Search results: Found 2

Listing 1 - 2 of 2
Sort by
Mechanisms Underpinning the Link between Emotion, Physical Health and Longevity

Author:
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452743 Year: Pages: 185 DOI: 10.3389/978-2-88945-274-3 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Public Health --- Science (General) --- Psychology
Added to DOAB on : 2018-02-27 16:16:44
License:

Loading...
Export citation

Choose an application

Abstract

The 1990’s was designated as ‘the decade of the brain’ and now, common mental disorders are described as ‘brain disorders’. Yet intense research interest on the brain has largely side-lined the body as a passive observer, disconnecting mental from physical health and contributing to further societal stigma on the nature of psychiatric illness and mental distress. The biopsychosocial pathway to premature mortality or longevity is a complex one, involving a host of closely intertwined mechanisms and moderating factors, some of which are investigated in this special issue. All the articles published here provide new insights into the pathways linking emotion, physical health and longevity, highlighting the tight linkage between mind, brain and body.

Mitochondrial Dysfunction in Aging and Diseases of Aging

Author:
ISBN: 9783039213276 9783039213283 Year: Pages: 270 DOI: 10.3390/books978-3-03921-328-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
License:

Loading...
Export citation

Choose an application

Abstract

This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process.

Keywords

aging --- mitochondria --- inflammation --- innate immunity --- adaptive immunity --- immunosenescence --- cell danger response --- healing cycle --- mitochondria --- purinergic signaling --- metabokines --- sphingolipids --- integrated cell stress response --- de-emergence --- crabtree effect --- pasteur effect --- coenzyme Q10 --- aging --- age-related diseases --- mitochondrial dysfunction --- mitochondria --- skin --- ageing --- reactive oxygen species --- photoageing --- 25(OH)D --- 1,25(OH)2D --- aging --- cytokines --- inflammation --- morbidity and mortality --- prevention --- reactive oxygen species --- ultraviolet --- aging --- mitochondria --- retina --- optic nerve --- diabetic retinopathy --- age-related macular degeneration --- glaucoma --- drug-induced mitochondrial toxicity --- polypharmacy --- aging --- mitochondrial dysfunction --- insulin resistance --- type 2 diabetes --- mitochondrial transfer --- exosomes --- mitochondrial --- genetic mutations --- cardiovascular disease --- heart failure --- cardiomyopathy --- mitochondria --- cancer --- nucleotide metabolism --- DNA damage --- NAD+ --- mitochondria --- ALS --- axonal transport --- mitophagy --- SOD1 --- Miro1 --- PINK1 --- Parkin --- multiple sclerosis --- mitochondria --- neuroinflammation --- neurodegeneration --- Parkinson’s disease --- mitochondria --- ageing --- neurodegenerative disease --- Alzheimer’s disease --- eIF2? --- metabolism --- mitochondria --- proteostasis --- stress response --- aging --- exercise --- mitochondria --- aerobic --- ROS --- inflammation --- senescence --- lysosome --- autophagy --- mitophagy --- n/a

Listing 1 - 2 of 2
Sort by
Narrow your search