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Programming the HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194810 Year: Pages: 140 DOI: 10.3389/978-2-88919-481-0 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology --- Medicine (General) --- Internal medicine
Added to DOAB on : 2015-11-16 15:44:59
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Abstract

Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.

Molecular mechanisms for reprogramming hippocampal development and function by early-life stress

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198061 Year: Pages: 100 DOI: 10.3389/978-2-88919-806-1 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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The early postnatal period is a crucial stage for hippocampal development. During this critical period, the neonatal hippocampus is highly sensitive to the detrimental consequences of adverse environmental factors. Extensive clinical and preclinical evidence has shown that traumatic events early in life have profound and persistent effects on hippocampal function and behavior. This research topic focuses on the acute and lasting effects of early-life stress on various developmental processes in the hippocampus, and aims to uncover the molecules that are responsible for early-life stress-programmed effects and underlie resilience or vulnerability to stress-related neuropsychiatric disorders later in life. We hope the articles in this research topic will provide novel insights and stimulate future studies on the mechanisms of early-life stress and brain development.

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