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Maîtrise des maladies infectieuses

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ISBN: 286883888X Year: Language: French
Publisher: EDP SCIENCES
Subject: Internal medicine
Added to DOAB on : 2014-07-31 11:10:22
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Contrairement à ce que l'on pourrait penser, les maladies infectieuses ne sont pas en voie de disparition, bien au contraire. Apprendre à mieux gérer ce fléau apparaît essentiel à une meilleure gestion des cas.Au cours d'une première partie, l'ouvrage présente la situation actuelle:- l'épidémiologie et la santé publique- les maladies infectieuses en médecine humaine et vétérinaire (passage des barrières d'espèces)- concepts d'émergence et de réémergence- pourquoi il y aura toujours des maladies infectieuses- dynamiques et limites des stratégies de prévention- perception et gestion du risque- succès et échecs dans le contrôle d'une épidémie- l'homme en cause.Une deuxième partie donnera des éléments de réponse au défi:- la recherche fondamentale- l'enseignement.

Why vaccines to HIV, HCV and Malaria have so far failed - Challenges to developing vaccines against immunoregulating pathogens

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199662 Year: Pages: 157 DOI: 10.3389/978-2-88919-966-2 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Microbiology --- Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2016-01-19 14:05:46
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Despite continuous progress in the development of anti-viral and anti-bacterial/parasite drugs, the high cost of medicines and the potential for re-infection, especially in high risk groups, suggest that protective vaccines to some of the most dangerous persistent infections are still highly desirable. There are no vaccines available for HIV, HCV and Malaria, and all attempts to make a broadly effective vaccine have failed so far. In this Research Topic we look into why vaccines have failed over the years, and what we have learn from these attempts. Rather than only showing positive results, this issue aims to reflect on failed efforts in vaccine development. Coming to understand our limitations will have theoretical and practical implications for the future development of vaccines to these major global disease burdens.

Keywords

Vaccine --- Infectious Disease --- HIV --- HCV --- Malaria --- influenza --- immunology --- Genetics

Biological Engagement Programs: Reducing Threats and Strengthening Global Health Security Through Scientific Collaboration

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452736 Year: Pages: 199 DOI: 10.3389/978-2-88945-273-6 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Public Health --- Science (General) --- Microbiology
Added to DOAB on : 2018-02-27 16:16:44
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Biological engagement programs are a set of projects or activities between partner countries that strengthen global health security to achieve mutually beneficial outcomes. Engagement programs are an effective way to work collaboratively towards a common threat reduction goal, usually with a strong focus on strengthening health systems and making the world a safer place. Cooperative programs are built upon trust and sharing of information and resources to increase the capacity and capabilities of partner countries. Biological engagement programs reduce the threat of infectious disease with a focus on pathogens of security concern, such as those pathogens identified by the U.S. Government as Biological Select Agent and Toxins. These programs seek to develop technical or scientific relationships between countries to combat infectious diseases both in humans and animals. Through laboratory biorisk management, diagnostics, pathogen detection, biosurveillance and countermeasure development for infectious diseases, deep relationships are fostered between countries. Biological engagement programs are designed to address dual-use issues in pathogen research by promoting responsible science methodologies and cultures. Scientific collaboration is a core mechanism for engagement programs are designed to strengthen global health security, including prevention of avoidable epidemics; detection of threats as early as possible; and rapid and effective outbreak response. This Research Topic discusses Biological Engagement Programs, highlighting the successes and challenges of these cooperative programs. Articles in this topic outlined established engagement programs as well as described what has been learned from historical cooperative engagement programs not focused on infectious diseases. Articles in this topic highlighted selected research, trainings, and programs in Biological Engagement Programs from around the world. This Topic eBook first delves into Policies and Lessons Learned; then describes Initiatives in Biosafety & Biosecurity; the core of this work documents Cooperative Research Results from the field; then lastly the Topic lays out potential Future Directions to the continued success of the World’s cooperative science in reducing the threat of infectious diseases.

Rabies Symptoms, Diagnosis, Prophylaxis and Treatment

Authors: ---
ISBN: 9783038426820 9783038426837 Year: Pages: 314 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2018-02-26 15:43:30
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Rabies is an acute, progressive, incurable viral encephalitis and one of the oldest described infectious diseases. All mammals are susceptible to infection, but rabid dogs are responsible for the greatest global burden. Bats and carnivores are the major wildlife reservoirs. More than 60,000 persons, primarily children, succumb each year after the bite from a rabid animal. This compilation describes new information on disease surveillance, diagnosis, prevention and control within Africa, Eurasia and the New World. Public health professionals, veterinarians, physicians, laboratory workers and conservation biologists should appreciate the novel communications provided from internationally renowned authors and the diversity of topics in this special issue on rabies.

Climate Information for Public Health Action

Authors: ---
Book Series: Routledge Studies in Environment and Health ISBN: 9781315115603 9781138069640 9781138069633 Year: Pages: 244 Language: English
Publisher: Taylor & Francis
Subject: Environmental Sciences --- Public Health
Added to DOAB on : 2019-01-15 13:34:22

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Policy-makers are increasingly concerned about the impact of climate variability and change on the health of vulnerable populations. Variations and trends in climatic factors and extreme weather events impact many health outcomes, including malaria, heat stress and undernutrition.   Climate Information for Public Health Action is based on the premise that climate knowledge and information can help protect the public from climate-sensitive health risks. With a focus on infectious disease, hydro-meteorological disasters and nutrition, the book explores why, when and how data on the historical, current and future (from days to decades) climate can be incorporated into health decision-making. Created as a collaborative effort between climate and health experts, this book targets a broad technical public health community, alongside development practitioners and policy-makers engaged in climate change adaptation. It may also guide climate experts in the development of climate services tailored to health needs. Written in an accessible, informative style, while maintaining the highest technical and scientific standards, it will also be a valuable resource for students and academics studying and working in the emerging field of environment and health.

Microbial Modulation of Host Apoptosis and Pyroptosis

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889192809 Year: Pages: 109 DOI: 10.3389/978-2-88919-280-9 Language: English
Publisher: Frontiers Media SA
Subject: Internal medicine --- Science (General)
Added to DOAB on : 2015-12-10 11:59:06
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Infectious disease is the result of an interactive relationship between a microbial pathogen and its host. In this interaction both the host and the pathogen attempt to manipulate each other using a complex network to maximize their respective survival probabilities. Programmed host cell death is a direct outcome of host-pathogen interaction and may benefit host or pathogen depending on microbial pathogenesis. Apoptosis and pyroptosis are two common programmed cell death types induced by various microbial infections. Apoptosis is non-inflammatory programmed cell death and can be triggered through intrinsic or extrinsic pathways and with or without the contribution of mitochondria. Pyroptosis is an inflammatory cell death and is typically triggered by caspase-1 after its activation by various inflammasomes. However, some non-canonical caspase-1-independent proinflammatory cell death phenomena have been reported. Microbial pathogens are able to modulate host apoptosis and pyroptosis through different triggers and pathways. The promotion and inhibition of host apoptosis and pyroptosis vary and depend on the microbe types, virulence, and phenotypes. For example, virulent pathogens and attenuated vaccine strains may use different pathways to modulate host cell death. Specific microbial genes may be responsible for the modulation of host cell death. Different host cells, including macrophages, dendritic cells, and T cells, can undergo apoptosis and pyroptosis after microbial infections. The pathways of host apoptosis and pyroptosis induced by different microbes may also differ. Different methods can be used to study the interaction between microbes and host cell death system. The articles included in this E-book report the cutting edge findings in the areas of microbial modulation of host apoptosis, pyroptosis and inflammasome.

Chemical Biology of Sterols, Triterpenoids and Other Natural Products: A Themed Issue in Honor of Professor W. David Nes on the Occasion of His 65th Birthday

Authors: ---
ISBN: 9783038974161 9783038974178 Year: Pages: 256 DOI: 10.3390/books978-3-03897-417-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2019-06-26 08:44:06
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Sterols and other isoprenoids are of great interest for their molecular structure and function in cell architecture and evolution, as well as for their importance in medicine and agriculture. Molecules’ 2019 Festschrift Special Issue in honor of the 65th birthday of Prof. W. David Nes, an internationally recognized chemical biologist and recipient of the George Schroepher medal for sterol research, focuses on recent developments in the chemistry, biosynthesis, and function of these polycyclic natural products. This volume of Molecules contains 16 leading-edge review articles and original research contributions from an international cast of scientists. This volume is grouped into three sections: (i) isoprenoid metabolome and diversity, (ii) clinical evaluation of sterol and triterpene structures and biosynthesis, and (iii) methods and synthesis of steroids and other compounds. The volume will be a valuable reference tool for those who study medicinal chemistry, protein chemistry, and biochemistry of isoprenoid lipids.

Keywords

Zingiber officinale --- gingerols --- cytotoxic activity --- oleanolic acid --- high-fat high-carbohydrate diet --- pre-diabetes --- glucose homeostasis --- insulin resistance --- atherosclerosis --- ROS --- HUVECs --- LOX-1 --- alkaloid --- granatane --- N-methylcadaverine --- N-methylpiperidine. reductive deamination --- Mucorales --- Rhizopus arrhizus --- sterol pattern --- antifungal effectivity --- gas chromatography-mass spectrometry (GC-MS) --- posaconazole --- sterol biosynthesis --- sterol 14?-demethylase --- sterol C24-methyltransferase --- mechanism-based inactivators --- antifungals --- azoles --- antiparasitic drugs --- human African trypanosomiasis --- Chagas disease --- synthesis --- squalene cyclase --- cycloartenol synthase --- triterpene --- fern --- Polystichum --- terpene --- isoprenoid --- divalent metal co-factor ligation --- antioxidant --- cholesterol --- degeneration --- oxysterol --- retina --- Smith-Lemli-Opitz syndrome --- algal sterols --- ergosterol biosynthesis --- infectious disease --- lipidomics --- oxyphytosterol --- pharmacognosy --- phytosterol --- sterolomics --- lupeol --- keratinocytes --- fibroblasts --- wound healing --- cell migration --- UV-radiation --- ZnO --- toxicity --- sterol content --- cholesterol --- leishmania --- solanaceae --- withanolides --- aurelianolides --- phytosterols --- mesocarp --- oilseed --- maturity --- pod-blast --- ?-tocopherol --- oil bodies --- campesterol --- stigmasterol --- ?-sitosterol --- sterol --- C4-demethylation complex (C4DMC) --- 4-methylsterol --- hormone --- steroid --- development --- genetic disease --- bile alcohol --- cholestanoic acid --- oxysterol --- sterolomics --- enzyme-assisted derivatization --- electrospray ionization-mass spectrometry --- Girard reagent --- n/a

Hurdles for Phage Therapy (PT) to Become a Reality

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ISBN: 9783039213917 9783039213924 Year: Pages: 484 DOI: 10.3390/books978-3-03921-392-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Microbiology
Added to DOAB on : 2019-12-09 11:49:15
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Alternative treatment modes for antibiotic-resistant bacterial pathogens have become a public health priority. Bacteriophages are bacterial viruses that infect and lyse bacterial cells. Since bacteriophages are frequently bacterial host species-specific and can often also infect antibiotic-resistant bacterial cells, they could represent ideal antimicrobials for fighting the antibiotic resistance crisis. The medical use of bacteriophages has become known as phage therapy. It is widely used in Russia, where phage cocktails are sold in pharmacies as an over-the-counter drug. However, no phage product has been registered for medical purposes outside of the former Soviet Union. The current Special Issue of Viruses contains a collection of papers from opinion leaders in the field who explore hurdles to the introduction of phage therapy in western countries. The articles cover diverse topics ranging from patent to regulatory issues, the targeting of suitable bacterial infections, and the selection and characterization of safe and efficient phage cocktails. Phage resistance is discussed, and gaps in our knowledge of phage–bacterium interactions in the mammalian body are revealed, while other articles explore the use of phages in food production and processing.

Keywords

Staphylococcus aureus --- bacteriophage --- phage therapy --- vB_SauM-fRuSau02 --- Twortlikevirus --- antibiotic --- antimicrobial resistance --- magistral preparation --- compounding pharmacy --- phage therapy --- regulatory framework --- personalized medicine --- bacteriophage --- phage --- horizontal gene transfer --- co-evolution --- phage therapy --- industrial phage application --- antimicrobial resistance (AMR) --- Germany --- pH stability --- phage-host interactions --- genomics --- antibiotic-resistance --- phage preparation --- lysins --- biofilms --- typhoid fever --- Salmonella Typhi --- extended-spectrum beta lactamases (ESBL) --- Democratic Republic of the Congo --- bacteriophages --- MALDI-MS --- Staphylococcus --- bacteriophages --- phage therapy --- Kayvirus --- Viral proteins --- bacteriophage --- therapy --- phage therapy --- bacterial disease --- infection --- target selection --- Bacteriophage --- phage therapy --- resistance --- adaptation --- prophage --- production --- regulation --- phage therapy --- viral genomes --- best practices --- IND --- high-throughput sequencing --- bacteriophages --- phages --- food safety --- foodborne illness --- phage therapy --- history of science --- science communication --- bacteriophage --- phage therapy --- sustainable agriculture --- zoonosis --- antibiotic resistance --- phage therapy --- experimental therapy --- phage cocktails --- anti-phage antibodies --- prophage --- immunomodulation --- phage therapy --- evolution --- bacterial resistance --- virulence --- Listeria ivanovii --- bacteriophages --- alginate --- production --- disinfection --- phagodisinfection --- virus–host interactions --- bacteriophage efficacy --- gastrointestinal tract --- phage therapy --- bacteriophage --- phage therapy --- antimicrobial resistance --- antibiotic --- global health --- developing countries --- infectious disease --- bacteriophage --- phage --- phage therapy --- phage-resistance --- phage therapy --- bacterial infection --- capsule depolymerase --- antibiotic --- animal model --- bacterial resistance --- bacteriophage --- immunology --- innate immunity --- adaptive immunity --- human host --- phage-human host interaction --- bacterial infection --- antibiotic resistance --- bacteriophage --- antibiotic therapy --- phage therapy --- cases report --- abortive infection --- prophage --- adsorption --- Enterococcus --- rhamnopolysaccharide --- bacteriophage --- phage therapy --- Staphylococcus aureus --- biofilm --- antimicrobial --- frequency of resistance --- phage sensitivity --- resistance management --- nontraditional antibacterial --- bacteriophages --- phage therapy --- antibiotic resistance --- Pseudomonas aeruginosa --- Escherichia coli --- Staphylococcus aureus --- Brussels --- Belgium --- phage biocontrol --- patent landscape --- crop production --- bacteriophage --- phage therapy --- multidrug-resistant bacteria --- antimicrobial resistance --- bacteriophage therapy --- compassionate use --- antibiotic resistance --- phage therapy --- PTMP --- ATMP --- regulatory framework --- pharmaceutical paradigm shift --- clinical trial --- magistral formula --- personalized medicine --- phage therapy --- E. faecalis --- OrthoMCL --- antimicrobial resistance --- capsule --- Galleria mellonella --- Klebsiella pneumoniae --- phage therapy --- n/a --- antimicrobial resistance --- bacteriophage --- personalised medicines --- phage therapy --- pharmaceutical legislation --- regulatory framework

Refugee, Migrant and Ethnic Minority Health

Authors: --- --- ---
ISBN: 9783039216444 9783039216451 Year: Pages: 526 DOI: 10.3390/books978-3-03921-645-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Sociology
Added to DOAB on : 2019-12-09 11:49:15
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International migration, particularly to Europe, has increased in the last few decades, making research on aspects of this phenomenon, including numbers, challenges, and successes, particularly vital. This Special Issue highlights this necessary and relevant area of research. It presents 37 articles including studies on diverse topics relating to the health of refugees and migrants. Most articles (28) present studies focusing on European host countries. The focus on Europe is justified if we take into consideration the increased number of refugees and migrants who have come to Europe in recent years. However, there are also articles which present studies from countries in other continents. The topics discussed in the Issue include healthcare utilization, infectious diseases, mother and child health, mental health, and chronic diseases. Finding from the included articles indicate that further development of guidelines and policies at both local and international levels is needed. Priorities must be set by encouraging and funding in-depth research that aims to evaluate the impact of existing policies and interventions. Such research will help us formulate recommendations for the development of strategies and approaches that improve and strengthen the integration of migrants and refugees into the host countries.

Keywords

breastfeeding --- complementary feeding --- Chinese --- immigrant mothers --- infant --- obesity --- post-traumatic stress disorder (PTSD) --- pain --- pain perception --- understanding of illness --- culture --- family-oriented societies --- refugee and migrant women --- sexual and reproductive health --- training --- knowledge --- confidence --- health care professionals --- emergency care --- triage --- healthcare system strengthening --- migrant health --- North Korean refugees --- depression --- early trauma --- negative automatic thoughts --- path analysis --- ambulance --- economic recession --- emergency medical service --- Greece --- primary healthcare system --- refugee --- triage --- public health --- asylum seeker --- Electronic Health Insurance Card --- refugee --- Germany --- refugee health --- asylum seekers --- migrants --- infectious diseases --- vaccination --- Italy --- refugee and migrant (R&M) health --- refugee crisis --- healthcare --- European Union (EU) --- migrant health --- preparedness --- communicable diseases --- tuberculosis --- LTBI --- refugee --- asylum --- infection --- IGRA --- infectious diseases --- migrant --- asylum seekers --- psychiatric emergency services --- involuntary treatment --- psychiatric hospitalization --- migrants --- sexual health --- help-seeking behavior --- systematic review --- aggression --- emergency department --- workplace violence --- migrants --- failed asylum seekers --- psychiatric emergency services --- psychiatric hospitalisation --- acute stress --- multidimensional intercultural training acculturation model (MITA) --- intercultural competence --- traumatic events --- mental health --- Middle Eastern refugee adolescents --- migration --- health --- infection --- linkage --- care --- sexual and reproductive health --- adolescent --- refugee --- migrant --- young women --- knowledge --- access --- experiences --- systematic review --- Africa --- obesity --- immigration --- education --- inequalities --- health survey --- refugee --- adolescent --- risk factor --- protective factor --- HIV --- AIDS --- stigma --- refugees --- migrants --- economic crisis --- Greece --- migration --- National Health System --- refugee --- Southeast Europe --- immigrant --- healthcare --- HBV --- CHB --- screening --- vaccination --- refugees --- migrants --- pregnancy --- migration --- refugees --- health care provision --- reception center --- sexual violence --- migrants --- refugees --- asylum seekers --- applicants for international protection --- Europe --- prevalence --- hepatitis C --- screening --- migrants --- viral hepatitis elimination --- European Union --- North African --- immigration --- health care --- emergency department --- disparities --- VPD --- immunisation strategies --- health systems --- refugees --- migrants --- cost effectiveness --- healthcare --- migration --- refugee --- asylum seeker --- medical service --- migrant --- medical care --- doctor --- Europe --- Germany --- fruit --- vegetable --- immigrant --- Portuguese --- health --- refugees women --- HIV --- mental health --- stigma --- discrimination --- access to care --- disease prevention --- public health --- stigma --- refugees --- migrants --- MMR vaccination --- measles --- vaccine hesitancy --- autism --- Rinkeby --- Tensta --- immigrants --- Polish --- religiosity --- lifestyle behavior --- smoking --- alcohol consumption --- physical activity --- overweight --- obesity --- migrant populations --- schistosomiasis/schistosoma --- strongyloidiasis/strongyloides --- screening/diagnosis --- treatment --- public health --- GRADE --- refugee --- health --- migration --- chronic disease --- infectious disease --- n/a

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