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Magnesium in the Central Nervous System

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ISBN: 9780987073051 Year: Pages: 356 DOI: 10.1017/UPO9780987073051 Language: English
Publisher: University of Adelaide Press
Subject: Medicine (General)
Added to DOAB on : 2012-05-15 03:00:19
License: University of Adelaide Press

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Abstract

Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium in particular remains elusive, largely because intracelluar levls are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesium’s involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behaviour. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesium’s role in biological systems that has inspired the collation of this volume of work.

Advances in Neuroimmunology

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ISBN: 9783038425700 9783038425717 Year: Pages: X, 150 DOI: 10.3390/books978-3-03842-571-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2017-12-06 12:41:40
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Abstract

Neuroimmunity is a relative new and rapidly expanding area of interest that critically impacts normal brain function and a wide range of neurological disorders. Neuroimmune mechanisms operate within the nervous system and between the nervous system and periphery. Glial cells of the nervous system play a primary role in neuroimmunity, through their ability to produce and respond to neuroimmune signaling factors, which serve a number of functions, such as homeostatic regulation of nervous system function and defense against insult and infection. Dysfunction of the neuroimmune system is now thought to be an important contributing factor to many disease and injury states.The purpose of this Special Issue is to provide a representative view of current research in this growing field, with an emphasis on the central nervous system.

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