Search results: Found 16

Listing 1 - 10 of 16 << page
of 2
>>
Sort by
9. Sammenhengen mellom mindfulness og eksekutiv funksjon hos profesjonelle fotballspillere (Book chapter)

Book title: Trender for idrettspsykologisk forskning i Skandinavia

Authors: --- --- --- --- et al.
ISBN: 9788202596903 9788202596903 Year: Pages: 18 DOI: 10.23865/noasp.39.ch9 Language: Norwegian
Publisher: Cappelen Damm Akademisk/NOASP (Nordic Open Access Scholarly Publishing)
Subject: Psychology
Added to DOAB on : 2018-07-28 11:01:02
License: Cappelen Damm Akademisk/NOASP (Nordic Open Access Scholarly Publishing)

Loading...
Export citation

Choose an application

Abstract

"Mindfulness has become a popular tool for athletes, but the knowledge about the&#xD;exact associations between trait mindfulness and key performance variables are lacking. This&#xD;is especially problematic for athletes competing at a higher level where minor costs of a trait or&#xD;an intervention could easily outweigh the benefits. In this study we investigated the association&#xD;between self-reported level of mindfulness and performance on two PC based tests of inhibitory&#xD;control on forty-two professional soccer players. The results showed that the observation&#xD;facet of mindfulness was associated with better performance on one of the tests, while the&#xD;non-judgement facet was associated with lower performance on both tests due to more impulsive&#xD;responding. These findings suggest that trait mindfulness and inhibitory control is related,&#xD;but that the relationship may not only be beneficial."&#xD;

Inhibitory Function in Auditory Processing

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196678 Year: Pages: 231 DOI: 10.3389/978-2-88919-667-8 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2016-08-16 10:34:25
License:

Loading...
Export citation

Choose an application

Abstract

There seems little doubt that from the earliest evolutionary beginnings, inhibition has been a fundamental feature of neuronal circuits - even the simplest life forms sense and interact with their environment, orienting or approaching positive stimuli while avoiding aversive stimuli. This requires internal signals that both drive and suppress behavior. Traditional descriptions of inhibition sometimes limit its role to the suppression of action potential generation. This view fails to capture the vast breadth of inhibitory function now known to exist in neural circuits. A modern perspective on inhibitory signaling comprises a multitude of mechanisms. For example, inhibition can act via a shunting mechanism to speed the membrane time constant and reduce synaptic integration time. It can act via G-protein coupled receptors to initiate second messenger cascades that influence synaptic strength. Inhibition contributes to rhythm generation and can even activate ion channels that mediate inward currents to drive action potential generation. Inhibition also appears to play a role in shaping the properties of neural circuitry over longer time scales. Experience-dependent synaptic plasticity in developing and mature neural circuits underlies behavioral memory and has been intensively studied over the past decade. At excitatory synapses, adjustments of synaptic efficacy are regulated predominantly by changes in the number and function of postsynaptic glutamate receptors. There is, however, increasing evidence for inhibitory modulation of target neuron excitability playing key roles in experience-dependent plasticity. One reason for our limited knowledge about plasticity at inhibitory synapses is that in most circuits, neurons receive convergent inputs from disparate sources. This problem can be overcome by investigating inhibitory circuits in a system with well-defined inhibitory nuclei and projections, each with a known computational function. Compared to other sensory systems, the auditory system has evolved a large number of subthalamic nuclei each devoted to processing distinct features of sound stimuli. This information once extracted is then re-assembled to form the percept the acoustic world around us. The well-understood function of many of these auditory nuclei has enhanced our understanding of inhibition's role in shaping their responses from easily distinguished inhibitory inputs. In particular, neurons devoted to processing the location of sound sources receive a complement of discrete inputs for which in vivo activity and function are well understood. Investigation of these areas has led to significant advances in understanding the development, physiology, and mechanistic underpinnings of inhibition that apply broadly to neuroscience. In this series of papers, we provide an authoritative resource for those interested in exploring the variety of inhibitory circuits and their function in auditory processing. We present original research and focused reviews touching on development, plasticity, anatomy, and evolution of inhibitory circuitry. We hope our readers will find these papers valuable and inspirational to their own research endeavors.

Regulation of Chemokine- Receptor Interactions and Functions

Author:
ISBN: 9783038427285 9783038427278 Year: Pages: 228 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biochemistry
Added to DOAB on : 2018-03-26 15:44:06
License:

Loading...
Export citation

Choose an application

Abstract

A hallmark of inflammation is the accumulation of leukocytes, which can serve to remove pathogens and necrotic tissue, but may also damage healthy tissue and exacerbate the inflammatory response. Our understanding of leukocyte recruitment in inflammation was revolutionized in the late 1980s by the discovery of chemokines (chemotactic cytokines), a family of small, secreted proteins that induce migration of selective subsets of leukocytes. Shortly afterwards, chemokines were found to exert their functions through the now familiar chemokine receptors, members of the G protein-coupled receptor superfamily. As their physiological and pathological functions were elucidated, chemokine receptors have become popular targets for drug development in inflammatory diseases as well as cancer metastasis and HIV infection. Extensive research has revealed that the functions of chemokines and their receptors are regulated at numerous levels, including: genetic mutations/polymorphisms; control of expression levels; ligand internalization via functional or decoy receptors; intrinsic selectivity of chemokine-receptor binding; hetero- or homo-oligomerization of chemokines or of receptors; alternative signalling pathways; interaction of chemokines with glycosaminoglycans; post-translational modifications; and binding to pathogen-derived inhibitors. This Special Issue of IJMS focused on the natural and pharmacological mechanisms by which the activities of chemokines and their receptors can be regulated.

Hidden Transfers of Assets and Hidden Payouts of Profit

Author:
ISBN: 9789616842709 Year: Volume: 1 Pages: 257 DOI: 10.4335/978-961-6842-70-9 Language: Slovenian
Publisher: Institute for Local Self-Government and Public Procurement Maribor
Subject: Political Science
Added to DOAB on : 2016-09-28 16:45:30
License:

Loading...
Export citation

Choose an application

Abstract

The concept of "hidden payout of profit” is characteristic for tax law, but inappropriate for corporate law, although it became deep-rooted in this field by practice. Within the context of corporate law it is not only about the problem of profit payouts, but also about the protection of the so-called tied up assets of a capital company within the so-called principle of capital preservation. The purpose of the corporate legislation is to prevent inadmissible interferences of shareholders or associates in the company's assets. Unlike corporate law, the purpose of tax law is to protect (fiscal) interests of the state, primarily to protect the tax base of the company as an independent and only subject to taxation, therefore the payouts of profit don’t have an effect on the amount of the tax base, irrespective of whether the company pays out the profit in an open or hidden way. Hidden payouts of profit - as the open ones - do not reduce the tax base for income. The subject of the discussion are both aspects - the corporate aspect of hidden transfers of assets and the tax aspects of hidden transfers of assets within the law of joint-stock companies and limited liability companies.

La pluralité interprétative

Author:
ISSN: 9782722601109 ISBN: 9782722601109 9782722601321 Year: Language: French
Publisher: Collège de France
Added to DOAB on : 2014-02-27 14:16:29
License: OpenEdition licence for Books

Loading...
Export citation

Choose an application

Abstract

L’étroitesse d’esprit, le dogmatisme, l’intolérance, le fanatisme sont, à des degrés divers, des formes d’enfermement dans un schéma mental. Pour y échapper, il faut accéder à la « pluralité interprétative » : devenir capable de « manipuler » ses propres représentations et ses idées pour adopter, au moins temporairement et en imagination, d’autres points de vue que le sien. Mais quelles sont les bases cérébrales et mentales d’une telle capacité chez l’enfant et chez l’adulte ? À travers quell...

Thermophiles and Thermozymes

Author:
ISBN: 9783038978169 9783038978176 Year: Pages: 198 DOI: 10.3390/books978-3-03897-817-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General)
Added to DOAB on : 2019-04-25 16:37:17
License:

Loading...
Export citation

Choose an application

Abstract

Interest in the study of life in hot environments, both with respect to the inhabiting microorganisms and the enzymes they produce, is currently very high. The biological mechanisms responsible for the resistance to high temperatures are not yet fully understood, whereas thermostability is a highly required feature for industrial applications. In this e-book, the invited authors provide diverse evidence contributing to the understanding of such mechanisms and the unlocking of the biotechnological potential of thermophiles and thermozymes.

Cognitive Development and Individual Variability

Authors: ---
ISBN: 9783039210527 / 9783039210534 Year: Pages: 158 DOI: 10.3390/books978-3-03921-053-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Philosophy
Added to DOAB on : 2019-08-28 11:21:27
License:

Loading...
Export citation

Choose an application

Abstract

The standard approach to cognitive development most frequently consists of cross-sectional studies comparing different ages and groups while restricted to a single task. The necessity to focus on the individual in an idiographic perspective, rather than on the task or the variable, has been repeatedly emphasized, most recently in several very important papers by Nesselroade and Molenaar. Variability has also emerged as a crucial characteristic. Moreover, understanding the developmental construction of a given cognitive achievement is imperative to understanding cognitive functioning in adulthood. The general objective of this book is to focus on the individual by studying intraindividual and interindividual variability in various cognitive tasks, that is, intraindividual variability across items of a given task (inconsistency), across various cognitive tasks (dispersion), and/or across years (intraindividual change), and of course, on interindividual differences in intraindividual variability. This book presents empirical studies that have been conducted by research groups in Europe and in North America, prominent in the field of variability and development or methodology. The 26 authors/co-authors include senior authors such as Lautrey, Schmiedek, Dauvier, van der Maas, Ghisletta, Stawski, MacDonald, and de Ribaupierre.

Development and Application of Herbal Medicine from Marine Origin

Authors: --- ---
ISBN: 9783039212217 / 9783039212224 Year: Pages: 140 DOI: 10.3390/books978-3-03921-222-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2019-08-28 11:21:27
License:

Loading...
Export citation

Choose an application

Abstract

Marine herbal medicine generally refers to the use of marine plants as original materials to develop crude drugs, or for other medical purposes. The term ‘marine plants’ usually denotes macroalgae grown between intertidal and subintertidal zones, including Chlorophyta, Phaeophyta, and Rhodophyta. Considerable progress has been made in the field of biomedical research into marine microalgae and microorganisms in the past decade. As the most important source of fundamental products in the world, marine plants have a very important role in biomedical research. Furthermore, worldwide studies have consistently demonstrated that many crude drugs derived from marine plants contain novel ingredients that may benefit health or can be used in the treatment of diseases; some have been developed into health foods, and some even into drugs. It is expected that there are many substances of marine plant origin that will have medical applications in terms of improving human health and are awaiting discovery.In this Special Issue, entitled “Development and Application of Herbal Medicine of Marine Origin”, we will provide a platform for researchers to publish biomedical studies on substances of marine plant origin. We welcome submissions from scientists and academics from across the world.

Special Issue Dedicated to Late Professor Takuo Okuda. Tannins and Related Polyphenols Revisited: Chemistry, Biochemistry and Biological Activities

Authors: --- ---
ISBN: 9783038978343 / 9783038978350 Year: Pages: 316 DOI: 10.3390/books978-3-03897-835-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2019-06-26 10:09:00
License:

Loading...
Export citation

Choose an application

Abstract

Antioxidative polyphenols represented by tannins and flavonoids are rich in numerous food sources and traditional natural medicines and currently attracting increased attention in health care and food industries because of their multiple biological activities that are favorable to human health. Commemorating the outstanding achievements on tannins by Dr. Takuo Okuda on the occasion of his passing away in December 2016, his colleagues, friends, and worldwide experts of polyphenol research have contributed 18 papers on their recent study to the Special Issue of Molecules. This book is its reprinted form. This covers reviews of structural features, historical usages, and biological activities of unique class of ellagitannins and condensed tannins, and original articles on the most up-to-date findings on the anticancer effect of green tea catechins, the antivirus effect of tannins comparing with the clinically used drugs, the analytical method of ellagitannins using quantitative NMR, the chemical structures of Hydrangea-blue complex (pigment) and condensed tannins in Ephedra sinica and purple prairie clover, and the relationship of condensed tannins in legumes and grape-marc with methane production in the in vitro ruminant system, and others. This book will be useful to natural product chemists and also to researchers in pharmaceutical and/or food industry.

Keywords

Dittrichia viscosa --- antifungal activities --- Candida spp. --- Malassezia spp. --- Microsporum canis --- Aspergillus fumigates --- Ephedra sinica --- proanthocyanidin --- oligomer --- thiolysis --- phloroglucinolysis --- TDDFT --- ECD --- neuraminidase --- inhibition --- tannins --- oseltamivir carboxylate --- zanamivir --- crystal structure --- molecular interactions --- oenothein B --- ellagitannin --- macrocyclic oligomer --- Onagraceae --- Myrtaceae --- Lythraceae --- antioxidants --- antitumor effect --- immunomodulatory effect --- anti-inflammation --- tannin composition --- purple prairie clover --- conservation method --- protein precipitation --- Escherichia coli --- Cynanchum wilfordii --- phenolic glycoside --- 2-O-?-laminaribiosyl-4-hydroxyacetophenone --- cynandione A --- thin layer chromatography --- Cynanchum auriculatum --- Acacia mearnsii bark --- wattle tannin --- proanthocyanidins --- biological activities --- tannins --- vegetable tanning --- European historic leathers --- colorimetric tests --- spectroscopy --- UV-Vis --- FTIR --- triple-negative breast cancer --- fatty acid synthase --- FASN inhibition --- polyphenolic FASN inhibitors --- (?)-epigallocatechin 3-gallate --- synthetic analogues --- apoptosis --- anticancer activity --- 1H-NMR --- quantitative NMR --- ellagitannin --- Geranium thunbergii --- geraniin --- Aluminum ion --- blue color development --- 5-O-caffeoylquinic acid --- 3-O-glucosyldelphinidin --- Hydrangea macrophylla --- ESI-mass --- metal complex --- Coreopsis lanceolata L. --- chalcone --- flavanone --- flavonol --- aurone --- Horner–Wadsworth–Emmons reaction --- condensed tannin --- bioactivity --- methanogenesis --- grape marc --- fatty acids --- in vitro batch fermentation --- neuroprotection --- PC12 --- NGF --- differentiation --- amyloid-? peptide --- taxanes --- hormesis --- polyphenol --- bamboo leaf extract --- overlay method --- ellagitannin --- structure --- revision --- (?)-epigallocatechin gallate --- immune checkpoint --- interferon-? --- epidermal growth factor --- lung tumor --- proanthocyanidins --- condensed tannins --- thiolysis --- NMR spectroscopy --- ultrahigh-resolution negative mode MALDI-TOF mass spectrometry --- antioxidant --- ORAC assay --- Acacia --- forage legume --- Trapa taiwanensis Nakai --- hydrolysable tannin --- stability --- gallotannin --- ellagitannin

Molecular Modeling in Drug Design

Authors: ---
ISBN: 9783038976141 Year: Pages: 220 DOI: 10.3390/books978-3-03897-615-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General) --- Science (General)
Added to DOAB on : 2019-04-05 10:34:31
License:

Loading...
Export citation

Choose an application

Abstract

This book is a printed edition of the Special Issue Molecular Modeling in Drug Design that was published in Molecules

Keywords

hyperlipidemia --- squalene synthase (SQS) --- molecular modeling --- drug discovery --- Traditional Chinese Medicine --- molecular dynamics simulation --- biophenols --- natural compounds --- amyloid fibrils --- Alzheimer’s disease --- ligand–protofiber interactions --- adhesion --- FimH --- rational drug design --- molecular dynamics --- molecular docking --- ligand binding --- EphA2-ephrin A1 --- PPI inhibition --- interaction energy --- in silico screening --- adenosine --- boron cluster --- adenosine receptors --- AR ligands --- aggregation --- promiscuous mechanism --- human ecto-5?-nucleotidase --- virtual screening --- enzymatic assays --- turbidimetry --- dynamic light scattering --- docking --- solvent effect --- binding affinity --- scoring function --- molecular dynamics --- target-focused pharmacophore modeling --- density-based clustering --- structure-based drug design --- AutoGrid --- grid maps --- probe energies --- method development --- steered molecular dynamics --- all-atom molecular dynamics simulation --- resultant dipole moment --- mechanical stability --- protein-peptide interactions --- molecular dynamics --- proteins --- molecular recognition --- protein protein interactions --- artificial intelligence --- deep learning --- neural networks --- property prediction --- quantitative structure-activity relationship (QSAR) --- quantitative structure-property prediction (QSPR) --- de novo design --- adenosine receptor --- metadynamics --- extracellular loops --- allosterism --- molecular dynamics --- cosolvent molecular dynamics --- drug design --- fragment screening --- docking

Listing 1 - 10 of 16 << page
of 2
>>
Sort by