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Ecritures discontinues

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ISBN: 9791030003970 DOI: 10.4000/books.pub.4652 Language: French
Publisher: Presses Universitaires de Bordeaux
Subject: Languages and Literatures
Added to DOAB on : 2019-12-06 13:15:42
License: OpenEdition Licence for Books

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Le reste

ISBN: 9782842697549 9782367812359 Year: Language: French
Publisher: Presses universitaires de la Méditerranée
Added to DOAB on : 2017-10-11 15:31:59
License: OpenEdition licence for Books

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Que reste-t-il, en ce début de siècle, des acquis de ta civilisation européenne qui soit susceptible d'être repris, réagencé, voire restauré ? Et qu'est-ce qui demeure intraitable, irreprésentable, persistant toutefois à hanter la réflexion et la création ? S'il est ce qui subsiste après une disparition, le reste est aussi ce qui a été exclu pour qu'un ensemble se constitue. Cependant, ce qui a été exclu subsiste, obligeant à reconsidérer les procédures qui ont produit cette part à la fois r...

Fragments : Entre brisure et création

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ISBN: 9782753579262 DOI: 10.4000/books.pur.46003 Language: French
Publisher: Presses universitaires de Rennes
Subject: Languages and Literatures
Added to DOAB on : 2019-12-06 13:15:47
License: OpenEdition Licence for Books

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Le mot "fragment" recouvre deux réalités textuelles différentes, associées à des formes d’écritures particulières, se présentant sous des aspects multiples et dans des contextes variés. Le fragment peut désigner un morceau extrait d’une œuvre, souvent perdu, inséré par un auteur dans son propre texte, auteur qui, ce faisant, le préserve de l’oubli tout en lui conférant d’autres significations. Mais une œuvre nouvelle peut également être délibérément fragmentée, caractérisée par la discontinuité, la rupture et le morcellement, stratégies d’écriture mises au service d’une création littéraire originale. Les contributions rassemblées dans ce volume mettent en lumière, à partir d’exemples variés, de l’Antiquité à nos jours, les caractéristiques principales et les enjeux respectifs de ces deux formes d’écriture fragmentaire, mais aussi les nombreuses convergences et similitudes qui peuvent se faire jour entre elles, repérables d’un siècle ou d’un genre à l’autre.

Analysis of Peptides and Proteins by Electrophoretic Techniques

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ISBN: 9783039212279 / 9783039212286 Year: Pages: 110 DOI: 10.3390/books978-3-03921-228-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-08-28 11:21:27
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The characterization of peptides and proteins is central to understanding their function and expression in biological matrices. Moreover, these macromolecules are important biomarkers of many human diseases. In recent years, the performance of separation techniques based on electromigration have significantly increased. The development of microdevices has reduced sample consumption and waste production while high-sensitivity detectors, such as mass spectrometry (MS) or laser-induced fluorescence (LIF), have significantly improved with regards to separation efficiency and detection limits. All of these advancements have led to appreciably enlarged fields of application. Nowadays, a multitude of studies using separation techniques based on electromigration to study proteins and peptides from numerous real matrices are available in the literature. This Special Issue covers the most recent knowledge and advances in the study of peptides and proteins using several electrophoresis techniques, as well as the characterization of relevant proteins and peptides in application areas such as clinical studies, functional foods, and toxicology.

Molecular Modeling in Drug Design

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ISBN: 9783038976141 Year: Pages: 220 DOI: 10.3390/books978-3-03897-615-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General) --- Science (General)
Added to DOAB on : 2019-04-05 10:34:31
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This book is a printed edition of the Special Issue Molecular Modeling in Drug Design that was published in Molecules

Keywords

hyperlipidemia --- squalene synthase (SQS) --- molecular modeling --- drug discovery --- Traditional Chinese Medicine --- molecular dynamics simulation --- biophenols --- natural compounds --- amyloid fibrils --- Alzheimer’s disease --- ligand–protofiber interactions --- adhesion --- FimH --- rational drug design --- molecular dynamics --- molecular docking --- ligand binding --- EphA2-ephrin A1 --- PPI inhibition --- interaction energy --- in silico screening --- adenosine --- boron cluster --- adenosine receptors --- AR ligands --- aggregation --- promiscuous mechanism --- human ecto-5?-nucleotidase --- virtual screening --- enzymatic assays --- turbidimetry --- dynamic light scattering --- docking --- solvent effect --- binding affinity --- scoring function --- molecular dynamics --- target-focused pharmacophore modeling --- density-based clustering --- structure-based drug design --- AutoGrid --- grid maps --- probe energies --- method development --- steered molecular dynamics --- all-atom molecular dynamics simulation --- resultant dipole moment --- mechanical stability --- protein-peptide interactions --- molecular dynamics --- proteins --- molecular recognition --- protein protein interactions --- artificial intelligence --- deep learning --- neural networks --- property prediction --- quantitative structure-activity relationship (QSAR) --- quantitative structure-property prediction (QSPR) --- de novo design --- adenosine receptor --- metadynamics --- extracellular loops --- allosterism --- molecular dynamics --- cosolvent molecular dynamics --- drug design --- fragment screening --- docking

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