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Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides

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ISBN: 9783039215829 / 9783039215836 Year: Pages: 212 DOI: 10.3390/books978-3-03921-583-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Cardiovascular
Added to DOAB on : 2019-12-09 11:49:16
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Abstract

The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs. Finally, the opportunity to target NPs in order to develop new therapeutic tools for a better treatment of CVDs has been developed over the years. The current Special Issue of the Journal covers all major aspects of the molecular implications of NPs in physiology and pathology of the cardiovascular system, including NP-based therapeutic approaches.

Keywords

PCSK9 --- natriuretic peptides --- adipose tissue --- lipid metabolism --- LDL receptor --- insulin --- natriuretic peptides --- hypertension --- stroke --- cardiac hypertrophy --- linkage analysis --- genetic variants --- animal models --- BNP --- NT-proBNP --- heart failure --- cardiac dysfunction --- forensic medicine --- postmortem biochemistry --- angiotensin receptor–neprilysin inhibitor --- natriuretic peptides --- renin–angiotensin system --- heart failure --- arterial hypertension --- natriuretic peptide --- vascular --- endothelial cell --- cardiomyocyte --- fibroblast --- inflammation --- heart failure --- hypertension --- angiogenesis --- heart failure --- natriuretic peptides --- preserved ejection fraction --- natriuretic peptides --- heart failure --- atrial fibrillation --- remodeling --- Idiopathic Pulmonary Arterial Hypertension (IPAH) --- Natriuretic Peptide Clearance Receptor (NPR-C) signaling --- atrial natriuretic peptide --- hypertension --- heart failure --- cardiometabolic disease --- obesity --- metabolic syndrome --- cGMP --- guanylyl cyclase receptor A --- natriuretic peptides --- natriuretic peptide --- cardiorenal syndrome --- vasopressor --- vasodilator --- kidney --- medulla --- renin-angiotensin-aldosterone system --- Atrial Natriuretic peptide --- natriuretic peptides --- cardiac remodelling --- cardiac hypertrophy --- vascular homeostasis --- atrial natriuretic peptide --- guanylyl cyclase/natriuretic peptide receptor-A --- gene-knockout --- gene-duplication --- hypertension --- congestive heart failure --- natriuretic peptides --- arterial hypertension --- pulmonary arterial hypertension --- heart failure --- stroke --- atrial fibrillation --- ARNi --- MANP

Extractable and Non-Extractable Antioxidants

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ISBN: 9783039214372 / 9783039214389 Year: Pages: 234 DOI: 10.3390/books978-3-03921-438-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2019-12-09 11:49:15
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Abstract

The Special Issue “Extractable and Non-Extractable Antioxidants” gives an updated view on antioxidants—both in their extractable and non-extractable form—in the different food groups, their products thereof, and food preparations as well as byproducts and biomass waste. The potential beneficial properties of these compounds and nutraceutical formulations are described in the various studies covered in this Special Issue.

Keywords

anthocyanins --- polyphenolic compounds --- classic extraction --- ultrasound assisted extraction --- antioxidant capacity --- daidzein --- cyclodextrin --- inclusion complex --- antioxidant activity --- trans-cinnamaldehyde --- ?-cyclodextrin --- self-inclusion --- anti-inflammation --- antioxidant --- Pleurotus ostreatus --- antioxidant activity --- polyphenols --- digestibility --- fermentation --- cereals --- legumes --- Chinese mistletoes --- phenolics --- phenolic contents --- antioxidant activity --- forest residues --- phenolic compounds --- natural antioxidants --- quercitrin --- value-added by-products --- Camellia sinensis --- black teas --- catechins --- antioxidant activity --- LC-ESI-Q-TOF-MS --- principal component analysis --- extractable --- non-extractable --- antioxidant activity --- agglomerative hierarchical clustering --- principal component analysis --- multivariate analysis --- nuclear magnetic spectroscopy --- nitric oxide scavengers --- pre-column HPLC method --- Aloysia triphylla --- phenolics --- antioxidants --- dietary supplements --- botanicals --- bioactive compounds --- antioxidants --- study approach --- integrated food research --- dedicated databases --- dietary assessment. --- biorefinery --- circular economy --- grape seed --- bio-based --- chemometrics --- Cagnulari marc --- Naviglio Extractor® --- green extraction --- endothelial cell --- oxidative stress --- polyphenols --- berries jam --- phenolic acids --- flavonols glycosides --- degradation --- HPLC-ESI/MS --- antioxidant properties --- digestive enzyme --- nutrient --- polymerization --- proanthocyanidins --- eggplant --- flour --- phenolics --- antioxidant activity --- functional ingredient --- sour cherry --- anthocyanins --- extractable polyphenols --- non-extractable polyphenols --- Italian popular recipes --- food composition database --- antioxidant properties --- extractable compounds --- non-extractable compounds --- ferric reducing antioxidant power (FRAP) --- total polyphenol content (TPC) --- n/a

Marine Anti-inflammatory Agents

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ISBN: 9783039215720 / 9783039215737 Year: Pages: 248 DOI: 10.3390/books978-3-03921-573-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2019-12-09 11:49:16
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Abstract

Acute inflammation is a highly regulated process, and its dysregulation can lead to the development of a chronic inflammatory state which is believed to play a main role in the pathogenesis of many diseases, including cancer. In recent years, the need to find new anti-inflammatory molecules has raised the scientific community´s interest for marine natural products. In this regard, the marine environment represents a source for isolating a wealth of bioactive compounds. In this Special Issue, the reported products have been obtained from microalgae, sea cucumber, octopus, squid, red alga-derived fungus, cnidarians, hard-shelled mussel, and sponges.

Keywords

THP-1 macrophages --- anti-inflammatory --- TLR4 --- NF-?B --- MAPK --- SPR analysis --- glycolipids --- MGDG --- skin --- inflammation --- epidermal hyperplasia --- microalgae --- Isochrysis galbana --- Frondanol --- Cucumaria frondosa --- DSS colitis --- colon inflammation --- zoantharia --- Tropical Eastern Pacific --- Zoanthus pulchellus --- zoanthamine --- inflammation --- fucoxanthin --- inflammation --- epidermal hyperplasia --- UVB --- photoprotection --- 6-bromoindole --- Geodia barretti --- anti-inflammatory activity --- dendritic cells --- T cell differentiation --- poor blood circulation --- Ecklonia cava --- phlorotannins --- pyrogallol-phloroglucinol-6,6-bieckol --- functional ingredients --- endothelial cell death --- vascular smooth muscle cell proliferation and migration --- inflammation --- anti-inflammatory --- bioactive molecules --- microalgae --- polysaccharides --- carotenoids --- polyunsaturated fatty acids --- fucoxanthin --- ultraviolet B --- denervation --- seafood waste --- polyunsaturated fatty acid --- NO inhibition --- fish oil --- marine nutraceuticals --- fish oil --- omega-3 --- eicosapentaenoic acid --- docosahexaenoic acid --- inflammation --- eicosanoid --- cytokine --- surgery --- critical illness --- parenteral nutrition --- signal transducer and activator of transcription 3 (STAT3) --- matrix metalloproteinases-9 (MMP-9) --- interleukin (IL) --- lipopolysaccharide (LPS) --- acute sickness behavior --- acute lung injury (ALI) --- prostaglandins --- clavulones --- punaglandins --- thromboxane --- inflammation --- marine vertebrates --- marine invertebrates --- diatoms --- macroalgae --- fucoxanthin --- rosmarinic acid --- NRLP3 --- inflammasome --- anti-oxidative --- anti-inflammatory --- photo-protection --- UVB

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MDPI - Multidisciplinary Digital Publishing Institute (3)


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CC by-nc-nd (3)


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eng (3)


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2019 (3)