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Emerging Zoonoses: Eco-Epidemiology, Involved Mechanisms and Public Health Implications

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196180 Year: Pages: 248 DOI: 10.3389/978-2-88919-618-0 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Public Health
Added to DOAB on : 2015-11-02 10:49:06
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Zoonoses are currently considered as one of the most important threats for public health worldwide. Zoonoses can be defined as any disease or infection that is naturally transmissible from vertebrate or invertebrate animals to humans and vice-versa. Approximately 75% of recently emerging infectious diseases affecting humans are diseases of animal origin; approximately 60% of all human pathogens are zoonotic. All types of potential pathogenic agents, including viruses, parasites, bacteria and fungi, can cause these zoonotic infections. From the wide range of potential vectors of zoonoses, insects are probably those of major significance due to their abundance, high plasticity and adaptability to different kinds of pathogens, high degrees of synanthropism in several groups and difficulties to apply effective programs of population control. Although ticks, flies, cockroaches, bugs and fleas are excellent insects capable to transmit viruses, parasites and bacteria, undoubtedly mosquitoes are the most important disease vectors. Mosquito borne diseases like malaria, dengue, equine encephalitis, West Nile, Mayaro or Chikungunya are zoonoses with increasing incidence in last years in tropical and temperate countries. Vertebrates can also transmit serious zoonoses, highlighting the role of some carnivorous animals in rabies dissemination or the spread of rodent borne diseases in several rural and urban areas. Moreover, the significance of other food borne zoonoses such as taeniasis, trichinellosis or toxoplasmosis may not been underestimated. According to WHO, FAO and OIE guidelines an emerging zoonotic disease can be defined as a zoonosis that is newly recognized or newly evolved, or that has occurred previously but shows an increase of incidence or expansion in geographical, host or vector range. There are many factors that can provoke or accelerate the emergence of zoonoses, such as environmental changes, habitat modifications, variations of human and animal demography, pathogens and vectors anomalous mobilization related with human practices and globalization, deterioration of the strategies of vector control or changes in pathogen genetics. To reduce public health risks from zoonoses is absolutely necessary to acquire an integrative perspective that includes the study of the complexity of interactions among humans, animals and environment in order to be able to fight against these issues of primary interest for human health. In any case, although zoonoses represent significant public health threats, many of them still remain as neglected diseases and consequently are not prioritized by some health international organisms.

Developments in Bovine Immunology - An Integrated View

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196326 Year: Pages: 112 DOI: 10.3389/978-2-88919-632-6 Language: English
Publisher: Frontiers Media SA
Subject: Allergy and Immunology --- Medicine (General)
Added to DOAB on : 2016-08-16 10:34:25
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The world’s population is predicted to hit 9 Billion by 2050, and with it food demand is predicted to increase substantially. The World Bank estimates that cereal and meat production needs to increase by 50% and 85% respectively between 2000 and 2030 to meet demand, putting serious pressure on the global agricultural industry. Critical to meeting this demand for food are mechanisms to reduce the incidence of animal disease. With in excess of 1.3 billion cattle globally, the total cost of infectious diseases is difficult to estimate. However in North America alone, the cost is predicted to be $18 billion annually. Non-infectious diseases also account for another major impediment to the production capacity and welfare of animals as well as the economic sustainability of farming. However animal diseases have implications that spread far beyond the farm gate. Infectious agents can also contaminate the food chain, and potentially affect human health. Controlling diseases, through better preventative and treatment methods requires a detailed understanding of the immune response in livestock species. Multiple studies have identified associations between variation in immune genes and disease susceptibility, which potentially opens up new avenues to select animals with superior disease resistance. Detailed understanding of immunity in cattle is leading to the design of more effective vaccines. Furthermore, appreciation of the significant differences between rodent and human immune responses has also led to bovine models being developed for some human diseases. The publication of the bovine genome and the advent of next-generation sequencing technologies have facilitated a massive expansion in our knowledge of the immune response in cattle. As a result there has been an explosion of exciting research findings including in metagenomics and epigenetics. Recently, there has been a welcome move to integrate our emerging understanding of the immune response with detailed studies of other important physiological processes including nutrition and reproduction. The interactions between the reproductive system, nutrition and the immune system are of particular interest, since each places significant demands on the animal at various stages through the production cycle. The interplay between these morphologically diffuse systems involves widely distributed chemical signals in response to environmental input, and each system must interact for the normal functioning of the other. A comprehensive “systems” approach is improving our understanding of normal physiological interactions between these systems and furthermore, how dysregulation can lead to disease. The successful translation of bovine immunological research into improved treatments for animal disease requires tight interaction between diverse scientific and clinical disciplines including immunology, microbiology, endocrinology, physiology, nutrition, reproduction and clinical veterinary medicine. With so much recent progress in the field, we believe that it is valuable and well-timed to review the broad variety of the relevant studies that attempt to increase our understanding through comprehensive collaboration between these disciplines. We are looking forward to a wide and vivid discussion of developments in bovine immunology and related issues, and we expect that our readers profoundly benefit from new exciting insights and fruitful collaborations.

Surveying Antimicrobial Resistance: Approaches, Issues, and Challenges to Overcome

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889451418 Year: Pages: 419 DOI: 10.3389/978-2-88945-141-8 Language: English
Publisher: Frontiers Media SA
Subject: Microbiology --- Science (General)
Added to DOAB on : 2017-07-06 13:27:36
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Why Antibiotic Resistance? The use of antibiotics in human and veterinary medicine may have consequences beyond their intended applications. The “One Health” concept recognizes that the health of humans is connected to the health of animals and the environment. Progress in molecular genetics is facilitating the rapid evaluation of the essentiality of these targets on a genomic scale. In 2015, a group of researchers established the International Conference on Antibiotic Resistance (IC2AR).The primary objective of this meeting is to bring together scientists involved in antibiotic resistance prevention and control. The IC2AR conducted its inaugural world congress in January 2015 at Caparica (Portugal). Antimicrobial resistance presents a significant challenge to scientists in the field of infectious diseases. The full knowledge of how antibiotics resistance is evolving and being transmitted between hosts in different ecosystems is taking on great importance. Necessary action includes research to define the scope of the problem including its various sources. This eBook comprises a series of original research and review articles dealing with the epidemiology of resistance in animal and zoonotic pathogens, mobile elements containing resistance genes, the omics of antimicrobial resistance, emerging antimicrobial resistance mechanisms, control of resistant infections, establishing antimicrobial use and resistance surveillance systems, and alternatives strategies to overcome the problem of antimicrobial resistance worldwide. Gilberto Igrejas, José Luis Capelo and Patrícia Poeta Scientific Committee of IC2AR, February 20th, 2017Why Antibiotic Resistance? The use of antibiotics in human and veterinary medicine may have consequences beyond their intended applications. The “One Health” concept recognizes that the health of humans is connected to the health of animals and the environment. Progress in molecular genetics is facilitating the rapid evaluation of the essentiality of these targets on a genomic scale. In 2015, a group of researchers established the International Conference on Antibiotic Resistance (IC2AR).The primary objective of this meeting is to bring together scientists involved in antibiotic resistance prevention and control. The IC2AR conducted its inaugural world congress in January 2015 at Caparica (Portugal). Antimicrobial resistance presents a significant challenge to scientists in the field of infectious diseases. The full knowledge of how antibiotics resistance is evolving and being transmitted between hosts in different ecosystems is taking on great importance. Necessary action includes research to define the scope of the problem including its various sources. This eBook comprises a series of original research and review articles dealing with the epidemiology of resistance in animal and zoonotic pathogens, mobile elements containing resistance genes, the omics of antimicrobial resistance, emerging antimicrobial resistance mechanisms, control of resistant infections, establishing antimicrobial use and resistance surveillance systems, and alternatives strategies to overcome the problem of antimicrobial resistance worldwide. Gilberto Igrejas, José Luis Capelo and Patrícia Poeta Scientific Committee of IC2AR, February 20th, 2017

Rabies Symptoms, Diagnosis, Prophylaxis and Treatment

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ISBN: 9783038426820 9783038426837 Year: Pages: 314 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2018-02-26 15:43:30
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Rabies is an acute, progressive, incurable viral encephalitis and one of the oldest described infectious diseases. All mammals are susceptible to infection, but rabid dogs are responsible for the greatest global burden. Bats and carnivores are the major wildlife reservoirs. More than 60,000 persons, primarily children, succumb each year after the bite from a rabid animal. This compilation describes new information on disease surveillance, diagnosis, prevention and control within Africa, Eurasia and the New World. Public health professionals, veterinarians, physicians, laboratory workers and conservation biologists should appreciate the novel communications provided from internationally renowned authors and the diversity of topics in this special issue on rabies.

Towards Elimination of Dog Mediated Human Rabies

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452996 Year: Pages: 148 DOI: 10.3389/978-2-88945-299-6 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Public Health --- Animal Sciences
Added to DOAB on : 2018-02-27 16:16:44
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Rabies is an ancient zoonotic viral disease that still exerts a high impact on human and animal health. The disease is almost 100% fatal after clinical signs appear, and it kills tens of thousands of people per year worldwide, particularly in Africa and many parts of Asia. Although the disease in humans can be prevented by timely post-exposure prophylaxis, its access and affordability is limited in rabies endemic countries. With 99% of infections in humans caused by rabid domestic dog bites, controlling the infection in this reservoir population has been proven to be most effective to reduce and eliminate human rabies cases. In this context, this Research Topic invited contributions on the control and elimination of dog mediated human rabies. Publications on epidemiological, educational, policy-related and economic aspects of dog and human rabies surveillance, implementation of control in dogs and humans and scientific documentation of success stories were consolidated. We hope that these articles contribute to reaching the ambitious goal, set by key players in global health, of the elimination of dog mediated human rabies by 2030.

Genetics of Acquired Antimicrobial Resistance in Animal and Zoonotic Pathogens

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453948 Year: Pages: 196 DOI: 10.3389/978-2-88945-394-8 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Microbiology
Added to DOAB on : 2018-11-16 17:17:57
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Development and spread of antimicrobial resistance is the result of an evolutionary process by which microorganisms adapt to antibiotics through several mechanisms including alteration of drug target by mutation and horizontal transfer of resistance genes. The concomitant occurrence of independent antimicrobial resistance mechanisms is a serious threat to human health and has appeared in several emerging epidemic clones over the past decade in humans and also in animals. The increasing prevalence of antimicrobial drug resistance among animal and zoonotic foodborne pathogens is of particular concern for public health. In this Ebook, we gathered a collection of articles which deal with the most important aspects of the genetics of acquired antimicrobial resistance extending from medically-important resistance, emerging epidemic resistant clones, main mobile genetic elements spreading resistance, resistomes, dissemination between animals and humans, to the “One Health” concept.

Veterinary Bacterial Zoonoses

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455928 Year: Pages: 97 DOI: 10.3389/978-2-88945-592-8 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Animal Sciences
Added to DOAB on : 2019-01-23 14:53:43
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Humans, animals and microorganisms all share the same planet, the last playing critical roles in the cycling of nitrogen and sulfur in nature and the degradation of organic materials. Unfortunately, micro-organismal populations also include infectious bacteria and viruses that cause diseases, with a few that have fatal consequences. We chose veterinary bacterial zoonoses as our Research Topic with the aim of delivering up-to-date scientific knowledge on the subject, addressing the topics of detection approaches, vaccine development and host immune response.Our Research Topic alludes to the One Health approach in addressing three important bacterial diseases, Brucella, Mycobacteria and Chlamydia. A short chapter also elaborates on a highly pathogenic field isolate of Mycobacterium avium spp. Avium and an atypical enteropathogenic Escherichia coli O98 as evolving zoonotic risks. The cover illustration is intended to raise our awareness of the fact that pets play a role in our life as passionate and compassionate friends, but that they also pose a health risk due to carrying a bacterial or a viral zoonotic agent. We hope our Research Topic will further the pursuit of these topics and spark research in other important diseases.

Educating the Global Workforce for Public Health

Authors: --- --- --- --- et al.
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889454471 Year: Pages: 87 DOI: 10.3389/978-2-88945-447-1 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Public Health
Added to DOAB on : 2018-11-16 17:17:57
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Good quality management of the health system demands a critical mass of health professionals with sound technical knowledge. The education that produces a workforce of appropriate size and skills is often a challenge in the delivery of quality health services. Incidentally, health professionals’ education has not kept pace with the new emerging challenges. Recent globalization of health has further led to international migration of health professionals, thereby leading to cross-border recognition of health workers with an appropriate skill-mix, knowledge, and competence. The Lancet Commission Report of 2010 highlighted the need to develop a common strategy at a global level for postgraduate medical, nursing, and public health education that reaches beyond the confines of national borders and the silos of individual professions. This vision would require a series of instructional and institutional reforms, which should be guided by two proposed outcomes: transformative learning and interdependence in education. The purpose of this Research Topic is to increase the shared understanding of the current status of the education of the health workforce around the globe, particularly those working in the public health sector. With this foundation, further research and evaluation studies can then be done with a perspective that addresses global workforce issues impacting access, prevention, and care.

Neglected and Emerging Tropical Diseases in South and Southeast Asia and Northern Australia

Authors: --- --- ---
ISBN: 9783038970897 9783038970903 Year: Pages: VIII, 154 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Internal medicine
Added to DOAB on : 2018-08-15 11:15:00
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This Special Issue focuses on recent research on the important emerging and neglected tropical diseases (NTDs) in South and South East Asia and Northern Australia. This region stretches from Afghanistan in the west to Papua New Guinea in the east, and includes the Indian subcontinent, mainland South-East Asia (Indo China), maritime South East Asia, and the tropical regions of Australia. Many of these areas are highly endemic for important NTDs and emerging infectious diseases including lymphatic filariasis, leprosy, soil-transmitted helminthiases (hookworm, Trichuris, Ascaris, and Strongyloides), food-borne trematodiases, schistosomiasis, dengue/chikungunya/zika, leptospirosis, meloidosis, scabies, trachoma, and yaws. Several of these diseases are targeted for elimination or enhanced control by the World Health Organization in the next 5 to 10 years, although some have chronic lasting sequelae needing lifelong management. Control methods used include preventive chemotherapy, enhanced screening and treatment, intensified disease management, vector control, interruption of human to animal transmission, environmental/sanitation improvements and disability prevention/mitigation.

Cadmium Sources and Toxicity

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ISBN: 9783038979845 / 9783038979852 Year: Pages: 130 DOI: 10.3390/books978-3-03897-985-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Public Health
Added to DOAB on : 2019-06-26 08:44:06
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Cadmium (Cd) is an environmental toxicant of continuing public health concern worldwide, because total diet studies have shown that Cd is present in virtually all foodstuffs. Consequently, foods that are frequently consumed in large quantities, such as rice, potatoes, wheat, leafy salad vegetables, and other cereal crops, are the most significant dietary Cd sources. Moreover, Cd has chemical propensities that confer the potential to interfere with the physiological functions of calcium and zinc. Evidence of a wide range of diverse, toxic effects of Cd is increasingly apparent. In this collection, environmental Cd exposure is linked to an increased risk of chronic kidney disease that is known to be a cause of morbidity and mortality worldwide. Cd is also implicated in an early onset of menarche and deaths from cancer, especially in the uterus, kidney, and urinary tract. Moreover, Cd-induced kidney injury is replicated in Sprague Dawley rats, as is Cd-induced periodontal disease. Experimental studies suggest that the development of kidneys in fetuses and the function of insulin-producing cells may be adversely affected by Cd and that metformin, an anti-diabetic drug, is ineffective in Cd-intoxicated Wistar rats.

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