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Seaweeds Secondary Metabolites: Successes in and/or Probable Therapeutic Applications

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ISBN: 9783039283002 9783039283019 Year: Pages: 320 DOI: 10.3390/books978-3-03928-301-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2020-04-07 23:07:08
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Abstract

Seaweeds are recognized as highly nutritious, and their use in gastronomy is increasing. Their health benefits and their potential to prevent several diseases have also been established. In this Special Issue several health effects are discussed, with more emphasis on their antitumor activity and potential use to treat Alzheimer’s disease. The key bioactive metabolites, from which phlorotannins can be highlighted, are presented, as well as some important in vivo studies. Altogether, the chapters provide in-depth information about the biological activities of seaweed metabolites, contributing to elucidate the health effects of seaweed.

Keywords

Padina pavonica --- osteosarcoma --- apoptosis --- algae --- chemo-preventive agent --- phytol --- fucosterol --- fatty acid --- laurinterol --- Laurencia --- antitumoral --- breast cancer explants --- organotypic culture --- ex vivo --- phlorotannin --- eckmaxol --- high-speed counter-current chromatography --- NMR spectroscopy --- mass spectrometry --- isolation and purification --- Ecklonia maxima --- fucoidan --- age-related macular degeneration --- VEGF --- oxidative stress --- Saccharina latissima --- Fucus vesiculosus --- Fucus distichus subsp. evanescens --- Fucus serratus --- Laminaria digitata --- Symphyocladia latiuscula --- bromophenols --- mushroom tyrosinase --- B16F10 --- melanin --- red seaweed --- bioactives --- extraction --- biorefinery --- seaweed --- gut microbiota --- prebiotics --- dietary fibre --- complex polysaccharides --- polyphenols --- polyunsaturated fatty acids --- carotenoids --- phytochemicals --- Padina pavonica --- marine algae --- osteoporosis --- bone metabolism --- bone health --- nutraceutical --- Bifurcaria bifurcata --- linear diterpenes --- extraction --- identification --- biological activities --- macroalgae --- high value applications --- phlorotannin --- amyloid-? aggregation --- insulin glycation --- dynamic simulation --- kidney --- ischemia-reperfusion injury --- Ecklonia cava --- phlorotannins --- Alzheimer’s disease --- seaweeds --- cholinesterases --- beta-secretase --- beta-amyloid aggregation --- neuroprotection --- K14HPV16 --- genotoxicity assay --- papillomavirus --- cancer --- seaweeds --- hyperpigmentation --- skin aging --- skincare --- photo-protection --- seaweeds --- secondary metabolites --- in vivo studies --- clinical trials --- health effects --- dieckol --- eckol --- fucoxanthin --- kahalalide F

Transmucosal Absorption Enhancers in the Drug Delivery Field

Authors: --- ---
ISBN: 9783039218486 9783039218493 Year: Pages: 406 DOI: 10.3390/books978-3-03921-849-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2020-01-30 16:39:46
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Abstract

Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.

Keywords

absorption enhancers --- sugar-based surfactants --- biocompatibility studies --- transmucosal drug delivery --- intestinal permeation enhancers --- sodium cholate (NaC) --- N-dodecyl-?-D-maltoside (DDM) --- small intestine --- enterocyte --- brush border --- tryptophan --- oral delivery --- insulin --- GLP-1 --- intestinal absorption --- amino acid --- cell-penetrating peptide --- combined microsphere --- chitosan --- cyclodextrin --- nasal delivery --- nose to brain transport --- penetration enhancer --- nasal formulation --- in vivo studies --- nose to brain delivery --- antiepileptic drug --- drug delivery --- block copolymers --- thermogel system --- chitosan derivatives --- amphiphilic polymers --- polymeric micelles --- quaternization --- curcumin --- intestinal delivery --- mucoadhesiveness --- cervicovaginal tumors --- cationic functionalization --- imatinib --- nanocrystals --- in situ hydrogel --- bioenhancer --- cytochrome P450 --- drug absorption enhancer --- efflux --- metabolism --- P-glycoprotein --- pharmacokinetic interaction --- tight junction --- Aloe vera --- gel --- whole leaf --- absorption enhancement --- Caco-2 --- confocal laser scanning microscopy --- F-actin --- FITC-dextran --- tight junctions --- transepithelial electrical resistance --- permeation enhancer --- oral delivery --- formulation --- permeability --- safety --- simulated intestinal fluid --- hydrophobization --- epithelium --- compound 48/80 --- chitosan --- nanoparticles --- mast cell activator --- vaccine adjuvant --- nasal vaccination --- absorption enhancer --- antimicrobial peptide --- Caco-2 --- claudin --- cell-penetrating peptide (CPP) --- drug delivery --- intestinal epithelial cells --- KLAL --- PN159 --- tight junction modulator --- oral macromolecule delivery --- oral peptides --- sodium caprate --- salcaprozate sodium --- epithelial permeability --- epithelial transport --- nasal permeability --- nose-to-brain --- simvastatin --- nanocapsules --- mucoadhesion --- CNS disorders --- chitosan --- nasal --- pulmonary --- drug administration --- absorption enhancers --- nanoparticle --- and liposome --- absorption enhancer --- gemini surfactant --- intestinal absorption --- poorly absorbed drug --- Caco-2 cells --- PTH 1-34 --- teriparatide --- nasal delivery --- pharmacokinetics --- osteoporosis --- man --- sheep --- clinical trial --- preclinical --- Caco-2 --- intestinal absorption --- nanomedicine --- nanoparticle --- oral delivery --- transferrin --- ocular drug delivery --- cornea --- penetration enhancers --- ocular conditions --- ophthalmology --- permeation enhancers --- absorption modifying excipients --- oral delivery --- nasal delivery --- ocular delivery --- vaginal delivery --- transmucosal permeation

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MDPI - Multidisciplinary Digital Publishing Institute (2)


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CC by-nc-nd (2)


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english (2)


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2020 (2)