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Biology of Cognitive Aging: Model Systems, Technologies and Beyond

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889451449 Year: Pages: 145 DOI: 10.3389/978-2-88945-144-9 Language: English
Publisher: Frontiers Media SA
Subject: Genetics --- Science (General)
Added to DOAB on : 2017-07-06 13:27:36
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Welcome! We, humans, tend to experience forgetfulness when we get old. The forgetfulness may become more serious memory impairment, dementia. Presumably, we have known it for a long time, but we still do not know the mechanism behind. A normal part of forgetfulness is called age-related memory impairment (AMI), which is considered the first step towards mild cognitive impairment (MCI; transition state) and dementia (disease state). The majority of dementia is attributable to Alzheimer’s disease (AD). Progression to dementia occurs at a high rate in patients with AMI. This eBook covers exciting but yet challenging field of cognitive aging. AMI is specific to neural tissues of the brain and is considered to be segmental aging. It happens not only to humans but also to a variety of species. Learning and memory are vulnerable to aging in a wide variety of model species, including worms, fruit flies, insects, snails, fishes, and rodents. Aging specifically reduces the ability to learn new information but leaves “old” memories and procedural memory intact. A comparative approach including the use of model systems seems to facilitate understanding of the molecular mechanisms that lead to AMI and AD. We advocate research on model systems. This eBook also provides the first manuscript co-authored with an AD patient to create a feedback loop from patients incorporated into research. We also included a manuscript on the semi-automated system that was inspired by such a feedback. Those may place a nice flavor to this exciting series of comparative research on cognitive aging. We hope you enjoy this eBook. Warm regards, Shin Murakami, Ph.D.Welcome! We, humans, tend to experience forgetfulness when we get old. The forgetfulness may become more serious memory impairment, dementia. Presumably, we have known it for a long time, but we still do not know the mechanism behind. A normal part of forgetfulness is called age-related memory impairment (AMI), which is considered the first step towards mild cognitive impairment (MCI; transition state) and dementia (disease state). The majority of dementia is attributable to Alzheimer’s disease (AD). Progression to dementia occurs at a high rate in patients with AMI. This eBook covers exciting but yet challenging field of cognitive aging. AMI is specific to neural tissues of the brain and is considered to be segmental aging. It happens not only to humans but also to a variety of species. Learning and memory are vulnerable to aging in a wide variety of model species, including worms, fruit flies, insects, snails, fishes, and rodents. Aging specifically reduces the ability to learn new information but leaves “old” memories and procedural memory intact. A comparative approach including the use of model systems seems to facilitate understanding of the molecular mechanisms that lead to AMI and AD. We advocate research on model systems. This eBook also provides the first manuscript co-authored with an AD patient to create a feedback loop from patients incorporated into research. We also included a manuscript on the semi-automated system that was inspired by such a feedback. Those may place a nice flavor to this exciting series of comparative research on cognitive aging. We hope you enjoy this eBook. Warm regards, Shin Murakami, Ph.D.

Die Zukunft der Vergangenheit in der Gegenwart

Authors: --- ---
ISBN: 9783205232322 Year: Pages: 285 Seiten Language: English|German
Publisher: Böhlau Grant: Austrian Science Fund - PUB 591
Added to DOAB on : 2019-08-02 11:21:12
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The volume contains 18 contributions to an international conference of archivists and historians dealing with the current situation of archives and archival science generally and specifically with the impact of digitization on archival core tasks and on the societal roles of archives.

Computer Science and Engineering Education for Pre-collegiate Students and Teachers

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ISBN: 9783038979401 9783038979418 Year: Pages: 142 DOI: 10.3390/books978-3-03897-941-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Education
Added to DOAB on : 2019-06-26 08:44:06
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Now more than ever, as a worldwide STEM community, we need to know what pre-collegiate teachers and students explore, learn, and implement in relation to computer science and engineering education. As computer science and engineering education are not always “stand-alone” courses in pre-collegiate schools, how are pre-collegiate teachers and students learning about these topics? How can these subjects be integrated? Explore six articles in this book that directly relate to the currently hot topics of computer science and engineering education as they tie into pre-collegiate science, technology, and mathematics realms. There is a systematic review article to set the stage of the problem. Following this overview are two teacher-focused articles on professional development in computer science and entrepreneurship venture training. The final three articles focus on varying levels of student work including pre-collegiate secondary students’ exploration of engineering design technology, future science teachers’ (collegiate students) perceptions of engineering, and pre-collegiate future engineers’ exploration of environmental radioactivity. All six articles speak to computer science and engineering education in pre-collegiate forums, but blend into the collegiate world for a look at what all audiences can bring to the conversation about these topics.

International Cooperation for Enhancing Nuclear Safety, Security, Safeguards and Non-proliferation

Authors: --- --- ---
Book Series: Springer Proceedings in Physics ISBN: 9783030429133 Year: Pages: 222 DOI: 10.1007/978-3-030-42913-3 Language: English
Publisher: Springer Nature
Subject: Mathematics --- Agriculture (General) --- Political Science --- Science (General)
Added to DOAB on : 2020-05-14 09:27:41
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This open access book examines key aspects of international cooperation to enhance nuclear safety, security, safeguards, and nonproliferation, thereby assisting in development and maintenance of the verification regime and fostering progress toward a nuclear weapon-free world. Current challenges are discussed and attempts made to identify possible solutions and future improvements, considering scientific developments that have the potential to increase the effectiveness of implementation of international regimes, particularly in critical areas, technology foresight, and the ongoing evaluation of current capabilities.

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