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Current Progress and Challenges in the Development of a Hepatitis C Virus Vaccine

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889457144 Year: Pages: 128 DOI: 10.3389/978-2-88945-714-4 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2019-01-23 14:53:43
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Abstract

More than 70 million people worldwide are infected with hepatitis C virus, a major cause of liver cirrhosis, liver failure and hepatocellular carcinoma world-wide. In the last decade, this cancer has emerged as the second leading cause of cancer death and the global burden is increasing by two million new infections per year, mainly due to injection drug use. An effective vaccine will be the most effective means to contain the spread of this virus worldwide. The articles in this Research Topic describe the progress that has been made towards a preventive vaccine and the challenges that still need to be overcome to ultimately achieve this goal.

MicroRNA as Biomarkers in Cancer Diagnostics and Therapy

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ISBN: 9783039212491 9783039212507 Year: Pages: 166 DOI: 10.3390/books978-3-03921-250-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Microbiology
Added to DOAB on : 2019-08-28 11:21:27
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This Special Issue celebrates the 25th anniversary of the discovery of the first microRNA. The size of the microRNome and complexity of animal body plans and organ systems suggests a role for microRNAs in cell fate determination and differentiation. More than 2000 sequences have been proposed to represent unique microRNA genes in humans, with an increasing number of mechanistic roles identified in developmental, physiological, and pathological processes. Thus, dysregulation of a few key microRNAs can have a profound global effect on the gene expression and molecular programs of a cell. This great potential for clinical intervention has captured the interest and imagination of researchers in many fields. However, very few fields have been as prolific as the field of cancer research. This Special Issue provides but a glimpse of the large body of literature of microRNA biology in cancer research, containing 4 original research studies and 4 review articles that focus on specific hematologic or solid tumors in disease. Collectively, these articles highlight state-of-the-art approaches and methodologies for microRNA detection in tissue, blood, and other body fluids in a range of biomarkers applications, from early cancer detection to prognosis and treatment response. The articles also address some of the challenges regarding clinical implementation.

Virus Bioinformatics

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ISBN: 9783039218820 9783039218837 Year: Pages: 330 DOI: 10.3390/books978-3-03921-883-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2020-04-07 23:07:08
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Virus bioinformatics is evolving and succeeding as an area of research in its own right, representing the interface of virology and computer science. Bioinformatic approaches to investigate viral infections and outbreaks have become central to virology research, and have been successfully used to detect, control, and treat infections of humans and animals. As part of the Third Annual Meeting of the European Virus Bioinformatics Center (EVBC), we have published this Special Issue on Virus Bioinformatics.

Keywords

bioinformatics --- virus --- comparative genomics --- software --- Base-By-Base --- BBB --- poxvirus --- ASFV --- MSA --- foot-and-mouth disease virus (FMDV) --- bovine soft palate --- nasopharynx --- transcriptomics --- proteomics --- bioinformatics --- virus-host interaction --- innate immune system --- interferon-stimulated genes (ISG) --- cellular immunity --- codon frequency distribution --- HPV58 --- minor capsid protein --- TLR agonist --- prophylaxis --- virus --- infection --- fluorescent reporter protein --- image quantification --- Hepatitis C virus --- Yellow Fever Virus --- polyomavirus --- Coxsackievirus B4 --- bivalve --- virome --- RNA-seq --- RNA viruses --- sncRNA --- ADAR --- RNAi --- Marek’s disease virus (MDV) --- RNA-seq --- transcriptome --- splicing --- polycistronic viral transcripts --- primary B cells --- RB1B --- CVI988/Rispens --- ICP0 --- DNA replication --- ori --- mitochondria --- Rickettsia --- gram-positive bacteria --- APMV --- Mimivirus --- giant virus --- eukaryogenesis --- flavivirus --- non-coding RNA --- secondary structure --- endogenous viral elements --- bioinformatics --- horizontal gene transfer --- virus-to-host gene transfer --- HMM --- tobacco mosaic virus --- Drosophila --- capsid protein --- deep sequencing --- virus genomics --- hepatitis C virus --- variant calling --- sequence interpretation --- drug resistance --- bioinformatics --- alignment --- assembly --- taxonomic classification --- time series --- data transformation --- DWT --- DFT --- PAA --- data compression --- compressive genomics --- RNAseq --- honey bees --- deformed wing virus --- quasispecies --- apiary pests --- recombination --- mRNA structure --- structure database --- secondary structure --- viral mRNA --- subVOG --- structurally related --- RNA structure --- structurally homogenous --- structurally related --- mRNA families --- Amebae viruses --- viral evolution --- protein domains --- mimivirus --- dsdna viruses --- translation machinery --- pandoravirus --- NCLDV --- virology --- virus bioinformatics --- software --- systems virology --- metagenomics --- virome --- viral taxonomy --- virus classification --- genome evolution --- bacteriophage --- virosphere --- chemical organization theory --- influenza A --- virus dynamics modeling --- complex networks analysis --- viral metagenome --- groundwater --- aquifer --- AquaDiva --- sequencing library preparation --- virus proteomics --- mass spectrometry --- virus diagnostics --- data analysis --- targeted proteomics --- peptide selection --- parallel reaction monitoring

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