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Metabolomics in the Analysis of Inflammatory Diseases (Book chapter)

Book title: Metabolomics

Authors: --- --- --- --- et al.
ISBN: 9789535100461 Year: DOI: 10.5772/31814 Language: English
Publisher: IntechOpen Grant: Wellcome Trust - 089384
Subject: Biology
Added to DOAB on : 2019-01-17 11:47:01
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Most infections and traumatic injuries are cleared or repaired relatively rapidly and metabolic homoeostasis is soon restored. However, there is a broad range of inflammatory&#xD;diseases which involve chronic activation of the immune system and, as a result, chronic&#xD;persistent inflammation. We have been studying the metabolic consequences of chronic&#xD;inflammatory diseases with the aim of identifying metabolic fingerprints which may&#xD;provide clues about why the localised tissue disease persists.

Central Immune Senescence, Reversal Potentials (Book chapter)

Book title: Senescence

Authors: ---
ISBN: 9789535101444 Year: Language: English
Publisher: IntechOpen Grant: Wellcome Trust - 079415
Subject: Biology
Added to DOAB on : 2019-01-17 11:47:01
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Ageing is a complex process that affects all living organisms. Senescence is not only conceivable in multicellular organisms, but also in unicellulars. Unlike certain diseases that&#xD;have specific morbidity rates, ageing is a physiological process that affects all individuals&#xD;that live long enough (unaffected by i.e. predation or famine) to experience senescence.

A Master Regulator of Oxidative Stress - The Transcription Factor Nrf2

Authors: --- ---
ISBN: 9789535128373 9789535128380 Year: Pages: 210 DOI: 10.5772/62743 Language: English
Publisher: IntechOpen
Subject: Biology
Added to DOAB on : 2019-10-03 07:51:49

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Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways.

Chromosomal Abnormalities - A Hallmark Manifestation of Genomic Instability

Authors: ---
ISBN: 9789535134732 9789535134749 Year: Pages: 204 DOI: 10.5772/65142 Language: English
Publisher: IntechOpen
Subject: Genetics
Added to DOAB on : 2019-10-03 07:51:50

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This edited book, Chromosomal Abnormalities - A Hallmark Manifestation of Genomic Instability, contains a series of chapters highlighting several aspects related to the generation of chromosomal abnormalities in genetic material. We are extremely grateful to the authors who had contributed with valuable information about the role of genomic instability in pathological disorders as well as in the evolution process.

Molecular Docking

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ISBN: 9781789233544 9781789233551 Year: Pages: 188 DOI: 10.5772/intechopen.69830 Language: English
Publisher: IntechOpen
Subject: Biology
Added to DOAB on : 2019-10-03 07:51:51

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Molecular docking has always been and will be on the forefront of developments in the eminent field of drug design and medicinal chemistry. At the early days, drug discovery was based on blackboard drawings and expert intuition. However, as times move on, the amount of available information and overall knowledge base that needs to be analyzed cannot be processed manually. This, coupled by the rapid growth in computational infrastructure and processing power, has allowed for the efficient use of molecular docking tools and algorithms to be considered in the greater field of drug discovery. In the postgenomic era, molecular docking has become the key player for the screening of hundreds of thousands of compounds against a repertoire of pharmacological targets.

Free Radicals, Antioxidants and Diseases

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ISBN: 9781789235647 9781789235654 Year: Pages: 148 DOI: 10.5772/intechopen.70075 Language: English
Publisher: IntechOpen
Subject: Biology
Added to DOAB on : 2019-10-03 07:51:51

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The current book entitled Free Radicals, Antioxidants, and Diseases gives an idea of detecting free radicals in vivo by newer techniques and provides insights into the roles played by various antioxidants in combating diseases caused by oxidative stress. The chapters included in this volume showcase new investigation in this field by the research groups around the world.

Glutathione in Health and Disease

Authors: ---
ISBN: 9781789842753 9781789842760 Year: Pages: 92 DOI: 10.5772/intechopen.70965 Language: English
Publisher: IntechOpen
Subject: Biology
Added to DOAB on : 2019-10-03 07:51:52

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Reduced glutathione (GSH) is the most important thiol in living organisms. It is the key component of antioxidant system and serves as a free radical scavenger. There is a cycle of GSH in biological systems and this cycle provides higher intracellular levels of GSH. GSH depletion and apparent oxidative stress may cause toxicity and can affect the general well-being of the organism. GSH was shown to be preventive against aging, cancer, heart disease, infections and dementia. This book is mainly focused on GSH in health and disease. The readers will gain qualified scientific knowledge on the diverse functions of GSH, the importance of GSH status against oxidative stress and the interaction between GSH and nervous system-related infections from this book.

In Vivo and Ex Vivo Gene Therapy for Inherited and Non-Inherited Disorders

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ISBN: 9781789857177 9781789857184 Year: Pages: 198 DOI: 10.5772/intechopen.72962 Language: English
Publisher: IntechOpen
Subject: Genetics
Added to DOAB on : 2019-10-03 07:51:52

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Ongoing advances in pharmaceutical biotechnology have paved the way to ground-breaking new biological therapeutic modalities, offering the possibility of a durable curative approach for a number of life-threatening diseases, for which the medical need is as yet unmet. Over the past decades, gene therapy has seen a massive transformation from a proof-of-concept approach to a clinical reality culminating in the regulatory approval of state-of-the-art products in the European Union and in the United States. This book captures some of the scientific progresses notably in gene transfer technologies and translational development of in vivo and ex vivo gene therapy interventions in the treatment of a broad range of complex and debilitating non-inherited and inherited disorders such as: human immunodeficiency virus 1 (HIV-1) infection, cancer, cystic fibrosis, hereditary retinopathies, haemophilia B, cardiac diseases, and chronic liver fibrosis.

Biogenic Amines

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ISBN: 9781789841336 9781789841343 Year: Pages: 88 DOI: 10.5772/intechopen.75221 Language: English
Publisher: IntechOpen
Subject: Biology
Added to DOAB on : 2019-10-03 07:51:53

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Biogenic amines (BAs) are low-molecular-mass organic bases that occur in plant- and animal-derived products. BAs in food can occur by free amino acid enzymatic decarboxylation and other metabolic processes. Usually, in the human body, amines contained in foods are quickly detoxified by enzymes such as amine oxidases or by conjugation; however, in allergic individuals or if monoamine oxidase inhibitors are applied, the detoxification process is disturbed and BAs accumulate in the body. Knowing the concentration of BAs is essential because they can affect human health and also because they can be used as freshness indicators to estimate the degree of food spoilage.

Adenosine Triphosphate in Health and Disease

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Book Series: Physiology ISSN: 26318261 ISBN: 9781838802035 9781838802042 Year: Volume: 3 Pages: 84 DOI: 10.5772/intechopen.73455 Language: English
Publisher: IntechOpen
Subject: Biology
Added to DOAB on : 2019-10-03 07:51:53

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This book covers a very important research field; specifically, it tries to decrease the gap between theoretical and clinical research. The tendency of world research is to gain a detailed insight into the living organs of animals and humans. However, we must not lose sight of the problems that these organs can present; for example, we need to understand their molecular and biochemical mechanisms, as well as new drug productions to counteract diseases. Very deep mechanisms can offer new therapeutic pathways in hematology and oncology, among other fields. However, at least 8-l0 years of further clinical studies are necessary to make a final decision regarding the real clinical importance of basic research. Ideally, an interdisciplinary efforts among basic and clinical researchers are necessary in common research fields. At the same time, genetic research is increasing dramatically (e.g. enzyme mutations). The primary aim of this book is to demonstrate how such research can be used in both fields. This book gathers knowledge from experts in basic and clinical science, biochemistry, pharmacology, molecular pharmacology, genetics, and other fields.

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