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The discipline of Synthetic Biology has recently emerged at the interface of biology and engineering. The definition of Synthetic Biology has been dynamic over time ever since, which exemplifies that the field is rapidly moving and comprises a broad range of research areas. In the frame of this Research Topic, we focus on Synthetic Biology approaches that aim at rearranging biological parts/ entities in order to generate novel biochemical functions with inherent metabolic activity. This Research Topic encompasses Pathway Engineering in living systems as well as the in vitro assembly of biomolecules into nano- and microscale bioreactors. Both, the engineering of metabolic pathways in vivo, as well as the conceptualization of bioreactors in vitro, require rational design of assembled synthetic pathways and depend on careful selection of individual biological functions and their optimization. Mathematical modelling has proven to be a powerful tool in predicting metabolic flux in living and artificial systems, although modelling approaches have to cope with a limitation in experimentally verified, reliable input variables. This Research Topic puts special emphasis on the vital role of modelling approaches for Synthetic Biology, i.e. the predictive power of mathematical simulations for (i) the manipulation of existing pathways and (ii) the establishment of novel pathways in vivo as well as (iii) the translation of model predictions into the design of synthetic assemblies.
Metabolic Engineering --- Metabolic Modelling --- metabolite profiling --- Protein scaffolds --- Protein Engineering --- Interaction domains --- Starch biosynthesis --- Membrane Transport Proteins --- reconstitution --- molecular dynamics simulations
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The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.
senescence MCF7 --- MDA-MB-231 --- metabolomics --- isotope tracing analysis --- gas chromatography–mass spectrometry (GC–MS) --- Kidrolase --- Erwinaze --- asparaginase --- glutaminase --- pharmacodynamics --- targeted metabolomics --- bladder cancer --- cancer progression --- in vitro --- metabolomic signatures --- endometabolome --- GC-MS --- metabolic pathways --- NMR --- HR MAS --- breast cancer --- metabolomics --- acylcarnitines --- hepatocellular carcinoma --- metabolite profiling --- metabolomics --- metabolomics --- metabolism --- prostate cancer --- biomarker --- early diagnosis --- prognosis --- cancer --- mTOR --- vitamin E --- SLC1A5 --- tocotrienols --- apoptosis --- cell growth --- cell transporters --- essential amino acids --- ASCT2 --- glutaminolysis --- alanine --- glutathione --- glutamate --- lung --- bio actives --- nutraceuticals --- volatile organic compound --- lung cancer --- breath analysis --- in vitro study --- biomarker --- breast cancer --- omics --- analytical platforms --- chemometric methods
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The present Special Issue, “Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis”, aims to collect and to disseminate some of the most significant and recent contributions in the interdisciplinary area of innovative extraction procedures from complex matrices followed by validated analytical methods using hyphenated instrument configurations to support the optimization of the whole process and the scale-up possibility
branched-chain keto acids --- serum --- muscle --- HPLC-Q-TOF/MS --- wood --- odor --- volatile organic compounds --- gas chromatography-olfactometry --- Wuyi Rock tea --- quality --- UPLC-QTOF MS --- UPLC-QqQ MS --- metabolite profiling --- metabolomics --- cluster analysis --- cultivars --- Lycium ruthenicun --- flavonoid --- ruthenicunoid A --- SIRT1 --- Asphodeline lutea --- HPLC-PDA --- heavy metals --- tyrosinase --- diabetes --- neurodegenerative disease --- color analysis --- pigments --- MAE --- HPLC-PDA --- SFE --- Thymus algeriensis --- rare earth elements --- flow injection --- inductively coupled plasma-mass spectrometry --- seawater --- Hericium erinaceuns mycelium --- high-speed counter-current chromatography (HSCCC) --- genistein --- daidzein --- Fe3O4 --- modification --- alginate --- alkaloid --- ultrasound assisted extraction --- gelatin --- actinidin --- bovine hide --- physicochemical properties --- gel strength --- Semen Cuscutae --- ultra-high-performance liquid chromatography coupled to electrospray ionization mass spectrometry --- chlorogenic acids --- flavonoids --- steamed Panax notoginseng --- saponins --- extraction --- optimization --- antioxidant activity --- response surface methodology --- hematopoiesis --- microwave processing --- response surface methodology --- minor ginsenosides --- blood-enriching activity --- hemostatic activity --- ionic liquids --- sample preparation --- microextraction --- solid-phase microextraction --- dispersive liquid-liquid microextraction --- single-drop microextraction --- stir bar sorptive extraction --- stir cake sorptive extraction --- rosuvastatin --- metformin --- HILIC --- LC-MS --- therapeutic drug monitoring --- oolong tea --- Tieguanyin tea cultivar --- metabolite profiling --- UPLC-QTOF MS --- metabolomics --- Ajuga genevensis --- near-infrared spectroscopy --- dry extract --- fluid bed process --- microNIR --- in-line monitoring --- total polyphenolic content --- antioxidant --- flavonoids --- mouse melanoma B16 cells --- Panax notoginseng --- surfactant --- n/a --- ultra-high-performance liquid chromatography tandem mass spectrometry --- GHB --- GHB glucuronide --- nails --- endogenous values --- walnut septum --- polyphenols --- phytosterols --- HPLC-MS/MS --- Ultra-Turrax extraction --- biological activity --- antioxidant activity --- experimental design --- optimization --- phytochemicals
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This book is a printed edition of the Special Issue Wine Fermentation that was published in Fermentation
anthocyanins --- extraction --- red wine --- color --- ultrasound --- microwave --- wine --- temperature control --- sensor placement --- CFD --- end-user software --- wine clarification --- extraction --- pectinase --- glycosidase --- protease --- phenoloxidase --- color --- aroma --- non-Saccharomyces yeasts --- pioneering winemaking techniques --- peculiar yeasts --- volatile acidity --- fermented drinks --- cluster thinning --- yield manipulation --- vine balance --- crop load --- Pinot noir --- Central Coast of California --- reductive off-odors --- reappearance --- wine --- volatile sulfur compounds --- polythionates as precursors --- elemental sulfur --- Saccharomyces --- yeast hybrids --- yeast mixtures --- spontaneous fermentation --- stuck and sluggish fermentation --- winemaking --- partially dehydrated grapes --- appassimento --- yeast --- Saccharomyces bayanus --- sensory --- Ontario --- climate change adaptation --- winemaking --- metabolite profiling --- non-targeted analysis --- classical chemical analysis --- metabolic modelling --- yeast physiology and metabolism --- vineyard management --- anthocyanins --- tannins --- polymeric pigments --- wine color --- grape maturity --- microwave-assisted extraction --- Merlot --- extraction methods --- color intensity --- phenolic content --- Saccharomyces --- Lachancea --- yeast hybrids --- metabolomics --- sulfur compounds --- oenological enzymes --- process control
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In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse as algae, fungi, anthozoans, and echinoderms. Even fish of the genus Pardachirus produce glycosides, which they use as shark repellents.
sponge --- saponins --- deep-sea --- Poecillastra compressa --- Neothyonidium magnum --- triterpene glycosides --- magnumosides --- sea cucumber --- cytotoxic activity --- radioactive irradiation --- sea cucumber --- Eupentacta fraudatrix --- triterpene glycoside --- liquid chromatography–tandem mass spectrometry --- metabolite profiling --- holostane --- nonholostane --- cucumarioside --- cytotoxic --- antifungal --- glycosides --- Conus pulicarius --- steroidal glycoside --- cholesterol sulfate --- cytotoxicity --- leukemia --- cancer --- frondoside A --- tumor growth --- metastases --- apoptosis --- invasion --- angiogenesis --- Culcita novaeguineae --- starfish --- polyhydroxysteroidal glycoside --- cytotoxicity --- mangrove-derived Streptomyces --- angucycline --- urdamycin --- marine organisms --- carbohydrate --- glycoside --- antioxidant --- anticoagulant --- anti-inflammatory --- antitumor --- antimicrobial --- glycolipids --- glycosphingolipids --- glycoglycerolipids --- natural products --- total synthesis --- triterpene glycosides --- saponin --- sea cucumber --- mass spectrometry --- MALDI --- ESI --- LC-MS --- Holothuroidea --- marine ginseng --- structure elucidation --- marine invertebrate --- natural products --- bioactive compounds --- antifungal --- antibacterial --- antioxidant --- Streptomyces --- angucycline glycosides --- saquayamycin --- cytotoxicity --- apoptosis --- SMMC-7721
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Obesity and related co-morbidities are increasing worldwide and pose a serious health problem. Changes in lifestyle and diet would be the best remedies to fight obesity; however, many people will still rely on medical aid. Marine organisms have been prolific in the production of bioactive compounds for many diseases, e.g., cancer, and promise to be an excellent source for natural-derived molecules and novel nutraceuticals. Bioactive compounds with beneficial activities towards obesity have been described from diverse marine organism including marine algae, bacteria, sponges, fungi, crustaceans or fish. This Special Issue will highlight the progress in the following topics: Bioactive compounds for the treatment of obesity and obesity-related co-morbidities (diabetes, fatty liver, hyperlipidemia) from marine organisms; the isolation of novel compounds, the bioactivity screening of marine organisms and the elucidation of molecular mode of action of marine bioactive compounds.
3T3-L1 cells --- fucan --- lipolytic --- obesity --- brown seaweed --- chitosan oligosaccharide --- obesity --- leptin --- JAK2-STAT3 --- adipogenesis --- collagen peptide --- skate skin --- high fat diet --- fatty acid metabolism --- cholesterol metabolism --- chitosan oligosaccharide --- glucolipid metabolism disorder --- high-fat diet --- inflammation --- peroxisome proliferator-activated receptor gamma --- cellularity --- adipocyte --- obesity --- nutrition --- fat --- proliferation --- white adipose tissue --- adipogenesis --- antiobesity --- adipocytes --- diphlorethohydroxycarmalol (DPHC) --- Skate skin --- Raja kenojei --- collagen --- body fat --- obesity --- Ishige okamurae --- marine alga --- obesity --- diabetes --- nutraceuticals --- zebrafish Nile red fat metabolism assay --- anti-obesity drugs --- chlorophyll derivatives --- murine pre-adipocytes --- PPAR? --- Arthrospira maxima --- dyslipidemia --- physical exercise --- obesity --- double-blind --- randomized controlled trial --- anti-obesity drugs --- metabolite profiling --- zebrafish Nile red fat metabolism assay --- uncoupling protein 1 --- bioactivity screening --- diabetes --- fatty liver disease --- cyanobacteria --- thermal proteome profiling --- mechanisms of action --- bioactive compound --- label-free quantitative proteomics --- marine biodiscovery --- marine sponges --- natural compounds --- bisabolane-related compounds --- bioactivity --- obesity --- whole small animal models
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