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Experimenting for Sustainable Transport

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Book Series: Transport, Development and Sustainability Series ISBN: 9780203994061 9780415271165 9780415271172 9781134488223 9781134488216 9781134488179 Year: DOI: 10.4324/9780203994061 Language: English
Publisher: Taylor & Francis
Subject: Agriculture (General) --- Architecture
Added to DOAB on : 2019-11-08 11:21:25
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Technological change is a central feature of modern societies and a powerful source for social change. There is an urgent task to direct these new technologies towards sustainability, but society lacks perspectives, instruments and policies to accomplish this. There is no blueprint for a sustainable future, and it is necessary to experiment with alternative paths that seem promising. Various new transport technologies promise to bring sustainability benefits. But as this book shows, important lessons are often overlooked because the experiments are not designed to challenge the basic assumptions about established patterns of transport choices. Learning how to organise the process of innovation implementation is essential if the maximum impact is to be achieved - it is here that strategic niche management offers new perspectives. The book uses a series of eight recent experiments with electric vehicles, carsharing schemes, bicycle pools and fleet management to illustrate the means by which technological change must be closely linked to social change if successful implementation is to take place. The basic divide between proponents of technological fixes and those in favour of behavioural change needs to be bridged, perhaps indicating a third way.

Keywords

niche --- development --- strategic --- management --- organized --- car --- sharing --- electric --- vehicles --- hybrid

Crosstalk between the osteogenic and neurogenic stem cell niches: how far are they from each other?

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197774 Year: Pages: 102 DOI: 10.3389/978-2-88919-777-4 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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Somatic stem cells reside in definite compartments, known as “niches”, within developed organs and tissues, being able to renew themselves, differentiate and ensure tissue maintenance and repair. In contrast with the original dogmatic distinction between renewing and non-renewing tissues, somatic stem cells have been found in almost every human organ, including brain and heart. The adult bone marrow, in particular, houses a complex multifunctional niche comprising hemopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), that intensely interact. HSCs represent the common precursors of all mature blood cells. MSCs are instead able to differentiate along multiple mesodermal lineages and are believed to represent the key somatic stem cell within the skeletogenic niche, being conceptually able to produce any tissue included within a mature skeletal segment (bone, cartilage, blood vessels, adipose tissue, and supporting connective stroma). Despite this high plasticity, the claim that MSCs could be capable of transdifferentiation along non-mesodermal lineages, including neurons, has been strongly argued. Adult osteogenic and neurogenic niches display wide differences: embryo origin, microenvironment, progenitors’ lifespan, lineages of supporting cells. Although similar pathways may be involved, it is hard to believe that the osteogenic and neurogenic lineages can share functional features. The outbreaking research achievements in the field of regenerative medicine, along with the pressing need for effective innovative tools for the treatment of neurodegeneration and neurologic disorders, have been forcing experimental clinical applications, which, despite their scientific weakness, have recently stimulated the public opinion. Based on this contemporary background, this Research Topic wish to provide an in-depth revision of the state of the art on relevant scientific milestones addressing the differences and possible interconnections and overlaps, between the osteogenic and the neurogenic niches. Dissertations on both basic research and clinical aspects, along with ethical and regulatory issues on the use of somatic stem cells for in vivo transplantation, have been covered.

The Vascular Niche in Tissue Repair: A Therapeutic Target for Regeneration

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889454105 Year: Pages: 174 DOI: 10.3389/978-2-88945-410-5 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology --- Biology --- Physiology
Added to DOAB on : 2018-11-16 17:17:57
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Tissues and organs have, although sometimes limited, the capacity for endogenous repair, which is aimed to re-establish integrity and homeostasis. Tissue repair involves pro- and anti-inflammatory processes, new tissue formation and remodelling. Depending on the local microenvironment, tissue repair results either in scar tissue formation or in regeneration. The latter aims to recapitulate the original tissue structure and architecture with the proper functionality. Although some organisms (such as planarians) have a high regenerative capacity throughout the body, in humans this property is more restricted to a few organs and tissues. Regeneration in the adult is possible in particular through the existence of tissue-resident pools of stem/progenitor cells. In response to tissue damage, these cells are activated, they proliferate and migrate, and differentiate into mature cells. Angiogenesis and neovascularization play a crucial role in tissue repair. Besides providing with oxygen and nutrients, angiogenesis generates a vascular niche (VN) consisting of different blood-derived elements and endothelial cells surrounded by basement membrane as well as perivascular cells. The newly generated VN communicates with the local stem/progenitor cells and contributes to tissue repair. For example, platelets, macrophages, neutrophils, perivascular cells and other VN components actively participate in the repair of skin, bone, muscle, tendon, brain, spinal cord, etc. Despite these observations, the exact role of the VN in tissue repair and the underlying mechanisms are still unclear and are awaiting further evidence that, indeed, will be required for the development of regenerative therapies for the treatment of traumatic injuries as well as degenerative diseases.

Chemical and Molecular Approach to Tumor Metastases

Authors: ---
ISBN: 9783038428954 9783038428961 Year: Pages: VIII, 256 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Oncology --- Biology
Added to DOAB on : 2018-07-05 12:45:05
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Dear Colleagues, Malignant tumors develop distant metastases, e.g., small clusters of cells that detach from the primitive site and colonize distant organs and tissues. Unlike the primary masses, metastases are often difficult to fully eradicate by surgery ablation and are almost always the primary object of chemo- and/or immune-therapies. The presence of metastases at tumor diagnosis is responsible for the unfavorable prognosis and of relapses even after initially successful tumor therapies. The lack of success of chemo- and immune-therapy approaches depends on many factors among which, the inadequate capacity of the anti-tumor drugs of reaching appropriate concentrations in the organs and tissues involved in the metastatic growth is a major concern. Another factor is the complexity of the metastasis biology and of their molecular behavior, evidencing a population of tumor cells with a genetic compartment different from that of the tumor of origin. The involvement of host cells and factors recruited by the metastatic cells and committed to support the metastatic growth is also an event crucial for the lack of success of the anti-tumor therapy. The knowledge of the molecular biology of metastases is mandatory to support the search for chemical agents to treat the metastatic determinants and to control of the neoplastic disease. This Special Issue on “Chemical and Molecular Approach to Tumor Metastases” will explore the impact of biology, molecular medicine and chemistry on all aspects related to tumor metastases from the biological and molecular aspects of the metastatic growth, including the relationships between the metastatic cells and the host environment, and the search for druggable determinants useful for the chemical analysis of agents selectively active against tumor metastases. With the combination of invited reviews and original papers from prominent scientists working on all aspects of molecular medicine and cancer therapy, such as, but not limited to: drug delivery, genomics, chemoprevention, drug discovery, we aim to sample recent progress in molecular and chemical aspects of therapy of malignant tumors. Clinical success studies and evidences of novel compounds are particularly welcome.

Postwachstumsgeographien

Authors: --- --- ---
Book Series: Sozial- und Kulturgeographie ISBN: 9783839451809 Year: Pages: 456 DOI: 10.14361/9783839451809 Language: German
Publisher: transcript Verlag Grant: Leibniz-Gemeinschaft - [grantnumber unknown]
Subject: Environmental Sciences
Added to DOAB on : 2020-08-04 23:59:50
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Discussing Borders, Escaping Traps

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ISBN: 9783830940456 Year: Pages: 230 DOI: https://doi.org/10.31244/9783830990451 Language: english
Publisher: Waxmann Verlag
Subject: Political Science
Added to DOAB on : 2020-10-29 14:04:58
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We live in strange times. Old borders are vanishing just before our astonished eyes, while new ones are rapidly emerging. Nearly three decades after the publication of Francis Fukuyama’s The End of History and the Last Man, the zeitgeist that predicted a bright future for mankind to a large extent turned out to be rather more of a dystopia. Crises in and outside Europe multiplied the number of border controls, triggered the construction of walls and fences and widened ideological gaps. The book Discussing Borders, Escaping Traps is a transdisciplinary and transspatial approach to investigating these vanishing, emerging and changing material and immaterial borders. It is the result of a two-year project by AreaS, a research group in area studies located at Østfold University College in Norway, and by partners of AreaS.

Religion, Welfare and Social Service Provision. Common Ground

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ISBN: 9783038977605 9783038977612 Year: Pages: 276 DOI: 10.3390/books978-3-03897-761-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Religion
Added to DOAB on : 2019-04-25 16:37:17
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Religion, Welfare, and Social Service Provision: Common Ground delves deeply into the partnerships forged between religious communities, government agencies and nonprofits to deliver social services to the needy. These pages offer a considered examination of how local faith entities have served those in their midst, and how the provision of those services has been impacted by evolving social policies. This foundational volume brings together the work of more than two dozen leading researchers, each providing long overdue scholarly inquiry into religiously affiliated helping and the many possibilities that it holds for effective cooperation.

Geoinformatics in Citizen Science

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ISBN: 9783039210725 9783039210732 Year: Pages: 206 DOI: 10.3390/books978-3-03921-073-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-08-28 11:21:27
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The book features contributions that report original research in the theoretical, technological, and social aspects of geoinformation methods, as applied to supporting citizen science. Specifically, the book focuses on the technological aspects of the field and their application toward the recruitment of volunteers and the collection, management, and analysis of geotagged information to support volunteer involvement in scientific projects. Internationally renowned research groups share research in three areas: First, the key methods of geoinformatics within citizen science initiatives to support scientists in discovering new knowledge in specific application domains or in performing relevant activities, such as reliable geodata filtering, management, analysis, synthesis, sharing, and visualization; second, the critical aspects of citizen science initiatives that call for emerging or novel approaches of geoinformatics to acquire and handle geoinformation; and third, novel geoinformatics research that could serve in support of citizen science.

Hardwood Reforestation and Restoration

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ISBN: 9783038977308 9783038977315 Year: Pages: 192 DOI: 10.3390/books978-3-03897-731-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Ecology
Added to DOAB on : 2019-08-28 11:21:28
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Hardwood-dominated temperate forests (mostly in Eastern North America, Europe, North East Asia) provide valuable renewable timber and numerous ecosystem services. Many of these forests have been subjected to harvesting or conversion to agriculture, sometimes over centuries, that have greatly reduced their former extent and diversity. Natural regeneration following harvesting or during post-agricultural succession has often failed to restore these forests adequately. Past harvesting practices and the valuable timber of some species have led to a reduction in their abundance. The loss of apex predators has caused herbivore populations to increase and exert intense browsing pressure on hardwood regeneration, often preventing it. Particularly important are fruit, nut and acorn bearing species, because of their vital role in forest food webs and biodiversity. Restoring hardwood species to natural forests in which they were formerly more abundant will require a number of forest management actions (e.g., resistant hybrids, deer exclosures/protectors, enrichment planting, underplanting, etc.). Similarly, reforesting areas that were once natural forests will also require new silvicultural knowledge. Global warming trends will intensify the need for interventions to maintain the diversity and function of temperate hardwood forests, as well as for increase hardwood reforestation.

The Interplay of Microbiome and Immune Response in Health and Diseases

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ISBN: 9783039216468 9783039216475 Year: Pages: 206 DOI: 10.3390/books978-3-03921-647-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2019-12-09 11:49:16
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[Increasing evidence suggests that microbiota and especially the gut microbiota (the microbes inhabiting the gut including bacteria, archaea, viruses, and fungi) plays a key role in human physiology and pathology. Recent findings indicate how dysbiosis—an imbalance in the composition and organization of microbial populations—could severely impact the development of different medical conditions (from metabolic to mood disorders), providing new insights into the comprehension of diverse diseases, such as IBD, obesity, asthma, autism, stroke, diabetes, and cancer. Given that microbial cells in the gut outnumber host cells, microbiota influences human physiology both functionally and structurally. Microbial metabolites bridge various—even distant—areas of the organism by way of the immune and hormone system. For instance, it is now clear that the mutual interaction between the gastrointestinal tract and the brain (gut–brain axis), often involves gut microbiota, indicating that the crosstalk between the organism and its microbial residents represents a fundamental aspect of both the establishment and maintenance of healthy conditions. Moreover, it is crucial to recognize that beyond the intestinal tract, microbiota populates other host organs and tissues (e.g., skin and oral mucosa). We have edited this eBook with the aim of publishing manuscripts focusing on the impact of microbiota in the development of different diseases and their associated treatments.]

Keywords

microbiota --- rheumatoid arthritis --- anti-TNF-? --- methotrexate --- etanercept --- disease activity --- microbiome --- health --- precision medicine --- genomics --- bacteriocins --- bacteriophages --- antibiotics --- gastrointestinal diseases --- dysbiosis --- gut barrier --- gut microbiota --- virus --- vaginal microbiota --- HIV --- HPV --- HSV2 --- cytokines --- chemokines --- innate immunity --- adaptive immunity --- microbiota --- autoimmunity --- etiopathogenesis --- Candida albicans --- 2,3-dihydroxy-4-methoxyBenzaldehyde --- melanin --- colitis --- anaerobic bacteria --- aerobic bacteria --- gut microbiota --- gut-liver axis --- chronic liver diseases --- fecal transplantation --- probiotics --- gut microbiota --- immunological niche --- dysbiosis --- cancer --- immune system --- cutaneous immunity --- microbiome --- Staphylococcus spp., T cells --- Staphylococcus aureus --- Staphylococcus epidermis --- commensals --- atopic dermatitis --- intravenous immunoglobulin G --- colitis --- dextran sulfate sodium --- mice --- inflammation --- cytokines --- Candida albicans --- Escherichia coli --- Enterococcus faecalis --- gut microbiota --- chemo free treatment --- lymphoid malignancies --- 16S rRNA gene --- chondroitin sulfate disaccharide --- co-occurrence network --- global network --- microbial interactions --- microbiome --- modularity --- superoxide dismutase --- gut microbiota --- macrophages --- TLR mimicry --- immune epigenetics --- metabolism --- sterile inflammation --- microbiota --- microbiome --- immunotherapy --- adoptive cell transfer (ACT) --- CAR T-cell --- TCR --- TIL --- checkpoint inhibitors --- immuno-oncology --- cancer --- diet --- n/a

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