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Modulators of hypothalamic-pituitary-gonadal axis for the control of spermatogenesis and sperm quality in vertebrates

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193585 Year: Pages: 159 DOI: 10.3389/978-2-88919-358-5 Language: English
Publisher: Frontiers Media SA
Subject: Internal medicine --- Medicine (General)
Added to DOAB on : 2016-03-10 08:14:32
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Spermatogenesis is a process highly conserved throughout vertebrate species and is mainly under hypothalamic-pituitary control. It occurs in the testis in a stepwise fashion so that committed spermatogonia develop into spermatocytes and enter meiosis to produce round spermatids. These undergo a morphological transformation (spermiogenesis) into mature spermatids (i.e.: spermatozoa), which are differentially released from Sertoli cells (spermiation) depending on the species. In mammals, further transformations are necessary to form mature spermatozoa, suitable for fertilization. Gonadotropins, mainly responsive to gonadotropin-releasing hormone, control spermatogenesis through specific receptors located at the gonadal level. However, besides the endocrine route, the chemical mediators may also act locally in the gonad. Indeed, it is documented that testis physiology, including steroidogenesis and spermatogenesis, does not fully account for traditional endocrine control but an intragonadal network of autocrine and/or paracrine regulators also exists, whose activity, via cell-to-cell communication, regulates germ cell progression and development of qualitatively mature spermatozoa. Of note, a number of testicular modulators, such as gonadotropin releasing hormone, Kiss-peptin, endocannabinoids, has been early isolated in the brain and latest in the gonads. To fully understand precise mechanisms underlying the functional interaction of this intricate network, needless to say, it is crucially required to have detailed information about modulators and target cells. Through synergy between the respective specializations of all the authors, this topic reviewed emerging knowledge about neuroendocrine and local mediators controlling germ cell progression and maturation.

Air Quality Integrated Assessment: A European Perspective

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Book Series: SpringerBriefs in Applied Sciences and Technology ISSN: 2191-530X ISBN: 9783319333489 9783319333496 Year: Pages: 110 DOI: 10.1007/978-3-319-33349-6 Language: English
Publisher: Springer
Subject: Environmental Sciences
Added to DOAB on : 2017-03-02 09:45:26
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This book reports on the results of an extended survey conducted across Europe within the framework of the APPRAISAL FP7 project to determine the extent to which an integrated assessment approach to air quality is being adopted, on the one hand, by regional and local authorities to develop air quality plans and, on the other, by researchers. Following a detailed analysis of the role and structure of the components of an integrated assessment study, the results of the survey are considered from a variety of perspectives. Above all, the book discusses the new light the survey sheds on emission abatement policies and measures planned at regional and local scales, and on their synergies/trade-offs with measures implemented at the national scale. Detailed consideration is given to the currently available modeling methodologies for identifying emission sources, assessing the effectiveness of emission reduction measures, and evaluating the impacts of emission abatement measures on human health. Current strengths and weaknesses revealed by the survey are explored, and the application of an integrated assessment tool in two case studies (in Brussels and Porto) is discussed. The book will appeal to all those interested in the use of integrated assessment in connection with the sources, effects and control of air pollution.

Näkökulmia tilintarkastukseen ja arviointiin

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ISBN: 9789520304386 Year: Pages: 267 DOI: 10.26530/OAPEN_629586 Language: Finnish
Publisher: Tampere University Press
Subject: Economics
Added to DOAB on : 2017-05-24 11:01:33
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This book Näkökulmia tilintarkastukseen ja arviointiin provides original scientific research about various current auditing and evaluation topics. Over the past decade, the field of auditing has seen substantial changes. The topic areas covered in the first chapters reflect established auditing topics such as the role and responsibility of auditors, transfer pricing, the quality of auditing and issues with audit reports. Other chapters address emerging concerns in performance evaluation and auditing. This book will be of value to practitioners, students and academics interested in contemporary aspects of auditing and evaluation.

Methodological Quality of Interventions in Psychology

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452491 Year: Pages: 120 DOI: 10.3389/978-2-88945-249-1 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Psychology
Added to DOAB on : 2018-02-27 16:16:44
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Evaluations of intervention programs seek to present high-quality design, measures and data to assess their merit and worth. While evaluations differ in their purpose, theoretical framework and methodology, their collective aim is to obtain relevant and meaningful information to inform practice, research, and policy. As such, evaluation findings serve to build a body of knowledge on effective approaches to promote designated psychological outcomes, critical to an individual's overall health and well-being. However, as examined in this e-book, methodological weaknesses directly limit the potential of evaluations of intervention programs. As discussed by Chacón-Moscoso and Sanduvete-Chaves, methodological weaknesses can be attributed to how to define and measure methodological quality and the contextual dependency of instruments designed to measure this quality.In response, this e-book provides a collection of studies on methodological approaches to promote the quality of psychological interventions. Specifically, 10 original works published in the Research Topic Methodological Quality of Interventions in Psychology are included. The papers are organized into two chapters. Concretely, Chapter 1 includes studies pertaining to methodological approaches to enhance the quality of psychological intervention, being context independent solutions. Furthermore, Chapter 2 presents original work in different areas (health, education, sport and social welfare) where methodological quality has been better assessed. Collectively, the papers in this e-book serve to expand the awareness of practitioners and researchers interested in psychological interventions of the critical role of methodological quality in this work. This research was funded by the projects 1150096 (Chilean National Fund of Scientific and Technological Development, FONDECYT); and PSI2015-71947-REDT (Spain’s Ministry of Economy and Competitiveness).

Qualitätsmonitor 2019

Authors: --- ---
ISBN: 9783954664030 9783954664344 Year: Language: German
Publisher: MWV Medizinisch Wissenschaftliche Verlagsgesellschaft Grant: Knowledge Unlatched - 103642
Subject: Medicine (General)
Added to DOAB on : 2019-01-15 13:33:12
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Die Qualität der Versorgung, ihre Sicherung, Verbesserung und Incentivierung sind das erklärte Ziel der Krankenhausgesetzgebung der letzten Jahre. Für die Diskussion über Bewertung, Vergütung und Kommunikation von Qualität im medizinischen Versorgungsgeschehen liefert der Qualitätsmonitor 2019 weitere Impulse. Das Werk greift jährlich relevante Themen aus stationärer und sektorenübergreifender Versorgung auf. Die Fachbeiträge gehen dabei der Frage nach, wie sich das Versorgungssystem unter Qualitätsaspekten gestalten lässt und wie Versorgungsqualität transparenter gemacht werden kann. Weiterhin werden Strukturanforderungen einer qualitätsorientierten medizinischen Versorgung diskutiert und die wissenschaftliche Evidenz zur Gestaltung relevanter Versorgungsbereiche zusammengefasst. Eine weitere Sektion zeigt Eckdaten zur Versorgungsstruktur und Qualitätsdaten der deutschen Krankenhäuser. Der Qualitätsmonitor 2019 unterstützt fundiert die Qualitätssicherungsdebatte in Deutschland.

Keywords

Medicine --- quality --- health care --- health system --- germany

Advanced Signaling Support for IP-based Networks

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ISBN: 9783731500377 Year: Pages: XXX, 333 p. DOI: 10.5445/KSP/1000035118 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Computer Science
Added to DOAB on : 2019-07-30 20:02:01
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This work develops a set of advanced signaling concepts for IP-based networks. It proposes a design for secure and authentic signaling and provides QoS signaling support for mobile users. Furthermore, this work develops methods which allow for scalable QoS signaling by realizing QoS-based group communication mechanisms and through aggregation of resource reservations.

Self-Reported Population Health: An International Perspective based on EQ-5D

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ISBN: 9789400775954 9789400775961 Year: Pages: 212 DOI: 10.1007/978-94-007-7596-1 Language: English
Publisher: Springer
Subject: Public Health --- Biotechnology --- Pharmacy and materia medica --- Medicine (General)
Added to DOAB on : 2014-07-25 14:27:36
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The EQ-5D instrument, as a standardized, cross-culturally validated measure of self-assessed health has a hugely important role in understanding population health within and across countries. Over the past two decades a wealth of international population health survey data have been accumulated by the EuroQol Group from research conducted in many countries across four continents. One of the success factors of the EQ-5D instruments has been the easy availability of national or international sets of EQ-5D data, as well as clear explanations and guidance for users. There is an unmet need to produce a comprehensive book that captures up-to-date and expanded information of EQ-5D self-reported health and index values. EQ-5D population norms and cross-country analyses are provided from representative national surveys of 20 countries and additional regional surveys. This book will be a must for those who believe that how people report and value health is very important.

Safer Healthcare: Strategies for the Real World

Authors: ---
ISBN: 9783319255576 9783319255590 Year: Pages: 157 DOI: 10.1007/978-3-319-25559-0 Language: English
Publisher: Springer
Subject: Pharmacy and materia medica --- Medicine (General) --- Biotechnology --- Electrical and Nuclear Engineering --- Business and Management --- Manufactures
Added to DOAB on : 2016-06-27 16:39:43
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The authors of this book set out a system of safety strategies and interventions for managing patient safety on a day-to-day basis and improving safety over the long term. These strategies are applicable at all levels of the healthcare system from the frontline to the regulation and governance of the system.There have been many advances in patient safety, but we now need a new and broader vision that encompasses care throughout the patient’s journey. The authors argue that we need to see safety through the patient’s eyes, to consider how safety is managed in different contexts and to develop a wider strategic and practical vision in which patient safety is recast as the management of risk over time. Most safety improvement strategies aim to improve reliability and move closer toward optimal care. However, healthcare will always be under pressure and we also require ways of managing safety when conditions are difficult. We need to make more use of strategies concerned with detecting, controlling, managing and responding to risk. Strategies for managing safety in highly standardised and controlled environments are necessarily different from those in which clinicians constantly have to adapt and respond to changing circumstances.This work is supported by the Health Foundation. The Health Foundation is an independent charity committed to bringing about better health and health care for people in the UK.The charity’s aim is a healthier population in the UK, supported by high quality health care that can be equitably accessed. The Foundation carries out policy analysis and makes grants to front-line teams to try ideas in practice and supports research into what works to make people’s lives healthier and improve the health care system, with a particular emphasis on how to make successful change happen.A key part of the work is to make links between the knowledge of those working to deliver health and health care with research evidence and analysis. The aspiration is to create a virtuous circle, using what works on the ground to inform effective policymaking and vice versa. Good health and health care are vital for a flourishing society. Through sharing what is known, collaboration and building people’s skills and knowledge, the Foundation aims to make a difference and contribute to a healthier population.

Continuous Quality Improvement - Advancing Understanding of Design, Application, Impact and Evaluation of CQI Approaches

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453771 Year: Pages: 100 DOI: 10.3389/978-2-88945-377-1 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Botany
Added to DOAB on : 2018-11-16 17:17:57
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Continuous Quality Improvement (CQI) methods are increasingly widely used to bridge the gaps between the evidence base for best clinical practice, what actually happens in practice, and the achievement of better population health outcomes. Among a range of quality improvement strategies, CQI methods are characterised by iterative and ongoing use of specific processes to identify quality problems, develop solutions, and implement and evaluate changes. The application of CQI processes in health is evolving and evidence of their success continues to emerge. There is, however, a need to enhance understanding of how best to implement, scale-up and evaluate CQI programs for the purpose of improving quality of care and population health outcomes in different contexts. This research topic aims to attract articles that add to knowledge of useful approaches to tailoring CQI methods for different contexts or purposes, and for implementation, scale-up and evaluation of CQI interventions/programs.

Quality in Design and Execution of Engineering Practice

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Book Series: Research in Design Series ISSN: 15697258 18798233 ISBN: 9781614992516 9781614992523 Year: Pages: 118 DOI: 10.3233/978-1-61499-252-3 Language: English
Publisher: IOS Press
Subject: Business and Management
Added to DOAB on : 2013-10-11 13:10:48
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Quality in Design and Execution of Engineering Practice is about quality management focused at fitness for purpose, rather than compliance with specifications, rules and regulations. The focus on getting execution in line with fitness for purpose is supported by a classification of seven different categories of quality, defined by their relevance for purpose, compliance with specifications, and actual execution. This classification facilitates decision making on desirable exemptions from specifications in the interest of both buyer and supplier. The author offers guidelines for quality management in different types of business units: License Giver, License Taker, Jobber and Consultant. Real life examples illustrate the author’s approach, which concerns a mindset rather than a recipe for effective quality management. The book is of interest to any manager who is striving for superior quality of products and services for his customers.

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