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From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder

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ISBN: 9783038427315 9783038427322 Year: Pages: VIII, 230 DOI: 10.3390/books978-3-03842-732-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2018-02-16 09:08:33
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Abstract

Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike.Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.

Gluten Related Disorders: People Shall not Live on Bread Alone

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ISBN: 9783038423577 9783038423560 Year: Pages: X, 242 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Internal medicine
Added to DOAB on : 2017-05-05 13:32:03
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Once upon a time, gluten was not part of the human diet, and therefore, there were no gluten-related disorders. With the advent of agriculture 10,000 years ago, the introduction of gluten-containing grains in the human diet created conditions for human diseases related to gluten exposure. These diseases, including celiac disease, non-celiac gluten sensitivity, and wheat allergy, have distinct pathophysiological mechanisms, serological markers, and long-term treatments, but similar, often overlapping clinical presentations. Though current research strives to clarify the boundaries between these entities, their differences can be difficult to distinguish.For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders has been a “work in progress”. New epidemiological studies have revealed that gluten-related disorders are not limited to European regions; rather, they are present worldwide.After centuries of neglected attention to celiac disease and other forms of gluten reaction, now we are observing another interesting phenomenon that is generating great confusion among health care professionals. Nearly 25% of Americans (many more than the projected 3 million celiac disease (CD) patients in the U.S.) are reducing or cutting gluten from their diets. This remarkable trend in the general population reflects the misconception that gluten can be harmful for everybody and, therefore, should be avoided to stay healthy, to lose weight, or even to prevent severe diseases.This Special Issue Book of Nutrients contains contributions from leading experts in the field of gluten-related disorders that will help dissipate this confusion by sharing their evidence-based science, which will help the reader to distinguish facts from fantasies.

Gluten-Free Diet

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ISBN: 9783038977360 9783038977377 Year: Pages: 318 DOI: 10.3390/books978-3-03897-737-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2019-04-25 16:37:17
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In the last few years, an increasing number of individuals have adopted a gluten free diet (GFD). A significant proportion of that includes patients affected by celiac disease (CD), who have to follow a strict GFD for medical purposes. However, a high number of individuals are currently following a GFD without medical counseling and without a specific diagnosis needing a gluten withdrawal from the diet. This is due to the frequently incorrect information diffused on the Internet and mass media on the topic of GFD. For these reasons, research on the GFD and its clinical use and biological effects is urgently needed.

Keywords

Celiac Disease --- depression --- gluten-free diet --- dietary adherence --- gluten --- gastric emptying --- cholecyst --- celiac disease --- non celiac gluten sensitivity --- gluten-free diet --- gastrointestinal symptoms --- quality of life --- Brazilian CD-QoL --- quality of life --- celiac disease --- questionnaire --- coeliac disease --- celiac disease --- gluten --- gluten-free diet --- fortification --- micronutrient --- cost --- celiac disease --- diagnosis --- gliadin --- gluten --- glutenin --- non-celiac gluten sensitivity --- oral food challenge --- pepsin --- wheat allergy --- celiac disease (CD) --- quality of life (QoL) --- gluten-free diet --- disease duration --- place of residence --- educational level --- economic status --- body mass index (BMI) --- celiac disease --- gluten-free diet --- gut microbiota --- gluten-free diet --- celiac disease --- children --- teenagers --- gluten-related disorders --- celiac disease --- gut microbiota --- gluten-free diet --- Pseudomonas --- gluten-free diet --- mineral --- deficiency --- calcium --- iron --- magnesium --- zinc --- celiac disease --- non-celiac gluten sensitivity --- gut motility --- gluten-free diet --- gluten-related disorders --- gluten-free diet --- coeliac disease --- non-coeliac gluten sensitivity --- irritable bowel syndrome --- mood disorders --- affective disorders --- depression --- major depressive disorder --- mental health --- nutrition --- celiac disease --- gluten-free diet --- diary recommended intake --- food habit --- body composition --- non-coeliac gluten sensitivity --- gluten --- wheat --- low FODMAP diet --- irritable bowel syndrome --- beta cell --- beta-cell stress --- celiac disease --- gluten-free diet --- high-fat diet-induced obesity --- intestinal permeability --- islet of Langerhans --- NOD mouse --- type 1 diabetes --- type 2 diabetes --- FODMAP intake --- celiac disease --- irritable bowel syndrome --- gluten-free diet --- gastrointestinal symptoms --- celiac disease --- gluten-free diet --- effectiveness --- adherence --- nutritionists --- clinic --- serology --- duodenal biopsies --- structured questionnaires --- peptides derived from gluten in faeces and urine --- gluten --- adherence --- serology --- villous atrophy --- mucosal recovery --- threshold --- celiac disease --- body composition --- gluten free diet --- children --- celiac disease --- gluten --- gluten-free diet --- screening --- outcome --- gluten sensitivity --- osteoporosis --- non-celiac gluten sensitivity --- gluten re-introduction --- gluten-free diet --- gastrointestinal symptoms --- celiac disease --- ?-gliadin --- 33-mer --- DQ2.5-glia-?1 --- DQ2.5-glia-?2 --- DQ2.5-glia-?3 epitopes --- wheat species --- n/a --- gluten --- gluten-free diet --- coeliac disease --- non-celiac gluten sensitivity --- non-coeliac wheat sensitivity --- gliadin --- microbiota

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