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Molecular Mechanism of Alzheimer's Disease

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ISBN: 9783039214075 / 9783039214082 Year: Pages: 228 DOI: 10.3390/books978-3-03921-408-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:16
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Abstract

Alzheimer’s disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer’s disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms, and various hypotheses will be examined in this Special Issue.

Keywords

?-secretase --- amyloid beta --- calcium signaling --- drug target discovery --- endoplasmic reticulum --- inositol 1,4,5-trisphosphate receptor --- ion channel --- oxidative stress --- ryanodine receptor --- therapy --- amyloid-? oligomer --- protein aggregation --- A?O receptors --- Alzheimer’s disease --- neurodegeneration --- amyloid ? --- Alzheimer’s disease --- cognitive function --- dairy products --- dementia --- inflammation --- microglia --- Alzheimer’s disease --- yeast --- Tau --- amyloid ? --- ubiquitin --- aggregation --- oligomerization --- prion --- CDK5R1 --- lncRNAs --- Alzheimer’s disease --- miR-15/107 --- NEAT1 --- HOTAIR --- MALAT1 --- heat shock response --- heat shock protein --- Alzheimer’s disease --- beta amyloid --- yeast --- Alzheimer’s disease --- complement receptor 1 --- CR1 length polymorphism --- CR1 density --- complement C3b/C4b receptor --- complement --- dementia --- molecular biology --- neurosciences --- genetic risk --- Alzheimer’s disease --- brain glucose metabolism --- neuronal differentiation --- neuronal degeneration --- Prolyl isomerases --- Pin1 --- type 2 diabetes --- type 3 diabetes --- miR-34c --- dendritic spine --- Alzheimer’s disease --- Alzheimer’s disease --- positron emission tomography (PET) --- magnetic resonance imaging (MRI) --- Alzheimer’s disease --- cystathionine-?-lyase CTH gene --- DNA methylation --- epigenetics --- epigenome-wide association study --- methylome --- methylenetetrahydrofolate reductase MTHFR gene --- nutrition --- S-adenosylmethionine --- vitamin B complex --- Alzheimer’s disease --- sleep disturbance --- sleep fragmentation --- slow-wave sleep --- amyloid beta --- tau --- proteostasis --- default-mode network --- cognitive behavioral therapy for insomnia --- APOE gene --- apolipoprotein E --- DNA methylation --- mild cognitive impairment --- Hispanics

Molecular Research of Endometrial Pathophysiology

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ISBN: 9783039214952 / 9783039214969 Year: Pages: 378 DOI: 10.3390/books978-3-03921-496-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Sociology
Added to DOAB on : 2019-12-09 16:10:12
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Abstract

The endometrium has been the subject of intense research in a variety of clinical settings, because of its importance in the reproductive process and its role in women’s health. In the past 15 years, significant efforts have been invested in defining the molecular phenotype of the receptive phase endometrium as well as of various endometrial pathologies. Although this has generated a wealth of information on the molecular landscape of human endometrium, there is a need to complement this information in light of the novel methodologies and innovative technical approaches. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms of endometrium and endometrium-related disorders. The progress made in the molecular actions of steroids, in the metabolism of steroids and intracrinology, in endometrial intracellular pathways, in stem cells biology, as well as in the molecular alterations underlying endometrium-related pathologies has been the focus of the reviews and papers included.

Keywords

RANK --- endometrium --- endometrial cancer --- prognosis --- immunohistochemistry --- gene expression --- endometriosis --- developmental pathway --- pathogenomics --- mesenchymal stem cells --- endometrial cancer --- mtDNA mutations --- deficit of complex I --- antioxidant response --- mitochondrial biogenesis --- mitochondrial dynamics --- mitophagy --- miRNA --- lncRNAs --- endometrial cancer --- endometriosis --- chronic endometritis --- cell contacts --- tight junction --- adherens junction --- gap junction --- endometrium --- implantation --- decidualization --- endometriosis --- endometrial cancer --- liquid biopsy --- uterine aspirate --- circulating tumour cells (CTCs) --- circulating tumour DNA (ctDNA) --- exosomes --- Vitamin D --- endometrium --- endometrial cancer --- endometrial cancer --- preclinical models --- translational research --- endometrial cancer --- type II endometrial carcinoma --- targeted therapy --- kinase inhibitor --- molecular marker --- protein kinase --- protein phosphatase --- PP2A --- PPP2R1A --- SMAP --- endometriosis --- infertility --- niche --- inflammation --- immunomodulation --- mesenchymal stem cell --- orthoxenograft --- uterine cancer --- avatar --- murine models --- personalized medicine --- targeted therapy --- preclinical studies --- translational research --- endometriosis --- TRP channels --- endometrial stromal cells --- eutopic and ectopic endometrium --- endometrial cell --- pathway --- proliferation --- decidualization --- migration --- angiogenesis --- regeneration --- breakdown --- implantation --- endometrial cancer --- orthotopic xenograft model --- estrogen dependent --- bioluminescence imaging --- contrast-enhanced CT scan --- endometrium --- adult stem cells --- endometrial regeneration --- stem cell markers --- endometriosis --- endometrial cancer --- decidualisation --- oestradiol --- aromatase --- testosterone --- dehydroepiandrosterone (DHEA) --- endometriosis --- endometrial cancer --- sulfatase --- endometriosis --- ectopic stroma --- microRNA --- small RNA sequencing --- EDN1 --- HOXA10 --- miR-139-5p --- miR-375 --- CTCF --- tumour suppressor gene --- haploinsufficiency --- zinc finger --- CRISPR/Cas9 --- cancer --- endometrial cancer --- gene editing --- phosphoinositide 3-kinase --- PIK3CA --- PIK3CB --- p110? --- p110? --- endometrial cancer --- LGR5 --- endometrium --- endometriosis --- menstrual cycle --- macrophages

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MDPI - Multidisciplinary Digital Publishing Institute (2)


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CC by-nc-nd (2)


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eng (2)


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2019 (2)