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DNA Replication Stress

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ISBN: 9783039213894 9783039213900 Year: Pages: 368 DOI: 10.3390/books978-3-03921-390-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 16:10:12
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Abstract

This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS Special Issue, I am very pleased to offer this collection of riveting articles centered on the theme of DNA replication stress. The blend of articles builds upon a theme that DNA damage has profound consequences for genomic stability and cellular homeostasis that affect tissue function, disease, cancer, and aging at multiple levels and through unique mechanisms. I thank the authors for their excellent contributions, which provide new insight into this fascinating and highly relevant area of genome biology.

Keywords

barley --- chromosome --- DNA replication pattern --- EdU --- mutagens --- DNA replication --- DNA damage --- DNA repair --- genome integrity --- A549 cells --- H1299 cells --- heterogeneity --- DNA damage response --- 8-chloro-adenosine --- DNA replication --- S phase --- origin firing --- TopBP1 --- ATR --- DNA fiber assay --- APE2 --- ATR-Chk1 DDR pathway --- Genome integrity --- SSB end resection --- SSB repair --- SSB signaling --- DNA replication stress --- genome stability --- ubiquitin --- replication fork restart --- translesion synthesis --- template-switching --- homologous recombination --- Fanconi Anemia --- G protein-coupled receptor (GPCR) --- aging --- DNA damage --- ?-arrestin --- G protein-coupled receptor kinase (GRK) --- interactome --- G protein-coupled receptor kinase interacting protein 2 (GIT2) --- ataxia telangiectasia mutated (ATM) --- clock proteins --- energy metabolism --- neurodegeneration --- cellular senescence --- ageing --- Alzheimer’s disease --- multiple sclerosis --- Parkinson’s disease --- lipofuscin --- SenTraGorTM (GL13) --- senolytics --- DNA replication --- DNA repair --- DNA damage response --- DNA translocation --- DNA helicase --- superfamily 2 ATPase --- replication restart --- fork reversal --- fork regression --- chromatin remodeler --- C9orf72 --- ALS --- motor neuron disease --- R loops, nucleolar stress --- neurodegeneration --- Difficult-to-Replicate Sequences --- replication stress --- non-B DNA --- Polymerase eta --- Polymerase kappa --- genome instability --- common fragile sites --- Microsatellites --- cancer --- DNA double-strand repair --- premature aging --- post-translational modification --- protein stability --- replication stress --- Werner Syndrome --- Werner Syndrome Protein --- dormant origins --- replicative stress --- replication timing --- DNA damage --- genome instability --- cancer --- Thermococcus eurythermalis --- endonuclease IV --- AP site analogue --- spacer --- DNA repair --- DNA repair --- double strand break repair --- exonuclease 1 --- EXO1 --- mismatch repair --- MMR --- NER --- nucleotide excision repair --- strand displacements --- TLS --- translesion DNA synthesis --- POL? --- mutation frequency --- mutations spectra --- SupF --- mutagenicity --- oxidative stress --- DNA damage --- DNA repair --- replication --- 8-oxoG --- epigenetic --- gene expression --- helicase --- cell cycle checkpoints --- genomic instability --- G2-arrest --- cell death --- repair of DNA damage --- adaptation --- n/a

State-of-the-art Laser Gas Sensing Technologies

Authors: --- ---
ISBN: 9783039283989 9783039283996 Year: Pages: 278 DOI: 10.3390/books978-3-03928-399-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-04-07 23:07:08
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Trace gas sensing technologies are widely used in many applications, such as environmental monitoring, life science, medical diagnostics, and planetary exploration. On the one hand, laser sources have developed greatly due to the rapid development of laser media and laser techniques in recent years. Some novel lasers such as solid-state, diode, and quantum cascade lasers have experienced significant progress. At present, laser wavelengths can cover the range from ultraviolet to terahertz, which could promote the development of laser gas sensing technologies significantly. On the other hand, some new gas sensing methods have appeared, such as photothermal spectroscopy and photoacoustic spectroscopy. Laser spectroscopy-based gas sensing techniques have the advantages of high sensitivity, non-invasiveness, and allowing in situ, real-time observation. Due to the rapid and recent developments in laser source as well as the great merits of laser spectroscopy-based gas sensing techniques, this book aims to provide an updated overview of the state-of-the-art laser gas sensing technologies.

Keywords

tunable mid-infrared solid-state laser --- thermal control --- all-fiber laser --- thermoelectric cooling --- finite-element analysis --- optical parametric oscillator --- Tm,Ho:LuVO4 laser --- PQS --- graphene saturable absorber --- mid-infrared --- single-frequency --- optical parametric oscillator (OPO) --- MgO:PPLN crystal --- continuous-wave (CW) --- diffuse integrating cavity --- TDLAS --- gas detection --- non-linearity --- quartz-enhanced photoacoustic spectroscopy --- quartz tuning fork --- gas sensing --- detection limit --- laser spectroscopy --- practical applications --- real-time observation --- optical sensing --- stokes vectors --- information processing technology --- tunable laser absorption spectroscopy --- mid-infrared fingerprint spectrum --- broadband spectrum --- trace gas detection --- wavelength modulation spectroscopy --- quantum cascade lasers --- interband cascade lasers --- carbon dioxide monitoring --- absorption spectroscopy --- temperature compensation --- wavelength modulation --- methane detection --- support vector machine --- chicken swarm optimization --- algorithm --- concentration prediction --- combustion diagnostic --- femtosecond laser --- two-photon femtosecond laser-induced fluorescence --- femtosecond laser-induced breakdown spectroscopy --- femtosecond laser electronic excitation tagging --- filament-induced nonlinear spectroscopy --- femtosecond laser-induced plasma spectroscopy --- hollow-core photonic crystal fiber --- GRIN fiber probe --- coupling efficiency --- gas sensing --- near-infrared --- C2H2 detection --- TDLAS --- time division multiplexing differential modulation --- a multi-reflection chamber --- laser absorption spectroscopy (LAS) --- combustion sensing --- direct absorption spectroscopy (DAS) --- wavelength modulation spectroscopy (WMS) --- design optimization --- noise reduction algorithms --- methane --- tunable diode laser --- wavelength modulation spectroscopy --- frequency modulation spectroscopy --- two-tone frequency modulation spectroscopy --- photothermal spectroscopy --- gas sensing --- detection limit --- laser spectroscopy --- practical applications --- intracavity gas detection --- interferometric gas detection --- deep-sea natural gas hydrate exploration --- 13CO2/12CO2 isotope ratio detection --- TDLAS technique --- mid-infrared ICL --- n/a

Biomimetic Radical Chemistry and Applications

Author:
ISBN: 9783039283927 9783039283934 Year: Pages: 300 DOI: 10.3390/books978-3-03928-393-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology --- Science (General)
Added to DOAB on : 2020-04-07 23:07:09
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The enormous importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted a strong interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an important research area. When studying free-radical-based chemical mechanisms, biomimetic chemistry and the design of established biomimetic models come into play to perform experiments in a controlled environment that is suitably designed to be in strict connection with cellular conditions. This Special Issue gives the reader a wide overview of biomimetic radical chemistry, where molecular mechanisms have been defined and molecular libraries of products are developed to also be used as traces for the discovery of some relevant biological processes. Several subjects are presented, with 12 articles and 6 reviews written by specialists in the fields of DNA, proteins, lipids, biotechnological applications, and bioinspired synthesis, having “free radicals” as a common denominator.

Keywords

type 2 diabetes --- glycogen phosphorylase --- anomeric spironucleosides --- 1,6-dioxa-4-azaspiro[4.5]decane --- [1,5]-radical translocation --- DNA --- guanine quadruplexes --- radicals --- electron holes --- oxidative damage --- photo-ionization --- time-resolved spectroscopy --- inhomogeneous reactions --- radiosensitizers --- stationary radiolysis --- pulse radiolysis --- modified nucleosides --- cellular response --- liposomal somatostatin --- retarded delivery --- free radicals --- isomerization --- trans lipid --- peroxidation --- photolysis --- laser flash photolysis --- ?-radiolysis --- singlet oxygen --- nucleosides --- free radicals --- reaction mechanism --- catalase activity --- iron(IV)-oxo --- hydrogen peroxide --- oxidation --- kinetic studies --- gold nanoparticles --- albumin --- EPR spectroscopy --- Raman spectroscopy --- circular dichroism --- beta cells --- diabetes --- confocal microscopy --- lipidomics --- membrane fluidity maps --- cell micropolarity maps --- DNA damage --- 5?,8-cyclopurines --- 8-oxo-dG --- free radicals --- pulse radiolysis --- gamma radiolysis --- Fenton reaction --- oligonucleotides --- oxidative DNA damage --- DNA replication stress --- replication fork stalling --- genomic and epigenomic instability --- DNA methylation --- histone modifications --- miRNAs --- iron porphyrin --- heme --- ATRPase --- iron-mediated ATRP --- bio-mimicking catalyst --- biomimetic radical reaction --- bioinspired chemical catalysis --- protein labeling --- DNA oxidation --- DNA hole transfer --- DNA --- quantum dynamics --- electron transfer --- charge transfer --- radical reaction --- azidoalkylation --- carboazidation --- sulfones --- azides --- Julia–Kocienski olefination --- DNA damage --- copper --- chemical nuclease --- intercalation --- free radical oxidation --- protein stability --- therapeutic proteins --- thiyl radicals --- oxidation --- fragmentation --- cross-link --- 2-thiouracil --- radiosensitizers --- ?OH and ?N3 radicals --- 2c-3e S?S-bonded intermediates --- pulse radiolysis --- TD-DFT methods --- thiobases --- nucleobase derivatives --- reactive aldehydes --- hydroxynonenal --- oxononenal --- free fatty acids --- mitochondrial uncoupling protein --- lipid bilayer membranes

Ironmaking and Steelmaking

Authors: ---
ISBN: 9783039213290 9783039213306 Year: Pages: 464 DOI: 10.3390/books978-3-03921-330-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Physics (General)
Added to DOAB on : 2019-12-09 16:10:12
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Abstract

Steel is a critical material in our societies and will remain an important one for a long time into the future. In the last two decades, the world steel industry has gone through drastic changes and this is predicted to continue in the future. The Asian countries (e.g. China, India) have been dominant in the production of steel creating global over-capacity, while the steel industry in the developed countries have made tremendous efforts to reinforce its global leadership in process technology and product development, and remain sustainable and competitive. The global steel industry is also facing various grand challenges in strict environmental regulation, new energy and materials sources, and ever-increasing customer requirements for high quality steel products, which has been addressed accordingly by the global iron and steel community. This Special Issue, “Ironmaking and Steelmaking”, released by the journal Metals, published 33 high quality articles from the international iron and steel community, covering the state-of-the-art of the ironmaking and steelmaking processes. This includes fundamental understanding, experimental investigation, pilot plant trials, industrial applications and big data utilization in the improvement and optimization of existing processes, and research and development in transformative technologies. It is hoped that the creation of this special issue as a scientific platform will help drive the iron and steel community to build a sustainable steel industry.

Keywords

ironmaking --- microwaves --- carbothermal reduction --- iron oxides --- emission spectrum --- ore-carbon briquette --- CO–CO2 atmosphere --- simulation --- re-oxidation --- reduction --- electroslag cladding --- high speed steel --- ductile cast iron --- composite roll --- bonding interface --- high-phosphorus iron ore --- fluorapatite --- carbothermal reduction --- vaporization dephosphorization --- iron ore pellets --- compressive strength (CS) --- prediction model --- artificial neural network --- principal component analysis --- crystallization behaviors --- crystallization rate --- anosovite crystals --- silicate crystals --- titanium slag --- blast furnace --- copper stave --- hydrogen attack --- slag crust --- heat-affected zone --- high heat input welding --- Ca deoxidation --- inclusion control --- intragranular acicular ferrite --- concentrate --- iron ore --- agglomerate --- structure --- phase analysis --- Mg deoxidation --- inclusions --- Al addition --- high-heat-input welding --- heat-affected zone --- toughness --- shot peening --- Barkhausen noise --- crystallite size --- carbon composite pellet --- direct reduction --- shrinkage --- kinetics --- rotary hearth furnace --- hydrogen plasma --- smelting reduction --- HPSR --- iron oxide --- plasma arc --- ionization degree --- sulfur distribution ratio --- liquid area --- carbon-saturated iron --- phosphate capacity --- sulfide capacity --- phosphorus distribution ratio --- sulfur distribution ratio --- evaluation of coupling relationship --- secondary refining process, CaO–based slags --- iron sulfate --- TG analysis --- thermal treatment --- iron oxide --- kinetics --- activation energy --- high-aluminum iron ore --- synergistic reduction --- high-manganese iron ore --- hercynite --- fayalite --- flow velocity --- casting speed --- gas flow rate --- flow pattern --- continuous casting --- Cr recovery --- self-reduction briquette --- reaction mechanism --- mold flux --- low fluorine --- internal crack --- surface roughness --- slag film --- vanadium titano-magnetite --- gas-based reduction --- carbon monoxide --- hydrogen --- and nitrogen --- kinetics --- pellet size --- liquid steel --- non-contact measurement --- oxides --- steel-making --- blast furnace --- solid flow --- cold experiment --- direct element method --- Wilcox–Swailes coefficient --- viscosity --- BaO --- CaO/Al2O3 ratio --- modified NPL model --- ultrafine particles exposure --- steelmaking factory --- chemical composition --- devolatilization --- torrefied biomass --- bio-coal --- volatile matter --- iso-conversional method --- Al-TRIP steel --- surface depression --- cracks --- non-metallic inclusion --- mold flux --- reactivity --- hot metal pre-treatment --- desiliconisation --- dephosphorisation --- solid and gaseous oxygen --- fork --- flat steel --- inclusions --- 33MnCrTiB --- slag --- carbon dioxide --- injection --- blast furnace --- converter --- combustion --- oxygen steelmaking --- refining kinetics --- slag formation --- penetration theory --- oxygen blast furnace --- COREX --- static process model --- integrated steel plant --- material flow --- energy consumption --- CO2 emissions --- oil-pipeline steel --- Ca-treatment --- non-metallic inclusions --- electrolytic extraction --- corrosion --- n/a

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