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Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile

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ISBN: 9783039213153 / 9783039213160 Year: Pages: 204 DOI: 10.3390/books978-3-03921-316-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2019-12-09 11:49:15
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Abstract

For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (either alone or in combination therapy) have faced a number of clinical challenges resulting from their limited spectrum of activity, high toxicity leading to significant side effects, resistance, poor water solubility, low bioavailability and short circulating time. In the past 10 years, various unconventional non-platinum metal-based agents have emerged as a potential alternative for cancer treatment. These compounds are highly effective and selective in cancers resistant to cisplatin and other chemotherapeutic agents. Research in this area has recently exploded with a relevant number of patents and clinical trials, in addition to reports in scientific journals. Furthermore, in parallel to the synthesis of coordination and organometallic compounds comprising many different metals and unconventional platinum-based derivatives, researchers are focused on optimizing mechanistic and pharmacological features of promising drug candidates. This Special Issue aims to highlight the latest advances in anticancer metallodrugs with a focus on unconventional anticancer agents, as well as novel activation, targeting and delivery strategies aimed at improving their pharmacological profile.

The Close Linkage between Nutrition and Environment through Biodiversity and Sustainability: Local Foods, Traditional Recipes and Sustainable Diets

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ISBN: 9783039213832 / 9783039213849 Year: Pages: 216 DOI: 10.3390/books978-3-03921-384-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2019-12-09 11:49:16
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The Close Linkage between Nutrition and Environment through Biodiversity and Sustainability: Local Foods, Traditional Recipes, and Sustainable Diets” is focused on the close correlation between the potential benefits and “functional role” of food and territory, and it includes papers on the characterization of local foods and traditional recipes as well as on the promotion of traditional dietary patterns and sustainable diets.

Keywords

Italian garlic --- carbohydrates --- fructans --- dietary fibre --- soluble sugars --- cultivar --- environmental conditions --- agave sap --- actinomycetes --- anticancer activity --- saponins --- metabolomics --- ecosystem goods and services --- environmental sustainability --- livelihood needs --- Schinziophyton rautanenii --- Southern Africa --- sustainable development goals --- sustainable diets --- alkaloids --- antimicrobial activity --- germplasm --- Klebsiella --- landraces --- lupanine --- Pseudomonas --- varieties --- traditional food --- antimicrobial --- bioassay --- PIRG --- fractions --- consumer culture theory --- post millennials --- cheese --- loyalty --- Cyprus --- traditional food --- traditional sausages --- conventional sausages --- traditional hams --- conventional hams --- traditional meat products --- pork --- fatty acids --- mountain --- sustainability --- altitude --- food --- health --- FTIR-ATR --- traditional Italian recipes --- chemometrics --- PCA --- Olea europaea L. --- olive oil --- geographical origin --- processing system --- harvesting time --- olive oil quality --- fatty acid composition --- sensorial evaluation --- consumer preferences --- agro-ecology biodiversity --- climate resilience --- health --- local foods --- bioactive components --- traditional recipes --- traditional dietary patterns --- edible plants --- Mediterranean --- innovative gastronomy --- tetraploid wheat --- metallomics --- macronutrients --- micronutrients --- plants adaptability --- Provolone del Monaco --- traditional foods --- biodiversity --- sustainability --- nutritional composition --- bioactive components --- typical/local foods --- environmental and socio-demographic factors --- traditional recipes --- sustainable diets --- traditional dietary patterns --- Food Composition Databases

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MDPI - Multidisciplinary Digital Publishing Institute (2)


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eng (2)


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2019 (2)