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Recent Development of Electrospinning for Drug Delivery

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ISBN: 9783039281404 9783039281411 Year: Pages: 206 DOI: 10.3390/books978-3-03928-141-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-04-07 23:07:09
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Abstract

Several promising techniques have been developed to overcome the poor solubility and/or membrane permeability properties of new drug candidates, including different fiber formation methods. Electrospinning is one of the most commonly used spinning techniques for fiber formation, induced by the high voltage applied to the drug-loaded solution. With modifying the characteristics of the solution and the spinning parameters, the functionality-related properties of the formulated fibers can be finely tuned. The fiber properties (i.e., high specific surface area, porosity, and the possibility of controlling the crystalline–amorphous phase transitions of the loaded drugs) enable the improved rate and extent of solubility, causing a rapid onset of absorption. However, the enhanced molecular mobility of the amorphous drugs embedded into the fibers is also responsible for their physical–chemical instability. This Special Issue will address new developments in the area of electrospun nanofibers for drug delivery and wound healing applications, covering recent advantages and future directions in electrospun fiber formulations and scalability. Moreover, it serves to highlight and capture the contemporary progress in electrospinning techniques, with particular attention to the industrial feasibility of developing pharmaceutical dosage forms. All aspects of small molecule or biologics-loaded fibrous dosage forms, focusing on the processability, structures and functions, and stability issues, are included.

Keywords

electrospinning --- gentamicin sulfate --- polylactide-co-polycaprolactone --- drug release kinetics --- tissue engineering --- growth factor --- diabetic --- wound healing --- nanocomposite --- electrospinning --- coaxial spinning --- core-sheath nanofibers --- biomedical --- drug delivery --- electrospinning --- scale-up --- processability --- biopharmaceuticals --- oral dosage form --- grinding --- aceclofenac --- nanofiber --- electrospinning --- scanning electron microscopy --- fourier transform infrared spectroscopy --- differential scanning calorimetry --- nanotechnology --- biotechnology --- probiotics --- Lactobacillus --- Lactococcus --- electrospinning --- nanofibers --- drying --- local delivery --- viability --- antibacterial activity --- bacterial bioreporters --- drug release --- electrospinning --- microfibers --- nanofibers --- UV imaging --- wetting --- in situ drug release --- nanofibers --- electrospinning --- poorly water-soluble drug --- piroxicam --- hydroxypropyl methyl cellulose --- polydextrose --- scanning white light interferometry --- nanotechnology --- nanofibers --- traditional electrospinning --- ultrasound-enhanced electrospinning --- drug delivery system --- haemanthamine --- plant-origin alkaloid --- electrospinning --- amphiphilic nanofibers --- self-assembled liposomes --- physical solid-state properties --- drug release --- electrospinning --- PCL --- gelatin --- clove essential oil --- antibacterial --- biocompatibility --- artificial red blood cells --- electrospinning and electrospray --- pectin --- oligochitosan --- hydrogel --- microcapsules --- electrospinning --- wound dressings --- solvent casting --- 3D printing --- polymeric carrier --- n/a

Advances in Electrochemical Energy Materials

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ISBN: 9783039286423 / 9783039286430 Year: Pages: 156 DOI: 10.3390/books978-3-03928-643-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Physics (General)
Added to DOAB on : 2020-06-09 16:38:57
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Electrochemical energy storage is becoming essential for portable electronics, electrified transportation, integration of intermittent renewable energy into grids, and many other energy and power applications. The electrode materials and their structures, in addition to the electrolytes, play key roles in supporting a multitude of coupled physicochemical processes that include electronic, ionic, and diffusive transport in electrode and electrolyte phases, electrochemical reactions and material phase changes, as well as mechanical and thermal stresses, thus determining the storage energy density and power density, conversion efficiency, performance lifetime, and system cost and safety. Different material chemistries and multiscale porous structures are being investigated for high performance and low cost. The aim of this Special Issue is to report the recent advances in materials used in electrochemical energy storage that encompass supercapacitors and rechargeable batteries.

Polymeric Foams

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ISBN: 9783039216321 9783039216338 Year: Pages: 322 DOI: 10.3390/books978-3-03921-633-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Chemical Engineering
Added to DOAB on : 2019-12-09 11:49:16
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Advances in nanotechnology have boosted the development of more efficient materials, with emerging sectors (electronics, energy, aerospace, etc.) demanding novel materials to fulfill the complex technical requirements of their products. This is the case of polymeric foams, which may display good structural properties alongside functional characteristics through a complex composition and (micro)structure in which a gas phase is combined with rigid ones, mainly based on nanoparticles, dispersed throughout the polymer matrix. In recent years, there has been an important impulse in the development of nanocomposite foams, extending the concept of nanocomposites to the field of cellular materials. This, alongside developments in new advanced foaming technologies which have allowed the generation of foams with micro, sub-micro, and even nanocellular structures, has extended the applications of more traditional foams in terms of weight reduction, damping, and thermal and/or acoustic insulation to novel possibilities, such as electromagnetic interference (EMI) shielding. This Special Issue, which consists of a total of 22 articles, including one review article written by research groups of experts in the field, considers recent research on novel polymer-based foams in all their aspects: design, composition, processing and fabrication, microstructure, characterization and analysis, applications and service behavior, recycling and reuse, etc.

Keywords

grey relational analysis --- multi-objective particle swarm optimization --- acoustic performances --- Ethylene Propylene Diene Monomer --- polyurethane foam composites --- DOPO --- itaconic acid --- ethyl cellulose --- phenolic foams --- composites --- adjacent façade --- PUR --- energy conservation --- heat transfer --- burning characteristic --- semi-rigid polyurethane foams --- aluminum microfibers --- quasi-static compression tests --- mechanical properties --- energy absorption capability --- foams --- polyamide --- crystalline --- thermal conductivity --- mechanical property --- functional --- biomaterials --- composites --- EMI --- cellulose foam --- polypropylene --- foaming quality --- impact property --- intrinsic toughness --- flame-retardant ABS microcellular foams --- phosphorus flame retardants --- MuCell® injection-molding foaming --- graphene oxide --- rigid polyurethane foam --- thermogravimetric analysis --- activation energies --- extrusion foaming --- super critical CO2 --- lignin --- sound absorption coefficient --- mechanical property --- Pluronic --- surfactants --- foams --- SANS --- multilayers --- epoxy composite foam adhesive --- core–shell rubber --- impact wedge–peel test --- automobile structural adhesives --- flame retardancy --- foams --- phosphorus --- ternary synergistic effect --- polypropylene --- fluoelastomer --- scCO2 foaming --- heterogeneous nucleation --- polypropylene --- cellulose nanofiber --- foam injection molding --- mechanical properties --- polystyrene foams --- 1,3,5-benzene-trisamides --- cell nucleation --- foam extrusion --- foam morphology --- supramolecular additives --- thermal insulation --- compression properties --- piezoelectric --- functional foam --- piezocomposite --- PZT --- expandable microspheres --- permittivity --- polyetherimide foams --- graphene --- multifunctional foams --- ultrasonication --- scCO2 --- electrical conductivity --- polymer waste --- polyurethane foam --- leaching test --- microstructure --- absorbent PMI foam --- metallic tube --- electromagnetic wave absorption --- mechanical properties --- failure mechanism --- polymers --- foams --- shock compression --- equation of state --- epoxy --- foams --- expandable microspheres --- graphene --- nanotubes --- conductivity --- syntactic foams --- n/a

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english (2)

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2020 (2)

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