Search results: Found 4

Listing 1 - 4 of 4
Sort by
Role of Natural Compounds in Inflammation and Inflammatory-Related Diseases

Author:
ISBN: 9783039215522 / 9783039215539 Year: Pages: 174 DOI: 10.3390/books978-3-03921-553-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-12-09 11:49:15
License:

Loading...
Export citation

Choose an application

Abstract

The papers reported here will contribute to proposing new insights into the mechanisms of several conditions, as well as suggesting new diagnostic alternatives and therapeutic targets in widespread pathologies such inflammation and inflammatory-based diseases. The discovery of the new is, as always, anchored in recourse to the old.

Marine Anti-inflammatory Agents

Authors: ---
ISBN: 9783039215720 / 9783039215737 Year: Pages: 248 DOI: 10.3390/books978-3-03921-573-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2019-12-09 11:49:16
License:

Loading...
Export citation

Choose an application

Abstract

Acute inflammation is a highly regulated process, and its dysregulation can lead to the development of a chronic inflammatory state which is believed to play a main role in the pathogenesis of many diseases, including cancer. In recent years, the need to find new anti-inflammatory molecules has raised the scientific community´s interest for marine natural products. In this regard, the marine environment represents a source for isolating a wealth of bioactive compounds. In this Special Issue, the reported products have been obtained from microalgae, sea cucumber, octopus, squid, red alga-derived fungus, cnidarians, hard-shelled mussel, and sponges.

Keywords

THP-1 macrophages --- anti-inflammatory --- TLR4 --- NF-?B --- MAPK --- SPR analysis --- glycolipids --- MGDG --- skin --- inflammation --- epidermal hyperplasia --- microalgae --- Isochrysis galbana --- Frondanol --- Cucumaria frondosa --- DSS colitis --- colon inflammation --- zoantharia --- Tropical Eastern Pacific --- Zoanthus pulchellus --- zoanthamine --- inflammation --- fucoxanthin --- inflammation --- epidermal hyperplasia --- UVB --- photoprotection --- 6-bromoindole --- Geodia barretti --- anti-inflammatory activity --- dendritic cells --- T cell differentiation --- poor blood circulation --- Ecklonia cava --- phlorotannins --- pyrogallol-phloroglucinol-6,6-bieckol --- functional ingredients --- endothelial cell death --- vascular smooth muscle cell proliferation and migration --- inflammation --- anti-inflammatory --- bioactive molecules --- microalgae --- polysaccharides --- carotenoids --- polyunsaturated fatty acids --- fucoxanthin --- ultraviolet B --- denervation --- seafood waste --- polyunsaturated fatty acid --- NO inhibition --- fish oil --- marine nutraceuticals --- fish oil --- omega-3 --- eicosapentaenoic acid --- docosahexaenoic acid --- inflammation --- eicosanoid --- cytokine --- surgery --- critical illness --- parenteral nutrition --- signal transducer and activator of transcription 3 (STAT3) --- matrix metalloproteinases-9 (MMP-9) --- interleukin (IL) --- lipopolysaccharide (LPS) --- acute sickness behavior --- acute lung injury (ALI) --- prostaglandins --- clavulones --- punaglandins --- thromboxane --- inflammation --- marine vertebrates --- marine invertebrates --- diatoms --- macroalgae --- fucoxanthin --- rosmarinic acid --- NRLP3 --- inflammasome --- anti-oxidative --- anti-inflammatory --- photo-protection --- UVB

Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges

Author:
ISBN: 9783039217069 / 9783039217076 Year: Pages: 348 DOI: 10.3390/books978-3-03921-707-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2019-12-09 11:49:16
License:

Loading...
Export citation

Choose an application

Abstract

Tissue fibrosis may occur for unknown causes or be the consequence of many pathological conditions including chronic inflammatory or infectious diseases, autoimmune disorders, graft rejection, or malignancy. On the other hand, malignant tumors have been identified in fibrotic tissues decades ago, and now accumulating evidence suggests that fibrotic lesions enhance the risk of cancer in several organs such as liver, lungs, and breast. Disruption of an organ parenchymal cells and of its normal structural scaffold during tissue fibrogenesis appears to induce loss of cell polarity, promoting uncontrolled cell proliferation that may eventually lead to cancer development. Many cellular and molecular abnormalities including aberrant expression of microRNAs, genetic and epigenetic alterations, evasion or delayed apoptosis, unregulated intracellular signal pathways, and dysregulation or defective intercellular communications have been proposed to explain this link between fibrogenesis and carcinogenesis. However, the precise mechanisms of this fibrosis-to-cancer transition remain unclear. This book presents a collection of reviews and original articles summarizing recent advances in understanding the molecular mechanisms of cancer development in fibrotic organs.

Keywords

lung cancer --- renal injury --- fibrosis --- crizotinib --- anaplastic lymphoma kinase --- cystic formation --- pulmonary fibrosis --- butylidenephthalide --- SOX2 --- type I collagen --- bleomycin --- YAP --- TAZ --- Hippo pathway --- fibrosis --- cancer --- mechanotransduction --- TGF-? --- Wnt --- uterine fibroid --- leiomyoma --- tumor --- tumor necrosis factor ? --- cytokine --- growth factor --- inflammation --- clinical symptoms --- pathophysiology --- therapy --- hepatocellular carcinoma --- cirrhosis --- regeneration --- inflammation --- cytokines --- genetic instability --- reactive oxygen species --- idiopathic pulmonary fibrosis (IPF) --- lung cancer (LC) --- non-small cell lung cancer (NSCLC) --- acute lung injury --- protein S --- apoptosis --- signal pathway --- Erk1/2 --- lipopolysaccharide --- uterine fibroid --- leiomyoma --- smooth muscle tumor of uncertain malignant potential --- leiomyosarcoma --- myometrium --- immunohistochemistry --- marker --- pathology --- tumor --- diagnosis --- cancer-associated fibroblasts --- tumor microenvironment --- nanoparticles --- breast cancer --- antitumor efficacy --- cirrhosis --- HBV --- HCV --- hepatocellular carcinoma --- idiopathic pulmonary fibrosis --- lung cancer --- pathogenesis --- common pathways --- hepatocellular carcinoma (HCC) --- fibrosis --- cancer-associated fibroblasts (CAFs) --- hepatic stellate cells (HSCs) --- tumor microenvironment --- hepatocellular carcinoma --- non-alcoholic steatohepatitis --- fibrosis --- hepatic stellate cells --- extracellular matrix --- carcinogenesis --- angiogenesis --- cancer-associated fibroblasts --- extracellular matrix --- fibrosis --- heterogeneity --- interstitial fluid pressure --- metabolic reprogramming --- transforming growth factor-? --- tumor stiffness --- GPR40 --- GPR120 --- DHA --- omega-3 fatty acid --- SREBP-1 --- hepatocytes --- EMT --- lncRNA --- metastasis --- miRNA --- SMAD --- TGF-? --- targeted therapy --- tumor microenvironment --- n/a

Long-Term Health Effects of the 9/11 Disaster

Authors: --- ---
ISBN: 9783039218127 / 9783039218134 Year: Pages: 298 DOI: 10.3390/books978-3-03921-813-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Philosophy
Added to DOAB on : 2019-12-09 11:49:16
License:

Loading...
Export citation

Choose an application

Abstract

The terrorist attacks on the World Trade Center towers on September 11, 2001, also referred as 9/11, was an iconic event in US history that altered the global and political response to terrorism. The attacks, which involved two planes hitting the twin towers in Lower Manhattan, New York City, resulted in the collapse of the buildings and over 2800 deaths of occupants of the buildings, fire, police and other responders and persons on the street in the vicinity of the collapsing buildings. The destroyed towers and the surrounding buildings have since been replaced but the health effects that resulted from the release of tons of dust, gases and debris as well as the life threat trauma are ongoing, and represent a major health burden among persons directly exposed. Hundreds of scientific publications have documented the physical and mental health effects attributed to the disaster. The current state-of-the-art in understanding the ongoing interactions of physical and mental health, especially PTSD, and the unique mechanisms by which pollutants from the building collapse, have resulted in long term pulmonary dysfunction, course of previously reported conditions, potential emerging conditions (e.g., heart disease and autoimmune diseases), as well as quality of life, functioning and unmet health care needs would be in the purview of this Special Issue on the 9/11 Disaster.

Keywords

counseling --- post-disaster --- psychotherapy --- mental health treatment --- treatment utilization --- World Trade Center --- indoor allergens sensitization --- asthma quality of life --- asthma control --- asthma outcomes --- mini asthma quality of life questionnaire --- asthma morbidity --- WTC-related asthma --- immunoglobulin E --- allergen exposure --- WTC attack --- respiratory symptoms --- lower Manhattan residents --- cleaning practices --- WTC --- fibrotic sarcoid --- injury --- inflammation --- fibrosis --- World Trade Center disaster --- pulmonary fibrosis --- dust --- injury --- physical health --- mental health --- World Trade Center disaster --- Short Form-12 (SF-12) --- HQoL --- 9/11 --- 9/11 disaster --- handgrip strength --- WTC responders --- PTSD --- depression --- aging --- 9/11 impact --- retirement --- chronic disease --- PTSD --- disaster --- income loss --- PTSD symptom change --- PCL score --- longitudinal analysis --- PTSD cluster --- WTC survivors --- 9/11 disaster --- obstructive sleep apnea --- comorbid insomnia --- sleep-related quality of life --- chronic sinusitis --- sleepiness --- WTC responders --- thyroid cancer --- 9/11 disaster --- World Trade Center --- surveillance bias --- sarcoidosis --- World Trade Center (WTC) --- Scadding stage --- lung function --- severe lung disease --- extrathoracic sarcoidosis --- cardiac sarcoidosis --- unmet mental health care needs --- Asian Americans --- World Trade Center attack --- disaster --- mental health conditions --- mental health service use --- health insurance --- social support --- stressful life events --- cognitive reserve --- cognitive decline --- latent class analysis --- disaster epidemiology --- PTSD --- airway physiology --- dust --- environmental health --- forced oscillation --- respiratory function --- small airway disease --- paresthesia --- neuropathic symptoms --- Cox regression --- hazard function --- World Trade Center exposure --- metabolic syndrome --- airway hyperreactivity --- World Trade Center --- disaster mental health --- evidence-based treatment --- mental health service utilization --- quality improvement --- 9/11 --- screening --- thyroid cancer --- biomarkers --- medical imaging --- pulmonary function tests --- lung injury --- occupational exposure --- epidemiological studies --- peripheral neuropathy --- prevalence --- World Trade Center --- rescue/recovery workers --- occupational exposure --- sarcoidosis --- World Trade Center --- 9/11 --- genetics --- firefighters --- FDNY --- 9/11 disaster --- asthma --- trigger(s) --- air pollution --- irritant(s) --- health-related quality of life --- n/a

Listing 1 - 4 of 4
Sort by
Narrow your search

Publisher

MDPI - Multidisciplinary Digital Publishing Institute (4)


License

CC by-nc-nd (4)


Language

eng (4)


Year
From To Submit

2019 (4)