Search results: Found 4

Listing 1 - 4 of 4
Sort by
Gene function in schistosomes: recent advances towards a cure

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195565 Year: Pages: 154 DOI: 10.3389/978-2-88919-556-5 Language: English
Publisher: Frontiers Media SA
Subject: Ecology --- Science (General) --- Genetics --- Microbiology
Added to DOAB on : 2016-01-19 14:05:46
License:

Loading...
Export citation

Choose an application

Abstract

Schistosomes are human parasites distributed worldwide in tropical and sub-tropical latitudes, especially in developing countries and impoverished regions. These neglected tropical disease (NTD) pathogens causes debilitating illnesses, which include hepatosplenomegaly, hepatic fibrosis, haemorrhagic necrotic ulcerations in the intestinal mucosa, urogenital tract diseases, in addition to cardiopulmonary, renal and neurologic lesions due to egg accumulation in the liver, intestines, uro-genital tissues and other sites. Urogenital schistosomiasis is a risk factor for bladder cancer and increases the risk of transmission of HIV infection. Despite extensive effort to control this NTD over the years, deployment on a considerable scale of commercially available drugs in endemic populations has induced the emergence of resistant isolates and raised the need to identify new targets for alternative therapies. Because of the availability of genomes of the three major species of human schistosomiasis, and through advances in functional genomics and live imaging, studies on schistosomes have now come into focus as models to investigate adaptations to parasitism and developmental biology of trematodes and cestodes, and indeed flatworms and Lophotrochozoans, at large. This Research Topic aims at gathering state-of-art essays on schistosome genetics, genetics, pathobiology and immunobiology. It also aims to highlight advances in understanding of the host-parasite relationship, in paradigms that address this NTD, and to discuss new perspectives and advances in chemotherapy and immunoprophylaxis.

Skin-Related Neglected Tropical Diseases (Skin-NTDs)—A New Challenge

Authors: ---
ISBN: 9783039212538 / 9783039212545 Year: Pages: 218 DOI: 10.3390/books978-3-03921-254-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2019-08-28 11:21:27
License:

Loading...
Export citation

Choose an application

Abstract

This Special Issue explores the range of clinical manifestations and epidemiology of both skin NTDs and common skin disease in endemic regions, the use of common diagnostic and management pathways, the different technologies that play a role in diagnosis and training, the role of patient involvement at a community level, as well as the assessment of the results of different initiatives in the field.

Keywords

Mycobacterium ulcerans --- animal reservoir --- transmission --- scabies --- Cushing syndrome --- iatrogenic --- topical corticosteroids --- teledermatology --- eHealth --- mHealth --- long range diagnosis --- dermatology --- telepathology --- technology --- skin disease --- podoconiosis --- lymphedema --- neglected tropical diseases --- NTDs --- mental health --- community engagement --- patient involvement --- stigma --- teledermatology --- Africa --- primary health care --- skin diseases --- tele-expertise --- yaws --- Treponema pallidum --- onchodermatitis --- onchocercal skin disease --- onchocerciasis --- ivermectin --- mycetoma --- clinical presentation --- review --- scabies --- neglected tropical diseases --- impetigo --- mass drug administration --- ivermectin --- integration --- neglected tropical diseases --- disease mapping --- mass drug administration --- morbidity management --- skin diseases --- mobile phone application --- NTDs --- dermatology --- mHealth --- leprosy --- leprosy --- leprosy diagnosis --- PCR --- slit skin smears --- point of care test --- skin biopsy --- early diagnosis --- scabies --- outbreak --- drought --- emergency state --- scabies --- diagnosis --- digital handheld microscope --- resource-poor setting --- Amerindian communities --- Amazon lowland --- case management --- integration --- mass drug administration --- neglected tropical diseases --- skin infections --- skin NTDs --- surveillance --- training --- tropical skin diseases --- n/a --- Mite-Gallery Unit (MGU) --- Entodermoscopy (EDS) --- Dry Dermatoscopy (d-DS) --- Wet Dermatoscopy (w-DS) --- Enhanced Dermatoscopy (e-DS) --- subcutaneous mycosis --- actinomycetoma --- eumycetoma --- sporotrichosis Community dermatology

Neglected and Emerging Tropical Diseases in South and Southeast Asia and Northern Australia

Authors: --- --- ---
ISBN: 9783038970897 9783038970903 Year: Pages: VIII, 154 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Internal medicine
Added to DOAB on : 2018-08-15 11:15:00
License:

Loading...
Export citation

Choose an application

Abstract

This Special Issue focuses on recent research on the important emerging and neglected tropical diseases (NTDs) in South and South East Asia and Northern Australia. This region stretches from Afghanistan in the west to Papua New Guinea in the east, and includes the Indian subcontinent, mainland South-East Asia (Indo China), maritime South East Asia, and the tropical regions of Australia. Many of these areas are highly endemic for important NTDs and emerging infectious diseases including lymphatic filariasis, leprosy, soil-transmitted helminthiases (hookworm, Trichuris, Ascaris, and Strongyloides), food-borne trematodiases, schistosomiasis, dengue/chikungunya/zika, leptospirosis, meloidosis, scabies, trachoma, and yaws. Several of these diseases are targeted for elimination or enhanced control by the World Health Organization in the next 5 to 10 years, although some have chronic lasting sequelae needing lifelong management. Control methods used include preventive chemotherapy, enhanced screening and treatment, intensified disease management, vector control, interruption of human to animal transmission, environmental/sanitation improvements and disability prevention/mitigation.

Prospects for Schistosomiasis Elimination

Authors: ---
ISBN: 9783039213573 / 9783039213580 Year: Pages: 308 DOI: 10.3390/books978-3-03921-358-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2019-12-09 11:49:15
License:

Loading...
Export citation

Choose an application

Abstract

Current efforts to limit the ravages of schistosomiasis are pushing the world closer to eliminating a chronic infection that has been associated with human life in the tropics since time immemorial. This notwithstanding, the disease remains a scourge for large populations in sub-Saharan Africa, Latin America, and Southeast Asia, and the main part of this book is made up by papers dealing with its current distribution, discussing ways and means to establish and implement improved control approaches. While chemotherapy limits the symptoms caused by schistosomiasis, the number of infected people will not decrease until the parasite's life cycle is interrupted. To that end, some papers focus on the intermediate snail host, which is notoriously difficult to control, while others discuss human hygiene and sanitation. The latter approach not only prevents infection through avoiding people being infected from the snail, but more importantly, also stops people infecting the snail by leaving contagious feces and urine in nature. With morbidity reduced by chemotherapy, the immediate target now is the interruption of transmission to be achieved by new tools, such as the novel chemotherapies, improved diagnostics (for humans, animals, and snails), and vaccines discussed in several of the papers. As made clear in this book, a complex infection requires new tools as well as work on many fronts, above all; however, a clear idea is needed as to how to skillfully combine the tools available and sustain implemented control activities.

Keywords

schistosomiasis --- Schistosoma --- vaccine --- zoonosis --- Asia --- Africa --- domestic animals --- buffalo --- cattle --- sheep --- goats --- Côte d’Ivoire --- coverage rate --- praziquantel --- preventive chemotherapy --- Schistosoma haematobium --- Schistosoma mansoni --- schistosomiasis --- diagnosis --- control and elimination --- DNA --- polymerase chain reaction --- schistosomiasis --- control --- elimination --- Africa --- operational research --- goals --- guidelines --- schistosomiasis --- vector control --- snail resistance --- gene drive --- transgenic snail --- schistosomiasis --- Kato-Katz --- POC-CCA --- young adults --- soil-transmitted helminths --- n/a --- Mayuge --- MDA coverage --- praziquantel --- S. mansoni --- systematic non-compliance --- treatment-opportunities --- Uganda --- climate change --- schistosomiasis --- distribution --- intermediate snail host --- transmission --- modelling --- schistosomiasis --- soil-transmitted-helminthiasis --- mapping --- preventive chemotherapy --- transmission control --- Gabon --- Central Africa --- schistosomiasis --- vaccine --- Sm14 --- FABP --- Schistosoma japonicum --- Oncomelania hupensis --- snail --- 28S ribosomal DNA --- PCR --- loop-mediated isothermal amplification (LAMP) --- pooled samples --- China --- schistosomiasis --- elimination --- praziquantel --- artemether --- combination therapy --- phylogeography --- Bulinus truncatus --- planorbidae --- Africa --- schistosomiasis --- neglected tropical diseases --- WIPO Re:Search --- BIO Ventures for Global Health --- cross-sector collaboration --- capacity-building --- drug discovery --- public-private partnerships --- GIS --- remote-sensing --- satellite --- international space station --- ECOSTRESS --- worldview --- spatio-temporal epidemiology --- climate change --- parasite --- schistosomiasis, leishmaniasis --- n/a --- schistosomiasis --- systems epidemiology --- systems thinking --- complexity --- neglected tropical diseases --- interdisciplinarity --- Schistosomiasis mansoni --- Caribbean --- elimination --- snail control --- Biomphalaria glabrata --- Schistosoma mekongi --- Neotricula aperta --- snail --- Cambodia --- Lao PDR --- elimination --- Asia --- control --- elimination --- epidemiology --- Schistosoma japonicum --- Schistosoma malayensis --- Schistosoma mekongi --- schistosomiasis --- Schistosomiasis --- Philippines --- schistosomiasis elimination --- S. japonicum zoonosis --- bovines --- schistosomiasis elimination --- snail control --- high-sensitivity diagnostics --- chemotherapy --- vaccine development --- health education --- sanitation

Listing 1 - 4 of 4
Sort by
Narrow your search