Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book offers a realistic, practical and accessible model to allow teachers to incorporate the best of recent brain-based research into their teaching. The five steps involve: making learning multi-sensory ensuring activities match the dominant intelligence of the learner matching types of learning to the gender of pupils using the lesson structure to fit the natural attention span of the brain managing the classroom environment to make it brain-friendly and active in supporting learning. Illustrated throughout with classroom examples from a wide range of subject areas, the book is highly practical in its focus and the ideas it contains can easily be adapted to work with all age ranges and types of school.

dominant --- intelligence --- multiple --- spatial --- finger --- puppet --- myers --- briggs --- type --- indicator

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastasize. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifiers and scaffold proteins. Mutant p53 protein can also transcriptionally regulate the expression of microRNAs, small non-coding RNAs that regulate gene expression at the posttranscriptional level. Each microRNA can putatively target the expression of hundred mRNAs and consequently impact on many cellular functions. Thus, gain of function mutant p53 proteins can exert their oncogenic activities through the modulation of both non-coding and coding regions of human genome. Over the past 3 decades, the regulation of p53 has been extensively studied. However, the regulation of mutant p53 remained largely unexplored. This snapshot focuses on recent discovery of mutant p53 GOF and regulation.

mutant p53 --- gain of function --- therapies --- mouse models --- Oncogenic addiction --- dominant netagive

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Gems have been used in the manufacture of jewellery and as ornaments since antiquity. Considering gems, recent statistics have shown that about 15 billion Euros are annually at stake. Nowadays, gemmology, i.e., the study of gem materials, is one of the most expanding fields in the earth sciences, positioned between academia and industry. As an applied science, in gemmology, the instruments used should be non- or microdestructive, and their cost should be reasonable both in terms of equipment and time consumption. Gemmology can also be used contribute to the development of pure science and in some cases, destructive techniques may have to be used. Taking into account the fact that gems are albeit rarely available for scientific research, this compilation of 20 articles by around 100 researchers from over 30 different institutions situated in 20 countries from around the globe, presented in the Special Issue entitled “Mineralogy and Geochemistry of Gems”, offers very good examples on the application of various methods for their study which will hopefully contribute to our better understanding of gem formation in general and will enhance scientific debates attracting more scientists from various disciplines to get involved in this field.

danburite --- trace elements --- REE --- femtosecond LA-ICP-MS --- CHNS elemental analyzer --- pegmatites --- skarn --- gemstones --- placer --- heavy and light minerals --- landforms --- climate --- geodynamic setting --- green quartz --- prase --- amethyst --- color --- amphibole --- actinolite --- skarn --- Serifos --- Greece --- zircon --- xenocryst --- alkali basalt --- Ratanakiri Volcanic Province --- trace elements --- O-isotopes and Hf-isotopes --- U-Pb --- (U-Th)/He --- granitic pegmatite --- gem-quality tourmaline --- Adamello Massif --- Central Alps --- Italy --- ruby --- Mogok --- Mong Hsu --- New South Wales --- trace elements --- LA-ICP-MS analysis --- inclusions --- U–Pb age-dating --- genetic diversity --- geographic typing --- corundum --- blue sapphire --- meta-ultramafic rocks --- LA-ICP-MS --- Rb-Sr and Sm-Nd isotopy --- Ilmenogorsky complex --- Ural Mountains --- metasomatism --- corundum megacrysts --- ruby --- sapphire --- plumasite --- metamorphic-metasomatic origin --- Greece --- zircon megacrysts --- placer deposits --- rare earth elements (REE) --- carbonatite-dominant melts --- Central Highlands --- Vietnam --- hyperspectral photoluminescence imaging --- LA-ICP-MS --- rubies --- corundum --- in-situ oxygen isotopes --- Paranesti Greece --- Nestos Shear Zone --- Secondary ion mass spectrometry (SIMS) --- emerald deposits --- classification --- typology --- metamorphism --- magmatism --- sedimentary --- alkaline metasomatism --- fluids --- stable and radiogenic isotopes --- genetic models --- exploration --- andradite --- demantoid --- gemstone --- Raman spectroscopy --- UV-Vis-NIR spectroscopy --- X-ray fluorescence spectroscopy --- gem-quality --- garnet --- gem-bearing pegmatite --- fluid inclusions --- P-T-X equilibria --- spodumene --- Ar/Ar dating --- blue sapphire --- anorthosites --- kyshtymites --- sapphire geochemistry --- Ilmenogorsky-Vishnevogorsky complex --- in situ LA-ICP-MS U-Pb zircon dating --- kyanite --- Mn-rich silicates --- Rhodope --- Thassos --- amphibolite facies --- metasomatism --- opal --- hyalite --- silica --- X-ray diffraction --- Raman --- Infrared --- 29Si nuclear magnetic resonance --- SEM --- provenance --- pearls --- freshwater --- saltwater --- LA-ICP-MS --- X-ray luminescence --- sapphires --- corundum --- in situ oxygen isotopes --- Orosmayo Argentina --- lamprophyre --- secondary ion mass spectrometry (SIMS) --- carbonatite --- gemstones --- corundum --- beryl --- jadeitite --- garnet --- quartz varieties --- Greece --- emeralds --- LA-ICP-MS --- UV-Vis-NIR --- FTIR --- Raman --- PL --- n/a