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Biomedical Chemistry. Current Trends and Developments

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ISBN: 9783110468755 9783110468878 Year: Pages: 361 DOI: 10.1515/9783110468755 Language: English
Publisher: De Gruyter
Subject: Biochemistry --- Organic Chemistry
Added to DOAB on : 2017-01-18 19:08:48
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Biomedical Chemistry provides readers with an understanding of how fundamental chemical concepts are used to combat some diseases. The authors explain the interdisciplinary relationship of chemistry with biology, physics, pharmacy and medicine. The results of chemical research can be applied to understand chemical processes in cells and in the body, and new methods for drug transportation. Also, basic chemical ideas and determination of disease etiology are approached by developing techniques to ensure optimum interaction between drugs and human cells. This Book is an excellent resource for students and researchers in health-related fields with frontier topics in medicinal and pharmaceutical chemistry, organic chemistry and biochemistry.

The Search for Biological Active Agent(s) From Actinobacteria

Authors: --- --- --- --- et al.
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455676 Year: Pages: 312 DOI: 10.3389/978-2-88945-567-6 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Microbiology
Added to DOAB on : 2019-01-23 14:53:43
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There is a large market demand for new drugs. The existing chronic or common ailments without cures, development of new diseases with unknown causes, and the widespread existence of antibiotic-resistant pathogens, have driven this field of research further by looking at all potential sources of natural products. To date, microbes have made a significant contribution to the health and well-being of people globally. The discoveries of useful metabolites produced by microbes have resulted in a significant proportion of pharmaceutical products in today’s market. Therefore, the investigation and identification of bioactive compound(s) producing microbes is always of great interest to researchers.

Actinobacteria are one of the most important and efficient groups of natural metabolite producers. Among the numerous genera, Streptomyces have been recognized as prolific producers of useful natural compounds, as they provide more than half of the naturally-occurring antibiotics isolated to-date and continue to emerge as the primary source of new bioactive compounds. Certainly, these potentials have attracted ample research interest and a wide range of biological activities have been subsequently screened by researchers with the utilization of different In vitro and In vivo model of experiments. Literature evidence has shown that a significant number of interesting compounds produced by Actinobacteria were exhibiting either strong anticancer or neuroprotective activity. The further in depth studies have then established the modulation of apoptotic pathway was involved in those observed bioactivities. These findings indirectly prove the biopharmaceutical potential possessed by Actinobacteria and at the same time substantiate the importance of diverse pharmaceutical evaluations on Actinobacteria. In fact, many novel compounds discovered from Actinobacteria with strong potential in clinical applications have been developed into new drugs by pharmaceutical companies. Together with the advancement in science and technology, it is predicted that there would be an expedition in discoveries of new bioactive compounds producing Actinobacteria from various sources, including soil and marine sources. In light of these current needs, and great interest in the scope of this research, this book seeks to contribute on the investigation of different biological active compound(s) producing actinobacteria which are exhibiting antimicrobial, antioxidant, neuroprotective, anticancer activities and similar.

Drug Development - A Case Study Based Insight into Modern Strategies

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ISBN: 9789533072579 Year: Pages: 656 DOI: 10.5772/2435 Language: English
Publisher: IntechOpen
Subject: Therapeutics
Added to DOAB on : 2019-10-03 07:51:48

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This book represents a case study based overview of many different aspects of drug development, ranging from target identification and characterization to chemical optimization for efficacy and safety, as well as bioproduction of natural products utilizing for example lichen. In the last section, special aspects of the formal drug development process are discussed. Since drug development is a highly complex multidisciplinary process, case studies are an excellent tool to obtain insight in this field. While each chapter gives specific insight and may be read as an independent source of information, the whole book represents a unique collection of different facets giving insight in the complexity of drug development.

Drug Discovery and Development - Present and Future

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ISBN: 9789533076157 Year: Pages: 542 DOI: 10.5772/1179 Language: English
Publisher: IntechOpen
Subject: Therapeutics
Added to DOAB on : 2019-10-03 07:51:48

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Drug discovery and development process aims to make available medications that are safe and effective in improving the length and quality of life and relieving pain and suffering. However, the process is very complex, time consuming, resource intensive, requiring multi-disciplinary expertise and innovative approaches. There is a growing urgency to identify and develop more effective, efficient, and expedient ways to bring safe and effective products to the market. The drug discovery and development process relies on the utilization of relevant and robust tools, methods, models, and validated biomarkers that are predictive of clinical effects in terms of diagnosis, prevention, therapy, and prognosis. There is a growing emphasis on translational research, a bidirectional bench to the bedside approach, in an effort to improve the process efficiency and the need for further innovations. The authors in the book discuss the current and evolving state of drug discovery and development.

Pharmacokinetics and Adverse Effects of Drugs - Mechanisms and Risks Factors

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ISBN: 9781789231380 9781789231397 Year: Pages: 162 DOI: 10.5772/intechopen.68518 Language: English
Publisher: IntechOpen
Subject: Therapeutics
Added to DOAB on : 2019-10-03 07:51:51

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This book is a fruit of a collaborative work from several international scientists. It will be a useful resource for researchers, students, and clinicians. Each individual chapter could serve as a prescribed reading for postgraduate students and clinicians specializing in and practicing clinical pharmacology and toxicology, pharmacotherapy and pharmacotherapeutics, pharmacovigilance, and toxicovigilance, as well as those involved in clinical research, drug discovery, and development. Every chapter in this book discusses and provides illustrations on the theme discussed based on authors' understanding and experience while summarizing existing knowledge. In doing so, each chapter provides a new insight that would benefit a novice as well as a seasoned reader in understanding the pharmacokinetic mechanisms and risk factors involved in the occurrence of adverse effects of drugs.

Molecular Insight of Drug Design

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ISBN: 9781789236323 9781789236330 Year: Pages: 130 DOI: 10.5772/intechopen.71744 Language: English
Publisher: IntechOpen
Subject: Therapeutics
Added to DOAB on : 2019-10-03 07:51:51

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The approaches in drug design are mainly comprised of these three multidisciplinary sciences. First, Bioinformatics has successfully gather biological data in form of biomolecular sequences, in order to construct knowledge on drug and vaccine design. It is of considerable importance for drug designers to comprehend the utilization of bioinformatics tools for resolving their research questions. Second, Nanotechnology has made possible the design and delivery of the nano-based drug. Third, Pharmaceutical Chemistry made it possible to investigate the adsorption, distribution, metabolism, and toxicology of the drug candidates in a fine-grained resolution.

Anticoagulant Drugs

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ISBN: 9781789236224 9781789236231 Year: Pages: 120 DOI: 10.5772/intechopen.70971 Language: English
Publisher: IntechOpen
Subject: Therapeutics
Added to DOAB on : 2019-10-03 07:51:51

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Anticoagulant drugs are among the most frequently prescribed drugs in everyday clinical practice. In the past decades, several new direct oral anticoagulants were developed that changed the anticoagulant therapy landscape considerably. This book provides an extensive overview of all the known anticoagulants that can be useful for studying different aspects of the haemostatic system or as a starting point for new drug development. It is also a valuable tool for clinicians providing a description of the mode of action and management of therapy for anticoagulant drugs used in everyday clinical practice in different clinical settings, including direct oral anticoagulants dabigatran, rivaroxaban, apixaban and edoxaban.

Drug Discovery - Concepts to Market

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ISBN: 9781789236965 9781789236972 Year: Pages: 192 DOI: 10.5772/intechopen.70151 Language: English
Publisher: IntechOpen
Subject: Therapeutics
Added to DOAB on : 2019-10-03 07:51:52

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The book ""Drug Discovery - Concepts to Market"" is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the latest drug discovery trends that have been revolutionized with up-to-date technological developments. This book comprises single chapters authored by various researchers and edited by an expert active in the drug development research area. All chapters are independently complete but united under a common research study topic. This publication aims to provide a thorough overview of the latest research efforts in this field from international authors and open new possible research paths for further novel developments.

Drug Discovery and Development - From Molecules to Medicine

Authors: ---
ISBN: 9789535121282 9789535142225 Year: Pages: 330 DOI: 10.5772/58659 Language: English
Publisher: IntechOpen
Subject: Oncology
Added to DOAB on : 2019-10-03 09:47:09

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It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.

Special Topics in Drug Discovery

Authors: ---
ISBN: 9789535127994 9789535128007 Year: Pages: 190 DOI: 10.5772/62591 Language: English
Publisher: IntechOpen
Subject: Therapeutics
Added to DOAB on : 2019-10-03 09:47:10

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Drug discovery involves multiple disciplines, technologies, and approaches. This book selects important topics related to drug discovery, including emerging tool (Chapter 1), cutting-edge approaches (Chapters 2, 3, and 4), examples of specific therapeutic area (Chapter 5), quality control in drug development (Chapter 6), and job and career opportunities in the pharmaceutical sector, a topic rarely covered by other books (Chapter 7). This book draws knowledge from experts actively involved in different areas of drug discovery from both industrial and academic settings. We hope that this book will facilitate your efforts in drug discovery.

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