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Modeling Disease Spread and Control

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453849 Year: Pages: 133 DOI: 10.3389/978-2-88945-384-9 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Animal Sciences
Added to DOAB on : 2018-11-16 17:17:57
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Mathematical models are useful tools to understand the epidemiology and agent-host interaction of diseases. They are developed and applied since over a century, but with increasing computer capacity, they become increasingly prominent as part of evidence based decision making. Mathematical models are frequently used to construct preparedness and contingency plans for highly contagious diseases such as foot-and-mouth disease. This allows proposing effective strategies to control the spread of the disease in case of an incursion, and avails useful tools to support decision making during an outbreak. They are also used to monitor, prevent and control endemic diseases within populations or farms. In addition, mathematical models improve our understanding of the contact structure between farms, pointing out risky elements in the contact network for disease introduction or further spread within the population. This Research Topic presents valuable studies presenting different aspects and implementations of mathematical modeling for disease spread and control in the veterinary field. The areas covered include model construction, network analysis, tools for decision makers, and cost-effective control of endemic diseases.

Process Modelling and Simulation

Authors: --- ---
ISBN: 9783039214556 9783039214563 Year: Pages: 298 DOI: 10.3390/books978-3-03921-456-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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Since process models are nowadays ubiquitous in many applications, the challenges and alternatives related to their development, validation, and efficient use have become more apparent. In addition, the massive amounts of both offline and online data available today open the door for new applications and solutions. However, transforming data into useful models and information in the context of the process industry or of bio-systems requires specific approaches and considerations such as new modelling methodologies incorporating the complex, stochastic, hybrid and distributed nature of many processes in particular. The same can be said about the tools and software environments used to describe, code, and solve such models for their further exploitation. Going well beyond mere simulation tools, these advanced tools offer a software suite built around the models, facilitating tasks such as experiment design, parameter estimation, model initialization, validation, analysis, size reduction, discretization, optimization, distributed computation, co-simulation, etc. This Special Issue collects novel developments in these topics in order to address the challenges brought by the use of models in their different facets, and to reflect state of the art developments in methods, tools and industrial applications.

Keywords

process model validation --- partial least square regression --- phytochemicals --- natural extracts --- wheat germ --- fluidized bed drying --- mathematical model --- moisture content --- condensation --- simulation --- Pharmaceutical Processes --- Mammalian Cell Culture --- sensitivity analysis --- parameter estimation --- Design of Experiments --- algebraic modeling language --- dynamic optimization --- model predictive control --- moving horizon estimation --- fluid bed granulation --- heat and mass balance --- population balance model --- binder dissolution --- kernel development --- robust optimization --- uncertainty --- point estimation method --- equality constraints --- parameter correlation --- barley --- simulation --- hydration --- swelling --- cooking --- porridge --- extents --- graph theory --- model identification --- observability --- optimal clustering --- parameter estimation --- state decoupling --- data-mining --- machine learning --- neural networks --- chemistry --- materials --- engineering --- energy --- grey-box model --- machine learning --- SOS programming --- process modeling --- scrap dissolution --- scrap melting --- thermodynamics --- kinetics --- dynamic converter modelling --- Combined Heat and Power --- gray-box model --- utility management --- CHP legislation --- optimization --- polyacrylonitrile-based carbon fiber --- coagulation bath --- dry-jet wet spinning process --- computational fluid dynamics --- wave resonance --- maximum wave amplitude --- reactor coolant pump --- vane --- costing stopping --- mathematical model --- idling test --- n/a

Dynamical Models of Biology and Medicine

Authors: --- --- ---
ISBN: 9783039212170 9783039212187 Year: Pages: 294 DOI: 10.3390/books978-3-03921-218-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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Mathematical and computational modeling approaches in biological and medical research are experiencing rapid growth globally. This Special Issue Book intends to scratch the surface of this exciting phenomenon. The subject areas covered involve general mathematical methods and their applications in biology and medicine, with an emphasis on work related to mathematical and computational modeling of the complex dynamics observed in biological and medical research. Fourteen rigorously reviewed papers were included in this Special Issue. These papers cover several timely topics relating to classical population biology, fundamental biology, and modern medicine. While the authors of these papers dealt with very different modeling questions, they were all motivated by specific applications in biology and medicine and employed innovative mathematical and computational methods to study the complex dynamics of their models. We hope that these papers detail case studies that will inspire many additional mathematical modeling efforts in biology and medicine

Keywords

hemodynamic model --- microcirculation load --- liquid-solid-porous media seepage coupling --- 2-combination --- graphical representation --- cell-based vector --- numerical characterization --- phylogenetic analysis --- intraguild predation --- random perturbations --- persistence --- stationary distribution --- global asymptotic stability --- quorum sensing --- chemostat --- mathematical model --- differential equations --- delay --- bifurcations --- dynamical system --- numerical simulation --- predator-prey model --- switched harvest --- limit cycle --- rich dynamics --- algae growth models --- uncertainty quantification --- asymptotic theory --- bootstrapping --- model comparison tests --- Raphidocelis subcapitata --- Daphnia magna --- spotting --- wildfire --- transport equations --- spotting distribution --- obesity --- mechano-electrochemical model --- articular cartilage --- cartilage degeneration --- cartilage loading --- optimal control --- hepatitis B --- delay differential equations (DDE) --- immune response --- drug therapy --- dynamic model --- flocculation --- global stability --- uniform persistence --- epidermis --- mathematical model --- bacterial inflammation --- bacterial competition --- chronic myeloid leukemia --- tyrosine kinase inhibitors --- immunomodulatory therapies --- combination therapy --- equilibrium points --- mathematical modeling --- prostate cancer --- androgen deprivation therapy --- data fitting --- generalized pseudo amino acid composition --- numerical characterization --- phylogenetic analysis --- identification of DNA-binding proteins --- n/a

Ultrasonic Cavitation Treatment of Metallic Alloys

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ISBN: 9783039281961 9783039281978 Year: Pages: 110 DOI: 10.3390/books978-3-03928-197-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-04-07 23:07:08
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This Special Issue scrutinizes the use of ultrasonic-cavitation melt treatment in technology of high-quality metallic alloys with improved mechanical properties, and assesses the driving mechanisms of cavitation-induced effects, such as grain refinement, degassing, wetting, and particle distribution. In this context, the research published in this Special Issue considers the interaction between the cavitation field and acoustic streaming with the melt flow and the suspended solid/liquid phases, the characterization and mapping of cavitation activity in a melt volume, and the possibility of achieving high efficiency in processing large melt volumes through technological approaches for the commercial implementation of ultrasonic processing technology.

Advances in Water Distribution Networks

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ISBN: 9783038975564 Year: Pages: 174 DOI: 10.3390/books978-3-03897-557-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Environmental Engineering
Added to DOAB on : 2019-03-08 11:42:05
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The Special Issue on Advances in Water Distribution Networks (WDNs) explores four important topics of research in the framework of WDNs, namely simulation and optimization modelling, topology and partitioning, water quality, and service effectiveness. With regard to the first topic, the following aspects are addressed: pressure-driven formulations, algorithms for the optimal location of control valves to minimize leakage, the benefits of water discharge prediction for the remote real time control of valves, and transients generated by pumps operating as turbines. In the context of the second topic, a topological taxonomy of WDNs is presented, and partitioning methods for the creation of district metered areas are compared. In relation to the third topic, the vulnerability to trihalomethane is assessed, and a statistical optimization model to minimize heavy metal releases is presented. Finally, the fourth topic focusses on the estimation of non-revenue water, including leakage and unauthorized consumption, and on the assessment of service under intermittent supply conditions.

Cell-Free Synthetic Biology

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ISBN: 9783039280223 9783039280230 Year: Pages: 152 DOI: 10.3390/books978-3-03928-023-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering --- Technology (General)
Added to DOAB on : 2020-01-30 16:39:46
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Cell-free synthetic biology is in the spotlight as a powerful and rapid approach to characterize and engineer natural biological systems. The open nature of cell-free platforms brings an unprecedented level of control and freedom for design compared to in vivo systems. This versatile engineering toolkit is used for debugging biological networks, constructing artificial cells, screening protein library, prototyping genetic circuits, developing new drugs, producing metabolites, and synthesizing complex proteins including therapeutic proteins, toxic proteins, and novel proteins containing non-standard (unnatural) amino acids. The book consists of a series of reviews, protocols, benchmarks, and research articles describing the current development and applications of cell-free synthetic biology in diverse areas.

Advances in Mechanical Systems Dynamics

Authors: --- ---
ISBN: 9783039281886 9783039281893 Year: Pages: 236 DOI: 10.3390/books978-3-03928-189-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Mechanical Engineering --- General and Civil Engineering --- Technology (General)
Added to DOAB on : 2020-04-07 23:07:08
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Modern dynamics was established many centuries ago by Galileo and Newton before the beginning of the industrial era. Presently, we are in the presence of the fourth industrial revolution, and mechanical systems are increasingly being integrated with electronic, electrical, and fluidic systems. This trend is present not only in the industrial environment, which will soon be characterized by the cyber-physical systems of industry 4.0, but also in other environments like mobility, health and bio-engineering, food and natural resources, safety, and sustainable living. In this context, purely mechanical systems with quasi-static behavior will become less common and the state-of-the-art will soon be represented by integrated mechanical systems, which need accurate dynamic models to predict their behavior. Therefore, mechanical system dynamics are going to play an increasingly central role. Significant research efforts are needed to improve the identification of the mechanical properties of systems in order to develop models that take non-linearity into account, and to develop efficient simulation tools. This Special Issue aims at disseminating the latest research achievements, findings, and ideas in mechanical systems dynamics, with particular emphasis on applications that are strongly integrated with other systems and require a multi-physical approach.

Biomedical Insights that Inform the Diagnosis of ME/CFS

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ISBN: 9783039283903 9783039283910 Year: Pages: 202 DOI: 10.3390/books978-3-03928-391-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2020-04-07 23:07:09
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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.

Keywords

myalgic encephalomyelitis --- chronic fatigue syndrome --- diagnosis --- symptoms --- muscles --- neurology --- myalgic encephalomyelitis --- chronic fatigue syndrome --- post-exertional malaise --- assessment --- patient-driven questionnaire --- participatory research --- myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) --- energy metabolism --- potential biomarkers --- fatigue syndrome --- chronic --- exercise --- hypoacetylation --- methylhistidine --- histone deacetylation --- myalgic encephalomyelitis --- chronic fatigue syndrome --- diagnostic biomarker --- inflammation and immunity --- metabolism --- mitochondria --- circadian rhythm --- neuro-inflammation --- myalgic encephalomyelitis --- chronic fatigue syndrome --- activin --- pathology --- biomarker --- cytokine --- machine learning --- reference intervals --- myalgic encephalomyelitis --- chronic fatigue syndrome --- ME/CFS --- diagnosis --- metabolism --- mitochondria --- inflammation --- immune system --- signaling --- gut microbiota --- tryptophan metabolism --- indoleamine-2,3-dioxygenase --- bistability --- kynurenine pathway --- substrate inhibition --- myalgic encephalomyelitis --- chronic fatigue syndrome --- mathematical model --- critical point --- immunological --- chronic fatigue syndrome --- myalgic encephalomyelitis --- biomarker --- neuroimmune --- Epstein Barr virus --- hypothalamic–pituitary–adrenal axis --- CFS (Chronic Fatigue Syndrome) --- ME (Myalgic Encephalomyelitis) --- medical retirement --- prognosis --- work rehabilitation --- n/a

Sediment Transport in Coastal Waters

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ISBN: 9783038978442 9783038978459 Year: Pages: 284 DOI: 10.3390/books978-3-03897-845-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Oceanography
Added to DOAB on : 2019-04-25 16:37:17
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The interface of 440,000 km long coastline in the world is subject to global change, with an increasing human pressure (land use, buildings, sand mining, dredging) and increasing population. Improving our knowledge on involved mechanisms and sediment transport processes, monitoring the evolution of sedimentary stocks and anticipating changes in littoral and coastal zones is essential for this purpose. The special issue of Water on &ldquo;Sediment transport in coastal waters&rdquo; gathers thirteen papers which introduce the current revolution in the scientific research related to coastal and littoral hydrosedimentary dynamics, and reflect the diversity of concerns on which research in coastal sediment transport is based, and current trends &mdash; topics and preferred methods &mdash; to address them.

Keywords

suspended sediment --- sediment transport --- coastal hydraulics --- Mekong --- river plume --- monsoon --- mathematical model --- geochemical map --- particle transfer process --- tidal current --- analysis of variance (ANOVA) --- Cluster analysis --- Mahalanobis’ generalized distances --- Seto Inland Sea --- East Coast Low --- nearshore processes --- coastal erosion --- coastal management --- climate change --- numerical modelling --- Southeast Australia --- soil erosion --- SWAT --- water scarcity --- sediment transport modelling --- Tafna catchment --- North Africa --- suspended sediment --- sediment transport --- lagoon --- geochemistry --- Ni mining --- sediment trap --- hydrodynamics --- New Caledonia --- dry season --- Senegal River delta --- Langue de Barbarie spit --- delta vulnerability --- river-mouth migration --- spit breaching --- ERA hindcast waves --- longshore sediment transport --- Vietnam --- South China Sea --- erosion --- recovery --- storminess --- winter monsoon --- typhoons --- shoreline --- waves forcing --- storms --- resilience --- post-storm recovery --- Bight of Benin --- seasonal cycle --- trend --- sand-mud mixture erosion --- numerical modelling --- non-cohesive to cohesive transition --- remote sensing reflectance --- turbidity --- seagrass beds --- bed shear stress --- fresh water runoff --- oceanic water intrusion --- suspended particulate matter --- aggregates --- flocculation --- biomass --- sediment --- turbidity --- remote-sensing --- MODerate Resolution Imaging Spectroradiometer (MODIS) --- Support Vector Regression (SVR) --- oligotrophic lagoon --- bathymetry --- reflectance --- seabed colour --- coral reef --- New Caledonia --- sediment transport --- cohesive sediments --- non cohesive sediments --- sand --- mud --- coastal erosion --- sedimentation --- morphodynamics --- suspended particulate matter --- bedload

Permanent Magnet Synchronous Machines

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ISBN: 9783039213504 9783039213511 Year: Pages: 282 DOI: 10.3390/books978-3-03921-351-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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Interest in permanent magnet synchronous machines (PMSMs) is continuously increasing worldwide, especially with the increased use of renewable energy and the electrification of transports. This book contains the successful submissions of fifteen papers to a Special Issue of Energies on the subject area of “Permanent Magnet Synchronous Machines”. The focus is on permanent magnet synchronous machines and the electrical systems they are connected to. The presented work represents a wide range of areas. Studies of control systems, both for permanent magnet synchronous machines and for brushless DC motors, are presented and experimentally verified. Design studies of generators for wind power, wave power and hydro power are presented. Finite element method simulations and analytical design methods are used. The presented studies represent several of the different research fields on permanent magnet machines and electric drives.

Keywords

PMSM (permanent magnet synchronous motor) --- DB-DTFC (deadbeat-direct torque and flux control) --- torque control --- stability --- permanent-magnet machine --- brushless machine --- Vernier machine --- flux switching machine --- multiphase machine --- outer rotor --- electric vehicle --- interior permanent magnet synchronous machines --- magnetic reluctance network --- brushless dc motor --- phase-advanced method --- winding inductance --- sub-fractional slot-concentrated winding --- field weakening --- periodic timer interrupt --- Brushless DC motors --- current ripples --- current spikes --- modeling --- back electromotive force --- R-C filter --- cogging torque --- permanent magnet synchronous generator --- small wind turbines --- finite element method --- renewable energy --- energy conversion --- finite element analysis --- pulse width modulation --- permanent magnet synchronous generator --- wind generator --- MPC --- PMSM --- vector control --- speed tracking --- brushless DC (BLDC) motor --- sensorless motor --- commutation error compensation --- free-wheeling period --- permanent magnet synchronous motor (PMSM) --- sliding mode observer (SMO) --- parameter perturbation --- predictive current control (PCC) --- digital simulation --- motor drives --- interior permanent-magnet machines --- finite-element analysis --- modeling --- automotive applications --- electric vehicle (EV) --- hybrid electric vehicle (HEV) --- mathematical model --- saturation --- coils --- design tools --- energy efficiency --- linear generator --- power control --- stator --- wave power --- permanent magnet synchronous generator --- electrical machine design --- permanent magnet material --- bulk electric system --- condition monitoring --- electrical signature analysis --- fault diagnosis --- predictive maintenance --- synchronous generator --- permanent magnet synchronous machine (PMSM) --- flying start --- sensorless control --- permanent magnet synchronous generator --- permanent magnet synchronous motor --- electric propulsion systems --- renewable energy --- energy conversion

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