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Current Strategies for the Biochemical Diagnosis and Monitoring of Mitochondrial Disease

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ISBN: 9783038972402 9783038972419 Year: Pages: 238 DOI: 10.3390/books978-3-03897-241-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Public Health --- Therapeutics
Added to DOAB on : 2018-10-16 10:00:26
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Mitochondrial disease constitutes a complex and heterogeneous group of disorders resulting from a defect in mitochondrial respiratory chain (MRC) enzyme activity. In view of the dual regulation of the MRC, exercised by both the mitochondrial and nuclear genome, mutations in either mitochondrial or nuclear DNA can result in a MRC deficiency. Whilst a single organ can be affected, MRC disorders often result in a multi-organ system presentation with prominent neurological and myopathic features. The diagnosis of MRC disorders can be complex, and requires a coordinated interplay of a number of disciplines. However, biochemical determination of metabolites in blood, cerebral spinal fluid (CSF) and/or urine are generally considered to be first-line investigations for the diagnosis of these disorders, although they lack sensitivity and specificity. Furthermore, there is a lack of consensus on the overall utility of monitoring other biochemical parameters, which may be of diagnostic value. For example, although oxidative stress may contribute to the pathogenesis of mitochondrial disorders, few centers monitor this as part of their diagnostic repertoire. Therefore, the purpose of this Special Issue was to highlight potential biomarkers of mitochondrial disease and to discuss the appropriateness of biochemical markers to monitor disease progression and therapeutic intervention.

Arguments minimalistes : Une présentation du Programme Minimaliste de Noam Chomsky

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ISBN: 9782847887716 DOI: 10.4000/books.enseditions.5588 Language: French
Publisher: ENS Éditions
Subject: Languages and Literatures
Added to DOAB on : 2019-12-06 13:15:31
License: OpenEdition Licence for Books

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Arguments minimalistes est une présentation systématique et détaillée du Programme Minimaliste défini par Noam Chomsky il y a une vingtaine d’années et qui n’a cessé d’évoluer depuis. Le livre dresse un état des lieux de la théorie générative d’aujourd’hui, en prenant pour point de départ les textes de Chomsky lui-même. Le minimalisme inaugure une nouvelle façon de penser syntaxiquement et il vaut la peine d’examiner en détail les arguments que Chomsky invoque à l’appui de ce nouveau programme, qui met l’accent sur un ensemble de facteurs relativement ignorés dans les modèles précédents, mais qui doivent être, selon Chomsky, pris en compte prioritairement quand on cherche à construire une théorie du langage pleinement adéquate, allant au delà de l’adéquation explicative. Le fait que le langage soit en relation d’interface avec d’autres systèmes cognitifs auxquels il doit livrer des représentations lisibles, la nécessité de représenter la dualité de la sémantique, celle de linéariser les objets structuralement complexes produits par le mécanisme computationnel sont autant de dimensions qui contribuent nécessairement à façonner la Faculté de Langage et doivent intervenir dans la construction des grammaires. Cette synthèse, qui vise aussi à familiariser le lecteur avec les techniques d’analyse minimaliste, s’adresse aux étudiants avancés et aux linguistes confirmés, intéressés par la syntaxe et par les modèles formels en linguistique.

Mutation Breeding in Chickpea: Perspectives and Prospects for Food Security

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ISBN: 9788376560717 9783110374254 Year: Pages: 148 DOI: 10.2478/9788376560717 Language: English
Publisher: De Gruyter
Subject: Botany --- Plant Sciences
Added to DOAB on : 2014-11-17 10:29:09
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The book by M. Imran Kozgar aims to cover the problems of mutation breeding in pulse crops in the light of issues related to food insecurity and malnutrition, which according to FAO are the major threats at the present time. So far the research on induction of mutation in pulse crops is negligible compared to cereal crops, though the pulse crops and especially the chickpea are the largest grown crops in India. The main objective of the book is to reveal and explore the possibility of inducing genetic variability in early generations of mutated chickpea, describe the positive aspects of mutagenic treatments, evaluate the content of mineral elements (iron, manganese, zinc and copper) and physiological parameters of isolated high yielding mutant lines. The author hopes that his book will help to advance studies on pulse crops, and that in the long term it will help to reduce the food insecurity and malnutrition problems presently persisting in various developing countries, including India.

Experimental and Thermodynamical Modeling of Ore-Forming Processes in Magmatic and Hydrothermal Systems

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ISBN: 9783038975151 / 9783038975168 Year: Pages: 216 DOI: 10.3390/books978-3-03897-516-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Environmental Sciences
Added to DOAB on : 2019-01-11 11:51:31
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This special issue book includes 10 original research papers that discuss and solve some problems of ore-forming processes in magmatic and hydrothermal systems. Some of these papers in the issue deal with experimental and thermodynamical modeling, while the others are devoted to analytical geochemistry, geochronology and genesis of some ore occurrences.I hope that these papers will be useful for scientists who work on the fundamental problems of ore-forming processes and the genesis of ore deposits, and will provide new ideas for future research.

The Interaction between Clause-Level Parameters and Context in Russian Morphosyntax

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Book Series: Slavistische Beitraege ISBN: 9783876905341 Year: Pages: 238 Language: German
Publisher: Peter Lang International Academic Publishing Group
Added to DOAB on : 2019-01-15 13:31:45
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In der Reihe Slavistische Beiträge werden vor allem slavistische Dissertationen des deutschsprachigen Raums sowie vereinzelt auch amerikanische, englische und russische publiziert. Darüber hinaus stellt die Reihe ein Forum für Sammelbände und Monographien etablierter Wissenschafter/innen dar.

Western-Pontic Culture Ambience and Pattern

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ISBN: 9783110500820 9783110498196 Year: Pages: 356 DOI: 10.1515/9783110500820 Language: English
Publisher: De Gruyter
Subject: History
Added to DOAB on : 2017-01-18 16:22:29
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'Western-Pontic Culture Ambience and Pattern' is dedicated to the memory of Eugen Comsa, an archaeologist whose work created the foundation of the Northern Balkan prehistory and was essential for the contemporary view of the prehistory of the North-western Pontic region.The volume brings together researchers in the field of Circumpontic archaeology from the Neolithic to the Iron Age period. The content of the volume is offered to students and scholars who seek a deeper understanding of the prehistory of the Western Pontic region, in particular the Balkans in their Eurasian context and more broadly to enhance the scholarly collections of academic, educational, public and private libraries throughout the world.

Berry Crop Production and Protection

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ISBN: 9783039210947 / 9783039210954 Year: Pages: 158 DOI: 10.3390/books978-3-03921-095-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General)
Added to DOAB on : 2019-08-28 11:21:27
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Berry crops include, but are not limited to, the genera: Fragaria (strawberry, Rosaceae), Ribes (currant and gooseberry, Grossulariaceae), Rubus (brambles: raspberry and blackberry; Rosaceae), Vaccinium (blueberry, cranberry and lingonberry; Ericaceae) and Vitis (grapes, Vitaceae). The significant role of these fruits in maintaining human health has increased their popularity and production, dramatically, across the world. This Special Issue of Agronomy covers berry crops in the areas of breeding, genetics, germplasm, production systems, propagation, plant and soil nutrition, pest and disease management, postharvest, health benefits, marketing and economics and other related areas. The aim will be to bring together a collection of valuable articles that will serve as a foundation of innovative ideas for production and protection of health-promoting berry crops in changed environment.

Nanoporous Materials and Their Applications

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ISBN: 9783038979685 / 9783038979692 Year: Pages: 168 DOI: 10.3390/books978-3-03897-969-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Physics (General)
Added to DOAB on : 2019-06-26 08:44:06
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This book is a special collection of articles dedicated to the preparation and characterization of nanoporous materials, such as zeolitic-type materials, mesoporous silica (SBA-15, MCM-41, and KIT-6), mesoporous metallic oxides, metal–organic framework structures (MOFs), and pillared clays, and their applications in adsorption, catalysis, and separation processes. This book presents a global vision of researchers from international universities, research centers, and industries working with nanoporous materials and shares the latest results on the synthesis and characterization of such materials, which have given rise to the special interest in their applications in basic and industrial processes.

Electrospun and Electrosprayed Formulations for Drug Delivery

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ISBN: 9783038979128 / 9783038979135 Year: Pages: 190 DOI: 10.3390/books978-3-03897-913-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-06-26 10:09:00
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This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.

SPIG2018

Authors: --- --- ---
ISBN: 9783038978503 9783038978510 Year: Pages: 288 DOI: 10.3390/books978-3-03897-851-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Physics (General) --- Nuclear Physics
Added to DOAB on : 2019-04-25 16:37:17
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This Special Issue covers a wide range of topics from fundamental studies to applications of ionized gases. It is dedicated to four topics of interest: 1. ATOMIC COLLISION PROCESSES (electron and photon interactions with atomic particles, heavy particle collisions, swarms, and transport phenomena); 2. PARTICLE AND LASER BEAM INTERACTION WITH SOLIDS (atomic collisions in solids, sputtering and deposition, and laser and plasma interactions with surfaces); 3. LOW TEMPERATURE PLASMAS (plasma spectroscopy and other diagnostic methods, gas discharges, and plasma applications and devices); 4. GENERAL PLASMAS (fusion plasmas, astrophysical plasmas, and collective phenomena). This Special Issue of Atoms will highlight the need for continued research on ionized gas physics in different topics ranging from fundamental studies to applications, and will review current investigations.

Keywords

strong-field physics --- attoscience --- bicircular field --- high-order harmonic generation --- above-threshold ionization --- spin-polarized electrons --- capacitively-coupled discharge --- oxygen --- particle-in-cell/Monte Carlo collision --- electron heating --- secondary electron emission --- Large Helical Device (LHD) --- deuterium experiment --- ion temperature of 10 keV --- plasma research --- spectroscopic study --- dispersion interferometer --- modified theories of gravity --- methods: analytical --- methods: numerical --- galaxies: elliptical --- galaxies: fundamental parameters --- non-equilibrium --- collisions --- radiation --- planetary atmospheric entry --- laser matter interaction --- laser-induced breakdown --- plasma --- spectroscopy --- streak camera --- plasma --- spectral lines --- Stark broadening --- oxygen --- silicon --- spectroscopy --- gas discharges --- plasma applications --- databases --- virtual observatory --- cross sections --- rate coefficients --- runway electron --- plasma current --- fusion plasma --- tokamak --- glow discharge --- argon --- nitrogen admixture --- discharge voltage --- diffuse discharge --- constricted discharge --- electrical theory of DBDs --- QV-plot --- instantaneous power --- rainbow scattering --- positron channeling effect --- time-dependent Schrödinger equation --- chiral single wall carbon nanotubes --- black hole physics --- cosmology --- quasar spectroscopy --- cosmological parameters --- ionized gas --- broad line region --- Rydberg atoms --- dynamic instability --- control of atomic states --- Förster resonance --- plasma spectroscopy --- Stark broadening --- plasma diagnostics --- line shape modeling --- Zeeman-Doppler broadening --- Balmer line series --- radiative recombination --- photoacoustic --- photothermal --- inverse problem --- thermal memory --- minimum volume cell --- neural networks --- thermal diffusivity --- conductivity --- linear coefficient of thermal extension --- AGN --- black holes --- gravitational waves --- binary black holes --- quasars --- photodetachment --- magnetically confined fusion --- neutral beam injection --- plasma heating --- optical cavity amplification --- low-energy electrons --- electron–molecule interactions --- astrochemistry --- laboratory plasma --- astrophysical plasma --- fusion plasma --- lasers --- stars --- extragalactic objects --- spectra --- spectroscopy --- scaling laws

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