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Biomedical Chemistry. Current Trends and Developments

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ISBN: 9783110468755 9783110468878 Year: Pages: 361 DOI: 10.1515/9783110468755 Language: English
Publisher: De Gruyter
Subject: Biochemistry --- Organic Chemistry
Added to DOAB on : 2017-01-18 19:08:48
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Biomedical Chemistry provides readers with an understanding of how fundamental chemical concepts are used to combat some diseases. The authors explain the interdisciplinary relationship of chemistry with biology, physics, pharmacy and medicine. The results of chemical research can be applied to understand chemical processes in cells and in the body, and new methods for drug transportation. Also, basic chemical ideas and determination of disease etiology are approached by developing techniques to ensure optimum interaction between drugs and human cells. This Book is an excellent resource for students and researchers in health-related fields with frontier topics in medicinal and pharmaceutical chemistry, organic chemistry and biochemistry.

Natural Products for Cancer Prevention and Therapy

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ISBN: 9783038973102 9783038973119 Year: Pages: 260 DOI: 10.3390/books978-3-03897-311-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Oncology --- Therapeutics
Added to DOAB on : 2018-11-07 10:17:54
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ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms.[This Special Issue book, “Natural Products for Cancer Prevention and Therapy”, is based on recent advances in natural products for cancer prevention and therapy. For this purpose, the authors of this book have been organizing a biennial international conference series. The first meeting (First International Conference on Natural Products for Cancer Prevention and Therapy) was held in Istanbul between 31 August and 2 September 2015, with the support and contribution of many valuable researchers in this field. The abstracts of the first conference were published in the Anticancer Drugs journal as a supplement. The second meeting, namely The Second International Conference on Natural Products for Cancer Prevention and Therapy, was held at Erciyes University, Kayseri, Turkey, between 8 and 11 November 2017. The abstracts of all of the presentations from the second meeting were published in the Special Issue of Proceedings by the MDPI publishing group. Furthermore, the conference report and the selected full-length papers based on the presentations at the meeting, as well as other papers based on natural products for cancer prevention and therapy, were published as a Special Issue of the Nutrients journal from MDPI. This Special Issue has contributions from various participants of the aforementioned conference, as well as other cancer and natural product researchers. These contributions include original research papers, authoritative and up-to-date reviews, and commentaries on the following topics and areas:•Natural products for the prevention and therapy of oncologic diseases•Mechanism of natural agents for anticancer and cancer preventive effects•In vitro, in vivo, and clinical studies related to natural agents and cancer•Combinatorial effects of phytochemicals and cancer chemotherapeutic drugs•Challenges and innovative approaches for anticancer drug development based on natural products•Emerging studies on anticancer phytochemicals]

Fungal Jewels: Secondary Metabolites

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889451364 Year: Pages: 203 DOI: 10.3389/978-2-88945-136-4 Language: English
Publisher: Frontiers Media SA
Subject: Microbiology --- Science (General)
Added to DOAB on : 2017-07-06 13:27:36
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Fungal natural products are friends and foes of humans such as deleterious mycotoxins, cytotoxic, carcinogenic compounds or beneficial compounds such as antibiotics, fungicides, insecticides, antiviral and antitumor metabolites. Understanding fungal diversity and estimation of fungal species on our planet poses a great challenge to researchers. This complexity is further multiplied by secondary metabolite diversity of fungi, which requires interdisciplinary studies. It is extremely important to understand the fungal secondary metabolism to stop human, animal and plant diseases caused by fungi and harvest their valuable metabolites. Furthermore, many secondary metabolite gene clusters are silenced under laboratory conditions. It is vital to develop effective methods to activate those clusters in order to discover novel potent metabolites. This e-book is a compilation of original review articles contributed by leading fungal secondary metabolite researchers with a wide range of expertise. Important aspects of fungal secondary metabolism, including regulation, genome mining, evolution, synthetic biology and novel methods have been discussed. This book will be a great source to those people, who are interested in understanding overall structure, diversity and regulation of production of these tiny but precious chemicals.

Harm and Benefit of Plant and Fungal Secondary Metabolites in Food Animal Production

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455065 Year: Pages: 100 DOI: 10.3389/978-2-88945-506-5 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Animal Sciences --- Nutrition and Food Sciences
Added to DOAB on : 2019-01-23 14:53:42
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Livestock species are either herbivores or omnivores that are maintained largely on plant-based diets. We have long appreciated the importance of understanding dietary plants from both nutritional and agronomic perspectives. However, it is increasingly clear that the fungi, bacteria and other microorganisms that live in the plants and animals are also significant factors in the ecology of agricultural animals. Many of the effects exerted on animals by dietary plants are attributable to secondary metabolites produced by the plants themselves or commensal microorganisms. Some fungal and plant secondary metabolites have multiple biological effects. We must be careful not to categorize a plant as strictly beneficial or harmful. Furthermore, we must be careful not to categorize even a particular plant or fungal compound as strictly beneficial or harmful. Rather, the harm or benefit of secondary metabolites are often dependent on the metabolic status of the animal, the interaction with other dietary factors including other secondary metabolites, and the dose received through the diet. This collection examines a range of agriculturally important plant and fungal products including essential oils, alkaloids, isoflavones and nitrates.

Marine Biomolecules

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196616 Year: Pages: 97 DOI: 10.3389/978-2-88919-661-6 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Chemistry (General) --- General and Civil Engineering --- Biotechnology
Added to DOAB on : 2016-08-16 10:34:25
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Oceans include the greatest extremes of pressure, temperature and light, and habitats can range from tropical waters to ocean trenches, several kilometers below sea level at high pressure. With its 70% of the surface of our planet marine ecosystem still remains largely unexplored, understudied and underexploited in comparison with terrestrial ecosystems, organisms and bioprocesses. The biological adaptation of marine organisms to a wide range of environmental conditions in the specific environment (temperature, salinity, tides, pressure, radiation, light, etc.) has made them an enormous reservoir of interesting biological material for both basic research and biotechnological improvements. As a consequence marine ecosystem is valued as a source of enzymes and other biomolecules exhibiting new functions and activities to fulfill human needs. Indeed, in recent years it has been recognised as an untapped source of novel enzymes and metabolites even though, with regard to the assignment of precise biological functions to genes, proteins and enzymes, it is still considered as the least developed. Using metagenomics to recover genetic material directly from environmental samples, this biogenetic diversification can be accessed but despite the contributions from metagenomic technologies the new field requires major improvements. A few words on the complexity of marine environments should be added here. This complexity ranges from symbiotic relationships to biology and chemistry of defence mechanisms and from chemoecology of marine invasions up to the strategies found in prokaryotes to adapt to extreme environments. The interdisciplinary study of this complexity will enable researchers to find an arsenal of enzymes and pathways greatly demanded in biotechnological applications. As far as marine enzymes are concerned they may carry novel chemical and stereochemical properties, thus biocatalytically oriented studies (testing of suitable substrates, appropriate checking of reaction conditions, study of stereochemical asset of catalysis) should be performed to appropriately reveal this “chemical biodiversity” which increases interest for these enzymes. Among other biomolecules, polysaccharides are the most abundant renewable biomaterial found on land and in oceans. Their molecular diversity is very interesting; except polysaccharides used traditionally in food and non-food industries, the structure and the functionality of most of them are unknown and unexplored. Brown seaweeds synthesize unique bioactive polysaccharides: laminarans, alginic acids and fucoidans. A wide range of biological activities (anticoagulant, antitumor, antiviral, anti-inflammation, etc.) have been attributed to fucoidans and their role with respect to structure-activity relationship is still under debate. In this Research Topic, we wish to centralize and review contributions, idea and comments related to the issues above. In particular results of enzymatic bioprospecting in gross marine environment will be acknowledged along with research for structural characterization and biological function of biomolecules such as marine polysaccharides and all kind of research related to the complexity of bioprocesses in marine environments. Inter- and multi-disciplinary approach to this field is favoured in this Research Topic and could greatly be facilitated by the web and open access nature as well.

The Molecular Aspect of Natural Secondary Metabolite Products in Health and Disease

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ISBN: 9783038971764 9783038971771 Year: Pages: 226 DOI: 10.3390/books978-3-03897-177-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Anthropology --- Social and Public Welfare --- Biology
Added to DOAB on : 2018-09-19 09:01:21
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ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms.[Natural secondary metabolite products, which are isolated from plants, animals, microorganisms, etc., are classified as polyketides, isoprenoids, steroids, aromatics, alkaloids, etc. Their chemical diversity and variety of biological activities have attracted the attention of chemists, biochemists, biologists, etc. This Special Issue on "The Molecular Aspect of Natural Secondary Metabolite Products in Health and Disease" is intended to offer biological active natural products as candidates and/or leads for pharmaceuticals, dietary supplements, functional foods, cosmetics, food additives, etc. The research fields of this Special Issue include natural products chemistry, phytochemistry, pharmacognosy, food chemistry, bioorganic synthetic chemistry, molecular pharmacology, molecular nutritional sciences, and other related research fields of bioactive natural secondary metabolite products. Original research and review articles on all topics in these research fields are invited. I look forward to receiving many submissions from outstanding expert on these research fields.

New Approaches for the Discovery of Pharmacologically-Active Natural Compounds

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ISBN: 9783039211043 / 9783039211050 Year: Pages: 158 DOI: 10.3390/books978-3-03921-105-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-08-28 11:21:27
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A major source of active compounds, natural products from different sources supply a large variety of molecules that have been approved for clinical use or used as the starting points of optimization programs. This book features nine papers (eight full articles and one review paper) written by more than 45 scientists from around the world. These papers illustrate the development and application of a broad range of computational and experimental techniques applied to natural product research. On behalf of the contributors to the book, our hope is that the research presented here contributes to advancements in the field, and encourages multidisciplinary teams, young scientists, and students to further advance in the discovery of pharmacologically-active natural compounds

Advances and New Perspectives in Marine Biotechnology

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ISBN: 9783038421061 9783038421092 Year: Volume: Volume 1 Pages: 428 DOI: 10.3390/books978-3-03842-109-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biotechnology
Added to DOAB on : 2015-10-22 10:01:02
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As the Century of Biology begins to bear fruit, through the translation of predictive biological understanding into applications that enhance the human condition and maintain biodiversity, the almost infinite potential of marine biological resources will be unlocked. Although Marine Biotechnology already has delivered products for medicine, food, bioenergy, nanomaterials, and bioremediation, less than 5% of our vast oceanic environment has been explored. Marine Biotechnology is a scientifically and economically expanding enterprise that is poised to harness the enormous but uncharted functional diversity of marine life, with its novel and rich array of biodesigns and biosynthetic capabilities. From this pursuit comes new genes, chemicals, materials, and inspirations for the benefit of industry, nutrition, and medicine, and which enable the sustainable use and management of the world’s oceans. This Special Issue in Marine Drugs highlights the cutting-edge developments in Marine Biotechnology with a collection of papers written by authors who are leading experts in the field, including selected papers from the 10th International Marine Biotechnology Conference (IMBC-2013), the premier meeting in marine biotechnology, which is held under the auspices of the International Marine Biotechnology Association.

Advances and New Perspectives in Marine Biotechnology

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ISBN: 9783038421078 9783038421108 Year: Volume: Volume 2 Pages: 654 DOI: 10.3390/books978-3-03842-110-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biotechnology
Added to DOAB on : 2015-10-22 10:04:44
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As the Century of Biology begins to bear fruit, through the translation of predictive biological understanding into applications that enhance the human condition and maintain biodiversity, the almost infinite potential of marine biological resources will be unlocked. Although Marine Biotechnology already has delivered products for medicine, food, bioenergy, nanomaterials, and bioremediation, less than 5% of our vast oceanic environment has been explored. Marine Biotechnology is a scientifically and economically expanding enterprise that is poised to harness the enormous but uncharted functional diversity of marine life, with its novel and rich array of biodesigns and biosynthetic capabilities. From this pursuit comes new genes, chemicals, materials, and inspirations for the benefit of industry, nutrition, and medicine, and which enable the sustainable use and management of the world’s oceans. This Special Issue in Marine Drugs highlights the cutting-edge developments in Marine Biotechnology with a collection of papers written by authors who are leading experts in the field, including selected papers from the 10th International Marine Biotechnology Conference (IMBC-2013), the premier meeting in marine biotechnology, which is held under the auspices of the International Marine Biotechnology Association.

Marine Glycosides

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ISBN: 9783038979029 9783038979036 Year: Pages: 264 DOI: 10.3390/books978-3-03897-903-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-05-09 17:16:14
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In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse as algae, fungi, anthozoans, and echinoderms. Even fish of the genus Pardachirus produce glycosides, which they use as shark repellents.The major interest in these compounds as potential drugs stems from their broad spectrum of biological effects. They have been shown to have antimicrobial, antifungal, anti-inflammatory, immune modulatory, and anticancer effects. The anticancer effects of marine glycosides include cell cycle suppression, the induction of apoptosis, and the inhibition of migration, invasion, and metastasis, as well as antiangiogenesis. Marine glycosides influence membrane permeability and have been shown to influence membrane transport at the molecular level through effects on transport carriers and pumps, as well as effects on ligand-gated and voltage-gated channels. Various marine glycosides have been shown to activate sphingomyelinase and ceramide synthesis, to inhibit topoisomerase activity, receptor tyrosine kinase activity, and multidrug resistance protein activity, and to antagonize eicosanoid receptors.This Special Issue covers the entire scope of marine organism-derived glycosides that are of potential value as pharmaceutical agents or leads. These include, but are not limited to, tetracyclic triterpene glycosides, other triterpene glycosides, steroid glycosides, and glycosides of non-isoprenoid aglycones.

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