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Engineering Synthetic Metabolons: From Metabolic Modelling to Rational Design of Biosynthetic Devices

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199211 Year: Pages: 130 DOI: 10.3389/978-2-88919-921-1 Language: English
Publisher: Frontiers Media SA
Subject: General and Civil Engineering --- Biotechnology
Added to DOAB on : 2016-01-19 14:05:46
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The discipline of Synthetic Biology has recently emerged at the interface of biology and engineering. The definition of Synthetic Biology has been dynamic over time ever since, which exemplifies that the field is rapidly moving and comprises a broad range of research areas. In the frame of this Research Topic, we focus on Synthetic Biology approaches that aim at rearranging biological parts/ entities in order to generate novel biochemical functions with inherent metabolic activity. This Research Topic encompasses Pathway Engineering in living systems as well as the in vitro assembly of biomolecules into nano- and microscale bioreactors. Both, the engineering of metabolic pathways in vivo, as well as the conceptualization of bioreactors in vitro, require rational design of assembled synthetic pathways and depend on careful selection of individual biological functions and their optimization. Mathematical modelling has proven to be a powerful tool in predicting metabolic flux in living and artificial systems, although modelling approaches have to cope with a limitation in experimentally verified, reliable input variables. This Research Topic puts special emphasis on the vital role of modelling approaches for Synthetic Biology, i.e. the predictive power of mathematical simulations for (i) the manipulation of existing pathways and (ii) the establishment of novel pathways in vivo as well as (iii) the translation of model predictions into the design of synthetic assemblies.

Wine Fermentation

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ISBN: 9783038976745 Year: Pages: 176 DOI: 10.3390/books978-3-03897-675-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biotechnology --- Technology (General)
Added to DOAB on : 2019-04-05 11:07:22
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This book is a printed edition of the Special Issue Wine Fermentation that was published in Fermentation

Methods in Computational Biology

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ISBN: 9783039211630 / 9783039211647 Year: Pages: 214 DOI: 10.3390/books978-3-03921-164-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Computer Science
Added to DOAB on : 2019-08-28 11:21:27
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Modern biology is rapidly becoming a study of large sets of data. Understanding these data sets is a major challenge for most life sciences, including the medical, environmental, and bioprocess fields. Computational biology approaches are essential for leveraging this ongoing revolution in omics data. A primary goal of this Special Issue, entitled “Methods in Computational Biology”, is the communication of computational biology methods, which can extract biological design principles from complex data sets, described in enough detail to permit the reproduction of the results. This issue integrates interdisciplinary researchers such as biologists, computer scientists, engineers, and mathematicians to advance biological systems analysis. The Special Issue contains the following sections:•Reviews of Computational Methods•Computational Analysis of Biological Dynamics: From Molecular to Cellular to Tissue/Consortia Levels•The Interface of Biotic and Abiotic Processes•Processing of Large Data Sets for Enhanced Analysis•Parameter Optimization and Measurement

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