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Malarial Subjects

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Book Series: Science in History ISBN: 9781107172364 Year: Pages: 350 DOI: 10.1017/9781316771617 Language: English
Publisher: Cambridge University Press Grant: Wellcome Trust
Subject: Medicine (General)
Added to DOAB on : 2019-01-15 13:34:15
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Malaria was considered one of the most widespread disease-causing entities in the nineteenth century. It was associated with a variety of frailties far beyond fevers, ranging from idiocy to impotence. And yet, it was not a self-contained category. The reconsolidation of malaria as a diagnostic category during this period happened within a wider context in which cinchona plants and their most valuable extract, quinine, were reinforced as objects of natural knowledge and social control. In India, the exigencies and apparatuses of British imperial rule occasioned the close interactions between these histories. In the process, British imperial rule became entangled with a network of nonhumans that included, apart from cinchona plants and the drug quinine, a range of objects described as malarial, as well as mosquitoes. Malarial Subjects explores this history of the co-constitution of a cure and disease, of British colonial rule and nonhumans, and of science, medicine and empire. This title is also available as Open Access.

Highlights on Anopheles nili and Anopheles moucheti, Malaria Vectors in Africa (Book chapter)

Book title: Anopheles mosquitoes

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ISBN: 9789535111887 Year: DOI: 10.5772/55153 Language: English
Publisher: IntechOpen Grant: Wellcome Trust - 86423
Subject: Internal medicine
Added to DOAB on : 2019-01-17 11:47:01
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In this chapter, we review knowledge gained so far on mosquitoes from An. moucheti and closely related species, as well as the An. nili complex. We highlight specific bionomical, ecological and genetic attributes that distinguish these species from the most well-known major African malaria vectors, providing opportunities for further research on neglected aspects of vector biology and control.

Adolpho Lutz - Febre amarela, malária e protozoologia - v.2, Livro 1

Authors: ---
ISBN: 9788575414071 Year: Pages: 956 DOI: http://dx.doi.org/10.7476/9788575414071 Language: Portuguese
Publisher: SciELO Books - Editora FIOCRUZ
Subject: Internal medicine
Added to DOAB on : 2014-10-10 16:59:42
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Organizada pelo historiador Jaime Benchimol e pela bióloga e historiadora da ciência Magali Romero Sá, é uma homenagem ao pesquisador e à sua trajetória. Adolpho Lutz foi o precursor das modernas campanhas sanitárias e dos estudos epidemiológicos envolvendo, sobretudo, o cólera, a febre tifóide, a peste bubônica e a febre amarela. Os quatro primeiros volumes da obra - que consistirá, quando completa, numa coleção de 21 livros acondicionados em cinco caixas - trazem: Primeiros Trabalhos: Alemanha, Suíça e Brasil (1878-1885); Hanseníase; Dermatologia e Micologia e ainda um suplemento contendo sumário, glossário e índices. Neles, os organizadores recuperaram o arquivo pessoal do cientista e de sua filha, a bióloga Bertha Lutz.

Doenças endêmicas: abordagens sociais, culturais e comportamentais

Authors: ---
ISBN: 9788575413944 Year: Pages: 376 DOI: http://dx.doi.org/10.7476/9788575413944 Language: Portuguese
Publisher: SciELO Books - Editora FIOCRUZ
Subject: Internal medicine
Added to DOAB on : 2014-10-15 18:54:11
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No mundo, cerca de meio bilhão de pessoas sofrem de enfermidades parasitárias endêmicas. Na América Latina, ainda se convive com velhas endemias como esquistossomose, malária, leshmanioses e hanseníase. A solução? Construir, de maneira solidária, o campo da saúde coletiva. Reunindo artigos de 35 conceituados pesquisadores latino-americanos, Doenças Endêmicas aproxima as abordagens teórico-metodológicas das ciências sociais e da epidemiologia. Certamente será útil para todos os profissionais interessados em desenvolver estratégias alternativas na formulação, implementação e avaliação de programas de controle de endemias.

Why vaccines to HIV, HCV and Malaria have so far failed - Challenges to developing vaccines against immunoregulating pathogens

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199662 Year: Pages: 157 DOI: 10.3389/978-2-88919-966-2 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Microbiology --- Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2016-01-19 14:05:46
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Despite continuous progress in the development of anti-viral and anti-bacterial/parasite drugs, the high cost of medicines and the potential for re-infection, especially in high risk groups, suggest that protective vaccines to some of the most dangerous persistent infections are still highly desirable. There are no vaccines available for HIV, HCV and Malaria, and all attempts to make a broadly effective vaccine have failed so far. In this Research Topic we look into why vaccines have failed over the years, and what we have learn from these attempts. Rather than only showing positive results, this issue aims to reflect on failed efforts in vaccine development. Coming to understand our limitations will have theoretical and practical implications for the future development of vaccines to these major global disease burdens.

Keywords

Vaccine --- Infectious Disease --- HIV --- HCV --- Malaria --- influenza --- immunology --- Genetics

Les Désorientés : Expériences des soldats français aux Dardanelles et en Macédoine, 1915-1918

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ISBN: 9782858312993 DOI: 10.4000/books.pressesinalco.20209 Language: French
Publisher: Presses de l’Inalco
Subject: History
Added to DOAB on : 2019-12-06 13:15:40
License: OpenEdition Licence for Books

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Plus de 80 000 soldats français ont été envoyés aux Dardanelles en 1915 par un gouvernement réticent, dans une expédition improvisée et organisée à la hâte. Quand l'échec devint évident, les survivants ont été convoyés vers Salonique pour une autre expédition encore plus importante en Macédoine, au total près de 400 000 soldats français sont passés par cette armée d’Orient. Les soldats partaient avec appréhension vers l’inconnu, mais les mots de Constantinople, Orient et Grèce, leur rappelaient des visions littéraires agréables, à eux comme à leur famille qui ignoraient tout du pays. Leurs mémoires montrent que les réalités furent tout sauf agréables : conditions naturelles, climat, approvisionnement, équipement, munitions, maladies ; mais leur correspondance, censurée et autocensurée, ne dit rien de cela en France et la presse se tait. Tout au contraire, elle répand l’image des plaisirs de Salonique que peuvent connaître les officiers et les correspondants de presse, image qui restera après la guerre et fait que leur contribution à la victoire des alliés sera sous‑estimée. Leurs souffrances et leurs sacrifices sont ignorés, on les croit « planqués » au soleil. Chez eux, l’amertume est grande : ils comprennent que gagner Constantinople est impossible, ils constatent que la Macédoine ne ressemble pas à la Grèce de leurs rêves, que toutes les populations ne sont pas grecques et que, même les Grecs, ne sont pas toujours heureux de les voir. Alors pourquoi aller mourir loin de chez soi quand votre propre gouvernement vous abandonne, en quoi cela contribue‑t‑il à défendre la France ? Ce livre, nourri des mémoires et souvenirs émouvants des soldats, témoigne à la fois de leurs conditions de vie et de combat extrêmement difficiles, de la crise morale qu’ils ont vécue en Macédoine telle qu’ils l’ont découverte avec sa toute sa diversité.

Macromolecular Structure Underlying Recognition in Innate Immunity

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455270 Year: Pages: 151 DOI: 10.3389/978-2-88945-527-0 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2019-01-23 14:53:42
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Immune molecules have evolved to distinguish “self “molecules from “non-self”, “altered self” and “danger” molecules. Recognition is mediated via interactions between pattern recognition receptor molecules (PPRs) and their ligands, which include hydrophobic and electrostatic interactions between amino acid residues on the PPRs and uncharged or charged groups on amino acid residues, sugar rings or DNA/RNA molecules. Recognition in innate immunity range from cases (C1q, mannin-binding protein etc) where recognition is orchestrated by interaction between many ligands with one receptor molecule, and density of interaction is necessary for strong specific recognition, distinct from weak non-specific binding, and cases such as TLRs and NLRs where recognition involves complexation of single receptor and ligand, followed by oligomerisation of the receptor molecule. The majority of PPR molecules bind and recognise a wide variety of ligands, e.g TLR4 recognises LPS (gram negative bacteria), Lipotechoic acid (gram positive bacteria), heat shock protein hsp60, respiratory syncytial virus fusion protein etc, molecules that are structurally dissimilar to each other. This indicates considerable flexibility in their binding domains (amino acid residue variations) and modes (hydrophobic and charged, direct or mediated via an adaptor molecule). However, in many cases there is a dearth of structural and molecular data available, required to delineate the mechanism of ligand binding underlining recognition in pathogen receptors in innate immunity. Insights into requirements of conformation, charge, surface etc in the recognition and function of innate immunity receptors and their activation pathways, based on current data can suggest valuable avenues for future work.

Breaking the cycle: Attacking the malaria parasite in the liver

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196951 Year: Pages: 173 DOI: 10.3389/978-2-88919-695-1 Language: English
Publisher: Frontiers Media SA
Subject: Allergy and Immunology --- Medicine (General) --- Microbiology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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Despite significant progress in the global fight against malaria, this parasitic infection is still responsible for nearly 300 million clinical cases and more than half a million deaths each year, predominantly in African children less than 5 years of age. The infection starts when mosquitoes transmit small numbers of parasites into the skin. From here, the parasites travel with the bloodstream to the liver where they undergo an initial round of replication and maturation to the next developmental stage that infects red blood cells. A vaccine capable of blocking the clinically silent liver phase of the Plasmodium life cycle would prevent the subsequent symptomatic phase of this tropical disease, including its frequently fatal manifestations such as severe anemia, acute lung injury, and cerebral malaria. Parasitologists, immunologists, and vaccinologists have come to appreciate the complexity of the adaptive immune response against the liver stages of this deadly parasite. Lymphocytes play a central role in the elimination of Plasmodium infected hepatocytes, both in humans and animal models, but our understanding of the exact cellular interactions and molecular effector mechanisms that lead to parasite killing within the complex hepatic microenvironment of an immune host is still rudimentary. Nevertheless, recent collaborative efforts have led to promising vaccine approaches based on liver stages that have conferred sterile immunity in humans – the University of Oxford's Ad prime / MVA boost vaccine, the Naval Medical Research Center’s DNA prime / Ad boost vaccine, Sanaria Inc.'s radiation-attenuated whole sporozoite vaccine, and Radboud University Medical Centre’s and Sanaria's derived chemoprophylaxis with sporozoites vaccines. The aim of this Research Topic is to bring together researchers with expertise in malariology, immunology, hepatology, antigen discovery and vaccine development to provide a better understanding of the basic biology of Plasmodium in the liver and the host’s innate and adaptive immune responses. Understanding the conditions required to generate complete protection in a vaccinated individual will bring us closer to our ultimate goal, namely to develop a safe, scalable, and affordable malaria vaccine capable of inducing sustained high-level protective immunity in the large proportion of the world’s population constantly at risk of malaria.

Travel Medicine - Series 1

Author:
ISBN: 9783038979043 9783038979050 Year: Pages: 68 DOI: 10.3390/books978-3-03897-953-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Pharmacy and materia medica --- Medicine (General)
Added to DOAB on : 2019-06-26 08:44:06
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This collection of papers describes the recent development of travel health and vaccination services delivered by pharmacists. It is the first dedicated collection of its type and provides a template for the continued growth of pharmacy practice in this area. The articles examine and report on aspects of such services in the UK, US, Canada, Australia, Switzerland, and South Africa, which will provide useful insight for those in other countries developing such pharmacy-based services.

Biological Potential and Medical Use of Secondary Metabolites

Authors: ---
ISBN: 9783039211876 9783039211883 Year: Pages: 284 DOI: 10.3390/books978-3-03921-188-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-08-28 11:21:27
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Many macro and micro species, from terrestrial and aquatic environments, produce structurally unique compounds and, in many countries, still are the primary sources of medicines. In fact, secondary metabolites are an important source of chemotherapeutic agents but are also lead compounds for synthetic modification and the optimization of biological activity. Therefore, the exploitation of secondary metabolites, or their inspired synthetic compounds, offers excellent opportunities for the pharmaceutical industry. This Medicines Special Issue focuses on the great potential of secondary metabolites for therapeutic application. The Special Issue contains 16 articles reporting relevant experimental results, and an overview of bioactive secondary metabolites, their biological effects, and new methodologies that improve and accelerate the process of obtained lead compounds with regard to new drug development. We would like to thank all 83 authors, from all over the world, for their valuable contributions to this Special Issue.

Keywords

Juniperus --- secondary metabolites --- diterpenes --- flavonoids --- lignans --- cytotoxic --- antitumor --- antibacterial --- amentoflavone --- deoxypodophyllotoxin --- frankincense --- Boswellia --- cembranoids --- cneorubenoids --- boswellic acids --- molecular docking --- Scabiosa --- flavonoids --- iridoids --- pentacyclic triterpenoids --- antioxidant --- anti-inflammatory --- antibacterial --- anticancer --- Cordyceps militaris --- xanthine oxidase --- antioxidant --- antibacterial --- cordycepin --- GC-MS --- Artemisia species --- Artemisia vachanica --- artemisinin --- HPLC-PAD --- Tajikistan --- Malus x domestica --- Tuscany --- ancient varieties --- nutraceutics --- antioxidants --- polyphenols --- sugars --- pectin --- defensins --- secondary metabolites --- plant defense --- antimicrobial and anticancer activity --- medicine --- innate immunity --- cannabis --- cannabinoids --- therapeutics --- toxicology --- analytical determination --- legalization --- natural products --- biosynthetic gene clusters --- secondary metabolites --- antiSMASH --- Mitragyna speciosa --- kratom --- secondary metabolites --- therapeutic uses --- toxicology --- analysis --- Maytenus chiapensis --- Celastraceae --- quinonemethide triterpenoids --- pristimerin --- tingenone --- HPLC-PDA --- Ocimum sanctum --- Lamiaceae --- (-)-rabdosiin --- cytotoxic activity --- triterpenoids --- phenolic derivatives --- nanoemulsion --- essential oils --- vector control --- infectious diseases --- TCM --- phytochemistry --- LC-MS/MS --- antioxidant activity --- ABTS --- DPPH --- FRAP --- ascorbic acid --- EGCG --- total phenolics --- antimicrobial activity --- sargaquinoic acid --- sarganaphthoquinoic acid --- antiplasmodial --- malaria --- PPAR-? --- sargahydroquinoic acid --- sarganaphthoquinoic acid --- sargachromenoic acid --- inflammation --- bowel diseases --- secondary metabolites --- biological activities --- medicinal applications --- plants --- seaweeds

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