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Carbohydrates: The yet to be tasted sweet spot of immunity

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196258 Year: Pages: 93 DOI: 10.3389/978-2-88919-625-8 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2016-08-16 10:34:25
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Abstract

Carbohydrates are extremely abundant bio-molecules; they are on all mammalian cell surfaces as well as on bacterial cell surfaces. In mammals most secreted proteins are glycosylated, with the glycan component comprising a significant amount by mass of the glycoprotein. Although, many years ago carbohydrate-protein recognition events were demonstrated as involved in invertebrate self-non self recognition, the contribution of carbohydrate-protein binding events to the mechanisms of the mammalian immune response was not embraced with the same enthusiasm. Adaptive immunity and the contribution of antibodies, T cells and T-lymphocyte sub-sets and protein antigen presentation dominated immunological theory. Unlike protein structures, carbohydrate structures are not template driven yet the numerous enzymes involved in carbohydrate biosynthesis and modification are encoded by a major component of the genome, and the expression of these enzymes is tightly regulated. As a consequence carbohydrate structures are also regulated, with different structures appearing according to the stage of cell differentiation and according to the age or health of the individual. The advent of technologies that have allowed carbohydrate structures and carbohydrate-protein binding events to be more easily interrogated has resulted in these types of interactions taking their place in modern immunology. We now know that glycans and their ligands (or lectins) are involved in numerous immunological pathways of both the innate and adaptive systems. However, it is clear that our understanding is still in its infancy, as more and more examples where carbohydrate structures contribute to aspects of the immune response are being recognised. The goal of this research topic is to explore the variety of roles undertaken by glycans and lectins in all aspects of the immune response. The particular focus is how the interactions of glycans with their ligands contribute to the mechanism of immune responses.

Looking Forward to the Future of Heparin: New Sources, Developments and Applications

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ISBN: 9783038429494 / 9783038429500 Year: Pages: 282 DOI: 10.3390/books978-3-03842-950-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-08-28 11:21:28
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Abstract

This book is a printed edition of the Special Issue Looking Forward to the Future of Heparin: New Sources, Developments and Applications that was published in Molecules

Keywords

thrombin inhibition --- LMWH --- antithrombin --- heparin oligosaccharides --- ternary complex --- heparin --- hepcidin --- iron homeostasis --- anemia --- heparin-induced thrombocytopenia --- diagnosis --- functional assay --- platelets --- heparin --- heparan sulphate --- TGF-? --- bone morphogenetic protein (BMP) --- growth and differentiation factor (GDF) --- GDNF --- BMP antagonists --- noggin --- sclerostin --- gremlin --- heparin --- enoxaparin --- subarachnoid hemorrhage --- edema --- brain injury --- inflammation --- cisplatin --- low molecular weight heparin (LMWH) --- ovarian cancer --- resistance --- heparin --- glycosaminoglycans --- chondroitin sulfate --- perylene diimide dyes --- dermatan sulfate --- fluorescent probe --- Heparin Red --- assay --- dermatan sulfate --- human plasma --- heparin --- alginate --- sulfated alginate --- biomaterials --- heparin --- heparan sulfate --- serglycin --- proteoglycan --- recombinant expression --- bioreactor --- theranostics --- solid lipid nanoparticles --- iron oxide nanoparticles --- heparin coating --- intestinal lymphatic absorption --- heparin --- heparin process --- manufacturing methods --- industrial --- super paramagnetic iron oxide nanoparticles (SPION) --- hyaluronic acid (HA) --- bovine serum albumin (BSA) --- Fe3O4·DA-BSA/HA --- paclitaxel (PTX) --- magnetic resonance imaging (MRI) --- low-molecular-weight heparin --- dalteparin --- NMR --- LC-MS --- affinity chromatography --- danaparoid sodium --- low molecular weight glycosaminoglycans --- orthogonal multi-analytical methods --- sequence and compositional investigations --- component quantitative analysis --- heparin --- crude heparin --- NMR --- quantitative NMR --- PCA --- chemometric --- HSQC --- bovine heparin --- porcine heparin --- molecular weight --- size exclusion chromatography --- pharmacopeia --- Fondaparinux sodium --- extended physicochemical characterization --- qNMR --- single crystal X-ray structure --- reference standard --- iduronic acid conformation --- Arixtra® --- n/a --- n/a --- n/a

Family Iridoviridae Molecular and Ecological Studies of a Family Infecting Invertebrates and Ectothermic Vertebrates

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ISBN: 9783039215164 / 9783039215171 Year: Pages: 234 DOI: 10.3390/books978-3-03921-517-1 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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Abstract

Ranaviruses and other viruses within the family Iridoviridae, infect a wide range of ecologically and commercially important ectothermic vertebrates, i.e., bony fish, amphibians, and reptiles, and invertebrates, including agricultural and medical pests and cultured shrimp and crayfish, and are responsible for considerable morbidity and mortality. Understanding the impact of these various agents on diverse host species requires the combined efforts of ecologists, veterinarians, pathologists, comparative immunologists and molecular virologists. Unfortunately, investigators involved in these studies often work in discipline-specific silos that preclude interaction with others whose insights and approaches are required to comprehensively address problems related to ranavirus/iridovirus disease. Our intent here is to breakdown these silos and provide a forum where diverse researchers with a common interest in ranavirus/iridovirus biology can profitably interact. As a colleague once quipped, “Three people make a genius.” We are hoping to do something along those lines by presenting a collection of research articles dealing with issues of anti-viral immunity, identification of a potentially novel viral genus exemplified by erythrocytic necrosis virus, viral inhibition of innate immunity, identification of novel hosts for lymphocystivirus and invertebrate iridoviruses, and modelling studies of ranavirus transmission. Collectively these and others will exemplify the breadth of ongoing studies focused on this virus family.

Keywords

amphibians --- histopathology --- immunohistochemistry --- Mexico --- outbreak --- ranavirus --- risk assessment --- Iridoviridae --- frog virus 3 --- FV3 --- ranavirus --- immunofluorescence --- intracellular localization --- iridovirus --- ranavirus --- epidemiology --- antibody --- ELISA --- virus isolation --- prevalence --- native-fish conservation --- biosecurity --- endemic disease --- Unconventional T cell --- nonclassical MHC --- antiviral immunity --- interferon --- DIV1 --- SHIV --- CQIV --- Macrobrachium rosenbergii --- Macrobrachium nipponense --- Procambarus clarkii --- white head --- susceptible species --- viral load --- erythrocytic necrosis virus (ENV) --- viral erythrocytic necrosis (VEN) --- Pacific salmon --- Pacific herring --- British Columbia --- SHIV --- DIV1 --- Decapodiridovirus --- Exopalaemon carinicauda --- susceptibility --- host --- ISDL --- amphibian --- Ranavirus --- frog virus 3 --- mathematical models --- Bayesian inference --- viral immune evasion --- immunomodulators --- NF-?B --- Imd --- DNA virus --- host-pathogen interactions --- IIV-6 --- Rana grylio virus (RGV) --- iridovirus core proteins --- protein interaction --- aquatic animals --- cross-species transmission --- yeast two-hybrid (Y2H) --- co-immunoprecipitation (Co-IP) --- megalocytivirus --- iridovirus --- European chub --- Lymphocystis disease virus --- Artemia spp. --- viral infection --- Sparus aurata --- viral transmission --- eDNA --- Ranavirus --- Common frog --- Rana temporaria --- early detection --- virus surveillance --- n/a --- transmission modelling --- susceptible-infected (SI) models --- emerging infection --- ranavirosis --- Iridoviridae --- disease dynamics --- ranavirus --- virus binding --- heparan sulfate --- Andrias davidianus ranavirus --- Rana grylio virus --- envelope protein --- lizard --- bearded dragon --- Pogona vitticeps --- cricket --- Gryllus bimaculatus

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