019-10-03 07:51:50

Loading...
Export citation

Choose an application

Abstract

The advent and rapid diffusion of advanced multidetector-row scanner technology offers comprehensive evaluation of different anatomic structures in daily practice. The aim of this book is to introduce the applications of CT imaging in not only general medicine but also in different fields especially in veterinary medicine, dentistry, and engineering. Recent developments in CT technology have led to a widening of its applications on many areas like material testing in engineering, 3D evaluation of teeth, and the vascular and cardiac evaluations of small animals.

Listing 1 - 10 of 33 << page
of 4
>>
Sort by