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Energy metabolism and behavior in the corticotropin-releasing factor family of peptides

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195374 Year: Pages: 114 DOI: 10.3389/978-2-88919-537-4 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General) --- Internal medicine --- Medicine (General)
Added to DOAB on : 2016-01-19 14:05:46
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Since Hans Selye's seminal work in the 1930s, there have been numerous advances with respect to our understanding of how the nervous and endocrine systems interact to help animals cope with stressors and how chronic stress may adversely impact health. Our modern understanding of stress essentially began in 1954 with the race to discover the hypothalamic releasing factor controlling ACTH secretion and mediating the endocrine response to stressors. Since the isolation of corticotropin releasing factor (CRF) in 1981, interest in CRF has focused not only on its hypophysiotropic function, but also its much broader role in coordinating many of the endocrine, behavioral and autonomic nervous system changes that occur during stress. The goal of this Research Topic is to solicit reviews and general research articles highlighting new research into stress and the hypothalamus-pituitary-adrenal (HPA) axis in the following areas: HPA axis interaction with energy regulating mechanisms during stress; and new studies on the role of CRF and urocortin and urocortins 2 and 3 in behavioral adaptation to stressors.

Prozessentwicklung für die Automatisierung der Herstellung und Anwendung von hochdichten Peptidmicroarrays

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Book Series: Schriften des Instituts für Mikrostrukturtechnik am Karlsruher Institut für Technologie / Hrsg.: Institut für Mikrostrukturtechnik ISSN: 18695183 ISBN: 9783731502746 Year: Volume: 28 Pages: getr. Zählung DOI: 10.5445/KSP/1000043424 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:02:00
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Peptidemicroarrays consist of a large variety of peptides immobilized on a solid support. Today many processes in the field ultra-high peptide-microarrays are performed manually and lack of reproducibility. Hence within this work three processes are developed for the standard use of peptide-microarrays.

Laserbasierte Verfahren zur Herstellung hochdichter Peptidarrays

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Book Series: Schriften des Instituts für Mikrostrukturtechnik am Karlsruher Institut für Technologie / Hrsg.: Institut für Mikrostrukturtechnik ISSN: 18695183 ISBN: 9783731502227 Year: Volume: 24 Pages: IX, 144 p. DOI: 10.5445/KSP/1000041118 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:02:00
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In this thesis, different laser based methods to produce high density peptide arrays were developed. They use laser radiation to structure special micro particles with amino acids. The particles are heated and fused to a substrate (Combinatorial Laser Fusing) or they are transferred trough a shock wave to another substrate (Combinatorial Laser Transfer). This way, microarrays with up to 1 million spots per cm² are produced whereas the number of chemical coupling cycles is minimized.

New edge of antibiotic development: antimicrobial peptides and corresponding resistance

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193011 Year: Pages: 144 DOI: 10.3389/978-2-88919-301-1 Language: English
Publisher: Frontiers Media SA
Subject: Microbiology --- Science (General)
Added to DOAB on : 2016-02-05 17:24:33
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Antimicrobial peptides, commonly isolated from several organisms, have been considered part of innate immune system and also as potential antimicrobial drugs. Besides its antimicrobial activity, some AMPs also have antifungal activity, inmmunomodulatory and antitumural activities. Lately not only nature has become a source of AMPs. Besides isolation of natural organisms, antimicrobial peptides might be improved or created using computational tools. This opens even more this so amazing field by creating infinite novel and remarkable possibilities. Overall the current issue highlights the relevance of such Research Topic with perspectives to develop entirely new molecules with vast application within health and agricultural field with higher affinity for its target with concomitant reduction of side effects.

Vaccines, Immunotherapy and New Antifungal Therapy Against Fungi: Updates in the New Frontier

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453276 Year: Pages: 183 DOI: 10.3389/978-2-88945-327-6 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Microbiology
Added to DOAB on : 2018-02-27 16:16:45
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Invasive fungal diseases have increased many fold over the past 50 years. Current treatment regimens typically require prolonged administration of antifungal medications that can have significant toxicity. Moreover, our present potent antifungal armamentarium fails to eradicate fungal pathogens from certain compromised hosts. Additionally, invasive fungal diseases continue to have unacceptably high mortality rates. A growing body of work has focused on the utility of vaccines and/or immunotherapy as a powerful tool in combating mycoses, either for the active treatment, as an adjuvant, or in the prevention of specific fungal pathogens. Also, it is growing the interest over new drugs development as second choice for treatment when traditional chemotherapy fail. This Research Topic will detail the exciting progress in developing vaccines, immunotherapy and new drugs for fungi.

Trends in Comparative Endocrinology and Neurobiology

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453993 Year: Pages: 238 DOI: 10.3389/978-2-88945-399-3 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology --- Medicine (General) --- Internal medicine
Added to DOAB on : 2018-11-16 17:17:57
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The comparative approach takes advantage of the biological diversity to select the most appropriate model organism to tackle a scientific question. Comparisons between the endocrine and nervous systems accross species have yielded major breakthroughs in endocrinology and neurobiology. For instance: a number of mammalian peptide hormones and neuropeptides have been originally identified in fish or amphibians; studies conducted in a sea slug founded the cellular and molecular basis of learning and memory; observations of neurogenesis in the forebrain of songbirds led to the discovery of adult neurogenesis in the mammalian brain. These examples illustrate the remarkable contribution of the comparative approach for the advancement of neuroendocrinological concepts.The present e-book is a unique collection of research articles and reviews that provide a representative overview of the latest developments in comparative endocrinology and neurobiology.

Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides

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ISBN: 9783039215829 / 9783039215836 Year: Pages: 212 DOI: 10.3390/books978-3-03921-583-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Cardiovascular
Added to DOAB on : 2019-12-09 11:49:16
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The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs. Finally, the opportunity to target NPs in order to develop new therapeutic tools for a better treatment of CVDs has been developed over the years. The current Special Issue of the Journal covers all major aspects of the molecular implications of NPs in physiology and pathology of the cardiovascular system, including NP-based therapeutic approaches.

Keywords

PCSK9 --- natriuretic peptides --- adipose tissue --- lipid metabolism --- LDL receptor --- insulin --- natriuretic peptides --- hypertension --- stroke --- cardiac hypertrophy --- linkage analysis --- genetic variants --- animal models --- BNP --- NT-proBNP --- heart failure --- cardiac dysfunction --- forensic medicine --- postmortem biochemistry --- angiotensin receptor–neprilysin inhibitor --- natriuretic peptides --- renin–angiotensin system --- heart failure --- arterial hypertension --- natriuretic peptide --- vascular --- endothelial cell --- cardiomyocyte --- fibroblast --- inflammation --- heart failure --- hypertension --- angiogenesis --- heart failure --- natriuretic peptides --- preserved ejection fraction --- natriuretic peptides --- heart failure --- atrial fibrillation --- remodeling --- Idiopathic Pulmonary Arterial Hypertension (IPAH) --- Natriuretic Peptide Clearance Receptor (NPR-C) signaling --- atrial natriuretic peptide --- hypertension --- heart failure --- cardiometabolic disease --- obesity --- metabolic syndrome --- cGMP --- guanylyl cyclase receptor A --- natriuretic peptides --- natriuretic peptide --- cardiorenal syndrome --- vasopressor --- vasodilator --- kidney --- medulla --- renin-angiotensin-aldosterone system --- Atrial Natriuretic peptide --- natriuretic peptides --- cardiac remodelling --- cardiac hypertrophy --- vascular homeostasis --- atrial natriuretic peptide --- guanylyl cyclase/natriuretic peptide receptor-A --- gene-knockout --- gene-duplication --- hypertension --- congestive heart failure --- natriuretic peptides --- arterial hypertension --- pulmonary arterial hypertension --- heart failure --- stroke --- atrial fibrillation --- ARNi --- MANP

Marine Bioactive Peptides: Structure, Function, and Therapeutic Potential

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ISBN: 9783039215324 / 9783039215331 Year: Pages: 442 DOI: 10.3390/books978-3-03921-533-1 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:16
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This Special Issue Book, “Marine Bioactive Peptides: Structure, Function, andTherapeutic Potential"" includes up-to-date information regarding bioactivepeptides isolated from marine organisms. Marine peptides have been found invarious phyla, and their numbers have grown in recent years. These peptidesare diverse in structure and possess broad-spectrum activities that have greatpotential for medical applications. Various marine peptides are evolutionaryancient molecular factors of innate immunity that play a key role in host defense.A plethora of biological activities, including antibacterial, antifungal, antiviral,anticancer, anticoagulant, endotoxin-binding, immune-modulating, etc., makemarine peptides an attractive molecular basis for drug design. This Special IssueBook presents new results in the isolation, structural elucidation, functionalcharacterization, and therapeutic potential evaluation of peptides found inmarine organisms. Chemical synthesis and biotechnological production of marinepeptides and their mimetics is also a focus of this Special Issue Book.

Keywords

sea cucumber --- ACE-inhibitory peptide --- molecular docking --- structure-activity relationship --- plastein reaction --- Gracilariopsis lemaneiformis --- ACE-inhibitory activity --- peptide --- molecular docking --- SHRs --- prostate cancer --- Anthopleura anjunae oligopeptide --- DU-145 cells --- PI3K/AKT/mTOR signaling pathway --- cod skin --- NA-inhibitory peptide --- influenza virus --- neuraminidase --- molecular docking --- adsorption --- host defense peptide --- antimicrobial peptide --- anti-LPS factor --- host?microbe relationship --- functional diversity --- invertebrate immunity --- crustacean --- antimicrobial activity --- antimicrobial peptide --- polychaeta --- innate immunity --- BRICHOS domain --- recombinant peptide --- ?-helix --- Rana-box --- nuclear magnetic resonance (NMR) --- antimicrobial peptide --- cytotoxicity --- ?-hairpin --- polyphemusins --- tachyplesins --- cell death --- signaling pathways --- Neptunea arthritica cumingii --- multi-functional peptides --- antioxidant activity --- ACE-inhibitory activity --- anti-diabetic activity --- Arenicola marina --- antimicrobial peptides --- arenicin --- complement --- C3a --- acid-sensing ion channel --- animal models --- pain relief --- toxin --- Ugr 9-1 --- APETx2 --- hairtail (Trichiurus japonicas) --- muscle --- peptide --- antioxidant activity --- half-fin anchovy hydrolysates --- Maillard reaction products --- antibacterial peptide --- identification --- self-production of hydrogen peroxide --- membrane damage --- Perinereis aibuhitensis --- decapeptide --- lung cancer --- cell proliferation --- apoptosis --- conotoxins --- conopeptides --- computational studies --- molecular dynamics --- machine learning --- docking --- review --- drug design --- ion channels --- Conus --- conotoxin --- transcriptome sequencing --- phylogeny --- venom duct --- abalone --- peptide --- vasculogenic mimicry --- metastasis --- MMPs --- HIF-1? --- dexamethasone --- myotube atrophy --- protein synthesis --- proteolytic system --- Pyropia yezoensis peptide --- PYP15 --- QAGLSPVR --- antihypertensive effect --- Caco-2 cell monolayer --- transport routes --- oyster zinc-binding peptide --- peptide-zinc complex --- caco-2 cells --- intestinal absorption --- zinc bioavailability --- Chlorella pyrenoidosa protein hydrolysate (CPPH) --- Chlorella pyrenoidosa protein hydrolysate-calcium chelate (CPPH-Ca) --- calcium absorption --- gene expression --- gut microbiota --- cone snails --- conotoxins --- ion channels --- function --- structure --- marine peptides --- arenicin-1 --- molecular symmetry --- structure–activity relationship --- antibacterial --- cytotoxic --- chemical synthesis --- molecular dynamics --- tilapia --- HUVEC --- angiotensin II --- NF-?B --- Nrf2 --- endothelial dysfunction --- conotoxin --- cone snail --- Conus --- Conus ateralbus --- Kalloconus --- n/a

Special Protein Molecules Computational Identification

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ISBN: 9783038970439 9783038970446 Year: Pages: VIII, 296 Language: english
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2018-08-09 12:10:11
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It is time consuming and costly to detect new molecules of some special proteins. These special proteins include cytokines, enzymes, cell-penetrating peptides, anticancer peptides, cancer lectins, G-protein-coupled receptors, etc. Researchers often employ computer programs to list some candidates, and to validate the candidates with molecular experiments. These computer programs are key to possible savings on wet experiment costs. Software results with high false positive will lead to high costs in the validation process.In this Special Issue, we focus on these computer program approaches and algorithms. Some "golden features" from protein primary sequences have been proposed for these problems, such as Chou’s PseAAC (pseudo amino acid composition). PseAAC has been tried on nearly all kinds of protein identification, together with SVM (support vector machines, a type of classifier). However, I prefer special features, and classification methods should be proposed for special protein molecules. "Golden features" cannot work well on all kinds of proteins. I hope that submissions will focus on a type of special protein molecule, collect related data sets, obtain better prediction performance (especially low false positives), and develop user-friendly software tools or web servers.

Targets, Tracers and Translation – Novel Radiopharmaceuticals Boost Nuclear Medicine

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ISBN: 9783039213139 / 9783039213146 Year: Pages: 214 DOI: 10.3390/books978-3-03921-314-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-12-09 11:49:15
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This is the fourth Special Issue in Pharmaceuticals within the last six years dealing with aspects of radiopharmaceutical sciences. It demonstrates the significant interest and increasing relevance to ameliorate nuclear medicine imaging with PET or SPECT, and also radiotherapeutical procedures.Numerous targets and mechanisms have been identified and have been under investigation over the previous years, covering many fields of medical and clinical research. This development is well illustrated by the articles in the present issue, including 13 original research papers and one review, covering a broad range of actual research topics in the field of radiopharmaceutical sciences.

Keywords

breast cancer --- 68Ga --- GRPR --- NPY(Y1)R --- peptide heterodimers --- PET/CT imaging --- sentinel lymph node --- dextran --- mannose --- 99mTc-radiopharmaceuticals --- glutamate --- metabotropic glutamate receptor subtype 5 --- [18F]PSS232 --- ketamine --- ceftriaxone --- positron emission tomography --- allosteric modulator --- MMPEP --- ABP688 --- pretargeting --- Fusarinine C --- rituximab --- click chemistry --- multimerization --- PET --- gallium-68 --- carbonic anhydrase IX --- girentuximab --- renal cell carcinomas --- 177Lu-radiopharmaceuticals --- radioimmunotherapy --- neuroinflammation --- microglia --- carbon-11 --- radiochemistry --- positron emission tomography --- hypoxia --- radiosensitizer --- benzotriazine-1,4-dioxide (BTDO), benzotriazine-1-monoxide (BTMO), tirapazamine (TPZ), SR 4317 --- radioiodination --- tropomyosin receptor kinase --- positron emission tomography --- neurodegeneration --- oncogenic fusions --- [11C]meta-hydroxyephedrine --- radiosynthesis --- separation --- apparent molar activity --- cholecystokinin-2 receptor --- minigastrin --- molecular imaging --- radiometals --- technetium-99m --- hydrazinonicotinic acid (HYNIC) --- PSMA-617 --- salivary gland uptake --- prostate cancer --- endoradiotherapy --- Chloramine T --- electrophilic radioiodination --- iodine-131 --- Iodo-Gen® --- oxidizing agent --- ?-CIT. --- tumor hypoxia --- PET --- small animal imaging --- azomycin nucleosides --- [18F]FMISO --- bombesin --- gastrin-releasing peptide --- gastrin-releasing peptide receptor --- tumor targeting --- 99mTc-radioligand --- metabolic stability --- neprilysin-inhibition --- phosphoramidon --- n/a --- n/a

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