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Novel Approaches to the Analysis of Family Data in Genetic Epidemiology

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199327 Year: Pages: 84 DOI: 10.3389/978-2-88919-932-7 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Genetics
Added to DOAB on : 2016-01-19 14:05:46
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Genome-wide association studies (GWAS) for complex disorders with large case-control populations have been performed on hundreds of traits in more than 1200 published studies (http://www.genome.gov/gwastudies/) but the variants detected by GWAS account for little of the heritability of these traits, leading to an increasing interest in using family based designs. While GWAS studies are designed to find common variants with low to moderate attributable risks, family based studies are expected to find rare variants with high attributable risk. Because family-based designs can better control both genetic and environmental background, this study design is robust to heterogeneity and population stratification. Moreover, in family-based analysis, the background genetic variation can be modeled to control the residual variance which could increase the power to identify disease associated rare variants. Analysis of families can also help us gain knowledge about disease transmission and inheritance patterns. Although a family-based design has the advantage of being robust to false positives, novel and powerful methods to analyze families in genetic epidemiology continue to be needed, especially for the interaction between genetic and environmental factors associated with disease. Moreover, with the rapid development of sequencing technology, advances in approaches to the design and analysis of sequencing data in families are also greatly needed. The 11 articles in this book all introduce new methodology and, using family data, substantial new findings are presented in the areas of infectious diseases, diabetes, eye traits, autism spectrum disorder and prostate cancer.

European Business Cycle Convergence

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Book Series: Hohenheimer volkswirtschaftliche Schriften ISBN: 9783631639740 Year: Pages: 218 Language: English
Publisher: Peter Lang International Academic Publishing Group
Subject: Business and Management --- Economics
Added to DOAB on : 2019-01-15 13:32:58
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Is the euro area getting closer with regard to business cycles? The study investigates the linkage between business cycle convergence and financial portfolio choice for a panel of 18 European countries. For this purpose an index is constructed which measures the similarity of investment portfolios. The idea is that financial portfolio choice has an impact on business cycles and contributes to convergence via the consumption-wealth linkage. The background of the analysis is the International Asset Pricing Model (IAPM). The results of fixed effects GMM TSLS estimations confirm the linkage. The effect is higher for country-pairs that are built by one euro area member and one member outside the euro area.

Machine Learning, Low-Rank Approximations and Reduced Order Modeling in Computational Mechanics

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ISBN: 9783039214099 / 9783039214105 Year: Pages: 254 DOI: 10.3390/books978-3-03921-410-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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The use of machine learning in mechanics is booming. Algorithms inspired by developments in the field of artificial intelligence today cover increasingly varied fields of application. This book illustrates recent results on coupling machine learning with computational mechanics, particularly for the construction of surrogate models or reduced order models. The articles contained in this compilation were presented at the EUROMECH Colloquium 597, « Reduced Order Modeling in Mechanics of Materials », held in Bad Herrenalb, Germany, from August 28th to August 31th 2018. In this book, Artificial Neural Networks are coupled to physics-based models. The tensor format of simulation data is exploited in surrogate models or for data pruning. Various reduced order models are proposed via machine learning strategies applied to simulation data. Since reduced order models have specific approximation errors, error estimators are also proposed in this book. The proposed numerical examples are very close to engineering problems. The reader would find this book to be a useful reference in identifying progress in machine learning and reduced order modeling for computational mechanics.

Keywords

parameter-dependent model --- surrogate modeling --- tensor-train decomposition --- gappy POD --- heterogeneous data --- elasto-viscoplasticity --- archive --- model reduction --- 3D reconstruction --- inverse problem plasticity --- data science --- model order reduction --- POD --- DEIM --- gappy POD --- GNAT --- ECSW --- empirical cubature --- hyper-reduction --- reduced integration domain --- computational homogenisation --- model order reduction (MOR) --- low-rank approximation --- proper generalised decomposition (PGD) --- PGD compression --- randomised SVD --- nonlinear material behaviour --- machine learning --- artificial neural networks --- computational homogenization --- nonlinear reduced order model --- elastoviscoplastic behavior --- nonlinear structural mechanics --- proper orthogonal decomposition --- empirical cubature method --- error indicator --- symplectic model order reduction --- proper symplectic decomposition (PSD) --- structure preservation of symplecticity --- Hamiltonian system --- reduced order modeling (ROM) --- proper orthogonal decomposition (POD) --- enhanced POD --- a priori enrichment --- modal analysis --- stabilization --- dynamic extrapolation --- computational homogenization --- large strain --- finite deformation --- geometric nonlinearity --- reduced basis --- reduced-order model --- sampling --- Hencky strain --- microstructure property linkage --- unsupervised machine learning --- supervised machine learning --- neural network --- snapshot proper orthogonal decomposition

Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides

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ISBN: 9783039215829 / 9783039215836 Year: Pages: 212 DOI: 10.3390/books978-3-03921-583-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Cardiovascular
Added to DOAB on : 2019-12-09 11:49:16
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The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs. Finally, the opportunity to target NPs in order to develop new therapeutic tools for a better treatment of CVDs has been developed over the years. The current Special Issue of the Journal covers all major aspects of the molecular implications of NPs in physiology and pathology of the cardiovascular system, including NP-based therapeutic approaches.

Keywords

PCSK9 --- natriuretic peptides --- adipose tissue --- lipid metabolism --- LDL receptor --- insulin --- natriuretic peptides --- hypertension --- stroke --- cardiac hypertrophy --- linkage analysis --- genetic variants --- animal models --- BNP --- NT-proBNP --- heart failure --- cardiac dysfunction --- forensic medicine --- postmortem biochemistry --- angiotensin receptor–neprilysin inhibitor --- natriuretic peptides --- renin–angiotensin system --- heart failure --- arterial hypertension --- natriuretic peptide --- vascular --- endothelial cell --- cardiomyocyte --- fibroblast --- inflammation --- heart failure --- hypertension --- angiogenesis --- heart failure --- natriuretic peptides --- preserved ejection fraction --- natriuretic peptides --- heart failure --- atrial fibrillation --- remodeling --- Idiopathic Pulmonary Arterial Hypertension (IPAH) --- Natriuretic Peptide Clearance Receptor (NPR-C) signaling --- atrial natriuretic peptide --- hypertension --- heart failure --- cardiometabolic disease --- obesity --- metabolic syndrome --- cGMP --- guanylyl cyclase receptor A --- natriuretic peptides --- natriuretic peptide --- cardiorenal syndrome --- vasopressor --- vasodilator --- kidney --- medulla --- renin-angiotensin-aldosterone system --- Atrial Natriuretic peptide --- natriuretic peptides --- cardiac remodelling --- cardiac hypertrophy --- vascular homeostasis --- atrial natriuretic peptide --- guanylyl cyclase/natriuretic peptide receptor-A --- gene-knockout --- gene-duplication --- hypertension --- congestive heart failure --- natriuretic peptides --- arterial hypertension --- pulmonary arterial hypertension --- heart failure --- stroke --- atrial fibrillation --- ARNi --- MANP

Swarm Robotics

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ISBN: 9783038979227 / 9783038979234 Year: Pages: 310 DOI: 10.3390/books978-3-03897-923-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Computer Science
Added to DOAB on : 2019-06-26 08:44:06
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Collectively working robot teams can solve a problem more efficiently than a single robot, while also providing robustness and flexibility to the group. Swarm robotics model is a key component of a cooperative algorithm that controls the behaviors and interactions of all individuals. The robots in the swarm should have some basic functions, such as sensing, communicating, and monitoring, and satisfy the following properties:

Keywords

3D model identification --- shape normalization --- weighted implicit shape representation --- panoramic view --- scale-invariant feature transform --- optimization --- meta-heuristic --- parallel technique --- Swarm intelligence algorithm --- artificial flora (AF) algorithm --- bionic intelligent algorithm --- particle swarm optimization --- artificial bee colony algorithm --- swarm robotics --- search --- surveillance --- behaviors --- patterns --- comparison --- swarm behavior --- Swarm Chemistry --- self-organization --- asymmetrical interaction --- genetic algorithm --- cooperative target hunting --- multi-AUV --- improved potential field --- surface-water environment --- signal source localization --- multi-robot system --- event-triggered communication --- consensus control --- time-difference-of-arrival (TDOA) --- Cramer–Rao low bound (CRLB) --- optimal configuration --- UAV swarms --- path optimization --- multiple robots --- formation --- sliding mode controller --- nonlinear disturbance observer --- system stability --- formation control --- virtual structure --- formation reconfiguration --- multi-agents --- robotics --- unmanned aerial vehicle --- swarm intelligence --- particle swarm optimization --- search algorithm --- underwater environment --- sensor deployment --- event-driven coverage --- fish swarm optimization --- congestion control --- modular robots --- self-assembly robots --- environmental perception --- target recognition --- autonomous docking --- formation control --- virtual linkage --- virtual structure --- formation reconfiguration --- mobile robots --- robotics --- swarm robotics --- formation control --- coordinate motion --- obstacle avoidance --- n/a

Refugee, Migrant and Ethnic Minority Health

Authors: --- --- ---
ISBN: 9783039216444 / 9783039216451 Year: Pages: 526 DOI: 10.3390/books978-3-03921-645-1 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Sociology
Added to DOAB on : 2019-12-09 11:49:15
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International migration, particularly to Europe, has increased in the last few decades, making research on aspects of this phenomenon, including numbers, challenges, and successes, particularly vital. This Special Issue highlights this necessary and relevant area of research. It presents 37 articles including studies on diverse topics relating to the health of refugees and migrants. Most articles (28) present studies focusing on European host countries. The focus on Europe is justified if we take into consideration the increased number of refugees and migrants who have come to Europe in recent years. However, there are also articles which present studies from countries in other continents. The topics discussed in the Issue include healthcare utilization, infectious diseases, mother and child health, mental health, and chronic diseases. Finding from the included articles indicate that further development of guidelines and policies at both local and international levels is needed. Priorities must be set by encouraging and funding in-depth research that aims to evaluate the impact of existing policies and interventions. Such research will help us formulate recommendations for the development of strategies and approaches that improve and strengthen the integration of migrants and refugees into the host countries.

Keywords

breastfeeding --- complementary feeding --- Chinese --- immigrant mothers --- infant --- obesity --- post-traumatic stress disorder (PTSD) --- pain --- pain perception --- understanding of illness --- culture --- family-oriented societies --- refugee and migrant women --- sexual and reproductive health --- training --- knowledge --- confidence --- health care professionals --- emergency care --- triage --- healthcare system strengthening --- migrant health --- North Korean refugees --- depression --- early trauma --- negative automatic thoughts --- path analysis --- ambulance --- economic recession --- emergency medical service --- Greece --- primary healthcare system --- refugee --- triage --- public health --- asylum seeker --- Electronic Health Insurance Card --- refugee --- Germany --- refugee health --- asylum seekers --- migrants --- infectious diseases --- vaccination --- Italy --- refugee and migrant (R&M) health --- refugee crisis --- healthcare --- European Union (EU) --- migrant health --- preparedness --- communicable diseases --- tuberculosis --- LTBI --- refugee --- asylum --- infection --- IGRA --- infectious diseases --- migrant --- asylum seekers --- psychiatric emergency services --- involuntary treatment --- psychiatric hospitalization --- migrants --- sexual health --- help-seeking behavior --- systematic review --- aggression --- emergency department --- workplace violence --- migrants --- failed asylum seekers --- psychiatric emergency services --- psychiatric hospitalisation --- acute stress --- multidimensional intercultural training acculturation model (MITA) --- intercultural competence --- traumatic events --- mental health --- Middle Eastern refugee adolescents --- migration --- health --- infection --- linkage --- care --- sexual and reproductive health --- adolescent --- refugee --- migrant --- young women --- knowledge --- access --- experiences --- systematic review --- Africa --- obesity --- immigration --- education --- inequalities --- health survey --- refugee --- adolescent --- risk factor --- protective factor --- HIV --- AIDS --- stigma --- refugees --- migrants --- economic crisis --- Greece --- migration --- National Health System --- refugee --- Southeast Europe --- immigrant --- healthcare --- HBV --- CHB --- screening --- vaccination --- refugees --- migrants --- pregnancy --- migration --- refugees --- health care provision --- reception center --- sexual violence --- migrants --- refugees --- asylum seekers --- applicants for international protection --- Europe --- prevalence --- hepatitis C --- screening --- migrants --- viral hepatitis elimination --- European Union --- North African --- immigration --- health care --- emergency department --- disparities --- VPD --- immunisation strategies --- health systems --- refugees --- migrants --- cost effectiveness --- healthcare --- migration --- refugee --- asylum seeker --- medical service --- migrant --- medical care --- doctor --- Europe --- Germany --- fruit --- vegetable --- immigrant --- Portuguese --- health --- refugees women --- HIV --- mental health --- stigma --- discrimination --- access to care --- disease prevention --- public health --- stigma --- refugees --- migrants --- MMR vaccination --- measles --- vaccine hesitancy --- autism --- Rinkeby --- Tensta --- immigrants --- Polish --- religiosity --- lifestyle behavior --- smoking --- alcohol consumption --- physical activity --- overweight --- obesity --- migrant populations --- schistosomiasis/schistosoma --- strongyloidiasis/strongyloides --- screening/diagnosis --- treatment --- public health --- GRADE --- refugee --- health --- migration --- chronic disease --- infectious disease --- n/a

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