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Klinische Prüfungen mit Arzneimitteln in der Schwangerschaft

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ISBN: 9783863952334 Year: DOI: 10.17875/gup2015-885 Language: German
Publisher: Universitätsverlag Göttingen
Subject: Law
Added to DOAB on : 2016-06-21 11:02:28
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The clinical trial on medicinal products stands in the area of conflict between important scientific progress in favour of future patients on the one hand and the necessary protection of human subjects on the other hand. This conflict grows more acute when vulnerable persons – like pregnant women – are included in medical research. Whereas there are specific regulations for minors or incapacitated persons in the German Medicinal Products Act, legal regulations for the inclusion of pregnant women are missing. Based on this uncertain legal situation solutions are developed, which will show a way out of the dilemma. Insofar as the applicable law does not provide a handle for this problem, a need for reform is shown.

India and the Patent Wars

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Book Series: ILR Press/Culture and Politics of Health Care Work ISBN: 9781501713460 9781501713972 9781501713989 Year: Language: English
Publisher: Cornell University Press Grant: Knowledge Unlatched - 101567
Added to DOAB on : 2018-01-25 11:01:47
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India and the Patent Wars examines struggles over patents and access to medicine among pharmaceutical producers, activists and others under a new global intellectual property regime. In the past two decades, intellectual property rights have expanded throughout the globe creating a world in which protections for patents and copyrights have increased and a growing range of knowledge and practices are claimed as property. Driving these changes are U.S. court decisions, the policies of multinational corporations, and the World Trade Organization (WTO). Resistance to this regime has emerged in low-income countries among public health activists concerned about the rising cost of medicines for HIV/AIDS and indigenous peoples who now see their knowledge as vulnerable and pursue ownership claims for their medical and cultural practices.

Advances and Trends in Development of Plant Factories

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889451395 Year: Pages: 203 DOI: 10.3389/978-2-88945-139-5 Language: English
Publisher: Frontiers Media SA
Subject: Botany --- Science (General)
Added to DOAB on : 2017-07-06 13:27:36
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The plant factory is a facility that aids the steady production of high-quality vegetables all year round by artificially controlling the cultivation environment (e.g., light, temperature, humidity, carbon dioxide concentration, and culture solution), allowing growers to plan production. By controlling theinternal environment,plant factories can produce vegetables about two to four times faster than by typical outdoor cultivation. In addition, as multiple cultivation shelves (a multi-shelf system) are used, the mass production of vegetables in a small space is facilitated. This research topic presents some new trends on intelligent measuring systems; environment controlled and optimization; favonoids; phenylpropanoids, transcriptomes, and bacteria.

The TRIPS Agreement Implementation in Brazil

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Book Series: Munich Intellectual Property Law Center - MIPLC ISBN: 9783845259628 Year: Volume: 25 DOI: http://dx.doi.org/10.5771/9783845259628 Language: en
Publisher: Nomos Verlagsgesellschaft mbH & Co. KG
Subject: Law
Added to DOAB on : 2018-11-05 12:58:39
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Environmental Fate of Emerging Organic Micro-Contaminants

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ISBN: 9783039213672 / 9783039213689 Year: Pages: 128 DOI: 10.3390/books978-3-03921-368-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Environmental Sciences
Added to DOAB on : 2019-12-09 11:49:15
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The toxicity and fate of pharmaceuticals and other emerging micro-organic contaminants in the natural and built environments have been the focus of much research over the last twenty years. Particular focus has recently centred on the fate of antimicrobial chemicals, including antibiotics and antifungals. The occurrence of such chemicals in the environment is thought to contribute to the selection of resistance in exposed microorganisms.This Special Issue (SI) brings together a broad range of recent advances in the field of emerging micro-organic contaminants, ranging from medicinal contaminants to industrial chemicals in the environment. Notably, these range from chemical extraction and large-scale analysis to adverse effects on non-target aquatic organisms and potential risk to humans via contaminated foodstuffs. Additionally, this Special Issue also presents novel contaminant treatment/degradation methods of both physical and biological nature.

Recent Advances in Water Management: Saving, Treatment and Reuse

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ISBN: 9783038970316 / 9783038970323 Year: Pages: 208 DOI: 10.3390/books978-3-03897-032-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Environmental Sciences
Added to DOAB on : 2019-08-28 11:21:28
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This book is a printed edition of the Special Issue Recent Advances in Water Management: Saving, Treatment and Reuse that was published in Water

Keywords

guidelines --- contaminated sites --- risk assessment --- China --- ferrous iron --- ferrous sulfide --- hydrogen sulfide --- odor control --- pumping mains --- sewerage --- pharmaceuticals --- micropollutant removal --- tezontle --- filter media --- active sites --- trickling filter --- anaerobic digester --- swine wastewater --- organic matter --- COD --- decomposition analysis --- global patent data --- research and development strategy --- water treatment technology --- anammox bacteria --- wastewater treatment --- nitrification --- denitrification --- zeolite --- combined sewer --- wastewater treatment --- microbiological quality --- surface water --- river --- lignin --- delignification --- pulp-and-paper-mill c --- wastewater --- white rot fungi --- B. adusta --- P. crysosporium --- foreign countries --- agricultural occupations --- water --- environmental education --- surveys --- sustainability --- milk production --- water --- footprint --- water recycling --- conservation --- partitioning --- efficiency --- forest waste --- palm mulch --- constructed wetlands --- vertical flow --- water treatment --- passive treatment systems --- anaerobic processes --- constructed wetlands --- ornamental plants --- treated wastewater reuse --- advanced oxidation processes (AOPs) --- activated carbon adsorption --- carbamazepine toxicity --- conventional treatment processes --- membrane technology --- occurrence --- food industry --- anticorrosive agent --- benzotriazole --- emerging contaminant --- oxygen injection --- Pb(II) --- nano illite/smectite clay --- adsorption kinetics --- adsorption thermodynamic

Drinking Water Quality and Human Health

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ISBN: 9783038977261 Year: Pages: 374 DOI: 10.3390/books978-3-03897-727-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Sociology --- Social Sciences
Added to DOAB on : 2019-04-05 10:34:31
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The quality of drinking water is paramount for public health. Despite important improvements in the last decades, access to safe drinking water is not universal. The World Health Organization estimates that almost 10% of the population in the world do not have access to improved drinking water sources. Among other diseases, waterborne infections cause diarrhea, which kills nearly one million people every year, mostly children under 5 years of age. On the other hand, chemical pollution is a concern in high-income countries and an increasing problem in low- and middle-income countries. Exposure to chemicals in drinking water may lead to a range of chronic non-communicable diseases (e.g., cancer, cardiovascular disease), adverse reproductive outcomes, and effects on children’s health (e.g., neurodevelopment), among other health effects. Although drinking water quality is regulated and monitored in many countries, increasing knowledge leads to the need for reviewing standards and guidelines on a nearly permanent basis, both for regulated and newly identified contaminants. Drinking water standards are mostly based on animal toxicity data, and more robust epidemiologic studies with accurate exposure assessment are needed. The current risk assessment paradigm dealing mostly with one-by-one chemicals dismisses the potential synergisms or interactions from exposures to mixtures of contaminants, particularly at the low-exposure range. Thus, evidence is needed on exposure and health effects of mixtures of contaminants in drinking water. Finally, water stress and water quality problems are expected to increase in the coming years due to climate change and increasing water demand by population growth, and new evidence is needed to design appropriate adaptation policies.This Special Issue of International Journal of Environmental Research and Public Health (IJERPH) focuses on the current state of knowledge on the links between drinking water quality and human health.

Keywords

Vibrio pathogens --- rural water resources --- public health --- sub-Saharan Africa --- diarrhoeal disease --- HWTS implementation --- water and sanitation --- drinking water guidance --- infant exposure --- chemical risk assessment --- duration extrapolation --- acute gastroenteritis --- risk --- tap water --- time series study --- turbidity --- urban area --- water operation data --- THMs --- cancer --- effect measure modification --- drinking water --- drinking water --- exposure assessment --- sodium --- potassium --- magnesium --- calcium --- spatial variations --- Denmark --- water safety plans --- drinking water quality --- risk management --- impact assessment --- Asia-Pacific region --- diarrhea --- fever --- cough --- Nigeria --- infant health --- drinking water --- inorganic manganese --- health-based guideline --- infants --- pharmaceuticals --- human health --- environment --- drug labels --- screening method --- LTD --- uncertainty factors --- risk assessment --- risk context --- biomonitoring --- dental health --- drinking water --- fluoride --- pharmacokinetic modeling --- waterborne disease outbreak --- simulation study --- health insurance data --- space–time detection --- drinking water --- nitrate --- cancer --- adverse reproductive outcomes --- methemoglobinemia --- thyroid disease --- endogenous nitrosation --- N-nitroso compounds --- E. coli --- monitoring --- drinking water --- water safety plan --- sanitary inspection --- gravity-fed piped water scheme --- risk management --- chlorination by-product --- France --- environmental exposure --- organic matter --- tap water --- trihalomethanes --- private wells --- groundwater --- drinking water --- animal feeding operation --- fecal coliforms --- enterococci --- E. coli --- Maryland --- nitrite --- disinfection by-product --- drinking water distribution systems --- seasonality --- atrazine --- community water system --- low birth weight --- preterm birth --- small for gestational age --- water contamination --- endocrine disruptor --- drinking water --- radioactivity --- annual effective dose --- carcinogenic --- chronic kidney disease --- end-stage renal disease --- water contaminants --- zinc --- ammonia --- chemical oxygen demand --- dissolved oxygen --- arsenic

Efficiency of Bank Filtration and Post-Treatment

Authors: ---
ISBN: 9783039213054 / 9783039213061 Year: Pages: 352 DOI: 10.3390/books978-3-03921-306-1 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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Riverbank filtration (RBF) schemes for the production of drinking water are increasingly challenged by new constituents of concern, such as organic micropollutants and pathogens in the source water and hydrological flow variations due to weather extremes. RBF and new technology components are integrated and monitoring and operating regimes are adopted to further optimize water treatment in bank filtration schemes for these new requirements. This Special Issue presents results from the EU project AquaNES “Demonstrating synergies in combined natural and engineered processes for water treatment systems” (www.aquanes.eu). Additionally, papers from other research groups cover the efficiency of bank filtration and post-treatment, advantages and limitations of combining natural and engineered processes, parameter-specific assessment of removal rates during bank filtration, and the design and operation of RBF wells. The feasibility, design, and operation of RBF schemes under specific site conditions are highlighted for sites in the US, India, and South Korea

Keywords

riverbank filtration --- removal efficacy --- dissolved organic carbon (DOC) --- pesticides --- pharmaceutical residues --- riverbank filtration --- organic matter degradation --- manganese --- riverbed --- climate change --- floods --- droughts --- column experiments --- PHREEQC --- decentralized capillary nanofiltration --- anoxic --- suboxic --- organic micropollutants --- bank filtrate --- groundwater --- sulphate --- dissolved organic matter --- high temperature --- sub-oxic conditions --- organic matter composition --- PARAFAC-EEM --- LC-OCD --- redox sensitivity --- micropollutants --- oxypurinol --- gabapentin --- river bank filtration --- hydrological trends --- sustainable water production --- well structure remodeling --- point-bar alluvial setting --- riverbank filtration --- site investigation --- hydrochemistry --- subsurface geology --- riverbank filtration --- organic micropollutants --- water quality --- environmental monitoring --- riverbank filtration --- collector wells --- performance --- entrance velocity --- river bank filtration --- attenuation --- organic micropollutants --- pharmaceuticals --- riverbank filtration --- small communities --- disinfection by-products --- trihalomethanes --- riverbank filtration (RBF) --- Krishna River --- southern India --- water treatment --- water quality --- salinity --- river bank filtration --- ultrafiltration --- surface water treatment --- energy efficiency --- out/in membrane comparison --- inline electrolysis --- bank filtration --- biofilm --- clogging --- filter cake --- pathogen barrier --- pressure loss --- slow sand filtration --- electro-chlorination --- smart villages --- disinfection --- river bank filtration --- rural water supply, online monitoring --- dissolved organic matter --- fluorescence excitation-emission matrix --- LC-OCD --- Nakdong River --- riverbank filtration --- bank filtration --- drinking water treatment --- inorganic chemicals --- organic micropollutants --- Ganga --- Yamuna --- Damodar --- riverbank filtration --- water quality --- organic carbon --- nitrate --- heavy metals --- microorganisms --- riverbank filtration --- riverside water source --- analytical method --- mirror-image method --- optimization --- riverbank filtration --- water quality --- bank filtrate portion --- iron --- manganese --- microorganisms --- system costs --- water supply --- storage tank --- drinking water hydropower --- turbine --- energy generation --- renewable energy

Modern Sample Preparation Approaches for Separation Science

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ISBN: 9783039214112 / 9783039214129 Year: Pages: 282 DOI: 10.3390/books978-3-03921-412-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Analytical Chemistry
Added to DOAB on : 2019-12-09 11:49:15
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This book will provide the most recent knowledge and advances in Sample Preparation Techniques for Separation Science. Everyone working in a laboratory must be familiar with the basis of these technologies, and they often involve elaborate and time-consuming procedures that can take up to 80% of the total analysis time. Sample preparation is an essential step in most of the analytical methods for environmental and biomedical analysis, since the target analytes are often not detected in their in-situ forms, or the results are distorted by interfering species. In the past decade, modern sample preparation techniques have aimed to comply with green analytical chemistry principles, leading to simplification, miniaturization, easy manipulation of the analytical devices, low costs, strong reduction or absence of toxic organic solvents, as well as low sample volume requirements.Modern Sample Preparation Approaches for Separation Science also provides an invaluable reference tool for analytical chemists in the chemical, biological, pharmaceutical, environmental, and forensic sciences.

Keywords

vitamins --- extraction --- determination --- review --- sample preparation --- matrix solid phase dispersion --- sorbent --- miniaturization --- on-line --- blueberry --- non-anthocyanin polyphenol --- vortex-assisted dispersive liquid-liquid microextraction --- response surface methodology --- desirability function approach --- nail --- curie temperature --- high-frequency heating --- liquid chromatography–tandem mass spectrometry --- caffeine --- amlodipine --- gas chromatography --- hydrogel --- hormones --- pectin --- polyvinyl alcohol --- sample preparation --- in-tube SPME --- UHPLC-MS/MS --- organic-based monoliths --- antipsychotics --- plasma samples --- schizophrenic’ patients --- salting-out assisted liquid–liquid extraction --- sugaring-out assisted liquid–liquid extraction --- hydrophobic-solvent assisted liquid–liquid extraction --- subzero-temperature assisted liquid–liquid extraction --- phenolic compounds --- sorbent-based techniques --- multi-spheres adsorptive micro-extraction (MSA?E) --- floating sampling technology --- caffeine and acetaminophen tracers --- environmental water matrices --- vortex-assisted dispersive liquid-liquid microextraction --- China herbal tea --- pesticides residue --- aflatoxins --- UPLC-MS/MS --- vortex-synchronized matrix solid-phase dispersion --- crab shells --- ionic liquids --- anthraquinones --- Cassiae Semen --- sample preparation --- nanocomposite --- pathogenic --- enrichment --- nucleic acid isolation --- sample preparation with TLC/HPTLC --- solvent front position extraction --- solvent delivery with a moving pipette --- automation --- LC–MS/MS --- environmental analysis --- whole water --- trace analysis --- SPE --- large volume --- in-line filter --- sand --- flow rate --- pharmaceuticals --- hormones --- pesticides --- space instrumentation --- liquid chromatography --- oligopeptides --- trapping system --- membrane-based microextraction --- barbiturates --- simultaneous determination --- whole blood --- urine --- liver --- sample preparation --- oxylipins --- protein precipitation --- liquid–liquid extraction --- solid-phase extraction --- biological samples --- chlorophenoxy acid herbicides --- HPLC --- hydrophobic in-tube solid-phase microextraction --- poly (OMA-co-TRIM) monolithic column --- rice grains --- gold --- sample preparation --- preconcentration --- geological samples

Advances in Near Infrared Spectroscopy and Related Computational Methods

Authors: ---
ISBN: 9783039280520 / 9783039280537 Year: Pages: 496 DOI: 10.3390/books978-3-03928-053-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Analytical Chemistry
Added to DOAB on : 2020-01-30 16:39:46
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In the last few decades, near-infrared (NIR) spectroscopy has distinguished itself as one of the most rapidly advancing spectroscopic techniques. Mainly known as an analytical tool useful for sample characterization and content quantification, NIR spectroscopy is essential in various other fields, e.g. NIR imaging techniques in biophotonics, medical applications or used for characterization of food products. Its contribution in basic science and physical chemistry should be noted as well, e.g. in exploration of the nature of molecular vibrations or intermolecular interactions. One of the current development trends involves the miniaturization and simplification of instrumentation, creating prospects for the spread of NIR spectrometers at a consumer level in the form of smartphone attachments—a breakthrough not yet accomplished by any other analytical technique. A growing diversity in the related methods and applications has led to a dispersion of these contributions among disparate scientific communities. The aim of this Special Issue was to bring together the communities that may perceive NIR spectroscopy from different perspectives. It resulted in 30 contributions presenting the latest advances in the methodologies essential in near-infrared spectroscopy in a variety of applications.

Keywords

hyperspectral imaging --- variety discrimination --- Chrysanthemum --- deep convolutional neural network --- DNA --- FTIR spectroscopy --- rapid identification --- PLS-DA --- animal origin --- near-infrared hyperspectral imaging --- raisins --- support vector machine --- pixel-wise --- object-wise --- maize kernel --- hyperspectral imaging technology --- accelerated aging --- principal component analysis --- support vector machine model --- standard germination tests --- blackberries --- Rubus fructicosus --- phenolics --- carotenoids --- bioanalytical applications --- near infrared --- chemometrics --- VIS/NIR hyperspectral imaging --- corn seed --- classification --- freeze-damaged --- image processing --- imaging visualization --- wavelength selection --- NIR spectroscopy --- binary dragonfly algorithm --- ensemble learning --- quantitative analysis modeling --- NIR --- SCiO --- pocket-sized spectrometer --- cheese --- fat --- moisture --- multivariate data analysis --- Fourier-transform near-infrared spectroscopy --- glucose --- fructose --- dry matter --- partial least square regression --- Ewing sarcoma --- Fourier transform infrared spectroscopy --- FTIR --- chemotherapy --- bone cancer --- calibration transfer --- NIR spectroscopy --- PLS --- quantitative analysis model --- melamine --- FT-IR --- NIR spectroscopy --- quantum chemical calculation --- anharmonic calculation --- overtones --- combination bands --- near infrared spectroscopy --- Trichosanthis Fructus --- geographical origin --- chemometric techniques --- crude drugs --- prepared slices --- support vector machine-discriminant analysis --- near-infrared fluorescence --- fluorescent probes --- Zn(II) --- di-(2-picolyl)amine --- living cells --- cellular imaging --- near-infrared (NIR) spectroscopy --- calibration transfer --- affine invariance --- multivariate calibration --- partial least squares (PLS) --- NIR --- direct model transferability --- MicroNIR™ --- SVM --- hier-SVM --- SIMCA --- PLS-DA --- TreeBagger --- PLS --- calibration transfer --- agriculture --- photonics --- imaging --- spectral imaging --- spectroscopy --- handheld near-infrared spectroscopy --- pasta/sauce blends --- partial least squares calibration --- nutritional parameters --- bootstrapping soft shrinkage --- partial least squares --- extra virgin olive oil --- adulteration --- FT-NIR spectroscopy --- near-infrared spectroscopy --- ethanol --- anharmonic quantum mechanical calculations --- isotopic substitution --- overtones --- combinations bands --- seeds vitality --- rice seeds --- near-infrared spectroscopy --- hyperspectral image --- discriminant analysis --- near-infrared spectroscopy --- counter propagation artificial neural network --- detection --- auxiliary diagnosis --- BRAF V600E mutation --- colorectal cancer --- tissue --- paraffin-embedded --- deparaffinized --- stained --- ultra-high performance liquid chromatography --- Folin–Ciocalteu --- total hydroxycinnamic derivatives --- phytoextraction --- near-infrared spectroscopy --- origin traceability --- data fusion --- Paris polyphylla var. yunnanensis --- Fourier transform mid-infrared spectroscopy --- near-infrared spectroscopy --- aquaphotomics --- water --- light --- near infrared spectroscopy --- water-mirror approach --- perturbation --- biomeasurements --- biodiagnosis --- biomonitoring --- Vitis vinifera L. --- proximal sensing --- precision viticulture --- near infrared --- chemometrics --- non-destructive sensor --- NIRS --- osteopathy --- late preterm --- brain --- splanchnic --- Raman spectroscopy --- hyperspectral imaging --- analytical spectroscopy --- counterfeit and substandard pharmaceuticals --- DFT calculations --- chemometrics --- PLSR --- API --- lumefantrine --- artemether --- antimalarial tablets --- FT-NIR spectroscopy --- PLS-R --- water --- glucose --- test set validation --- RMSEP --- hyperspectral image processing --- perfusion measurements --- clinical classifications --- n/a

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