Search results:
Found 3
Listing 1 - 3 of 3 |
Sort by
|
Choose an application
While there is a tremendous literature on the topic of wine and health ranging back to the days of Hippocrates, it is considered that there is an unlimited variety of wine, allowing for the association of senses, nutrition, and hedonism. The history of vine and wine has lasted for at least 7000 years. Vitis represent adaptable plants, and thanks to the large variety of strains, wine is an alchemical mix with unique properties, a rich and original composition in terms of polyphenols, and well known antioxidants. This explains why wine and health are closely linked to nutrition.
grape pomace --- polyphenols --- hypertension --- metabolites characterization --- N2a murine neuronal cells --- neuronal differentiation --- neurotrophic effects --- polyphenols --- apigenin --- resveratrol --- wine --- vine --- diet --- health --- dementia --- cardiovascular disease --- hydroxytyrosol --- tyrosol --- resveratrol --- EVOO --- olive oil --- RW --- red wine --- Mediterranean diet --- wine --- Mediterranean diet --- Okinawa diet --- health --- nrf2 --- alcohol --- polyphenols --- hormesis --- cardiovascular protection --- cancer --- Alzheimer --- metabolic disease --- red wine --- polyphenols --- cancers --- colorectal --- resveratrol derivatives --- synthesis strategies --- substituents phenyl rings --- biological targets --- efficacy towards diseases --- allergy --- antioxidant --- wine flavonoids --- polyphenols --- antioxidant capacity --- electrochemical technology --- wine --- n/a
Choose an application
Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease.
E. coli infection --- sepsis --- liver steatosis --- hypertriglyceridemia --- Mkp-1 --- inflammation --- asthma --- COPD --- MAPK --- respiratory viruses --- influenza --- rhinovirus --- RSV --- neuroblastoma --- neuronal differentiation --- dual-specificity phosphatases --- MAP kinases --- MAP kinase phosphatases --- atypical dual-specificity phosphatases --- pseudophosphatase --- MK-STYX (MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein) --- HDAC6 (histone deacetylase isoform 6) --- post-translational modification --- microtubules --- DUSP10 --- MAPK --- inflammation --- cancer --- fungal MKPs --- MAPKs --- signaling --- Msg5 --- Sdp1 --- Pmp1 --- Cpp1 --- dual-specificity phosphatases --- MAP kinases --- nucleotide receptors --- P2X7 --- P2Y13 --- BDNF --- cannabinoids --- granule neurons --- astrocytes --- TLR signaling --- hematopoietic cells --- integrated omics analysis --- dual-specificity phosphatase --- mitogen-activated protein kinase --- ubiquitination --- protein stability --- MAPK phosphatase --- atypical DUSP --- macrophage --- T cell --- cytokines --- inflammation --- circulating tumor cells (CTCs) --- DEPArray --- dual-specificity phosphatase --- HER2 --- brain metastasis --- single cell analysis --- triple-negative breast cancer (TNBC) --- MAP Kinase Phosphatase-2 --- DUSP-4 --- macrophages --- proliferation --- differentiation --- n/a
Choose an application
Alzheimer’s disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer’s disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms, and various hypotheses will be examined in this Special Issue.
?-secretase --- amyloid beta --- calcium signaling --- drug target discovery --- endoplasmic reticulum --- inositol 1,4,5-trisphosphate receptor --- ion channel --- oxidative stress --- ryanodine receptor --- therapy --- amyloid-? oligomer --- protein aggregation --- A?O receptors --- Alzheimer’s disease --- neurodegeneration --- amyloid ? --- Alzheimer’s disease --- cognitive function --- dairy products --- dementia --- inflammation --- microglia --- Alzheimer’s disease --- yeast --- Tau --- amyloid ? --- ubiquitin --- aggregation --- oligomerization --- prion --- CDK5R1 --- lncRNAs --- Alzheimer’s disease --- miR-15/107 --- NEAT1 --- HOTAIR --- MALAT1 --- heat shock response --- heat shock protein --- Alzheimer’s disease --- beta amyloid --- yeast --- Alzheimer’s disease --- complement receptor 1 --- CR1 length polymorphism --- CR1 density --- complement C3b/C4b receptor --- complement --- dementia --- molecular biology --- neurosciences --- genetic risk --- Alzheimer’s disease --- brain glucose metabolism --- neuronal differentiation --- neuronal degeneration --- Prolyl isomerases --- Pin1 --- type 2 diabetes --- type 3 diabetes --- miR-34c --- dendritic spine --- Alzheimer’s disease --- Alzheimer’s disease --- positron emission tomography (PET) --- magnetic resonance imaging (MRI) --- Alzheimer’s disease --- cystathionine-?-lyase CTH gene --- DNA methylation --- epigenetics --- epigenome-wide association study --- methylome --- methylenetetrahydrofolate reductase MTHFR gene --- nutrition --- S-adenosylmethionine --- vitamin B complex --- Alzheimer’s disease --- sleep disturbance --- sleep fragmentation --- slow-wave sleep --- amyloid beta --- tau --- proteostasis --- default-mode network --- cognitive behavioral therapy for insomnia --- APOE gene --- apolipoprotein E --- DNA methylation --- mild cognitive impairment --- Hispanics
Listing 1 - 3 of 3 |
Sort by
|
2019 (3)