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Schädigungsverhalten von in CFK-Laminaten eingebetteten Inserts unter bauteilnahen Beanspruchungen

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Book Series: Schriftenreihe des Instituts für Angewandte Materialien, Karlsruher Institut für Technologie ISSN: 21929963 ISBN: 9783731507192 Year: Volume: 72 Pages: XXXII, 264 p. DOI: 10.5445/KSP/1000073687 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:58
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Mechanical fasteners, so-called insert, offer the opportunity to allow for an inexpensive, detachable connection of thin-walled carbon fiber reinforced plastics (CFRP) parts to metal- or other plastic-based structures in the context of multi-material design. The present work is comprised of a systematic comparison of both insert types under near-application load conditions, whereby the strength as well as the damage behavior were evaluated.

Divertor Development for a Future Fusion Power Plant

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Book Series: Schriftenreihe des Instituts für Angewandte Materialien, Karlsruher Institut für Technologie ISSN: 21929963 ISBN: 9783866447387 Year: Volume: 1 Pages: VI, 136 p. DOI: 10.5445/KSP/1000024270 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:02:00
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Nuclear fusion is considered as a future source of sustainable energy supply. Since the H-mode discovery in ASDEX experiment ""Divertor I"" in 1982, the divertor has been an integral part of all modern tokamaks and stellarators. The major goal of this thesis is to develop a feasible divertor design for a fusion power plant to be built after ITER. The thesis describes the approach in the conceptual development of a helium-cooled divertor and the methods of verification and validation of the design.

Geschichte der Venezianischen Malerei, Band 4

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ISBN: 9783205796305 Year: Pages: 418 Seiten DOI: 10.26530/OAPEN_574657 Language: German
Publisher: Böhlau Grant: Austrian Science Fund - PUB 255
Added to DOAB on : 2015-09-07 11:01:18
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About a third of the present book deals with titian’s artistic entourage: Paris Bordone, Palma Vecchio and Bonifazio de’Pitati. And, on the other hand, artists as Lorenzo Lotto, Pordenone, Savoldo, proving to be more self-contained, especially Pordenone.

Advanced Glasses, Composites and Ceramics for High Growth Industries

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ISBN: 9783038979609 / 9783038979616 Year: Pages: 186 DOI: 10.3390/books978-3-03897-961-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Materials
Added to DOAB on : 2019-06-26 08:44:06
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Advanced Glasses, Composites and Ceramics for High-Growth Industries (CoACH) was a European Training Network (ETN) project (http://www.coach-etn.eu/) funded by the Horizon 2020 program. CoACH involved multiple actors in the innovation ecosystem for advanced materials, composed of five universities and ten enterprises in seven different European countries. The project studied the next generation of materials that could bring innovation in the healthcare, construction, and energy sectors, among others, from new bioactive glasses for bone implants to eco-friendly cements and new environmentally friendly thermoelectrics for energy conversion. The novel materials developed in the CoACH project pave the way for innovative products, improved cost competitiveness, and positive environmental impact. The present Special Issue contains 14 papers resulting from the CoACH project, showcasing the breadth of materials and processes developed during the project.

Friction Stir Welding and Processing in Alloy Manufacturing

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ISBN: 9783039212071 / 9783039212088 Year: Pages: 142 DOI: 10.3390/books978-3-03921-208-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Analytical Chemistry
Added to DOAB on : 2019-12-09 11:49:15
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Friction stir welding (FSW) is considered to be the most significant development in metal joining in decades and, in addition, is a ""green"" technology due to its energy efficiency, environmental friendliness, and versatility. This process offers a number of advantages over conventional joining processes. Furthermore, because welding occurs via the deformation of material at temperatures below the melting temperature, many problems commonly associated with joining of dissimilar alloys can be avoided, and thus, high-quality welds are produced. Due to this fact, FSW has been widely used in different industrial applications where metallurgical characteristics should be retained, such as in the aeronautic, naval, and automotive industries.

Towards Mechanism-based Treatments for Fragile X Syndrome

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ISBN: 9783039215058 / 9783039215065 Year: Pages: 250 DOI: 10.3390/books978-3-03921-506-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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It has been more than 25 years since the identification of the FMR1 gene and the demonstration of the causative role of CGG-repeat expansion in the disease pathology of fragile X syndrome (FXS), but the underlying mechanisms involved in the expansion mutation and the resulting gene silencing still remain elusive. Our understanding of the pathways impacted by the loss of FMRP function has grown tremendously, and has opened new avenues for targeted treatments for FXS. However, the failure of recent clinical trials that were based on successful preclinical studies using the Fmr1 knockout mouse model has forced the scientific community to revisit clinical trial design and identify objective outcome measures. There has also been a renewed interest in restoring FMR1 gene expression as a possible treatment approach for FXS. This special issue of Brain Sciences highlights the progress that has been made towards understanding the disease mechanisms and how this has informed the development of treatment strategies that are being explored for FXS.

Keywords

fragile X syndrome --- clinical trials --- targeted treatments --- drug development --- fragile X syndrome --- clinical trials --- treatment development --- best practices --- fragile X syndrome --- newborn screening --- early identification --- fragile X syndrome --- X chromosome --- females --- FMR1 --- anxiety --- avoidance --- cognition --- behavior --- brain --- Fragile X --- FMRP --- Fxr2 --- Fmr1 --- fragile X syndrome --- executive function --- working memory --- set-shifting --- cognitive flexibility --- inhibitory control --- attention --- planning --- processing speed --- Fragile X syndrome 1 --- Fragile X-associated Tremor/Ataxia Syndrome 2 --- CRISPR 3 --- Trinucleotide Repeat 4 --- Gene editing --- fragile X syndrome --- FMR1 gene --- voice of the person --- voice of the patient --- characteristics that have the greatest impact --- developmental disorders --- fragile X syndrome --- language development --- automated vocal analysis --- adeno-associated virus --- autism spectrum disorders --- cerebral spinal fluid --- fragile X mental retardation protein --- neurodevelopmental disorders --- viral vector --- fragile X syndrome --- gene reactivation --- RNA:DNA hybrid --- FMRP --- histone methylation --- DNA methylation --- FMR1 --- PRC2 --- fragile X syndrome --- unstable repeat diseases --- epigenetic gene silencing --- DNA methylation --- repeat instability --- pluripotent stem cells --- CGG Repeat Expansion Disease --- DNA instability --- expansion --- contraction --- mismatch repair (MMR) --- base excision repair (BER) --- transcription coupled repair (TCR) --- double-strand break repair (DSBR) --- Non-homologous end-joining (NHEJ) --- mosaicism --- protein synthesis --- Fragile X Syndrome --- biomarker --- iPSC --- fibroblast --- lymphoblast --- fragile X syndrome --- molecular biomarkers --- FMR1 --- FMRP --- intellectual disability --- Fmr1 KO mouse --- ASD --- n/a

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